Projects per year
Organisation profile
Organisation profile
We want to understand how gene regulatory pathways control animal development. There are currently more than 150 diverse chemical modifications found on RNA. RNA modifications affect gene expression by regulating RNA processing, stability and expression. We are using the C. elegans germline development as a model system to study the role of RNA modifications in germ cell proliferation and differentiation.
We aim to
- develop new methodologies to identify modified RNAs
- characterise the biological role of RNA modifying enzymes
- study the interactions between cellular metabolism and RNA modifications
Our research is currently supported by a prestigious UK Research and Innovation Future Leaders Fellowship (UKRI-FLF) awarded to Dr Alper Akay.
Collaborations and top research areas from the last five years
Profiles
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Alper Akay
- School of Biological Sciences - UKRI Future Leaders Fellow
- Cells and Tissues - Member
- RNA (epi)Genetics Lab - Group Lead
Person: Group Lead, Research Group Member, Academic, Teaching & Research
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Katarzyna Hencel
- School of Biological Sciences - Senior Research Associate
- RNA (epi)Genetics Lab - Member
Person: Member, Research & Analogous, Degree of Doctor of Philosophy
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Tim Pearson
- School of Biological Sciences - Senior Research Associate
- RNA (epi)Genetics Lab - Member
Person: Member, Research & Analogous
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A Multiwavelength Analytical Centrifuge platform for Solute Characterisation
Clarke, T., Akay, A., Butt, J., Crichton, P., Gates, A., Le Brun, N., Rowley, G., Swainsbury, D. & Hall, A.
Biotechnology and Biological Sciences Research Council
1/08/24 → 31/07/25
Project: Research
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Pre-mRNA splicing regulation in human cancers by snRNA modification Studentship
1/10/25 → 30/09/29
Project: Training
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U6 snRNA m6A modification is required for accurate and efficient splicing of C. elegans and human pre-mRNAs
Shen, A., Hencel, K., Parker, M. T., Scott, R., Skukan, R., Adesina, A. S., Metheringham, C. L., Miska, E. A., Nam, Y., Haerty, W., Simpson, G. G. & Akay, A., 27 Aug 2024, In: Nucleic Acids Research. 52, 15, p. 9139–9160 22 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)13 Downloads (Pure) -
Cryo-kinetics reveal dynamic effects on the chemistry of human dihydrofolate reductase
Adesina, A. S., Luk, L. Y. P. & Allemann, R. K., 15 Jul 2021, In: ChemBioChem. 22, 14, p. 2410-2414 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Downloads (Pure) -
Enhanced small neutral but not branched chain amino acid transport after epigenetic sodium coupled neutral amino acid transporter‐2 (SNAT2) cDNA expression in myoblasts
Pearson, T., Wendowski, O. & Powell, P. P., Jun 2021, In: Journal of Cachexia, Sarcopenia and Muscle. 12, 3, p. 811-822 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)18 Downloads (Pure)
Activities
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UEA Open Day
Alper Akay (Speaker)
2 Jul 2022Activity: Participating in or organising an event › Open day
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Jennifer Tullet
Alper Akay (Host)
22 Jun 2022Activity: Hosting a visitor › Hosting an academic visitor
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Eaton Primary School visit
Alper Akay (Speaker)
15 Mar 2022Activity: Participating in or organising an event › Schools engagement