Projects per year
Personal profile
Key Research Interests
I am a molecular biologist interested in RNA silencing. We use several model systems (human, mouse, virus, etc.). Our research combines genetics, cell and molecular biology with next generation sequencing and bioinformatics to study the role of microRNAs in various biological processes.
Current Research Projects
- The role of small RNAs in circulating tumour cells / metastasis
- Investigating miR-140 and RUNX2 in embryonic development
- Biological function of RNA structure in gene regulation
- Improving methods in next generation sequencing studies
Life in our research group
Our lab is based in the Biomedical Research Centre (BMRC) on the UEA main campus. We use molecular techniques to study small RNAs that regulate the expression of protein-coding genes. Our research is a mix of basic science and translational medicine. The weekly lab meeting is shared with several other groups interested in molecular disease mechanisms.
Ph.D. Positions
Click here for current Ph.D. opportunities at Norwich Medical School. Please feel free to email me to discuss projects outside of these areas and alternative funding sources.
Postdocs & Fellows
Please feel free to approach me to discuss possibilities.
Career
- Lecturer in RNA Biology, University of East Anglia (2018-present)
- Senior Research Associate, University of East Anglia (2017-2018)
- Ph.D. Medicine, University of East Anglia (2017)
- Research Associate, University of East Anglia (2010-2013)
- Geneticist, Cambridge University Hospitals NHS FT (2009-2010)
- B.Sc. (Hons) Biology, University of East Anglia (2009)
Teaching Interests
- Year 1 PBL
- Year 1 Genetics
- Year 2 Biochemistry
- Year 3 Cancer Genetics
- Year 3 Clinical Biochemistry
- Year 3 Research Dissertation
- M.Res. Clinical Science
- Ph.D. Medicine
Administrative Posts
- MBBS Module Lead for Year 3 Clinical Biochemistry SSC
- MBBS Applicant Interview Panel
- MBBS Undergraduate Personal Advisor
- MBBS Year 2 SAQ Examiner
- PGCert Clinical Education Personal Advisor
- M.Res. Clinical Science Examiner
- M.Sc. Clinical Research Examiner
- B.Sc. (Hons) Biology Examiner
Research Group or Lab Membership
Sergio Llaneza-Lago (postdoc)
Emma Bull (PhD student)
Polly Drewczynska (MRes student)
Calista Tink (MRes student)
Past:
Nicole Ball (PhD student; ASBMR Young Investigator Award, BES Best Oral Poster Prize)
Eloise Whittle (MRes student)
Joshua Atkin (MRes student)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Gwen Fish donation
Orthopaedics Trust (Prev. Gwendoline Fish Trust)
1/12/22 → 30/11/23
Project: Research
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3’ untranslated region structural elements in CYP24A1 are associated with infantile hypercalcaemia type 1
Ball, N., Duncan, S., Zhang, Y., Payet, R., Piec, I., Whittle, E., Tang, J. C. Y., Schoenmakers, I., Lopez, B., Chipchase, A., Kumar, A., Perry, L., Maxwell, H., Ding, Y., Fraser, W. D. & Green, D., Mar 2023, In: Journal of Bone and Mineral Research. 38, 3, p. 414-426 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
YBX1-interacting small RNAs and RUNX2 can be blocked in primary bone cancer using CADD522
Green, D., Singh, A., Tippett, V. L., Tattersall, L., Shah, K. M., Siachisumo, C., Ward, N. J., Thomas, P., Carter, S., Jeys, L., Sumathi, V., McNamara, I. R., Elliott, D. J., Gartland, A., Dalmay, T. & Fraser, W. D., Apr 2023, In: Journal of Bone Oncology. 39, 100474.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Downloads (Pure) -
Mechanistic insights into non-coding Y RNA processing
Billmeier, M., Green, D., Hall, A., Turnbull, C., Singh, A., Xu, P., Moxon, S. & Dalmay, T., 30 Mar 2022, In: RNA Biology. 19, 1, p. 468-480 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)7 Downloads (Pure) -
Methods of treatment and diagnosis of tumours
Green, D. & Fraser, W., 3 Mar 2022, 23 Dec 2019Research output: Patent
File5 Downloads (Pure) -
Coexistent CYP24A1 and PHEX Gene Mutations With Hypervitaminosis D Plus Hypercalcemia Treated With Fluconazole
Bawden, D., Fraser, W., Green, D. & Rehman, S. U., 21 Jul 2021, In: Journal of the Endocrine Society. 5, 1, A188.Research output: Contribution to journal › Abstract › peer-review
Prizes
Activities
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Euro Ewing Consortium (EEC) (External organisation)
Darrell Green (Member)
7 Mar 2023 → …Activity: Membership › Network, Working Group or Professional Association
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European FOSTER Consortium (Fight Osteosarcoma Through European Research) (External organisation)
Darrell Green (Member)
8 Dec 2022 → …Activity: Membership › Network, Working Group or Professional Association
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Genomics England (External organisation)
Darrell Green (Member)
9 Mar 2021 → …Activity: Membership › Network, Working Group or Professional Association
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Journal of Bone Oncology (Journal)
Darrell Green (Editorial board member)
19 Feb 2021 → …Activity: Editorial work › Publication editorial role
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Carcinogenesis (Journal)
Darrell Green (Peer reviewer)
1 Apr 2020Activity: Editorial work › Publication peer-review
Press/Media
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Breakthrough bone cancer drug could increase survival rate
7/03/23 → 20/03/23
324 items of Media coverage
Press/Media: Press / Media
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UEA scientists hail children's cancer breakthrough
8/03/23
1 item of Media coverage
Press/Media: Press / Media
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Tumour donated from five-year-old football fan who died of cancer leads to breakthrough drug
8/03/23
1 item of Media coverage
Press/Media: Press / Media
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Revolutionary new bone cancer drug could save children’s lives
8/03/23
1 item of Media coverage
Press/Media: Press / Media
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UEA bone cancer drug trials show survival rates increase
8/03/23
1 Media contribution
Press/Media: Press / Media