Projects per year
- Course Director C700 BSc Biochemistry
- Course Director C701 MSci Biochemistry
- Examination Board, School of Biological Sciences (member)
- Professor of Structural Biology, University of East Anglia
- Reader in Chemistry, University of East Anglia
- Senior Lecturer, University of East Anglia
- Lecturer, University of East Anglia
- STA Research Fellow, Tsukuba, Japan
- Lecturer, Birkbeck College, London
- Cray Research Fellow, Birkbeck College, London
- Royal Society Research Fellow, Beijing, China
- Ph.D. University of London
- B.Sc. Chemistry, University College London
Key Research Interests
I am interested in the structural basis for the molecular interactions which underpin biological processes. My group employs techniques in structural, molecular and computational biology to study fundamental problems in mechanistic enzymology and molecular recognition. I am particularly interested in the question of bacterial survival (life – respiration and uptake of nutrients, particularly metals; and death – production of cytotoxic proteins). The aim of this research is to provide insights into how the structures of bacterial proteins and their complexes with ligands and substrates (e.g. RNA/DNA, metal ions and sugars) determine the likelihood of survival of the bacterium. The group forms part of the UEA Centre for Molecular and Structural Biochemistry (CMSB) and has particular expertise in studies of metal and cofactor-rich proteins.
Current Research Projects
- Interactions of commensal bacteria with the gut
- Structural biology of plant biosynthetic enzymes
- Phytase structural enzymology and engineering
Life in our research group
We are based on the second floor of the School of Biological Sciences and form a part of the larger grouping of biological chemists and biochemists working within the Centre for Molecular and Structural Biochemistry. The research environment is excellent and we have access to a wide range of facilities either within the School, nearby in the University or elsewhere on the Norwich Research Park. We collect X-ray scattering and diffraction data at synchrotrons in the UK and elsewhere in Europe and beyond on a regular basis. We also collaborate widely and our work is multidisciplinary. This means that we have a wide range of literature to screen and we keep up to date with scientific developments by attending research seminars and international meetings.
Click here for current PhD opportunities in the School of Biological Sciences.
Click here for current PhD opportunities in the School of Chemistry.
But feel free to email me to discuss PhD, MPhil and MRes opportunities and and alternative sources of funding.
Areas of Expertise
Stuctural biology; X-ray crystallography; Macromolecular simulation and modelling.
- Molecular Enzymology in Biology & Medicine (BIO-6001A) [Organiser]
- Biochemistry Advanced Laboratory (BIO-6029Y) [Organizer]
- Protein Structure, Chemistry & Engineering (CHE-6601B)
- Research Skills in Biochemistry (CHE-4602Y)
Doctor of Philosophy, Birkbeck University of London
1982 → 1987
Award Date: 30 Jun 1987
Bachelor of Science, University College London
1979 → 1982
Award Date: 30 Jun 1982
Dive into details
Select a country/territory to view shared publications and projects
Thermophilic Xylanases for the Sustainable Production of Nutraceuticals from Fruit Waste
2/11/22 → 29/02/24
Structural studies of novel ubiquitin ligase inhibitors to develop their therapeutic potential
1/08/19 → 25/09/19
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier AtITPK4Whitfield, H. L., He, S., Gu, Y., Sprigg, C., Kuo, H-F., Chiou, T-J., Riley, A. M., Potter, B. V. L., Hemmings, A. M. & Brearley, C. A., Mar 2023, In: Biochemical Journal. 480, 6, p. 433–453 21 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Characterisation of a soil MINPP phytase with remarkable long-term stability and activity from Acinetobacter sp.Rix, G. D., Sprigg, C., Whitfield, H., Hemmings, A. M., Todd, J. D. & Brearley, C. A., 31 Aug 2022, In: PLoS One. 17, 8, e0272015.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Citations (Scopus)4 Downloads (Pure)
Insights to the structural basis for the stereospecificity of the Escherichia coli phytase, AppAAcquistapace, I., Thompson, E., Kuhn, I., Bedford, M., Brearley, C. & Hemmings, A., 6 Jun 2022, In: International Journal of Molecular Sciences. 23, 11, 6346.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)3 Downloads (Pure)
Structure of a cereal purple acid phytase provides new insights to phytate degradation in plantsFaba-Rodriguez, R., Gu, Y., Salmon, M., Dionisio, G., Brinch-Pedersen, H. A., Brearley, C. A. & Hemmings, A. M., 14 Mar 2022, In: Plant Communications. 3, 2, 100305.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Citations (Scopus)7 Downloads (Pure)
Allosteric site on SHIP2 identified through fluorescent ligand screening and crystallography: a potential new target for interventionWhitfield, H., Hemmings, A. M., Mills, S. J., Baker, K., White, G., Rushworth, S., Riley, A. M., Potter, B. V. L. & Brearley, C. A., 8 Apr 2021, In: Journal of Medicinal Chemistry. 64, 7, p. 3813–3826 14 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Citations (Scopus)18 Downloads (Pure)