Projects per year
Personal profile
Biography
Derek graduated from the University of Dundee with a BSc (Hons) in Molecular Biology and Biochemistry. He obtained his PhD from the University of Glasgow studying the role of Sla1p in linking actin dynamics to the endocytic machinery in budding yeast. Following post-doctoral positions in the Division of Cardiovascular Medicine, University of Cambridge and the Cardiovascular Division, King’s College London, he won a Career Development Award from the King’s College London British Heart Foundation (BHF) Centre of Research Excellence in 2010. In 2011, Derek won a BHF Intermediate Fellowship to investigate novel mechanisms of smooth muscle cell mechanotransduction. His research focusses on understanding how cells sense and respond to changes in their extracellular environment using state-of-the-art biophysical, cell biological and imaging techniques.
PhD positions
I currently have a PhD position advertised in my lab:
The impact of matrix stiffness on smooth muscle cell contractile function
Selected publications
Prelamin A Accumulation Attenuates Rac1 Activity and Increases the Intrinsic Migrational Persistence of Aged Vascular Smooth Muscle Cells
by Lauren J. Porter, Mark R. Holt, Daniel Soong, Catherine M. Shanahan and Derek T. Warren
Cells 2016, 5(4), 41;
DOI:10.3390/cells5040041
N-terminal nesprin-2 variants regulate β-catenin signalling.
Zhang Q, Minaisah RM, Ferraro E, Li C, Porter LJ, Zhou C, Gao F, Zhang J, Rajgor D, Autore F, Shanahan CM, Warren DT.
Exp Cell Res. 2016 Jul 15;345(2):168-79.
DOI: 10.1016/j.yexcr.2016.06.008.
The Use of Polyacrylamide Hydrogels to Study the Effects of Matrix Stiffness on Nuclear Envelope Properties.
Minaisah RM, Cox S, Warren DT.
Methods Mol Biol. 2016;1411:233-9.
DOI: 10.1007/978-1-4939-3530-7_15.
Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing.
Warren DT, Tajsic T, Porter LJ, Minaisah RM, Cobb A, Jacob A, Rajgor D, Zhang QP, Shanahan CM.
Cell Death Differ. 2015 Sep;22(9):1540-50.
DOI: 10.1038/cdd.2015.12.
Nesprins LINC the nucleus and cytoskeleton.
Mellad JA, Warren DT, Shanahan CM.
Curr Opin Cell Biol. 2011 Feb;23(1):47-54.
DOI: 10.1016/j.ceb.2010.11.006. Review.
Network
Projects
- 5 Finished
-
The impact of matrix stiffness on smooth muscle cell contractile function
1/10/18 → 30/03/22
Project: Training
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A highly photostable and versatile two-photon fluorescent probe for the detection of a wide range of intracellular nitric oxide concentrations in macrophages and endothelial cells
Arnau del Valle, C., Williams, L., Thomas, P., Johnson, R., Raveenthiraraj, S., Warren, D., Sobolewski, A., Muñoz, M. P., Galindo, F. & Marín, M. J., Sep 2022, In: Journal of Photochemistry and Photobiology B: Biology. 234, 112512.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)5 Downloads (Pure) -
Using polyacrylamide hydrogels to model physiological aortic stiffness reveals that microtubules are critical regulators of isolated smooth muscle cell morphology and contractility
Ahmed, S., Johnson, R. T., Solanki, R., Afewerki, T., Wostear, F. & Warren, D. T., 27 Jan 2022, In: Frontiers in Pharmacology. 13, 836710.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)4 Downloads (Pure) -
Mechanical programming of arterial smooth muscle cells in health and ageing
Johnson, R. T., Solanki, R. & Warren, D. T., Oct 2021, In: Biophysical Reviews. 13, 5, p. 757–768 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)10 Downloads (Pure) -
SUN1/2 are essential for RhoA/ROCK-regulated actomyosin activity in isolated vascular smooth muscle cells
Porter, S., Minaisah, R. M., Ahmed, S., Ali, S., Norton, R., Zhang, Q., Ferraro, E., Molenaar, C., Holt, M., Cox, S., Fountain, S., Shanahan, C. & Warren, D., 6 Jan 2020, In: Cells. 9, 1, 17 p., 132.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)38 Downloads (Pure) -
Emerging regulators of vascular smooth muscle cell migration
Afewerki, T., Ahmed, S. & Warren, D., Jun 2019, In: Journal of Muscle Research and Cell Motility. 40, 2, p. 185–196Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)38 Downloads (Pure)