Projects per year
Personal profile
Academic Background
Dr Monk is Professor of Developmental Epigenetics at the University of East Anglia and is the Cells & Tissues Theme Leader in the School of Biological Sciences. He obtained his PhD from Imperial College London in 2001 before completing several post-doc positions. In 2006 he moved to the Bellvitge Institute for Biomedical Research (IDIBELL) in Barcelona where he was awarded a prestigious Ramon Y Cajal career developmental fellowship. After 10 successful years at IDIBELL he relocated to UEA. His research team endeavours to understand the epigenetic mechanisms relevant to human diseases, focusing on the application of high-throughput genome technologies to analyse the interplay between genetic variations and DNA methylation. For many years his team has addressed the role of aberrant epigenetic regulation in imprinting disorders, as well as in common morbidities, including fetal growth and cancer. Current projects encompass developing novel low-input/single-cell techniques to understand epigenetic mosaicism, utilizing genome-editing technologies for site-specific epigenetic manipulation and understand role of embryonic DNA methylation and transcriptome dynamics on shaping adult phenotypic traits.
Collaborations and top research areas from the last five years
Projects
- 7 Finished
-
Ultralow methylation profiling – allowing for epigenetic biomarker analysis in limited biological samples
Monk, D. & Buhigas, C.
Norfolk & Norwich University Hospitals NHS Foundation Trust
1/07/24 → 30/06/25
Project: Research
-
Influence Of Prematurity and Early Nutritional Support On DNA Methylation In Very Preterm Infants
Monk, D. & Buhigas, C.
Norfolk & Norwich University Health Care Trust Charitable Fund
1/05/23 → 30/04/24
Project: Research
-
Transcriptome profiling in complicated pregnancies
Monk, D. & Buhigas, C.
Norfolk & Norwich University Health Care Trust Charitable Fund
1/05/23 → 30/04/24
Project: Research
-
Non-canonical imprinting, manifesting as post-fertilization placenta-specific parent-of-origin dependent methylation, is not conserved in humans
Daskeviciute, D., Chappell-Maor, L., Sainty, B., Arnaud, P., Iglesias-Platas, I., Simon, C., Okae, H., Arima, T., Vassena, R., Lartey, J. & Monk, D., 1 Apr 2025, In: Human Molecular Genetics. 34, 7, p. 626-638 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)5 Downloads (Pure) -
PIK3R1 and G0S2 are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation
Daskeviciute, D., Sainty, B., Chappell-Maor, L., Bone, C., Russell, S., Iglesias-Platas, I., Arnaud, P., Monteagudo-Sánchez, A., Greenberg, M. V. C., Chen, K., Manerao-Azua, A., Perez de Nanclares, G., Lartey, J. & Monk, D., 26 Jun 2025, In: Epigenetics. 20, 1, 2523191.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Downloads (Pure) -
Differential expression of PPP1R12A transcripts, including those harbouring alternatively spliced micro-exons, in placentae from complicated pregnancies
Frew, E., Sainty, R., Chappell-Maor, L., Bone, C., Daskeviciute, D., Russell, S., Buhigas, C., Iglesias-Platas, I., Lartey, J. & Monk, D., 1 Jun 2024, In: Placenta. 151, p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)16 Downloads (Pure) -
Novel 14q32.2 paternal deletion encompassing the whole DLK1 gene associated with Temple syndrome
Baena, N., Monk, D., Aguilera, C., Fraga, M. F., Fernández, A. F., Gabau, E., Corripio, R., Capdevila, N., Trujillo, J. P., Ruiz, A. & Guitart, M., 7 May 2024, In: Clinical Epigenetics. 16, 62.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)6 Downloads (Pure) -
Single-cell multi-omic analysis profiles defective genome activation and epigenetic reprogramming associated with human pre-implantation embryo arrest
Hernandez Mora, J. R., Buhigas, C., Clark, S., Del Gallego Bonilla, R., Daskeviciute, D., Monteagudo-Sánchez, A., Poo-Llanillo, M. E., Medrano, J. V., Simón, C., Meseguer, M., Kelsey, G. & Monk, D., 28 Feb 2023, In: Cell Reports. 42, 2, 112100.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)20 Downloads (Pure)