Projects per year
Personal profile
Academic Background
Dr Monk is Professor of Developmental Epigenetics at the University of East Anglia and is the Cells & Tissues Theme Leader in the School of Biological Sciences. He obtained his PhD from Imperial College London in 2001 before completing several post-doc positions. In 2006 he moved to the Bellvitge Institute for Biomedical Research (IDIBELL) in Barcelona where he was awarded a prestigious Ramon Y Cajal career developmental fellowship. After 10 successful years at IDIBELL he relocated to UEA. His research team endeavours to understand the epigenetic mechanisms relevant to human diseases, focusing on the application of high-throughput genome technologies to analyse the interplay between genetic variations and DNA methylation. For many years his team has addressed the role of aberrant epigenetic regulation in imprinting disorders, as well as in common morbidities, including fetal growth and cancer. Current projects encompass developing novel low-input/single-cell techniques to understand epigenetic mosaicism, utilizing genome-editing technologies for site-specific epigenetic manipulation and understand role of embryonic DNA methylation and transcriptome dynamics on shaping adult phenotypic traits.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Nutrition and the epigenome: early environmental factors influencing human developmental programming
1/10/20 → 30/09/25
Project: Research
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Transcriptome profiling in complicated pregnancies
Norfolk & Norwich University Health Care Trust Charitable Fund
1/05/23 → 30/04/24
Project: Research
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Non-canonical imprinting, manifesting as post-fertilization placenta-specific parent-of-origin dependent methylation, is not conserved in humans
Daskeviciute, D., Chappell-Maor, L., Sainty, B., Arnaud, P., Iglesias-Platas, I., Simon, C., Okae, H., Arima, T., Vassena, R., Lartey, J. & Monk, D., 1 Apr 2025, In: Human Molecular Genetics. 34, 7, p. 626-638 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Differential expression of PPP1R12A transcripts, including those harbouring alternatively spliced micro-exons, in placentae from complicated pregnancies
Frew, E., Sainty, R., Chappell-Maor, L., Bone, C., Daskeviciute, D., Russell, S., Buhigas, C., Iglesias-Platas, I., Lartey, J. & Monk, D., 1 Jun 2024, In: Placenta. 151, p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure) -
Novel 14q32.2 paternal deletion encompassing the whole DLK1 gene associated with Temple syndrome
Baena, N., Monk, D., Aguilera, C., Fraga, M. F., Fernández, A. F., Gabau, E., Corripio, R., Capdevila, N., Trujillo, J. P., Ruiz, A. & Guitart, M., 7 May 2024, In: Clinical Epigenetics. 16, 62.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Single-cell multi-omic analysis profiles defective genome activation and epigenetic reprogramming associated with human pre-implantation embryo arrest
Hernandez Mora, J. R., Buhigas, C., Clark, S., Del Gallego Bonilla, R., Daskeviciute, D., Monteagudo-Sánchez, A., Poo-Llanillo, M. E., Medrano, J. V., Simón, C., Meseguer, M., Kelsey, G. & Monk, D., 28 Feb 2023, In: Cell Reports. 42, 2, 112100.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)17 Downloads (Pure) -
Environmentally sensitive hotspots in the methylome of the early human embryo
Silver, M. J., Saffari, A., Kessler, N. J., Chandak, G. R., Fall, C. H. D., Issarapu, P., Dedaniya, A., Betts, M., Moore, S. E., Routledge, M. N., Herceg, Z., Cuenin, C., Derakhshan, M., James, P. T., Monk, D. & Prentice, A. M., 21 Feb 2022, In: eLife. 11, e72031.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)11 Downloads (Pure)