Christopher Hamilton

Search results

• 2022

  Potential of garlic oil as a biopesticide against all Aedes aegypti life stages

  Dusi, R., Morais, L., Magalhaes, N., Albnernaz, L., Hamilton, C. & Espindola, L., Jul 2022, In: Industrial Crops & Products. 181, 114780.

  Research output: Contribution to journal › Article › peer-review

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  5 Citations (Scopus)
• 2019

  Antimicrobial garlic-derived diallyl polysulfanes: Interactions with biological thiols in Bacillus subtilis

  Arbach, M., Santana, T. M., Moxham, H., Tinson, R., Anwar, A., Groom, M. & Hamilton, C., Jun 2019, In: Biochimica et Biophysica Acta - General Subjects. 1863, 6, p. 1050-1058 9 p.

  Research output: Contribution to journal › Article › peer-review

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  11 Citations (Scopus)

  18 Downloads (Pure)

• Mass spectrometric studies of Cu(I)-binding to the N-terminal domains of B. subtilis CopA and influence of bacillithiol

  Kay, K. L., Hamilton, C. J. & Le Brun, N. E., Jan 2019, In: Journal of Inorganic Biochemistry. 190, p. 24-30 7 p.

  Research output: Contribution to journal › Article › peer-review

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  7 Citations (Scopus)

  9 Downloads (Pure)

• Staphylococcus aureus uses the Bacilliredoxin (BrxAB)/Bacillithiol Disulfide reductase (YpdA) redox pathway to defend against oxidative stress under infections

  Linzner, N., Loi, V. V., Fritsch, V. N., Tung, Q. N., Stenzel, S., Wirtz, M., Hell, R., Hamilton, C. J., Tedin, K., Fulde, M. & Antelmann, H., 18 Jun 2019, In: Frontiers in Microbiology. 10, 1355.

  Research output: Contribution to journal › Article › peer-review

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  28 Citations (Scopus)

  19 Downloads (Pure)

• The disulfide stress response and protein S-thioallylation caused by allicin and diallyl polysulfanes in Bacillus subtilis as revealed by transcriptomics and proteomics

  Chi, B. K., Huyen, N. T. T., Loi, V. V., Gruhlke, M., Schaffer, M., Mäder, U., Maaß, S., Becher, D., Bernhardt, J., Arbach, M., Hamilton, C. J., Slusarenko, A. J. & Antelmann, H., 29 Nov 2019, In: Antioxidants. 8, 12, 605.

  Research output: Contribution to journal › Article › peer-review

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  20 Citations (Scopus)

  38 Downloads (Pure)
• 2018

  Mass spectrometric detection of iron nitrosyls, sulfide oxidation and mycothiolation during nitrosylation of the NO sensor [4Fe-4S] NsrR

  Crack, J. C., Hamilton, C. J. & Le Brun, N. E., 14 Jun 2018, In: Chemical Communications. 54, 47, p. 5992-5995 4 p.

  Research output: Contribution to journal › Article › peer-review

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  21 Citations (Scopus)

  12 Downloads (Pure)

• Physiological studies of Chlorobiaceae suggest that bacillithiol derivatives are the most widespread thiols in bacteria

  Hiras, J., Sharma, S. V., Raman, V., Tinson, R. A. J., Arbach, M., Rodrigues, D. F., Norambuena, J., Hamilton, C. J. & Hanson, T. E., 27 Nov 2018, In: mBIO. 9, 6, e01603-18.

  Research output: Contribution to journal › Article › peer-review

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  11 Citations (Scopus)

  19 Downloads (Pure)

• Protein S-bacillithiolation functions in thiol protection and redox regulation of the glyceraldehyde-3-phosphate dehydrogenase gap in Staphylococcus aureus under hypochlorite stress

  Imber, M., Huyen, N. T. T., Pietrzyk-Brzezinska, A. J., Loi, V. V., Hillion, M., Bernhardt, J., Thärichen, L., Kolšek, K., Saleh, M., Hamilton, C. J., Adrian, L., Gräter, F., Wahl, M. C. & Antelmann, H., 20 Feb 2018, In: Antioxidants & Redox Signaling. 28, 6, p. 410-430 21 p.

  Research output: Contribution to journal › Article › peer-review

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  45 Citations (Scopus)

  78 Downloads (Pure)

• Redox modulation at work: Natural phytoprotective polysulfanes from Alliums based on redox-active sulfur

  Anwar, A., Gould, E., Tinson, R., Iqbal, J. & Hamilton, C., Oct 2018, In: Current Pharmacology Reports. 4, 5, p. 397–407 11 p.

  Research output: Contribution to journal › Article › peer-review

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  8 Citations (Scopus)

  19 Downloads (Pure)

• The aldehyde dehydrogenase AldA contributes to the hypochlorite defense and is redox-controlled by protein S-bacillithiolation in Staphylococcus aureus

  Imber, M., Loi, V. V., Reznikov, S., Fritsch, V. N., Pietrzyk-Brzezinska, A. J., Prehn, J., Hamilton, C., Wahl, M. C., Bronowska, A. K. & Antelmann, H., May 2018, In: Redox Biology. 15, p. 557–568 12 p.

  Research output: Contribution to journal › Article › peer-review

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  25 Citations (Scopus)

  15 Downloads (Pure)
• 2017

  Diallyl polysulfides from Allium sativum as immunomodulators, hepatoprotectors, and antimycobacterial agents

  Oosthuizen, C., Arbach, M., Meyer, D., Hamilton, C. & Lall, N., 1 Jul 2017, In: Journal of Medicinal Food. 20, 7, p. 685-690 6 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Formal total synthesis of (+)-C9-deoxyomuralide from l-leucine using a double sacrificial chirality transfer approach

  Bulman Page, P. C., Goodyear, R. L., Horton, A. E., Chan, Y., Karim, R., O'Connell, M. A., Hamilton, C., Slawin, A. M. Z., Buckley, B. R. & Allin, S. M., 1 Dec 2017, In: The Journal of Organic Chemistry. 82, 23, p. 12209–12223 15 p.

  Research output: Contribution to journal › Article › peer-review

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  6 Citations (Scopus)

  30 Downloads (Pure)

• Real-time imaging of the bacillithiol redox potential in the human pathogen Staphylococcus aureus using a genetically encoded bacilliredoxin-fused redox biosensor

  Loi, V. V., Harms, M., Müller, M., Huyen, N. T. T., Hamilton, C. J., Hochgräfe, F., Pane-Farre, J. & Antelmann, H., May 2017, In: Antioxidants & Redox Signaling. 26, 15, p. 835-848 14 p.

  Research output: Contribution to journal › Article › peer-review

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  38 Citations (Scopus)

  16 Downloads (Pure)
• 2016

  In vitro and In vivo antimycobacterial, hepatoprotective and immunomodulatory activity of Euclea natalensis and its mode of action

  Lall, N., Kumar, V., Meyer, D., Gasa, N., Hamilton, C., Matsabisa, M. & Oosthuizen, C., 24 Dec 2016, In: Journal of Ethnopharmacology. 194, p. 740–748 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  18 Citations (Scopus)

  9 Downloads (Pure)

• Mass spectrometry of B. subtilis CopZ: Cu(I)-binding and interactions with bacillithiol

  Kay, K. L., Hamilton, C. J. & Le Brun, N. E., Jul 2016, In: Metallomics. 8, 7, p. 709-719 11 p.

  Research output: Contribution to journal › Article › peer-review

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  24 Citations (Scopus)

  23 Downloads (Pure)

• Think yellow and keep green—Role of sulfanes from garlic in agriculture

  Anwar, A., Gould, E., Tinson, R., Groom, M. & Hamilton, C. J., 30 Dec 2016, In: Antioxidants. 6, 1, 3.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  17 Citations (Scopus)

  12 Downloads (Pure)

• Thiol redox and pKa properties of mycothiol, the predomiant low molecular weight thiol cofactor in the Actinomycetes

  Sharma, S. V., Van Laer, K., Messens, J. & Hamilton, C. J., 15 Sep 2016, In: ChemBioChem. 17, 18, p. 1689–1692

  Research output: Contribution to journal › Letter › peer-review

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  22 Citations (Scopus)

  16 Downloads (Pure)
• 2015

  NsrR from Streptomyces coelicolor is a nitric oxide-sensing [4Fe-4S] cluster protein with a specialized regulatory function

  Crack, J., Munnoch, J. T., Dodd, E., Knowles, F., Al-Bassam, M., Kamali, S., Holland, A., Cramer, S., Hamilton, C., Johnson, M., Thomson, A., Hutchings, M. & Le Brun, N., 15 May 2015, In: The Journal of Biological Chemistry. 290, p. 12689-12704 6 p.

  Research output: Contribution to journal › Article › peer-review

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  68 Citations (Scopus)

  10 Downloads (Pure)

• Sulforaphane protects the liver against CdSe quantum dot-induced cytotoxicity

  Wang, W., He, Y., Yu, G., Li, B., Sexton, D. W., Wileman, T., Roberts, A. A., Hamilton, C. J., Liu, R., Chao, Y., Shan, Y. & Bao, Y., 25 Sep 2015, In: PLoS One. 10, 9, e0138771.

  Research output: Contribution to journal › Article › peer-review

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  26 Citations (Scopus)

  26 Downloads (Pure)

• The transcriptome of Euglena gracilis reveals unexpected metabolic capabilities for carbohydrate and natural product biochemistry

  O'neill, E. C., Trick, M., Hill, L., Rejzek, M., Dusi, R. G., Hamilton, C. J., Zimba, P. V., Henrissat, B. & Field, R. A., 2015, In: Molecular BioSystems. 11, 10, p. 2808-2820

  Research output: Contribution to journal › Article › peer-review
  90 Citations (Scopus)
• 2014

  Genome-wide transcriptome and antioxidant analyses on gamma-irradiated phases of Deinococcus radiodurans R1

  Luan, H., Meng, N., Fu, J., Chen, X., Xu, X., Feng, Q., Jiang, H., Dai, J., Yuan, X., Lu, Y., Roberts, A. A., Luo, X., Chen, M., Xu, S., Li, J., Hamilton, C., Fang, C. & Wang, J., 23 Jan 2014, In: PLoS One. 9, 1, e85649.

  Research output: Contribution to journal › Article › peer-review

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  37 Citations (Scopus)

  12 Downloads (Pure)

• Methylglyoxal resistance in Bacillus subtilis: contributions of bacillithiol-dependent and independent pathways

  Chandrangsu, P., Dusi, R., Hamilton, C. J. & Helmann, J. D., 1 Feb 2014, In: Molecular Microbiology. 91, 4, p. 706-715 10 p.

  Research output: Contribution to journal › Article › peer-review
  61 Citations (Scopus)

• Redox regulation in Bacillus subtilis: The bacilliredoxins BrxA(YphP) and BrxB(YqiW) function in de-bacillithiolation of S-Bacillithiolated OhrR and MetE

  Gaballa, A., Chi, B. K., Roberts, A. A., Becher, D., Hamilton, C., Antelmann, H. & Helmann, J. D., 20 Jul 2014, In: Antioxidants & Redox Signaling. 21, 3, p. 357-367 11 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)

• The importance of bacillithiol in the oxidative stress response of Staphylococcus aureus

  Posada, A. C., Kolar, S. L., Dusi, R. G., Francois, P., Roberts, A. A., Hamilton, C. J., Liu, G. Y. & Cheung, A., Jan 2014, In: Infection and Immunity. 82, 1, p. 316-332 17 p.

  Research output: Contribution to journal › Article › peer-review
  57 Citations (Scopus)
• 2013

  Analysis of mutants disrupted in bacillithiol metabolism in Staphylococcus aureus

  Rajkarnikar, A., Strankman, A., Duran, S., Vargas, D., Roberts, A. A., Barretto, K., Upton, H., Hamilton, C. J. & Rawat, M., 1 Jun 2013, In: Biochemical and Biophysical Research Communications. 436, 2, p. 128-133

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Biophysical Features of Bacillithiol, the Glutathione Surrogate of Bacillus subtilis and other Firmicutes

  Sharma, S. V., Arbach, M., Roberts, A. A., Macdonald, C. J., Groom, M. & Hamilton, C. J., 4 Nov 2013, In: ChemBioChem. 14, 16, p. 2160-2168

  Research output: Contribution to journal › Article › peer-review

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  51 Citations (Scopus)

  11 Downloads (Pure)

• Cross functionalities of Bacillus deacetylases involved in bacillithial biosynthesis and bacillitiol-S-conjugate detoxification pathways

  Fang, Z., Roberts, A. A., Weidman, K., Sharma, S. C., Claiborne, A., Hamilton, C. & Dos Santos, P. C., 2013, In: Biochemistry Journal. 454, 2, p. 239-247

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Distribution and infection-related functions of bacillithiol in Staphylococcus aureus

  Pöther, D-C., Gierok, P., Harms, M., Mostertz, J., Hochgräfe, F., Antelmann, H., Hamilton, C., Borovok, I., Lalk, M., Aharonowitz, Y. & Hecker, M., 1 Apr 2013, In: International Journal of Medical Microbiology. 303, 3, p. 114-123 10 p.

  Research output: Contribution to journal › Article › peer-review
  39 Citations (Scopus)

• Mechanistic studies of FosB: a divalent-metal-dependent bacillithiol-S-transferase that mediates fosfomycin resistance in Staphylococcus aureus

  Roberts, A. A., Sharma, S. V., Strankman, AW., Duran, SR., Rawat, M. & Hamilton, C. J., 1 Apr 2013, In: Biochemical Journal. 451, 1, p. 69-79 10 p.

  Research output: Contribution to journal › Article › peer-review
  66 Citations (Scopus)

• Regulation of Bacillus subtilis bacillithiol biosynthesis operons by Spx

  Gaballa, A., Antelmann, H., Hamilton, C. J. & Helmann, J. D., 1 Oct 2013, In: Microbiology. 159, Pt_10, p. 2025-2035

  Research output: Contribution to journal › Article › peer-review
  36 Citations (Scopus)

• S-Bacillithiolation protects conserved and essential proteins against hypochlorite stress in Firmicutes bacteria

  Chi, B. K., Roberts, A. A., Huyen, T. T. T., Bäsell, K., Becher, D., Albrecht, D., Hamilton, C. J. & Antelmann, H., 10 Apr 2013, In: Antioxidants & Redox Signaling. 18, 11, p. 1273-1295 23 p.

  Research output: Contribution to journal › Article › peer-review
  78 Citations (Scopus)

• Stability of aminooxy glycosides to glycosidase catalysed hydrolysis

  Iqbal, A., Chibli, H. & Hamilton, C., 9 Aug 2013, In: Carbohydrate Research. 377, p. 1-3

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)
• 2012

  Bacterial mechanisms of reversible protein S-thiolation: structural and mechanistic insights into mycoredoxins

  Antelmann, H. & Hamilton, CJ., Nov 2012, In: Molecular Microbiology. 86, 4, p. 759-764

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Conformational Changes in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase upon Substrate Binding: Role of N-terminal lobe and enantiomeric substrate preference

  Banoz-Sanz, J. I., Sanz-Aparicio, J., Whitfield, H., Hamilton, C., Brearley, C. A. & Gonzalez, B., 24 Aug 2012, In: The Journal of Biological Chemistry. 287, 35, p. 29237-29249 13 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)
• 2011

  A chemoenzymatic synthesis of 5a-carba-α-d-mannose-6-phosphate

  Williams, P. M., Sheldrake, G. N., Macdonald, S. J. F. & Hamilton, C. J., 15 Jul 2011, In: Carbohydrate Research. 346, 10, p. 1257-1261 5 p.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• Chemical and chemoenzymatic syntheses of bacillithiol, a unique low molecular weight thiol amongst low G + C Gram positive bacteria

  Sharma, S. V., Jothivasan, V. K., Newton, G. L., Upton, H., Wakabayashi, J. I., Kane, M. G., Roberts, A. A., Rawat, M., La Clair, J. J. & Hamilton, C. J., 25 Jul 2011, In: Angewandte Chemie International Edition. 50, 31, p. 7101-7104 4 p.

  Research output: Contribution to journal › Article › peer-review
  39 Citations (Scopus)
• 2010

  Characterization of the N-acetyl-α-d-glucosaminyll-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis

  Parsonage, D., Newton, G. L., Holder, R. C., Wallace, B. D., Paige, C., Hamilton, C., Dos Santos, P. C., Redinbo, M. R., Reid, S. D. & Claiborne, A., 27 Aug 2010, In: Biochemistry. 49, 38, p. 8398-8414 17 p.

  Research output: Contribution to journal › Article › peer-review
  46 Citations (Scopus)
• 2009

  Bacillithiol is an antioxidant thiol produced in Bacilli

  Newton, G. L., Rawat, M., La Clair, J. J., Jothivasan, V. K., Budiarto, T., Hamilton, C. J., Claiborne, A., Helmann, J. D. & Fahey, R. C., 2009, In: Nature Chemical Biology. 5, 9, p. 625-627 3 p.

  Research output: Contribution to journal › Article › peer-review
  225 Citations (Scopus)

• Mycothiol disulfide reductase: solid phase synthesis and evaluation of alternative substrate analogues

  Stewart, M. J. G., Jothivasan, V. K., Rowan, A. S., Wagg, J. & Hamilton, C. J., 20 Feb 2009, In: Organic & Biomolecular Chemistry. 6, 2, p. 385-390 6 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase

  Rowan, A. S., Nicely, N. I., Cochrane, N., Wlassoff, W. A., Claiborne, A. & Hamilton, C. J., 2009, In: Organic & Biomolecular Chemistry. 7, 19, p. 4029-4036 8 p.

  Research output: Contribution to journal › Article › peer-review
  42 Citations (Scopus)
• 2008

  Activity against Mycobacterium smegmatis and M. tuberculosis by extract of South African medicinal plants

  Mativandiela, S. P. N., Meyer, J. J. M., Hussein, A. A., Houghton, P. J., Hamilton, C. J. & Lall, N., Jun 2008, In: Phytotherapy Research. 22, 6, p. 841-845 5 p.

  Research output: Contribution to journal › Article › peer-review
  54 Citations (Scopus)

• Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes

  Jothivasan, V. K. & Hamilton, C. J., 2008, In: Natural Product Reports. 25, 6, p. 1091-1117 27 p.

  Research output: Contribution to journal › Article › peer-review
  118 Citations (Scopus)

• Mycothiol disulfide reductase: A continuous assay for slow time-dependent inhibitors

  Hamilton, C. J., Finlay, R. M. J., Stewart, M. J. G. & Bonner, A., 2008, In: Analytical Biochemistry. 388, 1, p. 91-96 6 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)
• 2007

  Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase

  Mahapatra, A., Mativandlela, S. P. N., Binneman, B., Fourie, P. B., Hamilton, C. J., Meyer, J. J. M., van der Kooy, F., Houghton, P. & Lall, N., 15 Dec 2007, In: Bioorganic & Medicinal Chemistry. 15, 24, p. 7638-7646 9 p.

  Research output: Contribution to journal › Article › peer-review
  78 Citations (Scopus)

• Practical synthesis of sugar monophosphonucleotides

  Wlassoff, W. A., Finlay, R. M. J. & Hamilton, C. J., 2007, In: Synthetic Communications. 37, 17, p. 2927-2934 8 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)
• 2006

  Recent developments in preparative enzymatic syntheses of carbohydrates

  Rowan, A. S. & Hamilton, C. J., 2006, In: Natural Product Reports. 23, 3, p. 412-443 32 p.

  Research output: Contribution to journal › Article › peer-review
  31 Citations (Scopus)

• Time-dependent inhibitors of trypanothione reductase: Analogues of the spermidine alkaloid lunarine and related natural products

  Hamilton, C. J., Saravanamuthu, A., Poupat, C., Fairlamb, A. H. & Eggleston, I. M., 1 Apr 2006, In: Bioorganic & Medicinal Chemistry. 14, 7, p. 2266-2278 13 p.

  Research output: Contribution to journal › Article › peer-review
  37 Citations (Scopus)
• 2004

  Enzymatic liberation of lycotetraose from the Solanum glycoalkaloid alpha-tomatine

  Woods, K., Hamilton, C. J. & Field, R. A., 2004, In: Carbohydrate Research. 339, 13, p. 2325-2328 4 p.

  Research output: Contribution to journal › Article
  14 Citations (Scopus)

• Enzymes in preparative mono- and oligo-saccharide synthesis

  Hamilton, C. J., 2004, In: Natural Product Reports. 21, 3, p. 365-385 21 p.

  Research output: Contribution to journal › Article
  24 Citations (Scopus)
• 2003

  Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase

  Hamilton, C. J., Saravanamuthu, A., Fairlamb, A. H. & Eggleston, I. M., 2003, In: Bioorganic & Medicinal Chemistry. 11, 17, p. 3683-3693 11 p.

  Research output: Contribution to journal › Article › peer-review
  31 Citations (Scopus)