Projects per year
Organisation profile
Organisation profile
Gastroenterology research focuses on intestinal and liver inflammation and the interaction of the gut microbiome, intestinal epithelial and liver cells and mucosal immune system.
There is also a strong interest in clinical studies addressing the pathogenesis and treatment of oesophageal and pancreatic cancer, of sclerosing cholangitis, and of intestinal failure. Studies range from disease models and in vitro interventions to clinical trials and large-scale epidemiological studies.
Gastroenterology has close links with the BBSRC-funded Quadram Institute Bioscience, the Earlham Institute and the EPIC (The European Prospective Investigation into Cancer and Nutrition) prospective study. Clinical staff have joint appointments with the Norfolk and Norwich University Hospital which facilitates patient recruitment and encourages productive interactions with gastrointestinal surgeons and other clinical teams. There are also numerous collaborative projects involving other researchers within the Medical School and more widely in UEA.
We have a solid reputation for acquisition of research grants and the training and supervision of postgraduate research students. Research from our group is published in the discipline’s top-ranking journals, and important contributions are regularly made to national and international guidelines. We cover a wide range of research areas including:
- Inflammatory bowel disease: pathogenesis and treatment (Biancheri, Brooks, Carding, Chan, Divekar, Forbes, Hart, Muller, Tremelling, Watson)
- Enteric infection: prevention and treatment (Carding, Divekar, Powell, Schuller, Tyler, Watson, Wileman)
- The aetiology and treatment of oesophageal and pancreatic cancer (Alexandre, Hart)
- Inflammation of the liver (Muller, Rushbrook)
- Intestinal epithelial cell death (Divekar, Watson)
- Microbial host interactions in the gut (Carding, Divekar, Schüller, Tyler, Watson)
- Autophagy (Powell, Wileman)
- Sclerosing cholangitis (Rushbrook)
- Intestinal failure (Forbes, Ruby)
- Dietary and life-style risk factors for gastrointestinal disease (Alexandre, Forbes, Hart, Muller)
- Surgical gastroenterology (Hernon, Stearn)
- Antibiotic resistance (Evans, Livermore
- Antibiotic discovery (Evans, McArthur, Steverding)
- Structural biology of microbial proteins (Dong).
Collaborations and top research areas from the last five years
Profiles
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Leo Alexandre
- Norwich Medical School - Consultant Clinical Associate Professor
- Metabolic Health - Member
- Norwich Epidemiology Centre - Member
- Gastroenterology and Gut Biology - Member
Person: Research Group Member, Academic, Teaching & Research
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Simon Carding
- Norwich Medical School - Research Leader
- Norwich Institute for Healthy Aging - Member
- Gastroenterology and Gut Biology - Member
Person: Research Group Member, Research Centre Member, Academic, Teaching & Research
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Simon Chan
- Norwich Medical School - Honorary Clinical Associate Professor
- Metabolic Health - Member
- Gastroenterology and Gut Biology - Member
Person: Honorary, Research Group Member, Research Centre Member
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Do LRP receptors protect against drusen formation?
Fight for Sight (British Eye Research Foundation)
1/04/25 → 31/03/26
Project: Research
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NIHR Health Protection research Unit in Gastrointestinal infections
Hunter, P., De La Iglesia, B., Deane, K., Geere, J., Hardeman, W., Lake, I., Tyler, K., Turner, D. & Varley, A.
National Institute for Health and Care Research
1/04/25 → 31/03/30
Project: Research
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Aldolase A, ein potenzielles Zielmolekül für die Krebstherapie
Steverding, D., 1 Apr 2025, In: Naturwissenschaftliche Rundschau. 78, p. 209-210 3 p.Research output: Contribution to journal › Article
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ATG16L1 WD domain and linker regulates lipid trafficking to maintain plasma membrane integrity to limit influenza virus infection
Bone, B., Griffith, L., Jefferson, M., Yamauchi, Y., Wileman, T. & Powell, P. P., 3 Apr 2025, (E-pub ahead of print) In: Autophagy.Research output: Contribution to journal › Article › peer-review
Open Access -
Composition of plant-based diets and the incidence and prognosis of inflammatory bowel disease: A multinational retrospective cohort study
Chen, J., Sun, Y., Dan, L., Wellens, J., Yuan, S., Yang, H., Tong, T. Y. N., Cross, A. J., Papadimitriou, N., Meyer, A., Dahm, C. C., Larsson, S. C., Wolk, A., Ludvigsson, J. F., Tsilidis, K., Giovannucci, E., Satsangi, J., Wang, X., Theodoratou, E., Chan, S. S. M., & 2 others , May 2025, In: The Lancet Regional Health - Europe. 52, 101264.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure)
Prizes
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Basil O’Connor Scholar Award, March of Dimes, USA (1989 - 1992)
Wileman, Tom (Recipient), 1989
Prize: Fellowship awarded competitively
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BBSRC Most Promising Innovator
McArthur, Michael (Recipient), 1 Aug 2011
Prize: Prize (including medals and awards)
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Claudia Adams Barr Innovative Cancer Research Award, USA (1988 - 1989)
Wileman, Tom (Recipient), 1988
Prize: Fellowship awarded competitively