Projects per year
Dr Monk is Professor of Developmental Epigenetics at the University of East Anglia and is the Cells & Tissues Theme Leader in the School of Biological Sciences. He obtained his PhD from Imperial College London in 2001 before completing several post-doc positions. In 2006 he moved to the Bellvitge Institute for Biomedical Research (IDIBELL) in Barcelona where he was awarded a prestigious Ramon Y Cajal career developmental fellowship. After 10 successful years at IDIBELL he relocated to UEA. His research team endeavours to understand the epigenetic mechanisms relevant to human diseases, focusing on the application of high-throughput genome technologies to analyse the interplay between genetic variations and DNA methylation. For many years his team has addressed the role of aberrant epigenetic regulation in imprinting disorders, as well as in common morbidities, including fetal growth and cancer. Current projects encompass developing novel low-input/single-cell techniques to understand epigenetic mosaicism, utilizing genome-editing technologies for site-specific epigenetic manipulation and understand role of embryonic DNA methylation and transcriptome dynamics on shaping adult phenotypic traits.
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Nutrition and the epigenome: early environmental factors influencing human developmental programming
1/10/20 → 30/09/25
Human Uterus Cell Atlas
1/01/20 → 30/06/22
Single-cell multi-omic analysis profiles defective genome activation and epigenetic reprogramming associated with human pre-implantation embryo arrestHernandez Mora, J. R., Buhigas, C., Clark, S., Del Gallego Bonilla, R., Daskeviciute, D., Monteagudo-Sánchez, A., Poo-Llanillo, M. E., Medrano, J. V., Simón, C., Meseguer, M., Kelsey, G. & Monk, D., 28 Feb 2023, In: Cell Reports. 42, 2, 112100.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbancesPignata, L., Cecere, F., Verma, A., Hay Mele, B., Monticelli, M., Acurzio, B., Giaccari, C., Sparago, A., Hernandez Mora, J. R., Monteagudo-Sánchez, A., Esteller, M., Pereda, A., Tenorio-Castano, J., Palumbo, O., Carella, M., Prontera, P., Piscopo, C., Accadia, M., Lapunzina, P., Cubellis, M. V. & 4 others, , 28 May 2022, In: Clinical Epigenetics. 14, 1, 71.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)3 Downloads (Pure)
Preimplantation genetic testing for a chr14q32 microdeletion in a family with Kagami-Ogata syndrome and Temple syndromeSabria-Back, J., Monteagudo-Sánchez, A., Sánchez-Delgado, M., Ferguson-Smith, A. C., Gómez, O., Pertierra Cartada, A., Tenorio, J., Nevado, J., Lapunzina, P., Pereda Aguirre, A., Giménez Sevilla, C., Toro Toro, E., Perez de Nanclares, G. & Monk, D., Mar 2022, In: Journal of Medical Genetics. 59, 3, p. 253-261 9 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile13 Downloads (Pure)
Trans-acting genetic variants causing multilocus imprinting disturbance (MLID): common mechanisms and consequencesEggermann, T., Yapici, E., Bliek, J., Pereda, A., Begemann, M., Russo, S., Tannorella, P., Calzari, L., de Nanclares, G. P., Lombardi, P., Temple, I. K., Mackay, D., Riccio, A., Kagami, M., Ogata, T., Lapunzina, P., Monk, D., Maher, E. R. & Tümer, Z., 16 Mar 2022, In: Clinical Epigenetics. 14, 41.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile4 Citations (Scopus)3 Downloads (Pure)
Prenatal diagnosis of Kagami-Ogata SyndromeColl, C. M., Bach, J. S., Renau, M. I., Alarcón Allen, A., Monk, D., Gómez del Rincón, O., Recasens, M. M. & Martínez Crespo, J. M., Jun 2021, In: Journal of Clinical Ultrasound. 49, 5, p. 498-501 4 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile3 Citations (Scopus)4 Downloads (Pure)