Adel Ersek

Adel Ersek

Dr

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Personal profile

Biography

Adel Ersek completed her Ph.D. (2008) in Cell and Molecular Biology at University of Nevada Reno, studying the haematopoietic support capacity of human mesenchymal stem cells and their cross lineage differentiation ability in the Experimental Hematology Lab of Professor Esmail D. Zanjani.  During her postgraduate years, she was also involved in researching haemoglobin switching influenced by hypoxia and stem cell source.  

As a postdoctoral research associate at Imperial Collage London, she has investigated the role of osteoclasts in the maintenance of the haematopoietic stem cells pool. Her aim was to understand how alterations of the bone component of the haematopoietic stem cells niche influence normal and malignant haematopoietic stem cells engraftment, survival and carcinogenesis. 

At The Kennedy Institute of Rheumatology, University of Oxford, she has successfully tested glycosphingolipid synthesis inhibitors capacity to modify the haematopoietic stem cell niche and ameliorate multiple myeloma bone disease in pre-clinical models. She has also investigated alterations of haematopoietic stem cell niche in glucocorticoid-induced osteoporosis and the role of the innate immune system in normal and osteoporotic bone fracture healing.  

In 2019 she has joined the UEA Medical School and currently working to unravel the cellular and molecular mechanisms that impact the onset, development and resolution of chronic inflammatory diseases, in particularly Ankylosing Spondylitis, where inflammation induced bone loss and inflammation driven inappropriate new bone formation occur. 

Expertise related to UN Sustainable Devlopment Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being