Search results

• 2024

  Applications of urinary extracellular vesicles in the diagnosis and active surveillance of prostate cancer

  Smith, S. F., Brewer, D. S., Hurst, R. & Cooper, C. S., 1 May 2024, In: Cancers. 16, 9, 1717.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  1 Citation (Scopus)

  9 Downloads (Pure)

• Cancer invasion and anaerobic bacteria: New insights into mechanisms

  Hurst, R., Brewer, D. S., Gihawi, A., Wain, J. & Cooper, C. S., 28 Mar 2024, In: Journal of Medical Microbiology. 73, 3, 001817.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  4 Downloads (Pure)

• Epidemiology of Cholesteatoma in the UK Biobank

  Wilson, E., Jennings, B. A., Khondoker, M., Philpott, C. M., Prinsley, P. & Brewer, D. S., 4 Dec 2024, (E-pub ahead of print) In: Clinical Otolaryngology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Genomic evolution shapes prostate cancer disease type

  Woodcock, D. J., Sahli, A., Teslo, R., Bhandari, V., Gruber, A. J., Ziubroniewicz, A., Gundem, G., Xu, Y., Butler, A., Anokian, E., Pope, B. J., Jung, C-H., Tarabichi, M., Dentro, S. C., Farmery, J. H. R., Van Loo, P., Warren, A. Y., Gnanapragasam, V., Hamdy, F. C., Bova, G. S., & 16 othersFoster, C. S., Neal, D. E., Lu, Y-J., Kote-Jarai, Z., Fraser, M., Bristow, R. G., Boutros, P. C., Costello, A. J., Corcoran, N. M., Hovens, C. M., Massie, C. E., Lynch, A. G., Brewer, D. S., Eeles, R. A., Cooper, C. S. & Wedge, D. C., 13 Mar 2024, In: Cell Genomics. 4, 3, 100511.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  1 Citation (Scopus)

  15 Downloads (Pure)

• Loss of function variants and locus heterogeneity in familial cholesteatoma

  Cardenas, R., Prinsley, P., Philpott, C., Bhutta, M. F., Wilson, E., Brewer, D. & Jennings, B., 4 Jan 2024, p. P03.007.C.

  Research output: Contribution to conference › Abstract

• The extracellular heparan sulfatase SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis

  Swart, M., Redpath, A. N., Ogbechi, J., Cardenas, R., Topping, L., Compeer, E. B., Goddard, M., Chanalaris, A., Williams, R., Brewer, D. S., Smart, N., Monaco, C. & Troeberg, L., 14 Aug 2024, In: Cellular and Molecular Life Sciences. 81, 350.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Ultra-sensitive detection of circulating tumour DNA enriches for patients with greater risk of recurrence in clinically localised prostate cancer

  Pope, B., Park, G., Lau, E., Belic, J., Lach, R., George, A., McCoy, P., Nguyen, A., Grima, C., Campbell, B., Jung, C., Ditter, E-J., Zhao, H., The Pan Prostate Cancer Group (PPCG), Wedge, D. C., Brewer, D. S., Lynch, A. G., Dev, H., Gnanapragasam, V. J., Rosenfeld, N., & 3 othersHovens, C. M., Corcoran, N. M. & Massie, C. E., Apr 2024, In: European Urology. 85, 4, p. 407-410 4 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)
• 2023

  Caution regarding the specificities of pan-cancer microbial structure

  Gihawi, A., Cooper, C. S. & Brewer, D. S., 9 Aug 2023, In: Microbial Genomics. 9, 8, 001088.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

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  19 Citations (Scopus)

  11 Downloads (Pure)

• Combining molecular subtypes with multivariable clinical models has the potential to improve prediction of treatment outcomes in prostate cancer at diagnosis

  Wardale, L., Cardenas, R., Gnanapragasam, V. J., Cooper, C. S., Clark, J. & Brewer, D. S., Jan 2023, In: Current Oncology. 30, 1, p. 157-170 14 p.

  Research output: Contribution to journal › Article › peer-review

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  22 Downloads (Pure)

• Gene-transcript expression in urine supernatant and urine cell-sediment are different but equally useful for detecting prostate cancer

  Yazbek Hanna, M., Winterbone, M., O'Connell, S. P., Olivan, M., Hurst, R., Mills, R., Cooper, C. S., Brewer, D. S. & Clark, J., 1 Feb 2023, In: Cancers. 15, 3, 789.

  Research output: Contribution to journal › Article › peer-review

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  3 Citations (Scopus)

  28 Downloads (Pure)

• Major data analysis errors invalidate cancer microbiome findings

  Gihawi, A., Ge, Y., Lu, J., Puiu, D., Xu, A., Cooper, C. S., Brewer, D. S., Pertea, M. & Salzberg, S. L., 9 Oct 2023, In: mBIO. 14, 5

  Research output: Contribution to journal › Article › peer-review

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  37 Citations (Scopus)

  11 Downloads (Pure)

• Quality Control in Metagenomics Data

  Gihawi, A., Cardenas, R., Hurst, R. & Brewer, D. S., 1 Jun 2023, Metagenomic Data Analysis. Mitra, S. (ed.). New York: Springer, p. 21-54 34 p. (Methods in Molecular Biology; vol. 2649).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  4 Citations (Scopus)

• Whole exome sequencing study identifies candidate loss of function variants and locus heterogeneity in familial cholesteatoma

  Cardenas, R., Prinsley, P., Philpott, C., Bhutta, M. F., Wilson, E., Brewer, D. S. & Jennings, B. A., 15 Mar 2023, In: PLoS One. 18, 3, e0272174.

  Research output: Contribution to journal › Article › peer-review

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  2 Citations (Scopus)

  19 Downloads (Pure)
• 2022

  A model to detect significant prostate cancer integrating urinary peptide and extracellular vesicle RNA data

  Connell, S., Frantzi, M., Latosinska, A., Webb, M., Mullen, W., Pejchinovski, M., Salji, M., Mischak, H., Cooper, C., Clark, J. & Brewer, D., 14 Apr 2022, In: Cancers. 14, 8, 1995.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  8 Citations (Scopus)

  15 Downloads (Pure)

• APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types

  Jakobsdottir, G. M., Brewer, D. S., Cooper, C., Green, C. & Wedge, D. C., 21 May 2022, In: BMC Biology. 20, 117.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  14 Citations (Scopus)

  15 Downloads (Pure)

• Microbiomes of urine and the prostate are linked to human prostate cancer risk groups

  Hurst, R., Meader, E., Gihawi, A., Rallapalli, G., Clark, J., Kay, G. L., Webb, M., Manley, K., Curley, H., Walker, H., Kumar, R., Schmidt, K., Crossman, L., Eeles, R. A., Wedge, D. C., Lynch, A. G., Massie, C. E., Yazbek-Hanna, M., Rochester, M., Mills, R. D., & 7 othersMithen, R. F., Traka, M. H., Ball, R. Y., O'Grady, J., Brewer, D. S., Wain, J. & Cooper, C. S., Aug 2022, In: European Urology Oncology. 5, 4, p. 412-419 8 p.

  Research output: Contribution to journal › Article › peer-review

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  14 Downloads (Pure)

• Rare germline variants are associated with rapid biochemical recurrence after radical prostate cancer treatment: a PPCG study

  Burns, D., Anokian, E., Saunders, E. J., Bristow, R. G., Fraser, M., Reimand, J., Schlomm, T., Sauter, G., Brors, B., Korbel, J., Weischenfeldt, J., Waszak, S. M., Corcoran, N. M., Jung, C-H., Pope, B. J., Hovens, C. M., Cancel-Tassin, G., Cussenot, O., Loda, M., Sander, C., & 16 othersHayes, V. M., Dalsgaard Sorensen, K., Lu, Y-J., Hamdy, F. C., Foster, C. S., Gnanapragasam, V., Butler, A., Lynch, A. G., Massie, C. E., CR-UK/Prostate Cancer UK, ICGC, The PPCG, Woodcock, D. J., Cooper, C. S., Wedge, D. C., Brewer, D. S., Kote-Jarai, Z. & Eeles, R. A., Aug 2022, In: European Urology. 82, 2, p. 201-211 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  2 Citations (Scopus)

  34 Downloads (Pure)

• The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates

  Buhigas, C., Warren, A. Y., Leung, W-K., Whitaker, H. C., Luxton, H. J., Hawkins, S., Kay, J., Butler, A., Xu, Y., Woodcock, D. J., Merson, S., Frame, F. M., Sahli, A., Abascal, F., CRUK-ICGC Prostate Cancer Group, Martincorena, I., Bova, G. S., Foster, C. S., Campbell, P., Maitland, N. J., & 7 othersNeal, D. E., Massie, C. E., Lynch, A. G., Eeles, R. A., Cooper, C. S., Wedge, D. C. & Brewer, D. S., 22 Sep 2022, In: Molecular Cancer. 21, 183.

  Research output: Contribution to journal › Article › peer-review

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  6 Citations (Scopus)

  12 Downloads (Pure)

• Whole exome sequencing study identifies candidate loss of function variants and locus heterogeneity in familial cholesteatoma

  Cardenas, R., Prinsley, P., Philpott, C., Bhutta, M. F., Wilson, E., Brewer, D. S. & Jennings, B. A., 16 Jul 2022, biorxiv.

  Research output: Working paper › Preprint

  Open Access
• 2021

  Integration of urinary EN2 protein & cell-free RNA data in the development of a multivariable risk model for the detection of prostate cancer prior to biopsy

  Connell, S. P., Mills, R., Pandha, H., Morgan, R., Cooper, C., Clark, J. & Brewer, D., 1 May 2021, In: Cancers. 13, 9, 2102.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  7 Citations (Scopus)

  23 Downloads (Pure)

• The urine biomarker PUR-4 is positively associated with the amount of Gleason 4 in human prostate cancers

  Ball, R., Cardenas, R., Winterbone, M., Yazbek Hanna, M., Parker, C. C., Hurst, R., Brewer, D., D'Sa, L., Mills, R., Cooper, C. & Clark, J., 3 Nov 2021, In: Life. 11, 11, 1172.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  1 Citation (Scopus)

  34 Downloads (Pure)
• 2020

  A novel stratification framework for predicting outcome in patients with prostate cancer

  Luca, B., Moulton, V., Ellis, C., Edwards, D. R., Campbell, C., Cooper, R. A., Clark, J., Brewer, D. S. & Cooper, C. S., 12 May 2020, In: British Journal of Cancer. 122, 10, p. 1467–1476 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  7 Citations (Scopus)

  104 Downloads (Pure)

• Convergence of prognostic gene signatures suggests underlying mechanisms of human prostate cancer progression

  Luca, B., Moulton, V., Ellis, C., Connell, S. P., Brewer, D. & Cooper, C., 16 Jul 2020, In: Genes. 11, 7, 802.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  6 Citations (Scopus)

  63 Downloads (Pure)

• Development of a multivariable risk model integrating urinary cell DNA methylation and cell-free RNA data for the detection of significant prostate cancer

  Connell, S. P., O'Reilly, E., Tuzova, A., Webb, M., Hurst, R., Mills, R., Zhao, F., Bapat, B., Cooper, C., Perry, A., Clark, J. & Brewer, D., 15 May 2020, In: The Prostate. 80, 7, p. 547-558 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  19 Citations (Scopus)

  81 Downloads (Pure)

• Pan-cancer analysis of whole genomes

  The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, 5 Feb 2020, In: Nature. 578, p. 82-93 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  1692 Citations (Scopus)

  20 Downloads (Pure)

• Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy

  Woodcock, D., Riabchenko, E., Taavitsainen, S., Kankainen, M., Gundem, G., Brewer, D., Ellonen, P., Lepistö, M., Golubeva, Y., Warner, A., Tolonen, T., Jasu, J., Isaacs, W. B., Emmert-Buck, M. R., Nykter, M., Visakorpi, T., Bova, G. S. & Wedge, D. C., 8 Oct 2020, In: Nature Communications. 11, 5070 .

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  41 Citations (Scopus)

  12 Downloads (Pure)

• Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

  Bailey, M. H., Meyerson, W. U., Dursi, L. J., Wang, L-B., Dong, G., Liang, W-W., Weerasinghe, A., Li, S., Li, Y., Kelso, S., MC3 Working Group, PCAWG novel somatic mutation calling methods working group, Saksena, G., Ellrott, K., Wendl, M. C., Wheeler, D. A., Getz, G., Simpson, J. T., Gerstein, M. B., Ding, L., & 1 othersPCAWG Consortium, 21 Sep 2020, In: Nature Communications. 11, 4748.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  27 Citations (Scopus)

• Sex differences in oncogenic mutational processes

  Li, C. H., Prokopec, S. D., Sun, R. X., Yousif, F., Schmitz, N., Al-Shahrour, F., Boutros, P. C., PCAWG Tumour Subtypes and Clinical Translation & PCAWG Consortium, 28 Aug 2020, In: Nature Communications. 11, 1, 4330.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  57 Citations (Scopus)

  7 Downloads (Pure)

• The landscape of viral associations in human cancers

  Zapatka, M., Borozan, I., Brewer, D., Iskar, M., Grundhoff, A., Alawi, M., Desai, N., Sültmann, H., Moch, H., Cooper, C., Eils, R., Ferretti, V. & Lichter, P., Mar 2020, In: Nature Genetics. 52, 3, p. 320–330 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  240 Citations (Scopus)

  45 Downloads (Pure)
• 2019

  A four-group urine risk classifier for predicting outcome in prostate cancer patients

  Connell, S. P., Yazbek Hanna, M., McCarthy, F., Hurst, R., Webb, M., Curley, H., Walker, H., Mills, R., Ball, R., Sanda, M., Pellegrini, K., Patil, D., Perry, A., Schalken, J., Pandha, H., Whitaker, H. C., Dennis, N., Stuttle, C., Mills, I., Guldvik, I., & 4 othersParker, C. C., Brewer, D., Cooper, C. & Clark, J., Oct 2019, In: BJU International. 124, 4, p. 609-620 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  31 Citations (Scopus)

  43 Downloads (Pure)

• epiCaPture: a urine DNA methylation test for early detection of aggressive prostate cancer

  O'Reilly, E., Tuzova, A., Walsh, A., Russell, N., O’Brien, O., Kelly, S., Dhomhnallain, O., DeBarra, L., Dale, C., Brugman, R., Clarke, G., Schmidt, O., O'Meachair, S., Patil, D., Pellegrini, K., Fleshner, N., Garcia, J., Zhao, F., Finn, S., Mills, R., & 11 othersY. Hanna, M., Hurst, R., McEvoy, E., Gallagher, W., Manecksha, R., Cooper, C., Brewer, D., Bapat, B., Sanda, M., Clark, J. & Perry, A., 2019, In: JCO Precision Oncology. 3, 3, p. 1-18 18 p.

  Research output: Contribution to journal › Article › peer-review

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  37 Citations (Scopus)

  34 Downloads (Pure)

• Methodology for the at-home collection of urine samples for prostate cancer detection

  Webb, M., Manley, K., Olivan, M., Guldvik, I., Palczynska, M., Hurst, R., Connell, S. P., Mills, I., Brewer, D., Mills, R., Cooper, C. & Clark, J., 2019, In: Biotechniques. 68, 2, p. 65-71 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  10 Citations (Scopus)

  31 Downloads (Pure)

• Potential for diagnosis of infectious disease from the 100,000 Genomes Project Metagenomic Dataset: Recommendations for reporting results

  Magiorkinis, G., Matthews, P. C., Wallace, S. E., Jeffery, K., Dunbar, K., Tedder, R., Mbisa, J. L., Hannigan, B., Vayena, E., Simmonds, P., Brewer, D. S., Gihawi, A., Rallapalli, G., Lahnstein, L., Fowler, T., Patch, C., Maleady-Crowe, F., Lucassen, A. & Cooper, C., 14 Oct 2019, In: Wellcome Open Research. 4, 155.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  7 Citations (Scopus)

  33 Downloads (Pure)

• SEPATH: Benchmarking the search for pathogens in human tissue whole genome sequence data leads to template pipelines

  Gihawi, A., Rallapalli, G., Hurst, R., Cooper, C., Leggett, R. M. & Brewer, D., 22 Oct 2019, In: Genome Biology. 20, 208.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  8 Citations (Scopus)

  64 Downloads (Pure)

• Transcriptome-wide effects of sphingosine kinases knockdown in metastatic prostate and breast cancer cells: Implications for therapeutic targeting

  Alshaker, H., Wang, Q., Brewer, D. & Pshezhetskiy, D., 27 Mar 2019, In: Frontiers in Pharmacology. 10, 12 p., 303.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  20 Citations (Scopus)

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• 2018

  A urine based DNA methylation Assay, ProCUrE, to identify clinically significant prostate cancer

  Zhao, F., Olkhov-Mitsel, E., Kamdar, S., Jeyapala, R., Garcia, J., Hurst, R., Yazbek Hanna, M., Mills, R., Tuzova, A., O'Reilly, E., Kelly, S., Cooper, C., Brewer, D., Perry, A., Clark, J., Fleshner, N. & Bapat, B., 23 Nov 2018, In: Clinical Epigenetics. 10, 147.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  30 Citations (Scopus)

  14 Downloads (Pure)

• DESNT: a poor prognosis category of human prostate cancer

  Luca, B-A., Brewer, D. S., Edwards, D. R., Edward, S., Whitaker, H. C., Merson, S., Denis, N., Cooper, R. A., Hazell, S., Warren, A. Y., The CancerMap Group, Eeles, R., Lynch, A. G., Ross-Adams, H., Lamb, A. D., Neal, D. E., Sethia, K., Mills, R. D., Ball, R. Y., Curley, H., & 3 othersClark, J., Moulton, V. & Cooper, C. S., Dec 2018, In: European Urology Focus. 4, 6, p. 842-850 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  28 Citations (Scopus)

  64 Downloads (Pure)

• Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

  Wedge, D. C., Gundem, G., Mitchell, T., Woodcock, D. J., Martincorena, I., Ghori, M., Zamora, J., Butler, A., Whitaker, H., Kote-Jarai, Z., Alexandrov, L. B., Van Loo, P., Massie, C. E., Dentro, S., Warren, A. Y., Verrill, C., Berney, D. M., Dennis, N., Merson, S., Hawkins, S., & 66 othersHowat, W., Lu, Y-J., Lambert, A., Kay, J., Kremeyer, B., Karaszi, K., Luxton, H., Camacho, N., Marsden, L., Edwards, S., Matthews, L., Bo, V., Leongamornlert, D., McLaren, S., Ng, A., Yu, Y., Zhang, H., Dadaev, T., Thomas, S., Easton, D. F., Ahmed, M., Bancroft, E., Fisher, C., Livni, N., Nicol, D., Tavaré, S., Gill, P., Greenman, C., Khoo, V., Van As, N., Kumar, P., Ogden, C., Cahill, D., Thompson, A., Mayer, E., Rowe, E., Dudderidge, T., Gnanapragasam, V., Shah, N. C., Raine, K., Jones, D., Menzies, A., Stebbings, L., Teague, J., Hazell, S., Corbishley, C., de Bono, J., Attard, G., Isaacs, W., Visakorpi, T., Fraser, M., Boutros, P. C., Bristow, R. G., Workman, P., Sander, C., Hamdy, F. C., Futreal, A., McDermott, U., Al-Lazikani, B., Lynch, A. G., Bova, G. S., Foster, C. S., Brewer, D. S., Neal, D. E., Cooper, C. S. & Eeles, R. A., 16 Apr 2018, In: Nature Genetics. 50, p. 682–692 11 p.

  Research output: Contribution to journal › Article › peer-review

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  167 Citations (Scopus)

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• 2017

  Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

  Camacho, N., Van Loo, P., Edwards, S., Kay, J., Matthews, L., Haase, K., Clark, J., Dennis, N., Thomas, S., Kremeyer, B., Zamora, J., Butler, A. P., Gundem, G., Merson, S., Luxton, H., Hawkins, S., Ghori, M., Marsden, L., Lambert, A., Karaszi, K., & 36 othersPelvender, G., Massie, C., Kote-Jarai, ZS., Raine, K., Jones, D., Howat, W., Hazell, S., Livni, N., Fisher, C., Ogden, C., Kumar, P., Thompson, A., Nicol, D., Mayer, E., Dudderidge, T., Yu, Y., Zhang, H., Shah, N., Gnanapragasam, V., Isaacs, W., Visakorpi, T., Hamdy, F., Berney, D., Verrill, C., Warren, A., Wedge, D., Lynch, A., Foster, C., Lu, Y. J., Bova, G. S., Whitaker, H., McDermott, U., Neal, D., Eeles, R., Cooper, C. & Brewer, D., 25 Sep 2017, In: PLoS Genetics. 13, 9, e1007001.

  Research output: Contribution to journal › Article › peer-review

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  32 Citations (Scopus)

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• 2016

  Mutational signatures of ionizing radiation in second malignancies

  Behjati, S., Gundem, G., Wedge, D. C., Roberts, N. D., Tarpey, P. S., Cooke, S. L., Van Loo, P., Alexandrov, L. B., Ramakrishna, M., Davies, H., Nik-Zainal, S., Hardy, C., Latimer, C., Raine, K. M., Stebbings, L., Menzies, A., Jones, D., Shepherd, R., Butler, A. P., Teague, J. W., & 64 othersJorgensen, M., Khatri, B., Pillay, N., Shlien, A., Futreal, P. A., Badie, C., Cooper, C. S., Eeles, R. A., Easton, D., Foster, C., Neal, D. E., Brewer, D. S., Hamdy, F., Lu, Y-J., Lynch, A. G., Massi, C. E., Ng, A., Whitaker, H. C., Yu, Y., Zhang, H., Bancroft, E., Berney, D., Camacho, N., Corbishley, C., Dadaev, T., Dennis, N., Dudderidge, T., Edwards, S., Fisher, C., Ghori, J., Gnanapragasam, V. J., Greenman, C., Hawkins, S., Hazell, S., Howat, W., Karaszi, K., Kay, J., Kote-Jarai, Z., Kremeyer, B., Kumar, P., Lambert, A., Leongamornlert, D., Livni, N., Luxton, H., Matthews, L., Mayer, E., Merson, S., Nicol, D., Ogden, C., O'Meara, S., Pelvender, G., Shah, N. C., Tavare, S., Thomas, S., Thompson, A., Verrill, C., Warren, A., Zamora, J., McDermott, U., Bova, G. S., Richardson, A. L., Flanagan, A. M., Stratton, M. R. & Campbell, P. J., 12 Sep 2016, In: Nature Communications. 7, 12605.

  Research output: Contribution to journal › Article › peer-review

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  186 Citations (Scopus)

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• Prostate single nucleotide polymorphism provides a crucial clue to cancer aggression in active surveillance patients

  Cooper, C. S., Clark, J., Brewer, D. S. & Edwards, D. R., Feb 2016, In: European Urology. 69, 2, p. 229-230 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  2 Citations (Scopus)
• 2015

  A gene expression based predictor for high risk myeloma treated with intensive therapy and autologous stem cell rescue

  Wu, P., Walker, B. A., Broyl, A., Kaiser, M., Johnson, D. C., Kuiper, R., van Duin, M., Gregory, W. M., Davies, F. E., Brewer, D., Hose, D., Sonneveld, P. & Morgan, G. J., 2015, In: Leukemia & Lymphoma. 56, 3, p. 594-601 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  5 Citations (Scopus)

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• Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

  Cooper, C. S., Eeles, R. A., Wedge, D. C., Van Loo, P., Gundem, G., Alexandrov, L. B., Kreymer, B., Butler, A., Lynch, A., Edwards, S. E., Camacho, N., Massie, C. E., Kote-Jarai, Z., Dennis, N., Merson, S., Leongamornlert, D. A., Zamora, J., Kay, J., Luxton, H. J., Corbishley, C., & 53 othersThomas, S., Nik-Zainal, S., Ramakrishna, M., O'Meara, S., Matthews, L., Clark, J., Hurst, R., Mithen, R., Bristow, R. G., Boutros, P. C., Fraser, M., Cooke, S., Raine, K., Jones, D., Menzies, A., Stebbings, L., Hinton, J., Teague, J., McLaren, S., Mudie, L., Hardy, C., Anderson, E., Joseph, O., Goody, V., Robinson, B., Maddison, M., Gamble, SJ., Greenman, C., Berney, D., Hazell, S., Livni, N., the ICGC Prostate Group, Fisher, C., Ogden, C., Kumar, P., Thompson, A., Woodhouse, C. J., Nicol, D., Mayer, E., Dudderidge, T., Shah, N., Gnanapragasam, V., Voet, T., Campbell, P., Futreal, P. A., Easton, D. F., Warren, A. Y., Foster, C. S., Stratton, M. R., Whitaker, H. C., McDermott, U., Brewer, D. S. & Neal, D. E., Apr 2015, In: Nature Genetics. 47, p. 367–372 6 p.

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• HES5 silencing is an early and recurrent change in prostate tumourigenesis

  Massie, C. E., Spiteri, I., Ross-Adams, H., Luxton, H. J., Kay, J., Whitaker, H. C., Dunning, M. J., Lamb, A. D., Ramos-Montoya, A., Brewer, D., Cooper, C., Eeles, R. A., Warren, A. Y., Tavaré, S., Neal, D. E. & Lynch, A. G., 1 Apr 2015, In: Endocrine-Related Cancer (ERC). 22, 2, p. 131-144 14 p.

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• Mutation detection in formalin-fixed prostate cancer biopsies taken at the time of diagnosis using next generation DNA sequencing

  Manson-Bahr, D., Ball, R., Gundem, G., Mills, R., Rochester, M., Goody, V., O'Meara, S., Flather, M., Keeling, M., Yazbek Hanna, M., Hurst, R., Curley, H., Clark, J., Brewer, D., Mcdermott, U. & Cooper, C., 2015, In: Journal of Clinical Pathology. 68, p. 212-217 6 p.

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  17 Citations (Scopus)

• The evolutionary history of lethal metastatic prostate cancer

  Gundem, G., Van Loo, P., Kremeyer, B., Alexandrov, L. B., Tubio, J. M. C., Papaemmanuil, E., Brewer, D., Kallio, H., Högnäs, H., Annala, M., Kivinummi, K., Goody, V., Latimer, C., O'Meara, S., Dawson, K., Isaacs, W., Emmert-Buck, M. R., Nykter, M., Foster, C. S., Kote-Jarai, Z., & 11 othersEaston, D. F., Whitaker, H. C., ICGC Prostate UK Group*, Neal, D. E., Cooper, C. S., Eeles, R. A., Visakorpi, T., Campbell, P., McDermott, U., Wedge, D. C. & Bova, G. S., 16 Apr 2015, In: Nature. 520, 7547, p. 353–357 5 p.

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• 2014

  Benzo[a]pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice

  Zuo, J., Brewer, D., Arlt, V. M., Cooper, C. & Phillips, D. H., 8 Oct 2014, In: BMC Genomics. 15, 880.

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• Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer

  Merson, S., Yang, Z. H., Brewer, D., Olmos, D., Eichholz, A., McCarthy, F., Fisher, G., Kovacs, G., Berney, D. M., Foster, C. S., Møller, H., Scardino, P., Cuzick, J., Cooper, C. S., Clark, J. & Transatlantic Prostate Group, 18 Mar 2014, In: British Journal of Cancer. 110, 6, p. 1655-1662 8 p.

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  26 Citations (Scopus)

• Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

  Tubio, J. M. C., Li, Y., Ju, Y. S., Martincorena, I., Cooke, S. L., Tojo, M., Gundem, G., Pipinikas, C. P., Zamora, J., Raine, K., Menzies, A., Roman-Garcia, P., Fullam, A., Gerstung, M., Shlien, A., Tarpey, P. S., Papaemmanuil, E., Knappskog, S., Van Loo, P., Ramakrishna, M., & 31 othersDavies, H. R., Marshall, J., Wedge, D. C., Teague, J. W., Butler, A. P., Nik-Zainal, S., Alexandrov, L., Behjati, S., Yates, L. R., Bolli, N., Mudie, L., Hardy, C., Martin, S., McLaren, S., O'Meara, S., Anderson, E., Maddison, M., Gamble, S., Foster, C., Warren, A. Y., Whitaker, H., Brewer, D., Eeles, R., Cooper, C., Neal, D., Lynch, A. G., Visakorpi, T., Isaacs, W. B., van't Veer, L., Caldas, C. & ICGC Breast Cancer Group, 1 Aug 2014, In: Science. 345, 6196, 1251343.

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  293 Citations (SciVal)

• Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

  Ju, Y. S., Alexandrov, L. B., Gerstung, M., Martincorena, I., Nik-Zainal, S., Ramakrishna, M., Davies, H. R., Papaemmanuil, E., Gundem, G., Shlien, A., Bolli, N., Behjati, S., Tarpey, P. S., Nangalia, J., Massie, C. E., Butler, A. P., Teague, J. W., Vassiliou, G. S., Green, A. R., Du, M-Q., & 31 othersUnnikrishnan, A., Pimanda, J. E., Teh, B. T., Munshi, N., Greaves, M., Vyas, P., El-Naggar, A. K., Santarius, T., Collins, V. P., Grundy, R., Taylor, J. A., Hayes, D. N., Malkin, D., Foster, C. S., Warren, A. Y., Whitaker, H. C., Brewer, D., Eeles, R., Cooper, C., Neal, D., Visakorpi, T., Isaacs, W. B., Bova, G. S., Flanagan, A. M., Futreal, P. A., Lynch, A. G., Chinnery, P. F., McDermott, U., Stratton, M. R., Campbell, P. J. & ICGC Breast Cancer Group, 1 Oct 2014, In: eLife. 3, e02935.

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