Charles Brearley

Professor

  • 1.48 Biology

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Personal profile

Career

  • Professor, School of Biological Sciences, UEA (2019-)
  • Reader, School of Biological Sciences, UEA (2016 - 2019)
  • Senior Lecturer, School of Biological Sciences, UEA (2009 - 2016)
  • Lecturer, School of Biological Sciences, UEA (2001 - 2008)
  • British Council Visiting Researcher, Max-Planck-Institut für Molekulare Pflanzenphysiologie, Germany (1998) 
  • BBSRC Advanced Research Fellow, Dept Plant Sciences, University of Cambridge (1997-2000)
  • Postdoctoral Research Associate, Dept Plant Sciences, University of Cambridge (1990-1997)
  • Postdoctoral Researcher, Dept Pharmacy, Brighton Polytechnic (1986-1989)
  • Ph.D. University of Wales (1986)

 

External Activities

  • Member of Biochemical Society Theme Panel V 'Signalling' (2010 - 2015)

Enterprise and Engagement Activities

  • Plenary Speaker 2nd International Phytase Summit, Rome (December 2012)
  • Consultant to AB Vista (UK) Ltd (Marlborough, UK) and AB Enzymes GmbH (Darmstadt, Germany)
  • BBSRC IPA Award BB/M022978/1 (30/09/2015 - 29/09/2018) - Mapping the Catalytic Landscape of a Novel Phytase (Hemmings PI, Brearley Co-I)
  • BBSRC LINK Award BB/N002024/1 (27/06/2016 - 26/11/2018) - Phytases beyond phosphate, how inositol improves feed conversion ratio in poulty (Brearley PI, Hajihosseini Co-I)

Key Research Interests and Expertise

Research in this laboratory addresses the biochemistry and cell biology of inositol phosphates and the enzmes that interconvert them, commonly in plants but also in animal digestive situations where plant materials are components of animal feed.   Our research is aligned closely with the needs of, and supported by, industry.  Our expertise in inositol phosphate analysis and biochemistry is applied in a number of fields ranging from germination biology, particularly malting scenarios, to human disease. Our research exploits the disciplines of enzymology and, with Dr Hemmings (CHE), structural biology. Together, we have solved structures of a number of enzymes of inositol metabolism and have developed powerful probes of enzyme function relevant to inositol phosphate signalling in disease contexts.

Current Collaborators

  • Prof. Tzyy-Jen Chiou (Agricultural Biotechnology Research Center, Academia Sinica, Taiwan)
  • Prof. Barry Potter (University of Oxford)

PhD Positions

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Biography

Studied Biochemistry at the University of Stirling and took a PhD in plant biochemistry at UCNW, Bangor. Undertook post doctoral work in the field of cryopreservation (Brighton) and inositol phosphate biochemistry (Cambridge). Won a BBSRC Advanced Research Fellowship and spent time at the Max-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam, Germany.

Google Scholar Profile: https://scholar.google.co.uk/citations?user=WEkkWN0AAAAJ

Network

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