Projects per year
Personal profile
Key Responsibilities
My group at The Sainsbury Laboratory is made of researchers and technologists working at the boundary of genomic biology and computer science.
Our exciting projects range from bioinformatics and genomics to image analysis and machine learning. We bring together biology, computational science and bioinformatics to make the most of big data and help answer big questions.
We develop deep learning models to predict proteins of importance in plant pathogen interactions.
We develop software and pipelines to analyse high throughput genomics, proteomic sequence data and high throughput image data generated throughout the laboratory.
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PIKOBODIES: Made-to-order plant disease resistance genes using receptor-nanobody fusions
Kamoun, S., MacLean, D., Menke, F., Smoker, M. & Youles, M.
1/11/23 → 31/10/28
Project: Research
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A tool for identifying causative mutations from sequencing data without a reference genome
MacLean, D. & Rallapalli, G.
Biotechnology and Biological Sciences Research Council
1/04/15 → 20/01/17
Project: Research
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Transcriptional regulation in effector-triggered immunity via NB-LRR resistance genes RPS4 & RRS1
Jones, J., MacLean, D. & Smoker, M.
Biotechnology and Biological Sciences Research Council
7/01/13 → 6/01/16
Project: Research
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Mechanisms of nuclear suppression of host immunity by Arabidopsis downy mildew effectors
Jones, J., Caillaud, M., Jones, A., MacLean, D., Smoker, M. & Wirthmueller, L.
Biotechnology and Biological Sciences Research Council
1/12/12 → 28/05/16
Project: Research
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Maximizing the potential for sustainable and durable resistance to the wheat yellow rust pathogen
Kamoun, S., Uauy, C., Badebo, A., Bayles, R., Chhuneja, P., Hovmoller, M., McGuire, S., Singh, K., Waynera, R., Wulff, B. & MacLean, D.
Biotechnology and Biological Sciences Research Council
1/10/12 → 30/09/17
Project: Research
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The transcriptional landscape of plant infection by the rice blast fungus Magnaporthe oryzae reveals distinct families of temporally co-regulated and structurally conserved effectors
Yan, X., Tang, B., Ryder, L. S., MacLean, D., Were, V. M., Eseola, A. B., Cruz-Mireles, N., Ma, W., Foster, A. J., Osés-Ruiz, M. & Talbot, N. J., May 2023, In: Plant Cell. 35, 5, p. 1360-1385 26 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (Scopus)5 Downloads (Pure) -
Accurate plant pathogen effector protein classification ab initio with deepredeff: An ensemble of convolutional neural networks
Kristianingsih, R. & MacLean, D., 17 Jul 2021, In: BMC Bioinformatics. 22, 372.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)6 Downloads (Pure) -
The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity
Thor, K., Jiang, S., Michard, E., George, J., Scherzer, S., Huang, S., Dindas, J., Derbyshire, P., Leitão, N., Defalco, T. A., Köster, P., Hunter, K., Kimura, S., Gronnier, J., Stransfeld, L., Kadota, Y., Bücherl, C. A., Charpentier, M., Wrzaczek, M., Maclean, D., & 6 others, 24 Sept 2020, In: Nature. 585, 7826, p. 569–573 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile220 Citations (SciVal)80 Downloads (Pure) -
Protein engineering expands the effector recognition profile of a rice NLR immune receptor
De la Concepcion, J. C., Franceschetti, M., MacLean, D., Terauchi, R., Kamoun, S. & Banfield, M. J., 19 Sept 2019, In: eLife. 8, 47713.Research output: Contribution to journal › Article › peer-review
Open AccessFile96 Citations (SciVal)26 Downloads (Pure) -
Rapid fine mapping of causative mutations from sets of unordered, contig-sized fragments of genome sequence
Rallapalli, G., Corredor-Moreno, P., Chalstrey, E., Page, M. & Maclean, D., 7 Jan 2019, In: BMC Bioinformatics. 20, 9.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (SciVal)33 Downloads (Pure)