Projects per year
Andrew studied for his B.Sc.(Adv.) at the Australian National University and received a First Class Honours degree in 2009. He began his Ph.D. in 2010 with Assoc. Prof. Russell Barrow at the Research School of Chemistry as an Alan Sargeson Scholar, focusing on the synthesis of biologically active natural products from fungi used by tribes from Papua New Guinea. In 2014, he won an Endeavour Research Fellowship to train with Assoc. Prof. Gregory Dake at the University of British Columbia, Department of Chemistry, Vancouver, Canada. Whilst at UBC Andrew designed new organometallic controlled reactions to prepare natural products.
In 2015, Andrew moved to the University of East Anglia, School of Pharmacy to work with Dr Lesley Howell, examining the protein-protein interaction of Mcl-1 and NOXA, proteins which regulate apoptosis and are commonly exploited by cancers. In 2016, Andrew began working with Prof. Mark Searcey, on common fruit metabolites as anti-inflammatory agents, and the targeting of small molecules to DNA trinucleotide repeat disorders.
Andrew took up a position as an Independent Research Fellow in the School of Pharmacy in February 2017, and as a Lecturer in Medicinal Chemistry in April 2019. His research interests include developing new methods to target protein-protein interactions, finding new pharmaceutical leads and chemical probes for protein-protein interactions, and designing new molecular recognition structures for delivery of cytotoxic warheads.
1/09/21 → 31/08/23
Insights into the structure-activity relationship of glycosides as positive allosteric modulators acting on P2X7 receptorsPiyasirananda, W., Beekman, A., Ganesan, A., Bidula, S. & Stokes, L., 1 Feb 2021, In : Molecular Pharmacology. 99, 2, p. 163-174 12 p.
Research output: Contribution to journal › ArticleOpen AccessFile1 Citation (Scopus)12 Downloads (Pure)
In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discoveryHowell, L. A. & Beekman, A. M., 1 Feb 2021, In : RSC Chemical Biology. 2, 1, p. 215-219 5 p.
Research output: Contribution to journal › ArticleOpen AccessFile27 Downloads (Pure)
Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancersGoddard, Z. R., Beekman, A. M., Cominetti, M. M. D., O'Connell, M. A., Chambrier, I., Cook, M. J., Marin, M. J., Russell, D. A. & Searcey, M., 1 Feb 2021, In : RSC Medicinal Chemistry. 12, 2, p. 288-292 5 p.
Research output: Contribution to journal › ArticleOpen AccessFile1 Citation (Scopus)13 Downloads (Pure)
A peptide-duocarmycin conjugate targeting the Thomsen-Friedenreich antigen has potent and selective antitumour activityCartwright, O. C., Beekman, A. M., Cominetti, M. M. D., Russell, D. A. & Searcey, M., 15 Jul 2020, In : Bioconjugate Chemistry. 31, 7, p. 1745–1749 5 p.
Research output: Contribution to journal › ArticleOpen AccessFile4 Citations (Scopus)1 Downloads (Pure)
Beekman, A., Cominetti, M., Cartwright, O., Boger, D. L. & Searcey, M., Dec 2019, In : MedChemComm. 10, 12, p. 2170-2174 5 p.
Research output: Contribution to journal › ArticleOpen AccessFile9 Downloads (Pure)