Projects per year
Personal profile
Academic Background
I am the scientific group leader for RNA research at Norwich Medical School. I first trained as a biomedical scientist at Addenbrooke’s Hospital in Cambridge before completing my PhD at the University of East Anglia with a focus on microRNA and bone cancer. I undertook postdoctoral training at UEA expanding on this work, developing single-cell RNA sequencing in circulating tumour cells, before setting up my own group in 2018.
Key Research Interests
Our lab is based at the BCRE on the Norwich Research Park, which is one of five BBSRC funded research and innovation campuses in the UK and one of the largest concentrations of life sciences researchers in Europe. On the park, there are four other research institutes, the 6th largest acute teaching hospital in the UK and more than 40 biotech spin-outs. The close proximity of the research institutes, the hospital and biotechs has allowed us to establish important collaborations as well as access to state-of-the-art research facilities and scientific and clinical expertise. In our lab, we use molecular techniques and computational approaches to study RNA silencing. Our research is a mix of basic and translational with projects ranging from fundamental mechanisms to drug development. The weekly lab meeting is shared with several other groups interested in molecular disease mechanisms.
Administrative Posts
University REF 2029 PCE Champion for UoA1: Clinical Medicine
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Project Driven Group Lead, EURO EWING Consortium (EEC)
23 Oct 2024 → …
Chair of Research Sub-Committee, Bone Cancer Research Trust
22 Jun 2024 → 8 Mar 2025
Grant Review Panel Member, Cellular and Developmental Biology Board, Narodowe Centrum Nauki (Polish equivalent to BBSRC / MRC)
22 Apr 2024 → …
Member, EURO EWING Consortium (EEC)
7 Mar 2023 → …
Member, Fight Osteosarcoma Through European Research (FOSTER)
8 Dec 2022 → …
Fellow, Higher Education Academy
1 Dec 2021 → …
Editorial Board Member, Journal of Bone Oncology
19 Feb 2021 → …
Board of Trustees, Bone Cancer Research Trust
5 Feb 2020 → 8 Mar 2025
Editorial Board Member, FEBS Open BIO
20 Jan 2020 → 31 May 2024
Collaborations and top research areas from the last five years
-
Investigating microRNAs in metastatic circulating tumour cells at single-cell resolution
3/02/25 → 2/02/26
Project: Research
-
Investigating the RNA structurome of fusion-positive rhabdomyosarcoma
Children’s Cancer and Leukaemia Group
1/10/24 → 30/09/27
Project: Research
-
-
Peter Stebbings Memorial Charity donation
Peter Stebbings Memorial Charity
12/09/24 → 11/09/25
Project: Research
-
Preclinical research (pharmacology, toxicology and MTD) of the lead compound CADD522
3/07/24 → 3/07/26
Project: Research
-
Bayesian unsupervised clustering identifies clinically relevant osteosarcoma subtypes
Llaneza-Lago, S., Fraser, W. D. & Green, D., Jan 2025, In: Briefings in Bioinformatics. 26, 1, bbae665.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Post-treatment late and long-term effects in bone sarcoma: A scoping review
Khan, K., Kane, K., Davison, Z. & Green, D., Jun 2025, In: Journal of Bone Oncology. 52, 100671.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Biological sample collection to advance research and treatment: A Fight Osteosarcoma Through European Research (FOSTER) and Euro Ewing Consortium (EEC) statement
Green, D., van Ewijk, R., Tirtei, E., Andreou, D., Baecklund, F., Baumhoer, D., Bielack, S. S., Botchu, R., Boye, K., Brennan, B., Capra, M., Cottone, L., Dirksen, U., Fagioli, F., Fernandez, N., Flanagan, A. M., Gambarotti, M., Gaspar, N., Gelderblom, H., Gerrand, C., & 36 others , 15 Aug 2024, In: Clinical Cancer Research. 30, 16, p. 3395–3406 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Downloads (Pure) -
3’ untranslated region structural elements in CYP24A1 are associated with infantile hypercalcaemia type 1
Ball, N., Duncan, S., Zhang, Y., Payet, R., Piec, I., Whittle, E., Tang, J. C. Y., Schoenmakers, I., Lopez, B., Chipchase, A., Kumar, A., Perry, L., Maxwell, H., Ding, Y., Fraser, W. D. & Green, D., Mar 2023, In: Journal of Bone and Mineral Research. 38, 3, p. 414-426 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)13 Downloads (Pure) -
Bridged bicyclic carboxylic acids for treating osteosarcoma and Ewing sarcoma
Green, D. & Fraser, W., 2 Nov 2023, IPC No. A61K 31/191, A61P 35/00, Patent No. PCT/EP/2023/061092, 27 Apr 2023Research output: Patent
Open AccessFile13 Downloads (Pure)
Prizes
-
Best Paper Prize for Research Innovation
Green, Darrell (Recipient), 2023
Prize: Prize (including medals and awards)
-
Freedom of the City of London - for "impactful work in oncology"
Green, Darrell (Recipient), 19 Apr 2024
Prize: Prize (including medals and awards)
-
Press/Media
-
Pioneering research identifies three subtypes of osteosarcoma for better treatment
10/01/25
1 item of Media coverage
Press/Media: Media Coverage or Contribution
-
Breakthrough study set to change how osteosarcomas are diagnosed and treated
20/12/24
1 Media contribution
Press/Media: UEA Press Release
-
CCLG funds new rhabdomyosarcoma research, thanks to Special Named Funds
6/09/24
1 Media contribution
Press/Media: Media Coverage or Contribution
-
UEA leads Europe-wide project to revolutionise childhood bone cancer treatment and research
28/06/24
1 Media contribution
Press/Media: UEA Press Release
-
New study to reveal the differences between individual cancer cells in Ewing sarcoma and osteosarcoma tumours
26/06/24
1 Media contribution
Press/Media: Media Coverage or Contribution