Projects per year
- Consultant Rheumatologist
|1995-2003: Arthritis Research Campaign Senior Fellow/ Senior Lecturer Kings College London; Honorary Consultant Rheumatologist Guy's and St Thomas’ Hospital Trust;
2003-Present: Professor of Chronic Disease and Genetic Epidemiology, Norwich Medical School, University of East Anglia; Honorary Consultant Rheumatologist, Norfolk and Norwich University Trust
Director the University of East Anglia’s Norwich Epidemiology Centre
Key Research Interests
Research focus: identifying the predictors of onset and outcome of common chronic diseases, translating insights into strategies for prevention and improved patient care.
Key projects as PI:
This is the largest longstanding inception cohort of patients with rheumatoid arthritis globally (5,500 patients; 20 years follow up). The register provides a definitive data source on inflammatory arthritis occurrence and has been referenced by NICE, NHSE and HQIP. NOAR data is available for sharing with the research community.
Investigation of inflammation and the risk of multimorbidity through artificial intelligence in 'big data'
Inflammatory drivers of long-term comorbidity trajectories: an AI investigation of mulitimorbidity (inflAIM)
NIHR Development Award 2020
Inflammation, nutrition, and the evolution of multiple long term conditions – an AI-based analysis of intersectionality in longitudinal health data (the InflAIM programme)
NIHR Programme Grant for Applied Research 2023
The programme centres on the investigation of chronic inflammation as a key biological driver underlying many chronic health conditions. Modifying the exposure to chronic inflammation offers a direct path to MLTC prevention. Chronic inflammation may also bridge the gap between nutrition and multiple long term conditions (MLTC), and explain social disparities. The programme will produce the tools, data, analytics and targeted interventions needed to improve the lives of people at risk of MLTC. Collaboration between UEA, Norfolk and Waveney ICB, London School of Hygiene and Tropical Medicine, the Universities of Southampton, Exeter, Chester and Hertfordshire, and Evergreen Life.
Studies of nutritional bioactives and arthritis
Dietary Intervention trial to examine the protective effect of broccoli bioactives (specifically sulforaphane) on osteoarthriti
Versus Arthritis Funded
Identifying the dietary signatures of arthritis through metabolomics
Versus Arthritis Funded 2023
Outcomes of Ankle Joint Replacement
Prospective study of patient reported outcomes in ankle joint replacement
Versus Arthritis Funded
Dynamic risk modelling
Prospective study and nested analysis
Pragmatic randomised trial
NIHR funded trial,
2018-21: Senior Adviser for NHS Improvement’s Getting it Right First Time (GIRFT) programme in Rheumatology
2023: Report on the provision of clinical services for Fibromyalgia in Norfolk
- Data Science and Statistics
- Public Health, Health Services & Primary Care
Collaborations and top research areas from the last five years
Dive into details
Select a country/territory to view shared publications and projects
1/06/23 → 31/05/24
1/06/22 → 31/12/23
1/04/19 → 31/03/24
Cognitive impairment in the immune-mediated inflammatory diseases compared with age-matched controls: systematic review and meta-regressionGwinnutt, J. M., Toyoda, T., Barraclough, M., Verstappen, S. M. M., Hornberger, M. & Macgregor, A., Feb 2023, In: Seminars in Arthritis and Rheumatism. 58, 152131.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)
Identifying axial spondyloarthritis in patients with inflammatory bowel disease using computed tomographyLim, C. S. E., Hamilton, L., Low, S. B. L., Toms, A., Macgregor, A. & Gaffney, K., 1 Jul 2023, In: Journal of Rheumatology. 50, 7, p. 895-900 6 p., jrheum.220362.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)4 Downloads (Pure)
Influence of social support, financial status, and lifestyle on the disparity between inflammation and disability in rheumatoid arthritisGwinnutt, J. M., Norton, S., Hyrich, K. L., Lunt, M., Combe, B., Rincheval, N., Ruyssen-Witrand, A., Fautrel, B., McWilliams, D. F., Walsh, D. A., Nikiphorou, E., Kiely, P. D. W., Young, A., Chipping, J. R., MacGregor, A. & Verstappen, S. M. M., May 2023, In: Arthritis Care & Research. 75, 5, p. 1026-1035 10 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile5 Citations (Scopus)1 Downloads (Pure)
Multimorbidity pattern and risk of dementia in later life: an 11-year follow-up study using a large community cohort and linked electronic health recordsKhondoker, M., Macgregor, A., Bachmann, M. O., Hornberger, M., Fox, C. & Shepstone, L., May 2023, In: Journal of Epidemiology and Community Health. 77, 5, p. 285-292 8 p., jech-2022-220034.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile4 Citations (Scopus)13 Downloads (Pure)
Outcomes in Ankle Replacement Study (OARS): Radiological and patient-reported outcomes in the first 12 months after ankle arthroplastySmith, T. O., Dainty, J., Loveday, D. T., Toms, A., Goldberg, A. J., Watts, L., Pennington, M. W., Dawson, J., van der Meulen, J. & MacGregor, A. J., 1 Aug 2023, In: The Bone & Joint Journal. 105-B, 8, p. 895-904 10 p.
Research output: Contribution to journal › Article › peer-review1 Citation (Scopus)