Projects per year
- Professor, School of Biological Sciences, UEA (2019-)
- Reader, School of Biological Sciences, UEA (2016 - 2019)
- Senior Lecturer, School of Biological Sciences, UEA (2009 - 2016)
- Lecturer, School of Biological Sciences, UEA (2001 - 2008)
- British Council Visiting Researcher, Max-Planck-Institut für Molekulare Pflanzenphysiologie, Germany (1998)
- BBSRC Advanced Research Fellow, Dept Plant Sciences, University of Cambridge (1997-2000)
- Postdoctoral Research Associate, Dept Plant Sciences, University of Cambridge (1990-1997)
- Postdoctoral Researcher, Dept Pharmacy, Brighton Polytechnic (1986-1989)
- Ph.D. University of Wales (1986)
- Member of Biochemical Society Theme Panel V 'Signalling' (2010 - 2015)
Enterprise and Engagement Activities
- Plenary Speaker 2nd International Phytase Summit, Rome (December 2012)
- Consultant to AB Vista (UK) Ltd (Marlborough, UK) and AB Enzymes GmbH (Darmstadt, Germany)
- BBSRC IPA Award BB/M022978/1 (30/09/2015 - 29/09/2018) - Mapping the Catalytic Landscape of a Novel Phytase (Hemmings PI, Brearley Co-I)
- BBSRC LINK Award BB/N002024/1 (27/06/2016 - 26/11/2018) - Phytases beyond phosphate, how inositol improves feed conversion ratio in poulty (Brearley PI, Hajihosseini Co-I)
Key Research Interests and Expertise
Research in this laboratory addresses the biochemistry and cell biology of inositol phosphates and the enzmes that interconvert them, commonly in plants but also in animal digestive situations where plant materials are components of animal feed. Our research is aligned closely with the needs of, and supported by, industry. Our expertise in inositol phosphate analysis and biochemistry is applied in a number of fields ranging from germination biology, particularly malting scenarios, to human disease. Our research exploits the disciplines of enzymology and, with Dr Hemmings (CHE), structural biology. Together, we have solved structures of a number of enzymes of inositol metabolism and have developed powerful probes of enzyme function relevant to inositol phosphate signalling in disease contexts.
- Prof. Tzyy-Jen Chiou (Agricultural Biotechnology Research Center, Academia Sinica, Taiwan)
- Prof. Barry Potter (University of Oxford)
Studied Biochemistry at the University of Stirling and took a PhD in plant biochemistry at UCNW, Bangor. Undertook post doctoral work in the field of cryopreservation (Brighton) and inositol phosphate biochemistry (Cambridge). Won a BBSRC Advanced Research Fellowship and spent time at the Max-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam, Germany.
Google Scholar Profile: https://scholar.google.co.uk/citations?user=WEkkWN0AAAAJ
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1/10/18 → 30/09/22
A high sensitivity elemental mass spectrometry facility to support metallo-biology research on the Norwich Research Park
1/05/18 → 30/04/19
1/10/17 → 31/03/21
Whitfield, H., Gilmartin, M., Baker, K., Riley, A. M., Godage, H. Y., Potter, B. VL., Hemmings, A. M. & Brearley, C. A., 11 Oct 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8838–8846
Research output: Contribution to journal › ArticleOpen AccessFile3 Citations (Scopus)12 Downloads (Pure)
Arabidopsis inositol phosphate kinases, IPK1 and ITPK1, constitute a metabolic pathway in maintaining phosphate homeostasisKuo, H-F., Hsu, Y-Y., Lin, W-C., Chen, K-Y., Munnik, T., Brearley, C. A. & Chiou, T-J., Aug 2018, In : The Plant Journal. 95, 4, p. 613-630
Research output: Contribution to journal › ArticleOpen AccessFile35 Citations (Scopus)18 Downloads (Pure)
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase is a distant IPK member with a singular inositide binding site for axial 2-OH recognitionGonzalez, B., Banos-Sanz, J. I., Villate, M., Brearley, C. A. & Sanz-Aparicio, J., 25 May 2010, In : Proceedings of the National Academy of Sciences. 107, 21, p. 9608-9613 6 p.
Research output: Contribution to journal › Article39 Citations (Scopus)
The Arabidopsis ATP-binding cassette protein ATMRP5/ATABCC5 is a high-affinity inositol hexakisphosphate transporter involved in guard cell signaling and phytate storageNagy, R., Grob, H., Weder, B., Green, P., Klein, M., Frelet-Barrand, A., Schjoerring, J. K., Brearley, C. & Martinoia, E., 27 Nov 2009, In : Journal of Biological Chemistry. 284, p. 33614-33622 9 p.
Research output: Contribution to journal › Article137 Citations (Scopus)
A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian GutStentz, R., Osborne, S., Horn, N., Li, A., Hautefort, I., Bongaerts, R., Rouyer, M., Bailey, P., Shears, SB., Hemmings, A., Brearley, C. A. & Carding, S., 1 Feb 2014, In : Cell Reports. 6, 4, p. 646-656 11 p.
Research output: Contribution to journal › ArticleOpen AccessFile46 Citations (Scopus)11 Downloads (Pure)