Projects per year
Areas of Expertise
Click here for current PhD opportunities in CHE. But feel free to email me to discuss projects outside these areas and alternative sources of funding.
1987. BSc. University of Bath.
1990. PhD. University of Warwick
1990 – 1991. Alexander von Humboldt Fellow, University of Heidelberg
1992 – 2001. Lecturer and Senior Lecturer, Cardiff University
2001 – 2007. Reader, Queen Mary, University of London.
Catalysis is a key technology that enables the sustainable discovery, synthesis and manufacture of new pharmaceuticals, agrochemicals and materials. My approach to achieving these goals involves the design and synthesis of novel organometallic compounds, and to investigate these as catalysts for the efficient enantioselective synthesis of high value chiral organic compounds from low value starting materials. These products are then used to generate new and potentially bioactive chiral heterocycles for application in drug-discovery programmes.
More information is available on the group website.
Selected Recent Publications
Application of Ferrocene-Based Palladacycle Precatalysts to Enantioselective Aryl-Aryl Kumada Coupling.
R. A. Arthurs, D. L. Hughes and C. J. Richards, Eur. J. Inorg. Chem. 2022, e202101077.
Copper(I) Complexes of P-Stereogenic Josiphos and Related Ligands
R. A. Arthurs, A. C. Dean, D. L. Hughes and C. J. Richards, Eur. J. Org. Chem. 2021, 2719-2725.
Planar Chiral Palladacycle Precatalysts for Asymmetric Synthesis
R. A. Arthurs, D. L. Hughes and C. J. Richards, Org. Biomol. Chem. 2020, 18, 5466.
Stereoselective Synthesis of all Possible Phosferrox Ligand Diastereoisomers Displaying Three Elements of Chirality: Stereochemical Optimization for Asymmetric Catalysis
R. A. Arthurs, D. L. Hughes and C. J. Richards, J. Org. Chem. 2020, 85, 4838.
Ferrocenyloxazoline-Derived Planar Chiral Palladacycles: C-H Activation, Transmetalation, and Reversal of Diastereoselectivity
R. A. Arthurs, D. L. Hughes and C. J. Richards, Organometallics, 2019, 38, 4271.
Stereoselective and Stereospecific Reactions of Cobalt Sandwich Complexes. Application to the Synthesis of a New Class of Single Enantiomer Bulky Planar Chiral P-N and P-P Ligands
R. A. Arthurs, P. N. Horton, S. J. Coles and C. J. Richards Chem. Eur. J. 2018, 24, 4310.
Enantiopure Planar Chiral and Chiral-at-Metal Iridacycles Derived from Bulky Cobalt Sandwich Complexes
R. A. Arthurs, C. C. Prior, D. L. Hughes, V. S. Oganesyan and C. J. Richards, Organometallics, 2018, 37, 4204.
Catalyst Optimisation for Asymmetric Synthesis by Ligand Chirality Element Addition – A Perspective on Stereochemical Cooperativity
C. J. Richards and R. A. Arthurs, Chem. Eur. J. 2017, 48, 11460.
Deuterium as a Stereochemically Invisible Blocking Group for Chiral Ligand Synthesis
R. A. Arthurs and C. J. Richards, Org. Lett. 2017, 19, 702.
Enantiopure ferrocene-based planar-chiral iridacycles: stereospecific control of iridium-centred chirality
R. A. Arthurs, M. Ismail, C. C. Prior, V. S. Oganesyan, P. N. Horton, S. J. Coles and C. J. Richards, Chem. Eur. J. 2016, 22, 3065
Key Research Interests
For a summary of current research interest please follow this link.
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- 14 Finished
Rate and Stereoselectivity Relationships in Catalysis
20/06/22 → 15/08/22
Stereochemical Evolution for Catalyst Discovery
Richards, C. & Ojo, S.
7/01/19 → 31/03/21
Developing & Testing 2nd Generation Oncology Focused Potent & Bioselective PermaLink-derived ADCs (MRC iCASE)
1/10/17 → 30/09/21
Sequential Catalytic Reactions for the Asymmetric Synthesis of Novel Heterocyclic Building Blocks
19/06/17 → 11/08/17
GSK part studentship 2016
1/10/16 → 30/09/20
Application of a ferrocene-based palladacycle precatalyst to enantioselective aryl-aryl Kumada couplingArthurs, R. A., Hughes, D. L. & Richards, C. J., 29 Mar 2022, In: European Journal of Inorganic Chemistry. 2022, 9, e202101077.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)12 Downloads (Pure)
Copper(I) complexes of P-stereogenic Josiphos and related ligandsArthurs, R. A., Dean, A. C., Hughes, D. L. & Richards, C. J., 14 May 2021, In: European Journal of Organic Chemistry. 2021, 18, p. 2719-2725 7 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)15 Downloads (Pure)
Functionalization of [2.2]paracyclophanes via a reductive sulfanylation reactionDeschamps, D., Lohier, J-F., Richards, C. J., Gaumont, A-C. & Perrio, S., 1 Jan 2021, In: The Journal of Organic Chemistry. 86, 1, p. 507-514 8 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Citations (Scopus)2 Downloads (Pure)
Synthetic approaches to N- and 4-substituted 1,4-dihydro-3(2H)-isoquinolinone derivativesO’Sullivan, M. J., Hatley, R. J. D., Wellaway, C. R., Bew, S. P. & Richards, C. J., 5 Nov 2021, In: Tetrahedron. 100, 132455.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Planar chiral palladacycle precatalysts for asymmetric synthesisArthurs, R. A., Hughes, D. L. & Richards, C. J., 28 Jul 2020, In: Organic & Biomolecular Chemistry. 18, 28, p. 5466-5472 7 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile5 Citations (Scopus)8 Downloads (Pure)