Projects per year
Professor of Nutrigenetics, Head of Nutrition and Preventive Medicine in Norwich Medical School, Director of Norfolk Institute of Healthy Ageing (NIHA)
Our research investigates the impact of select dietary components (in particular n-3 fatty acids) and a Mediterranean-style dietary pattern on cardio-metabolic and cognitive health. We also investigate nutrient-genotype interactions with a focus on the APOE genotype, establishing the aetiology of genotype-health associations and dietary strategies to mitigate the effects of the ‘at-risk’ APOE4 allele.
Having completed my first degree in Nutrition and Biochemistry at University College Cork (Ireland), I moved to the UK to complete my PhD. I have been based here ever since, apart from a one-year stay at Auckland Medical School (NZ).
I enjoy the outdoors and in particular running, good food and wandering around supermarkets, social and historical fiction, and travel and its planning.
British Nutrition Society
American Society of Nutrition
International Society for the Study of Fatty Acids and Lipids (ISSFAL)
Nutrigenomics Organisation (NuGO)
Deputy Editor or equivalent of the British Journal of Nutrition (BJN) and the Journal of Nutritional Sciences (JNS), Frontiers in Nutrition, and Editorial Advisory Board member for the Nutrition Bulletin,
Academic Expert and Scientific Advisory Committee member of ILSI Europe,
Federation of European Nutrition Societies (FENS), External Communication and Public Trust Panel, UK representative
Joint National Co-ordinator and Gene Variant Group (GVG) lead for COST- POSITIVe: Inter-individual variation in response to consumption of plant food bioactives and determinants involved, an EU Framework Programme supported by Horizon 2020,
Member of HEFCE, UoA6, REF assessment panel 2010-present
Key Research Interests and Expertise
I am Head of the NUTRIGENETICS group within the Department of Nutrition and Preventive Medicine, with our key research interests being:
- n-3 fatty acids and cardio-metabolic health, with a focus on plasma lipids, and vascular and hepatic function,
- Cognition and Alzheimer’s disease,
- Aetiology of APOE4 genotype-chronic disease associations,
- Determinants of flavonoid metabolism.
A large proportion of our research involves human intervention trials (RCTs). In addition, we employ a variety of wild-type and transgenic rodent models and cell and molecular techniques to investigate underlying mechanisms, and to inform the foci of our RCTs.
Examples of ongoing RCTs include:
- Apple Tree (ESRC-NIHR funded, 2019-2024): Active Prevention in People at Risk of Dementia through Lifestyle, Behaviour change and Technology to build resilience, 20+ research partners
NuBrain (BBSRC-MRC-NIHR funded (UK NRP), 2019-2022: UK Consortium for Optimal Nutrition for Healthy Brain Ageing, Newcastle, Norwich, Edinburgh, Manchester.
MedEx (Alzheimer’s Research UK-MRC funded, 2018-2021): Diet, physical activity and dementia risk in UK adults: Epidemiology and MedEx feasibility study, Norwich, Newcastle, Birmingham and Aberdeen.
CANN (Centre of Nutrition Memory and Learning, CNLM, University of Illinois funded, 2015-2020): A Randomised Controlled Trial in ‘At Risk’ Humans investigating the Cognitive Benefits of Combined Flavonoid/Fatty Acid and Underlying Mechanisms of Action: The Cognitive Aging Nutrition and Neurogenesis (CANN) trial (n=240), Norwich, Melbourne, Illinois
Prof Neal Cohen, Dr Ryan Larsen: University of Illinois, US
Prof Andrew Scholey, Prof Andrew Pipingas: Swinburne University, Melbourne, Australia
Prof Trevor Mori, University of Western Australia, Perth, Australia
Prof Dr Matthias Schulze, DIFE, Potsdam, Germany
Prof Jose Lopez Miranda, University of Cordoba, Spain
Prof Miguel Martinez Gonzalez, Dr Cristina Razquin Burillo, Universidad de Navarra, Spain
Prof Marienne Geleijnse, Wageningen University, The Netherlands
Prof Julie Lovegrove, Dr Kim Jackson, University of Reading, UK
Prof John Mathers, Newcastle University, UK
Dr Sarah Aldred, University of Birmingham, UK
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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The efficacy of n-3 polyunsaturated fatty acids in people with aspirin exacerbated airways disease and uncontrolled asthma
1/04/21 → 31/03/24
1/09/19 → 31/08/22
The APPLE TREE programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce
Cooper, C., Minihane, A., Brodaty, H., Kales, H., Lang, I., Ritchie, K. & Rodda, J.
1/01/19 → 31/12/23
1/04/13 → 31/07/22
APOE4 genotype exacerbates the impact of menopause on cognition and synaptic plasticity in APOE‐TR micePontifex, M. G., Martinsen, A., Saleh, R. N. M., Harden, G., Tejera, N., Müller, M., Fox, C., Vauzour, D. & Minihane, AM., May 2021, In: The FASEB Journal. 35, 5, e21583.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)19 Downloads (Pure)
APOE genotype modifies the plasma oxylipin response to omega-3 polyunsaturated fatty acid supplementation in healthy individualsSaleh, R., West, A., Ostermann, A., Schebb, N. H., Calder, P. & Minihane, A-M., 17 Sep 2021, In: Frontiers in Nutrition. 8, 15 p., 723813.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Citations (Scopus)4 Downloads (Pure)
Coughlan, G., Lim, M., Larsen, R., White, D., Gillings, R., Irvine, M., Scholey, A., Cohen, N., Legido Quigley, C., Hornberger, M. & Minihane, A-M., 2021, In: Brain Communications. 3, 2, fcab085.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile14 Downloads (Pure)
Effects of a Mediterranean diet on blood pressure: A systematic review and meta-analysis of randomised controlled trials and observational studiesCowell, O., Mistry, N., Deighton, K., Matu, J., Griffiths, A., Minihane, A-M., Mathers, J., Shannon, O. & Servo, M., 1 Apr 2021, In: Journal of Hypertension. 39, 4, p. 729-739 11 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile10 Citations (Scopus)1 Downloads (Pure)
Feasibility and acceptability of a multi-domain intervention to increase Mediterranean diet adherence and physical activity in older UK adults at risk of dementia: Protocol for the MedEx-UK randomised controlled trialShannon, O. M., Lee, V., Bundy, R., Gillings, R., Jennings, A., Stephan, B., Hornberger, M., Balanos, G., Paddick, S. M., Hanson, S., Hardeman, W., Holmes, R., Garner, N., Aldred, S., Siervo, M., Mathers, J. C. & Minihane, A-M., 5 Feb 2021, In: BMJ Open. 11, 2, e042823.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)26 Downloads (Pure)