Organisation profile

We want to understand how gene regulatory pathways control animal development. There are currently more than 150 diverse chemical modifications found on RNA. RNA modifications affect gene expression by regulating RNA processing, stability and expression. We are using the C. elegans germline development as a model system to study the role of RNA modifications in germ cell proliferation and differentiation. 

We aim to 

- develop new methodologies to identify modified RNAs

- characterise the biological role of RNA modifying enzymes

- study the interactions between cellular metabolism and RNA modifications

Our research is currently supported by a prestigious UK Research and Innovation Future Leaders Fellowship (UKRI-FLF) awarded to Dr Alper Akay. 

Collaborations and top research areas from the last five years

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