Projects per year
Personal profile
Administrative Posts
- Course Director C700 BSc Biochemistry
- Course Director C701 MSci Biochemistry
- Examination Board, School of Biological Sciences (member)
Career
- Professor of Structural Biology, University of East Anglia
- Reader in Chemistry, University of East Anglia
- Senior Lecturer, University of East Anglia
- Lecturer, University of East Anglia
- STA Research Fellow, Tsukuba, Japan
- Lecturer, Birkbeck College, London
- Cray Research Fellow, Birkbeck College, London
- Royal Society Research Fellow, Beijing, China
- Ph.D. University of London
- B.Sc. Chemistry, University College London
Key Research Interests
I am interested in the structural basis for the molecular interactions which underpin biological processes. My group employs techniques in structural, molecular and computational biology to study fundamental problems in mechanistic enzymology and molecular recognition. I am particularly interested in the question of bacterial survival (life – respiration and uptake of nutrients, particularly metals; and death – production of cytotoxic proteins). The aim of this research is to provide insights into how the structures of bacterial proteins and their complexes with ligands and substrates (e.g. RNA/DNA, metal ions and sugars) determine the likelihood of survival of the bacterium. The group forms part of the UEA Centre for Molecular and Structural Biochemistry (CMSB) and has particular expertise in studies of metal and cofactor-rich proteins.
Current Research Projects
- Interactions of commensal bacteria with the gut
- Structural biology of plant biosynthetic enzymes
- Phytase structural enzymology and engineering
Life in our research group
We are based on the second floor of the School of Biological Sciences and form a part of the larger grouping of biological chemists and biochemists working within the Centre for Molecular and Structural Biochemistry. The research environment is excellent and we have access to a wide range of facilities either within the School, nearby in the University or elsewhere on the Norwich Research Park. We collect X-ray scattering and diffraction data at synchrotrons in the UK and elsewhere in Europe and beyond on a regular basis. We also collaborate widely and our work is multidisciplinary. This means that we have a wide range of literature to screen and we keep up to date with scientific developments by attending research seminars and international meetings.
Research Studentships
Click here for current PhD opportunities in the School of Biological Sciences.
Click here for current PhD opportunities in the School of Chemistry.
But feel free to email me to discuss PhD, MPhil and MRes opportunities and and alternative sources of funding.
Areas of Expertise
Stuctural biology; X-ray crystallography; Macromolecular simulation and modelling.
Teaching Interests
- Molecular Enzymology in Biology & Medicine (BIO-6001A) [Organiser]
- Biochemistry Advanced Laboratory (BIO-6029Y) [Organizer]
- Protein Structure, Chemistry & Engineering (CHE-6601B)
- Research Skills in Biochemistry (CHE-4602Y)
Education/Academic qualification
Doctor of Philosophy, Towards the Rational Design of Inhibitors of Human Renin, Birkbeck University of London
1982 → 1987
Award Date: 30 Jun 1987
Bachelor of Science, Chemistry, University College London
1979 → 1982
Award Date: 30 Jun 1982
Collaborations and top research areas from the last five years
Projects
- 17 Finished
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Thermophilic Xylanases for the Sustainable Production of Nutraceuticals from Fruit Waste
2/11/22 → 29/02/24
Project: Research
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Synthesis and evaluation of X-ray structure inspired ubiquitin ligase inhibitors as anticancer lead compounds
Hemmings, A., Angulo, J., Chantry, A., Hemmings, A., Stephenson, G. R. & Storr, T.
1/10/20 → 31/03/25
Project: Research
-
Structural studies of novel ubiquitin ligase inhibitors to develop their therapeutic potential
1/08/19 → 25/09/19
Project: Research
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3,3′-Diindolylmethane (DIM): A molecular scaffold for inhibition of WWP1 and WWP2, members of the NEDD4 family HECT E3 ligases
Dudey, A. P., Hughes, G. R., Rigby, J. M., Monaco, S., Stephenson, G. R., Storr, T. E., Angulo, J., Chantry, A. & Hemmings, A. M., 18 Feb 2025, In: ACS Omega. 10, 6, p. 5963–5972 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)4 Downloads (Pure) -
Metalloid transporters in plants: Bridging the gap in molecular structure and physiological exaptation
Sharma, Y., Hemmings, A. M., Deshmukh, R. & Pareek, A., 13 Mar 2025, In: Journal of Experimental Botany. 76, 5, p. 1370-1389 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)8 Downloads (Pure) -
Observation of the assembly of the nascent mineral core at the nucleation site of human mitochondrial ferritin
Bradley, J. M., Bugg, Z., Moore, G. R., Hemmings, A. M. & Le Brun, N. E., 23 Apr 2025, In: Journal of the American Chemical Society. 147, 16, p. 13699–13710 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
An improved synthesis of 2,3-diamino-5,6-dichloropyrazine: A useful heterocyclic scaffold
Rigby, J. M., Chantry, A., Hemmings, A. M., Richards, C. J., Stephenson, G. R. & Storr, T. E., Dec 2024, In: Synthesis. 56, 23, p. 3587-3592 6 p.Research output: Contribution to journal › Article › peer-review
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Crystal structure and enzymology of Solanum tuberosum inositol tris/tetrakisphosphate kinase 1 (StITPK1)
Whitfield, H. L., Faba Rodriguez, R., Shipton, M. L., Li, A. W. H., Riley, A. M., Potter, B. V. L., Hemmings, A. M. & Brearley, C. A., 2 Jan 2024, In: Biochemistry. 63, 1, p. 42-52 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Downloads (Pure)
Prizes
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Fellow of the Higher Education Academy
Hemmings, Andrew (Recipient), 13 Dec 2019
Prize: Other distinction
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Fellow of the Royal Society of Chemistry
Hemmings, Andrew (Recipient), 1 Nov 2019
Prize: Other distinction