Projects per year
Personal profile
Academic Background
I am the scientific group leader for RNA research at Norwich Medical School. I first trained as a biomedical scientist at Addenbrooke’s Hospital in Cambridge before completing my PhD at the University of East Anglia with a focus on microRNA and bone cancer. I undertook postdoctoral training at UEA expanding on this work, developing single-cell RNA sequencing in circulating tumour cells, before setting up my own group in 2018.
Key Research Interests
Our lab is based in the Biomedical Research Centre (BMRC) on the UEA main campus. We use molecular techniques and computational approaches to study RNA-based gene silencing. Our research is a mix of basic and translational with projects ranging from fundamental mechanisms to drug development. The weekly lab meeting is shared with several other groups interested in molecular disease mechanisms.
Administrative Posts
People, Culture and Environment Champion for REF 2029 (UoA1: Clinical Medicine)
Research Group or Lab Membership
Emma Bull (PhD student)
Amy Harden (PhD student)
Charlotte Stephens (MSc student)
Kirsty Soanes (PhD student)
Archana Singh (postdoc)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Chair of Research Sub-Committee, Bone Cancer Research Trust
22 Jun 2024 → …
Grant Review Panel Member, Cellular and Developmental Biology Board, Narodowe Centrum Nauki (Polish equivalent to BBSRC / MRC)
22 Apr 2024 → …
Member, Euro Ewing Consortium (EEC)
7 Mar 2023 → …
Member, Fight Osteosarcoma Through European Research (FOSTER)
8 Dec 2022 → …
Fellow, Higher Education Academy
1 Dec 2021 → …
Editorial Board Member, Journal of Bone Oncology
19 Feb 2021 → …
Board of Trustees, Bone Cancer Research Trust
5 Feb 2020 → …
Editorial Board Member, FEBS Open BIO
20 Jan 2020 → 31 May 2024
Collaborations and top research areas from the last five years
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Investigating the RNA structurome of fusion-positive rhabdomyosarcoma
Children’s Cancer and Leukaemia Group
1/10/24 → 30/09/27
Project: Research
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Peter Stebbings Memorial Charity donation
Peter Stebbings Memorial Charity
12/09/24 → 11/09/25
Project: Research
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Preclinical research (pharmacology, toxicology and MTD) of the lead compound CADD522
3/07/24 → 3/07/26
Project: Research
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The role of RNA structure in Ewing sarcoma
The Richard Jenner Memorial Trust
1/02/24 → 31/01/26
Project: Research
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Bayesian unsupervised clustering identifies clinically relevant osteosarcoma subtypes
Llaneza Lago, S., Fraser, W. D. & Green, D., 2 Dec 2024, (Accepted/In press) In: Briefings in Bioinformatics.Research output: Contribution to journal › Article › peer-review
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Biological sample collection to advance research and treatment: A Fight Osteosarcoma Through European Research (FOSTER) and Euro Ewing Consortium (EEC) statement
Green, D., van Ewijk, R., Tirtei, E., Andreou, D., Baecklund, F., Baumhoer, D., Bielack, S. S., Botchu, R., Boye, K., Brennan, B., Capra, M., Cottone, L., Dirksen, U., Fagioli, F., Fernandez, N., Flanagan, A. M., Gambarotti, M., Gaspar, N., Gelderblom, H., Gerrand, C., & 36 others , 15 Aug 2024, In: Clinical Cancer Research. 30, 16, p. 3395–3406 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
3’ untranslated region structural elements in CYP24A1 are associated with infantile hypercalcaemia type 1
Ball, N., Duncan, S., Zhang, Y., Payet, R., Piec, I., Whittle, E., Tang, J. C. Y., Schoenmakers, I., Lopez, B., Chipchase, A., Kumar, A., Perry, L., Maxwell, H., Ding, Y., Fraser, W. D. & Green, D., Mar 2023, In: Journal of Bone and Mineral Research. 38, 3, p. 414-426 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)10 Downloads (Pure) -
Bridged bicyclic carboxylic acids for treating osteosarcoma and Ewing sarcoma
Green, D. & Fraser, W., 2 Nov 2023, IPC No. A61K 31/191, A61P 35/00, Patent No. PCT/EP/2023/061092, 27 Apr 2023Research output: Patent
Open AccessFile11 Downloads (Pure) -
YBX1-interacting small RNAs and RUNX2 can be blocked in primary bone cancer using CADD522
Green, D., Singh, A., Tippett, V. L., Tattersall, L., Shah, K. M., Siachisumo, C., Ward, N. J., Thomas, P., Carter, S., Jeys, L., Sumathi, V., McNamara, I. R., Elliott, D. J., Gartland, A., Dalmay, T. & Fraser, W. D., Apr 2023, In: Journal of Bone Oncology. 39, 100474.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)37 Downloads (Pure)
Prizes
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FMH Prize for Innovation from Research
Green, Darrell (Recipient), 29 Jun 2023
Prize: Prize (including medals and awards)
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Freedom of the City of London
Green, Darrell (Recipient), 19 Apr 2024
Prize: Prize (including medals and awards)
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John and Pamela Salter Award
Green, Darrell (Recipient), 1 Sep 2015
Prize: Fellowship awarded competitively
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Press/Media
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CCLG funds new rhabdomyosarcoma research, thanks to Special Named Funds
6/09/24
1 Media contribution
Press/Media: Media Coverage or Contribution
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UEA leads Europe-wide project to revolutionise childhood bone cancer treatment and research
28/06/24
1 Media contribution
Press/Media: UEA Press Release
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New study to reveal the differences between individual cancer cells in Ewing sarcoma and osteosarcoma tumours
26/06/24
1 Media contribution
Press/Media: Media Coverage or Contribution
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UEA academics receive Freedom of the City of London for impactful work
25/04/24
1 Media contribution
Press/Media: Media Coverage or Contribution
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