Projects per year
Personal profile
Areas of Expertise
Biography
1987 BSc. University of Bath.
1990 PhD. University of Warwick.
1990 – 1991 Alexander von Humboldt Fellow, University of Heidelberg.
1992 – 2001 Lecturer and Senior Lecturer, Cardiff University.
2001 – 2007 Reader, Queen Mary, University of London.
2007 – 2025 Reader, University of East Anglia.
2025 – Honorary position, University of East Anglia.
My research involves the design and generation of novel organometallic compounds for application as catalysts in asymmetric organic synthesis. In addition to the synthesis of natural products, the resulting methodologies are also applied to the discovery of pharmaceuticals. Underpinning much of this work is the use of multiple stereochemical elements to vary and systematically optimise the activity and selectivity of a target compound. The importance of catalysis and stereoselectivity in origin of life studies is also of interest.
Selected Recent Publications
Programmable wide-range pH gradients for NMR titrations: application to antibody-drug conjugate linker group modifications
M. Wallace, J. M. Sharpe, K. Baj, M. Ngwube, J. Thirlway, P. L. K. Higgs, G. R. Stephenson, J. A. Iggo, T. E. Storr and C. J. Richards, Analyst 2025, 150, 2872-2879.
Double Asymmetric Synthesis: Faster Reactions are More Selective and a Model to Estimate Relative Rate
C. J. Richards and O. Stephen Ojo, Org. Biomol. Chem. 2023, 21, 7115-7128.
An Expedient Copper-Catalysed Asymmetric Synthesis of γ-Lactones and γ-Lactams. Application to the Synthesis of Lucidulactone A
O. Stephen Ojo, D. L. Hughes and C. J. Richards, Org. Biomol. Chem. 2023, 21, 4144-4149.
Application of Ferrocene-Based Palladacycle Precatalysts to Enantioselective Aryl-Aryl Kumada Coupling.
R. A. Arthurs, D. L. Hughes and C. J. Richards, Eur. J. Inorg. Chem. 2022, e202101077.
Copper(I) Complexes of P-Stereogenic Josiphos and Related Ligands
R. A. Arthurs, A. C. Dean, D. L. Hughes and C. J. Richards, Eur. J. Org. Chem. 2021, 2719-2725.
Planar Chiral Palladacycle Precatalysts for Asymmetric Synthesis
R. A. Arthurs, D. L. Hughes and C. J. Richards, Org. Biomol. Chem. 2020, 18, 5466.
Stereoselective Synthesis of all Possible Phosferrox Ligand Diastereoisomers Displaying Three Elements of Chirality: Stereochemical Optimization for Asymmetric Catalysis
R. A. Arthurs, D. L. Hughes and C. J. Richards, J. Org. Chem. 2020, 85, 4838.
Ferrocenyloxazoline-Derived Planar Chiral Palladacycles: C-H Activation, Transmetalation, and Reversal of Diastereoselectivity
R. A. Arthurs, D. L. Hughes and C. J. Richards, Organometallics, 2019, 38, 4271.
Stereoselective and Stereospecific Reactions of Cobalt Sandwich Complexes. Application to the Synthesis of a New Class of Single Enantiomer Bulky Planar Chiral P-N and P-P Ligands
R. A. Arthurs, P. N. Horton, S. J. Coles and C. J. Richards Chem. Eur. J. 2018, 24, 4310.
Catalyst Optimisation for Asymmetric Synthesis by Ligand Chirality Element Addition – A Perspective on Stereochemical Cooperativity
C. J. Richards and R. A. Arthurs, Chem. Eur. J. 2017, 48, 11460.
Deuterium as a Stereochemically Invisible Blocking Group for Chiral Ligand Synthesis
R. A. Arthurs and C. J. Richards, Org. Lett. 2017, 19, 702.
Enantiopure ferrocene-based planar-chiral iridacycles: stereospecific control of iridium-centred chirality
R. A. Arthurs, M. Ismail, C. C. Prior, V. S. Oganesyan, P. N. Horton, S. J. Coles and C. J. Richards, Chem. Eur. J. 2016, 22, 3065
Collaborations and top research areas from the last five years
Projects
- 14 Finished
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Rate and Stereoselectivity Relationships in Catalysis
Richards, C. (Principal Investigator)
20/06/22 → 15/08/22
Project: Research
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Stereochemical Evolution for Catalyst Discovery
Richards, C. (Principal Investigator) & Ojo, S. (Researcher)
7/01/19 → 31/03/21
Project: Research
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Developing & Testing 2nd Generation Oncology Focused Potent & Bioselective PermaLink-derived ADCs (MRC iCASE)
Richards, C. (Principal Investigator)
1/10/17 → 30/09/21
Project: Training
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Sequential Catalytic Reactions for the Asymmetric Synthesis of Novel Heterocyclic Building Blocks
Richards, C. (Principal Investigator)
19/06/17 → 11/08/17
Project: Research
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Synthesis and evaluation of 4-(α-arylvinyl)pyridines as activated linker groups for application in antibody–drug conjugates
Andrew, J., Sharpe, J., Wallace, M., Thirlway, J., Kerigan Higgs, P., Stephenson, G. R., Storr, T. & Richards, C., 16 Jun 2026, In: Organic & Biomolecular Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Programmable wide-range pH gradients for NMR titrations: Application to antibody–drug conjugate linker group modifications
Wallace, M., Sharpe, J. M., Baj, K., Ngwube, M., Thirlway, J., Kerigan Higgs, P. L., Stephenson, G. R., Iggo, J. A., Storr, T. E. & Richards, C. J., 7 Jul 2025, In: Analyst. 150, 13, p. 2872-2879 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)20 Downloads (Pure) -
An improved synthesis of 2,3-diamino-5,6-dichloropyrazine: A useful heterocyclic scaffold
Rigby, J. M., Chantry, A., Hemmings, A. M., Richards, C. J., Stephenson, G. R. & Storr, T. E., 14 Nov 2024, In: Synthesis. 56, 23, p. 3587-3592 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Downloads (Pure) -
The multifaceted chemistry of [2.2]paracyclophane-based thioethers with palladium(II) complexes
Deschamps, D., Gazzeh, H., Bonciani, A., Richards, C. J., Gaumont, A.-C. & Perrio, S., 26 Feb 2024, In: European Journal of Organic Chemistry. 27, 8, e202301181.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus) -
An expedient copper-catalysed asymmetric synthesis of γ-lactones and γ-lactams. Application to the synthesis of lucidulactone A
Ojo, O. S., Hughes, D. L. & Richards, C. J., 21 May 2023, In: Organic and Biomolecular Chemistry. 21, 19, p. 4144-4149 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)6 Downloads (Pure)