Projects per year
Organisation profile
Organisation profile
We want to understand how gene regulatory pathways control animal development. There are currently more than 150 diverse chemical modifications found on RNA. RNA modifications affect gene expression by regulating RNA processing, stability and expression. We are using the C. elegans germline development as a model system to study the role of RNA modifications in germ cell proliferation and differentiation.
We aim to
- develop new methodologies to identify modified RNAs
- characterise the biological role of RNA modifying enzymes
- study the interactions between cellular metabolism and RNA modifications
Our research is currently supported by a prestigious UK Research and Innovation Future Leaders Fellowship (UKRI-FLF) awarded to Dr Alper Akay.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Alper Akay
- School of Biological Sciences - UKRI Future Leaders Fellow
- Cells and Tissues - Member
- RNA (epi)Genetics Lab - Group Lead
Person: Group Lead, Research Group Member, Academic, Teaching and Research
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Katarzyna Hencel
- School of Biological Sciences - Senior Research Associate
- RNA (epi)Genetics Lab - Member
Person: Member, Research and Analogous
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Tim Pearson
- School of Biological Sciences - Senior Research Associate
- RNA (epi)Genetics Lab - Member
Person: Member, Research and Analogous
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Pre-mRNA splicing regulation in human cancers by snRNA modification Studentship
1/10/25 → 30/09/29
Project: Training
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A Multiwavelength Analytical Centrifuge platform for Solute Characterisation
Clarke, T., Akay, A., Butt, J., Crichton, P., Gates, A., Le Brun, N., Rowley, G., Swainsbury, D. & Hall, A.
Biotechnology and Biological Sciences Research Council
1/08/24 → 31/07/25
Project: Research
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Optimising age-specific insulin signalling to slow down reproductive ageing increases fitness in different nutritional environments
Sultanova, Z., Shen, A., Hencel, K., Carlsson, H., Crighton, Z., Clifton, D., Akay, A. & Maklakov, A. A., May 2025, In: Aging Cell. 24, 5, e14481.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
U6 snRNA m6A modification is required for accurate and efficient splicing of C. elegans and human pre-mRNAs
Shen, A., Hencel, K., Parker, M. T., Scott, R., Skukan, R., Adesina, A. S., Metheringham, C. L., Miska, E. A., Nam, Y., Haerty, W., Simpson, G. G. & Akay, A., 27 Aug 2024, In: Nucleic Acids Research. 52, 15, p. 9139–9160 22 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)28 Downloads (Pure) -
Cryo-kinetics reveal dynamic effects on the chemistry of human dihydrofolate reductase
Adesina, A. S., Luk, L. Y. P. & Allemann, R. K., 15 Jul 2021, In: ChemBioChem. 22, 14, p. 2410-2414 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Downloads (Pure)
Activities
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UEA Open Day
Alper Akay (Speaker)
2 Jul 2022Activity: Participating in or organising an event › Open day
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Jennifer Tullet
Alper Akay (Host)
22 Jun 2022Activity: Hosting a visitor › Hosting an academic visitor
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Eaton Primary School visit
Alper Akay (Speaker)
15 Mar 2022Activity: Participating in or organising an event › Schools engagement