Projects per year
Personal profile
Areas of Expertise
Neurodegeneration, Brain Health, Dementia, Sleep, Pathological Ageing
Biography
Dr Lazar is an associate professor and principal investigator in the School of Health Sciences with a strong research interest in the significance of human sleep and circadian rhythmicity in brain health. With more than 15 years of experience in sleep research Alpar has studied sleep and cognition in children and adults presenting normal and pathological development and ageing. Following his PhD studies at Semmelweis University Budapest where he investigated the sleep physiological correlates of Asperger syndrome, he soon joined the Surrey Sleep Research Centre, UK where he studied the genetics of sleep-wake regulation and chronotype. His work has contributed to a better understanding of the impact of sleep-wake homeostasis and circadian rhythmicity on brain activity and cognition. As he gradually became interested in ageing and neurodegeneration Alpar joined the University of Cambridge where he investigated the role of early sleep disturbances in Huntington’s disease (HD), an autosomal dominant neurodegenerative disorder, and showed that sleep is one of the earliest homeostatic processes to go wrong in HD. Alpar joined UEA by the end of 2016 and spearheaded the launch of the Sleep and Brain Research Unit. He has been awarded a Wellcome trust Seed Award in Science to study the impact of genetic risk factors for developing Alzheimer’s disease on sleep-wake regulation and cognition. Alpar also holds a UEA innovation development grant, a UKRI-Zinc Healthy Ageing Catalyst Award and leads on the Sleep and Brain Health Research programme at UEA.
Key Responsibilities
Head of Sleep and Brain Research Unit (SBRU)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Semmelweis University
Award Date: 30 Jun 2010
Keywords
- Neuroscience, Biological Psychiatry & Neuropsychiatry
- sleep
- dementia
- Psychology
- cognition
- Anatomy & Physiology
- circadian
- genetic variants
Media Expertise
- Neuroscience
- Sleep
- Healthy Ageing
- Dementia
Network
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The clinical, social and cost effectiveness of a decision support tool to optimise community-based tailored management of sleep (TIMES) for people living with dementia or mild cognitive impairment and sleep disturbance
Killett, A., Broomfield, N., Khondoker, M., Lazar, A., Loke, Y. & Shepstone, L.
National Institute for Health and Care Research
1/02/22 → 31/01/27
Project: Research
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Investigating a common developmental origin for sensory issues and disturbed sleep, in Autism
6/10/19 → 6/04/23
Project: Research
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Circadian/diurnal rhythm profiles of serum and salivary melatonin, cortisol and cortisone, determined by liquid chromatography tandem mass spectrometry (LC-MS/MS)
Webb, B., Dunn, R., Ball, N., Fraser, W., Lazar, A., Michalak, A., Voysey, Z. & Tang, J. C. Y., 14 Nov 2022, p. P93.Research output: Contribution to conference › Abstract › peer-review
Open Access -
Contrasting effects of sleep restriction, total sleep deprivation, and sleep timing on positive and negative affect
Groeger, J. A., Lo, J. C-Y., Santhi, N., Lazar, A. S. & Dijk, D-J., 17 Aug 2022, In: Frontiers in Behavioral Neuroscience. 16, 911994.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)11 Downloads (Pure) -
Early sleep and circadian markers of alzheimer's disease: the impact of apoe- epsilon 4 on sleep-wake regulation, brain activity and cognition in humans
Lazar, A. S., Michalak, A., Shabana, Z., Mann, A., Vite, T. G., Conway, T., Grove, V., Tsigarides, J., Gill, N., Tang, J., Mioshi, E., Wagner, A., Renoult, L., Lazar, Z. I., Clark, I., Minihane, A. -M. & Hornberger, M., Oct 2022, In: Journal of Sleep Research. 31, S1, e13739.Research output: Contribution to journal › Abstract
Open Access -
Frequency Characteristics of Sleep
Lázár, A. S., Lázár, Z. I. & Bódizs, R., 11 Aug 2022, The Oxford Handbook of EEG Frequency. Gable, P., Miller, M. & Bernat, E. (eds.). Oxford University Press, (Oxford Library of Psychology).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Reported sleep duration reveals segmentation of the adult life-course into three phases
Coutrot, A., Lazar, A. S., Richards, M., Manley, E., Wiener, J. M., Dalton, R. C., Hornberger, M. & Spiers, H. J., 13 Dec 2022, In: Nature Communications. 13, 7697.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)3 Downloads (Pure)
Press/Media
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People sleep least in their early 30s to early 50s: Research (Jan 23)
Michael Hornberger & Alpar Lazar
1/01/23 → 3/01/23
8 items of Media coverage
Press/Media: Press / Media
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People sleep least in their early 30s to early 50s: Research (Dec 22)
Michael Hornberger & Alpar Lazar
22/12/22 → 31/12/22
66 items of Media coverage
Press/Media: Press / Media
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UEA launches new project for World Sleep Day
18/03/22
1 item of Media coverage
Press/Media: UEA Press Release
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Does insomnia raise your risk of Alzheimer's? Scientists have feared for years that lack of sleep can be linked to dementia, now a ground-breaking experiment could uncover the truth
20/04/19
1 item of Media coverage
Press/Media: Press / Media
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Introducing the launch of the sleep disturbances and dementia research unit
5/04/19
1 item of Media coverage
Press/Media: Press / Media