Projects per year
Personal profile
Biography
ResearcherID profile: http://www.researcherid.com/rid/F-6698-2011
PhD Positions
Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.
Ganesan obtained a BSc (Hons) in Chemistry at the National University of Singapore (1986). He completed his PhD in synthetic methodology and total synthesis under the supervision of Clayton Heathcock at the Department of Chemistry, University of California-Berkeley (1992) and was subsequently a postdoctoral fellow with Gregory Verdine at the Department of Chemistry at Harvard University. In 1993, he joined the Institute of Molecular and Cell Biology in Singapore as a Senior Research Chemist at the Centre for Natural Product Research and in 1996 became Principal Investigator of the Institute’s Medicinal and Combinatorial Chemistry group. In 1999 he joined the University of Southampton as a Reader in the Combinatorial Chemistry Centre for Excellence. In 2011 he became the Chair of Chemical Biology at UEA’s School of Pharmacy. He is Director of Postgraduate Research and Head of the Healthy Ageing research theme within the School.
Ganesan is co-founder of the biotech company Karus Therapeutics and Chair of the EU COST Action CM1406, 'Epigenetic Chemical Biology'. He sits on the IUPAC Subcommittee for Medicinal Chemistry and Drug Development and the Royal Society of Chemistry's Bioorganic & Medicinal Chemistry Sector committee.
Ganesan's research centres around chemical biology, medicinal chemistry and organic synthesis with an emphasis on biologically active natural products and epigenetics.
Selected publications
Davidson, S. M.; Foote, K.; Kunuthur, S.; Gosain, R.; Tan, N.; Tyser, R.; Zhao, Y. J.; Graeff, R.; Ganesan, A.; Duchen, M. R.; Patel, S.; Yellon, D. M.
Cardiovasc. Res. 2015, 108, 357–366.
DOI: 10.1093/cvr/cvv226
Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase
Tortorici, M.; Borrello, M. T.; Tardugno, M.; Chiarelli, L. R.; Pilotto, S.; Ciossani, G.; Vellore, N. A.; Bailey, S. G.; Cowan, J.; O’Connell, M.; Crabb, S. J.; Packham, G.; Mai, A.; Baron, R.; Ganesan, A.; Mattevi, A.
ACS Chem. Biol. 2013, 8, 1677–1682.
DOI: 10.1021//cb4001926
Total Synthesis and Stereochemical Assignment of Burkholdac B, a Depsipeptide HDAC Inhibitor
Benelkebir, H.; Donlevy, A. M.; Packham, G.; Ganesan, A.
Org. Lett. 2011, 13, 6334–6337.
DOI: 10.1021/ol202197q
Determination of Molecular Torsion Angles Using Nuclear Singlet Relaxation
Tayler, M. C. D.; Marie, S.; Ganesan, A.; Levitt, M. H.
J. Am. Chem. Soc. 2010, 132, 8225–8227.
DOI: 10.1021/ja1012917
Identification of a Chemical Probe for NAADP by Virtual Screening
Naylor, E.; Arredouani, A.; Vasudevan, S. R.; Lewis, A. M.; Parkesh, R.; Mizote, A.; Rosen, D.; Thomas, J. M.; Izumi, M.; Ganesan, A.; Galione, A.; Churchill, G. C.
Nat. Chem. Biol. 2009, 5, 220-226.
DOI: 10.1038/nchembio.150
Key Research Interests
Histone Methylation Inhibitors
G. Packham (U. Southampton) and A. Ganesan
2007-2011
£91,000
BBSRC
NAADP Receptor Antagonists
A. Gansan
2009-2012
£351,000
Areas of Expertise
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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Discovery of novel secondary metabolites from marine organisms
Royal Embassy of Saudi Arabia Cultural Bureau, London
1/10/23 → 30/09/24
Project: Training
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Antibiotic producing microbes from the marine and endophytic environment
Royal Embassy of Saudi Arabia Cultural Bureau, London
1/06/22 → 31/05/24
Project: Training
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Phytochemical and Antimicrobial Studies on Antibacterial Plants
Royal Embassy of Saudi Arabia Cultural Bureau, London
1/10/21 → 30/09/24
Project: Training
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Developing an Innovative Trans-National Education Approach to the Teaching of Natural Products Chemistry (Phase II).
Matthews, S., Ganesan, A., Mcdermott, P. & Waller, Z.
1/06/19 → 30/04/24
Project: Other
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Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase
Tortorici, M., Borrello, M. T., Tardugno, M., Chiarelli, L. R., Pilotto, S., Ciossani, G., Vellore, N. A., Bailey, S. G., Cowan, J., O'Connell, M., Crabb, S. J., Packham, G., Mai, A., Baron, R., Ganesan, A. & Mattevi, A., 16 Aug 2013, In: ACS Chemical Biology. 8, 8, p. 1677-1682 6 p.Research output: Contribution to journal › Article › peer-review
56 Citations (Scopus) -
Synthesis of N-Acyl-N,O-acetals Mediated by Titanium Ethoxide
Li, M., Luo, B., Liu, Q., Hu, Y., Ganesan, A., Huang, P. & Wen, S., 3 Jan 2014, In: Organic Letters. 16, 1, p. 10-13 4 p.Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus) -
Intra- and intermolecular alkylation of N,O-acetals and π-activated alcohols catalyzed by in situ generated acid
Hamon, M., Dickinson, N., Devineau, A., Bolien, D., Tranchant, M-J., Taillier, C., Jabin, I., Harrowven, D. C., Whitby, R. J., Ganesan, A. & Dalla, V., 7 Mar 2014, In: Journal of Organic Chemistry. 79, 5, p. 1900-1912 13 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
Euglenatides, potent antiproliferative cyclic peptides isolated from the freshwater photosynthetic microalga Euglena gracilis
Ganesan, A., Aldholmi, M., Ahmad, R., Carretero-Molina, D., Pérez-Victoria, I., Martín, J., Reyes, F., Genilloud, O., Gourbeyre, L., Gefflaut, T., Carlsson, H., Maklakov, A., Field, R. A., O'Neill, E., Wilkinson, B. & O'Connell, M., 7 Jun 2022, In: Angewandte Chemie International Edition. 61, 23, e202203175.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)6 Downloads (Pure) -
From hit seeking to magic bullets: The successful union of epigenetic and fragment based drug discovery (EPIDD + FBDD)
Vaidergorn, M. M., da Silva Emery, F. & Ganesan, A., 14 Oct 2021, In: Journal of Medicinal Chemistry. 64, 19, p. 13980-14010 31 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus)
Activities
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EU COST Action 'Epigenetics: Bench to Bedside' (External organisation)
A. Ganesan (Chair)
2010 → …Activity: Membership › Network, Working Group or Professional Association
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Organic Division Executive, Royal Society of Chemistry (External organisation)
A. Ganesan (Member)
2007 → 2011Activity: Membership › Committee
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IUPAC Subcommitee for Medicinal Chemistry and Drug Development (External organisation)
A. Ganesan (Member)
2006 → …Activity: Membership › Committee
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High-throughput Chemistry and New Technologies Subject Group, Royal Society of Chemistry (External organisation)
A. Ganesan (Treasurer)
2006 → …Activity: Membership › Committee
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Tokyo Institute of Technology
A. Ganesan (Visiting professor)
2004 → …Activity: Visiting an external institution › Visiting Appointment