Projects per year
Key Research Interests and Expertise
- The biology of the bacterial pathogen Acinetobacter baumannii
- Evolution of bacterial drug resistance mechanisms
- Transmission of drug resistance in bacterial populations
- Population dynamics of bacterial pathogens
The evolution and spread of antibiotic resistance
Bacteria can become resistant to antibiotics through a number of different mechanisms. These include intrinsic mechanism that all members of the bacterial species posses and that they switch on or ‘ramp up’ when exposed to antibiotics, and mechanisms that the bacteria acquire from external sources that can then be exchanged between bacteria.
My work centres on understanding which mechanisms bacteria are using to become resistant to antibiotics, and how these are evolving and being transferred in bacterial populations. An example of current work is investigating the effect of non-antibiotic drugs, such as cancer chemotherapies, on promoting antibiotic resistance. Many drugs used in healthcare coincidently have antibacterial properties, and therefore bacteria develop resistance against these. However, in doing so, some bacteria can become more resistant to antibiotics at the same time, even without having been exposed to any antibiotics. This ‘cross-resistance’, where exposure to one drug (e.g. a cancer chemotherapy) causes resistance to a different drug (e.g. an antibiotic) is not well understood despite its potential to have a major impact on the evolution and spread of antibiotic resistance. By understanding how different drugs cause cross-resistance to antibiotics we will gain a more holistic view of antibiotic resistance that can be exploited in the design and development of new drugs, and in the management and use of existing drugs.
If you have obtained or have the option to obtain funding to complete a PhD, I would be interested to hear from you. Please email me to discuss further.
Sept 2006 – Nov 2009: PhD in Medical Microbiology, University of Edinburgh, UK
Nov 2009 – Jul 2011: Post-doctoral Research Associate, University of Manchester, UK
Aug 2011 – Sep 2012: Post-doctoral Research Associate, University of Liverpool, UK
Oct 2012 – Sep 2013: Lecturer in Microbiology and Medical Biotechnology, Anglia Ruskin University, Cambridge, UK
Sep 2013 – Jul 2016: Senior Lecturer in Microbiology and Medical Biotechnology, Anglia Ruskin University, Cambridge, UK
Sep 2015 – Jul 2016: Deputy Head of Department (Acting), Biomedical and Forensic Sciences, Anglia Ruskin University, UK
Jul 2016 – Present: Lecturer in Medical Microbiology, University of East Anglia, UK
- The biology of Acinetobacter baumannii
- Antibiotic resistance in Gram-negative bacterial pathogens
- Natural transformation in Streptococcus pneumoniae
- Population evolution in Pseudomonas aeruginosa
- Bacterial genomics
- Lecturing on the Gateway to Medicine course
- Tutor for 1st Year Student Selected Studies (SSS) Genetics
- Supervisor for SSS Research
- Gateway to Medicine Problem-Based Learning (PBL) and SSS tutor
- Advisor to medical students
Associate Editor for Frontiers in Microbiology
- 19/10/2016 University of Cambridge, UK (External examiner)
- 29/06/2018 UEA, UK (Internal examiner)
- 20/07/2018 Queen Mary University of London, UK (External examiner)
- 27/07/2108 University of Bristol, UK (External examiner)
- 29/10/2018 UEA, UK (Internal examiner)
- 08/02/2019 University of Barcelona, Spain (External examiner)
- 29/05/2019 Queen Mary University of London, UK (External examiner)
- 30/06/2020 UEA, UK (Internal examiner)
- 19/11/2020 UEA, UK (Internal examiner)
- Director of the MRC Doctoral Antimicrobial Research Training (DART) iCASE programme
- UEA Microbiological Safety Officer
- UEA Genetic Modification Safety Officer
- Chair, UEA Biological Hazards and Genetic Modification Review Committee
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Doctor of Philosophy, University of Edinburgh
2006 → 2009
Bachelor of Science, University of Edinburgh
2001 → 2005
Dive into details
Select a country/territory to view shared publications and projects
- 2 Active
1/10/20 → 30/09/23
1/01/19 → 31/12/21
Diversity of carbapenem-resistant Acinetobacter baumannii and bacteriophage-mediated spread of the Oxa23 carbapenemaseAbouelfetouh, A., Mattock, J., Turner, D., Li, E. & Evans, B., 29 Nov 2021, (Accepted/In press) In: Microbial Genomics.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Downloads (Pure)
Evans, B., Kumar, A. & Castillo-Ramirez, S., 30 Mar 2021, In: Frontiers in Microbiology. 12, 670975.
Research output: Contribution to journal › Editorial › peer-reviewOpen AccessFile3 Citations (Scopus)8 Downloads (Pure)
Variability in carbapenemase activity of intrinsic OxaAb (OXA-51-like) β-lactamase enzymes in Acinetobacter baumanniiTakebayashi, Y., Findlay, J., Heesom, K. J., Warburton, P. J., Avison, M. B. & Evans, B. A., Mar 2021, In: Journal of Antimicrobial Chemotherapy. 76, 3, p. 587–595 9 p.
Research output: Contribution to journal › Article › peer-review3 Citations (Scopus)
Evans, B., 4 Jun 2020, In: Microbial Genomics. 6, 6, 000381.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile9 Citations (Scopus)17 Downloads (Pure)
Origin of OXA-23 variant OXA-239 from a recently emerged lineage of Acinetobacter baumannii International Clone VGrana-Miraglia, L., Evans, B., Lopez Jacome, L., Hernández-Durán, M., Colín-Castro, C., Volkow-Fernández, P., Cevallos, M., Franco-Cendejas, R. & Castillo-Ramirez, S., 8 Jan 2020, In: mSphere. 5, 1, e00801.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile13 Citations (Scopus)8 Downloads (Pure)