Projects per year
Organisation profile
Organisation profile
Gastroenterology research focuses on intestinal and liver inflammation and the interaction of the gut microbiome, intestinal epithelial and liver cells and mucosal immune system.
There is also a strong interest in clinical studies addressing the pathogenesis and treatment of oesophageal and pancreatic cancer, of sclerosing cholangitis, and of intestinal failure. Studies range from disease models and in vitro interventions to clinical trials and large-scale epidemiological studies.
Gastroenterology has close links with the BBSRC-funded Quadram Institute Bioscience, the Earlham Institute and the EPIC (The European Prospective Investigation into Cancer and Nutrition) prospective study. Clinical staff have joint appointments with the Norfolk and Norwich University Hospital which facilitates patient recruitment and encourages productive interactions with gastrointestinal surgeons and other clinical teams. There are also numerous collaborative projects involving other researchers within the Medical School and more widely in UEA.
We have a solid reputation for acquisition of research grants and the training and supervision of postgraduate research students. Research from our group is published in the discipline’s top-ranking journals, and important contributions are regularly made to national and international guidelines. We cover a wide range of research areas including:
- Inflammatory bowel disease: pathogenesis and treatment (Biancheri, Brooks, Carding, Chan, Divekar, Forbes, Hart, Muller, Tremelling, Watson)
- Enteric infection: prevention and treatment (Carding, Divekar, Powell, Schuller, Tyler, Watson, Wileman)
- The aetiology and treatment of oesophageal and pancreatic cancer (Alexandre, Hart)
- Inflammation of the liver (Muller, Rushbrook)
- Intestinal epithelial cell death (Divekar, Watson)
- Microbial host interactions in the gut (Carding, Divekar, Schüller, Tyler, Watson)
- Autophagy (Powell, Wileman)
- Sclerosing cholangitis (Rushbrook)
- Intestinal failure (Forbes, Ruby)
- Dietary and life-style risk factors for gastrointestinal disease (Alexandre, Forbes, Hart, Muller)
- Surgical gastroenterology (Hernon, Stearn)
- Antibiotic resistance (Evans, Livermore
- Antibiotic discovery (Evans, McArthur, Steverding)
- Structural biology of microbial proteins (Dong).
Network
Profiles
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Leo Alexandre
- Norwich Medical School - Consultant Clinical Associate Professor
- Norwich Epidemiology Centre - Member
- Gastroenterology and Gut Biology - Member
Person: Research Group Member, Academic, Teaching & Research
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Simon Carding
- Norwich Medical School - Research Leader
- Norwich Institute for Healthy Aging - Member
- Gastroenterology and Gut Biology - Member
Person: Research Group Member, Research Centre Member, Academic, Teaching & Research
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Simon Chan
- Norwich Medical School - Honorary Clinical Associate Professor
- Gastroenterology and Gut Biology - Member
Person: Honorary, Research Group Member
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Sex, Menopause and spontaneous Alzheimer’s disease
Pontifex, M., Muller, M. & Vauzour, D.
1/10/22 → 30/09/24
Project: Research
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A single arm pilot study of Brodalumab in the treatment of Primary Sclerosing Cholangitis
Elzubeir, A., ffrench-Constant, C., Alexandre, L., Rushbrook, S., Pond, M., Shepstone, L. & Swart, A. M.
National Institute for Health and Care Research
1/10/22 → 30/09/25
Project: Fellowship
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Das Angiopoietin-ähnliche Protein 4 hemmt die Metastasenbildung
Steverding, D., 1 Jan 2023, In: Naturwissenschaftliche Rundschau. 76, p. 47-49 3 p.Research output: Contribution to journal › Article
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Draft genome sequence of a preterm infant-derived isolate of Candida parapsilosis
James, S. A., Telatin, A., Baker, D., Evans, R., Clarke, P., Hall, L. J. & Carding, S. R., 27 Feb 2023, In: Microbiology Resource Announcements. 12, 3Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation
Martínez-Sánchez, L. D. C., Ngo, P. A., Pradhan, R., Becker, L-S., Boehringer, D., Soteriou, D., Kubankova, M., Schweitzer, C., Koch, T., Thonn, V., Erkert, L., Stolzer, I., Günther, C., Becker, C., Weigmann, B., Klewer, M., Daniel, C., Amann, K., Tenzer, S., Atreya, R. & 8 others, , Feb 2023, In: Gut. 72, 2, p. 275-294 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)1 Downloads (Pure)
Prizes
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Basil O’Connor Scholar Award, March of Dimes, USA (1989 - 1992)
Wileman, Tom (Recipient), 1989
Prize: Fellowship awarded competitively
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Claudia Adams Barr Innovative Cancer Research Award, USA (1988 - 1989)
Wileman, Tom (Recipient), 1988
Prize: Fellowship awarded competitively
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Parker B. Francis Pulmonary Research Fellowship, USA (1985 - 1988)
Wileman, Tom (Recipient), 1985
Prize: Fellowship awarded competitively