Projects per year
We want to understand how gene regulatory pathways control animal development. There are currently more than 150 diverse chemical modifications found on RNA. RNA modifications affect gene expression by regulating RNA processing, stability and expression. We are using the C. elegans germline development as a model system to study the role of RNA modifications in germ cell proliferation and differentiation.
We aim to
- develop new methodologies to identify modified RNAs
- characterise the biological role of RNA modifying enzymes
- study the interactions between cellular metabolism and RNA modifications
Our research is currently supported by a prestigious UK Research and Innovation Future Leaders Fellowship (UKRI-FLF) awarded to Dr Alper Akay.
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- School of Biological Sciences - Senior Research Associate
- RNA (epi)Genetics Lab - Member
Person: Member, Research & Analogous
- School of Biological Sciences - UKRI Future Leaders Fellow
- Cells and Tissues - Member
- RNA (epi)Genetics Lab - Group Lead
Person: Group Lead, Research Group Member, Academic, Teaching & Research
Person: Member, Degree of Doctor of Philosophy
The function of the RNA methylome in animals
1/01/20 → 29/02/24
Gut Health and Food Safety
Wileman, T., Man, A. & Pearson, T.
Biotechnology and Biological Sciences Research Council
1/04/12 → 31/03/18
Cryo-kinetics reveal dynamic effects on the chemistry of human dihydrofolate reductaseAdesina, A. S., Luk, L. Y. P. & Allemann, R. K., 15 Jul 2021, In: ChemBioChem. 22, 14, p. 2410-2414 5 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile9 Downloads (Pure)
Enhanced small neutral but not branched chain amino acid transport after epigenetic sodium coupled neutral amino acid transporter‐2 (SNAT2) cDNA expression in myoblastsPearson, T., Wendowski, O. & Powell, P. P., Jun 2021, In: Journal of Cachexia, Sarcopenia and Muscle. 12, 3, p. 811-822 12 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Citations (Scopus)5 Downloads (Pure)
Non‐canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virusWang, Y., Sharma, P., Jefferson, M., Zhang, W., Bone, B., Kipar, A., Bitto, D., Coombes, J. L., Pearson, T., Man, A., Zhekova, A., Bao, Y., Tripp, R. A., Carding, S. R., Yamauchi, Y., Mayer, U., Powell, P. P., Stewart, J. P. & Wileman, T., 15 Mar 2021, In: The EMBO Journal. 40, 6, e105543.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile21 Citations (Scopus)27 Downloads (Pure)
UEA Open Day
Alper Akay (Speaker)2 Jul 2022
Activity: Participating in or organising an event › Open day
Alper Akay (Host)22 Jun 2022
Activity: Hosting a visitor › Hosting an academic visitor
Eaton Primary School visit
Alper Akay (Speaker)15 Mar 2022
Activity: Participating in or organising an event › Schools engagement