Dmitry Pshezhetskiy

Search results

• 2023

  Circulating chromosome conformation signatures significantly enhance PSA positive predicting value and overall accuracy for prostate cancer detection

  Pchejetski, D., Hunter, E., Dezfouli, M., Salter, M., Powell, R., Green, J., Naithani, T., Koutsothanasi, C., Alshaker, H., Jaipuria, J., Connor, M. J., Eldred-Evans, D., Fiorentino, F., Ahmed, H., Akoulitchev, A. & Winkler, M., 29 Jan 2023, In: Cancers. 15, 3, 821.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  3 Citations (Scopus)

  10 Downloads (Pure)
• 2022

  Monocytes acquire prostate cancer specific chromatin conformations upon indirect co-culture with prostate cancer cells

  Alshaker, H., Hunter, E., Salter, M., Ramadass, A., Westra, W., Winkler, M., Green, J., Akoulitchev, A. & Pchejetski, D., 19 Aug 2022, In: Frontiers in Oncology. 12, 990842.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  2 Citations (Scopus)

  15 Downloads (Pure)

• On the survival of individuals diagnosed with type 2 diabetes mellitus in the United Kingdom: A retrospective matched cohort study

  Ncube, N., Kulinskaya, E., Steel, N. & Pchejetski, D., 1 Apr 2022, In: Diabetes Epidemiology and Management. 6, 100065.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  1 Citation (Scopus)

  30 Downloads (Pure)
• 2021

  A case of severe dry eye disease with corneal melting as presenting complaint of acute myeloid leukaemia

  Pchejetski, D., Alshaker, H., Babovic, R. & Maw, K., 2021, In: SAGE Open Medical Case Reports. 9

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  17 Downloads (Pure)

• Chromatin conformation changes in peripheral blood can detect prostate cancer and stratify disease risk groups

  Alshaker, H., Mills, R., Hunter, E., Salter, M., Ramadass, A., Skinner, B. M., Westra, W., Green, J., Akoulitchev, A., Winkler, M. & Pchejetski, D., 28 Jan 2021, In: Journal of Translational Medicine. 19, 1, 46.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  8 Citations (Scopus)

  15 Downloads (Pure)
• 2020

  Bradycardia and syncope as sole manifestations of a cranial lesion: a case report

  Pchejetski, D., Kenbaz, M., Alshaker, H. & Jesudason, K., 31 Jan 2020, In: Journal of Medical Case Reports. 14, 1, 24.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  1 Citation (Scopus)

  36 Downloads (Pure)

• Dynamic early identification of hip replacement implants with high revision rates. Study based on the NJR data from UK during 2004-2012

  Begun, A., MacGregor, A. J., Pchejetski, D. & Kulinskaya, E., 4 Aug 2020, In: PLoS One. 15, 8, e0236701.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  2 Citations (Scopus)

  19 Downloads (Pure)

• Sphingosine kinase 1 in breast cancer: A new molecular marker and a therapy target

  Alshaker, H., Thrower, H. & Pchejetski, D., 20 Mar 2020, In: Frontiers in Oncology. 10, 14 p., 289.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  20 Citations (Scopus)

  21 Downloads (Pure)
• 2019

  Transcriptome-wide effects of sphingosine kinases knockdown in metastatic prostate and breast cancer cells: Implications for therapeutic targeting

  Alshaker, H., Wang, Q., Brewer, D. & Pshezhetskiy, D., 27 Mar 2019, In: Frontiers in Pharmacology. 10, 12 p., 303.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  20 Citations (Scopus)

  20 Downloads (Pure)
• 2018

  Field template-based design and biological evaluation of new sphingosine kinase 1 inhibitors

  Alshaker, H., Srivats, S., Monteil, D., Wang, Q., Low, C. M. R. & Pchejetski, D., Nov 2018, In: Breast Cancer Research and Treatment. 172, 1, p. 33–43 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  13 Citations (Scopus)

  20 Downloads (Pure)
• 2017

  An unusual case of disseminated intravascular coagulation

  Pchejetski, D., Kenbaz, M., Alshaker, H., Rajput, D. & Jesudason, K., 3 Apr 2017, In: Oxford Medical Case Reports. 2017, 4, omx009.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  27 Downloads (Pure)

• Combination of RAD001 (everolimus) and docetaxel reduces prostate and breast cancer cell VEGF production and tumour vascularisation independently of sphingosine-kinase-1

  Alshaker, H., Wang, Q., Böhler, T., Mills, R., Winkler, M., Arafat, T., Kawano, Y. & Pchejetski, D., 14 Jun 2017, In: Scientific Reports. 7, 3493.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  25 Citations (Scopus)

  14 Downloads (Pure)

• Core shell lipid-polymer hybrid nanoparticles with combined docetaxel and molecular targeted therapy for the treatment of metastatic prostate cancer

  Wang, Q., Alshaker, H., Böhler, T., Srivats, S., Chao, Y., Cooper, C. & Pchejetski, D., 19 Jul 2017, In: Scientific Reports. 7, 5901.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  64 Citations (Scopus)

  39 Downloads (Pure)

• New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth

  Alshaker, H., Wang, Q., Srivats, S., Chao, Y., Cooper, C. & Pchejetski, D., Oct 2017, In: Breast Cancer Research and Treatment. 165, 3, p. 531–543

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  20 Citations (Scopus)

  42 Downloads (Pure)
• 2016

  Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1α and sphingosine kinase 1

  Alshaker, H., Wang, Q., Kawano, Y., Arafat, T., Böhler, T., Winkler, M., Cooper, C. & Pchejetski, D., 4 Nov 2016, In: Oncotarget. 7, 49, p. 80943-80956 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  34 Citations (Scopus)

  26 Downloads (Pure)

• Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer

  Pchejetski, D., Alfraidi, A., Sacco, K., Alshaker, H., Muhammad, A. & Monzon, L., Aug 2016, In: Journal of Cancer Research and Clinical Oncology. 142, 8, p. 1659–1671 13 p.

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

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  22 Citations (Scopus)

  20 Downloads (Pure)

• Leptomeningeal carcinomatosis as the primary presentation of relapse in breast cancer

  Sacco, K., Muhammad, A., Saleem, W., Alshaker, H., Monzon, L., Islam, M. R. & Pchejetski, D., Aug 2016, In: Oncology Letters. 12, 2, p. 779-782 4 p.

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

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  8 Citations (Scopus)

  21 Downloads (Pure)

• miR-515-5p controls cancer cell migration through MARK4 regulation

  Pardo, O. E., Castellano, L., Munro, C. E., Hu, Y., Mauri, F., Krell, J., Lara, R., Pinho, F. G., Choudhury, T., Frampton, A. E., Pellegrino, L., Pshezhetskiy, D., Wang, Y., Waxman, J., Seckl, M. J. & Stebbing, J., 1 Apr 2016, In: EMBO Reports. 17, 4, p. 570-584 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  92 Citations (Scopus)

  12 Downloads (Pure)

• The emerging role of FTY720 (Fingolimod) in cancer treatment

  White, C., Alshaker, H., Cooper, C., Winkler, M. & Pchejetski, D., 2 Feb 2016, In: Oncotarget. 7, 17, p. 23106-23127 22 p.

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

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  125 Citations (Scopus)

  17 Downloads (Pure)
• 2015

  Leptin receptor-dependent and -independent STAT3 phosphorylation in oestrogen receptor-negative breast cancer

  Alshaker, H., Krell, J., Frampton, A. E., Wang, Q., Cooper, C., Winkler, M., Yaguee, E., Pchejetski, D. & Alshaker, H., 2015, In: International Journal of Molecular Medicine. 36, p. S6 1 p.

  Research output: Contribution to journal › Abstract › peer-review

• Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma

  Alshaker, H., Sacco, K., Alfraidi, A., Muhammad, A., Winkler, M. & Pchejetski, D., 10 Sep 2015, In: Oncotarget. 6, 34, p. 35556-35563 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  46 Citations (Scopus)

  12 Downloads (Pure)

• Sphingosine kinase 1 contributes to leptin-induced STAT3 phosphorylation through IL-6/gp130 transactivation in oestrogen receptor-negative breast cancer

  Alshaker, H., Wang, Q., Frampton, A. E., Krell, J., Waxman, J., Winkler, M., Stebbing, J., Cooper, C., Yaguee, E. & Pchejetski, D., Jan 2015, In: Breast Cancer Research and Treatment. 149, 1, p. 59-67 9 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)
• 2014

  Castrate-resistant prostate cancer: the future of antiandrogens

  Pshezhetskiy, D., Alshaker, H. & Stebbing, J., 30 Jan 2014, In: Trends in Urology & Men’s Health. 5, 1

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

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  10 Downloads (Pure)

• Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway

  Alshaker, H., Krell, J., Frampton, A. E., Waxman, J., Blyuss, O., Zaikin, A., Winkler, M., Stebbing, J., Yaguee, E. & Pchejetski, D., 25 Oct 2014, In: Breast Cancer Research. 16, 426.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  11 Downloads (Pure)

• Spontaneous antibodies against Engrailed-2 (EN2) protein in patients with prostate cancer

  Annels, N. E., Simpson, G. R., Denyer, M., McGrath, S. E., Falgari, G., Killick, E., Eeles, R., Stebbing, J., Pchejetski, D., Cutress, R., Murray, N., Michael, A. & Pandha, H., Aug 2014, In: Clinical and Experimental Immunology. 177, 2, p. 428-438 11 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)
• 2013

  Chapter Six – Therapeutic Potential of Targeting SK1 in Human Cancers

  Alshaker, H., Sauer, L., Monteil, D., Ottaviani, S., Srivats, S., Böhler, T. & Pchejetski, D., 2013, Advances in Cancer Research: The Role of Sphingolipids in Cancer Development and Therapy. Norris, J. S. (ed.). Elsevier, Vol. 117. p. 143-200 58 p. (Advances in Cancer Research; vol. 117).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
  46 Citations (Scopus)
• 2012

  A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumour responses to chemotherapy

  Stebbing, J., Sharma, A., North, B., Athersuch, T. J., Zebrowski, A., Pchejetski, D., Coombes, R. C., Nicholson, J. K. & Keun, H. C., Apr 2012, In: Annals of Oncology. 23, 4, p. 860-866 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  44 Citations (Scopus)

• Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1

  Pchejetski, D., Foussal, C., Alfarano, C., Lairez, O., Calise, D., Guilbeau-Frugier, C., Schaak, S., Seguelas, M-H., Wanecq, E., Valet, P., Parini, A. & Kunduzova, O., Sep 2012, In: European Heart Journal. 33, 18, p. 2360-9 10 p.

  Research output: Contribution to journal › Article › peer-review
  124 Citations (Scopus)

• Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection

  Nunes, J., Naymark, M., Sauer, L., Muhammad, A., Keun, H., Sturge, J., Stebbing, J., Waxman, J. & Pchejetski, D., 28 Feb 2012, In: British Journal of Cancer. 106, 5, p. 909-915 7 p.

  Research output: Contribution to journal › Article › peer-review
  47 Citations (Scopus)

• Differential control of hypoxia-inducible factor 1 activity during pro-inflammatory reactions of human haematopoietic cells of myeloid lineage

  Gibbs, B. F., Yasinska, I. M., Pchejetski, D., Wyszynski, R. W. & Sumbayev, V. V., Nov 2012, In: International Journal of Biochemistry & Cell Biology. 44, 11, p. 1739-49 11 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis

  Caley, M. P., Kogianni, G., Adamarek, A., Gronau, J. H., Rodriguez-Teja, M., Fonseca, A-V., Mauri, F., Sandison, A., Rhim, J. S., Pchejetski, D., Palmieri, C., Cobb, J. P., Waxman, J. & Sturge, J., Apr 2012, In: The Journal of Pathology. 226, 5, p. 775-783 9 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)
• 2011

  The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1α protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6

  Pchejetski, D., Nunes, J., Coughlan, K., Lall, H., Pitson, S. M., Waxman, J. & Sumbayev, V. V., Feb 2011, In: Immunology and Cell Biology. 89, 2, p. 268-74 7 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)

• Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer

  Pchejetski, D., Böhler, T., Stebbing, J. & Waxman, J., Oct 2011, In: Nature Reviews Urology. 8, 10, p. 569-578 10 p.

  Research output: Contribution to journal › Article › peer-review
  46 Citations (Scopus)
• 2010

  Circulating sphingosine-1-phosphate inversely correlates with chemotherapy-induced weight gain during early breast cancer

  Pchejetski, D., Nunes, J., Sauer, L., Sidhu, J., Sharma, A., Keun, H. C., Waxman, J. & Stebbing, J., Nov 2010, In: Breast Cancer Research and Treatment. 124, 2, p. 543-9 7 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Cytokine and Adhesion Molecule Expression Evolves Between the Neutrophilic and Lymphocytic Phases of Viral Meningitis

  Makis, A., Shipway, D., Hatzimichael, E., Galanakis, E., Pshezhetskiy, D., Chaliasos, N., Stebbing, J. & Siamopoulou, A., 13 Sep 2010, In: Journal of Interferon & Cytokine Research. 30, 9, p. 661-665 5 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1

  Pchejetski, D., Bohler, T., Brizuela, L., Sauer, L., Doumerc, N., Golzio, M., Salunkhe, V., Teissié, J., Malavaud, B., Waxman, J. & Cuvillier, O., 1 Nov 2010, In: Cancer Research. 70, 21, p. 8651-61 11 p.

  Research output: Contribution to journal › Article › peer-review
  126 Citations (Scopus)

• Inflammatory cytokines and aromatase inhibitor-associated musculoskeletal syndrome: A case-control study

  Henry, N. L., Pchejetski, D., A'Hern, R., Nguyen, A. T., Charles, P., Waxman, J., Li, L., Storniolo, A. M., Hayes, D. F., Flockhart, D. A., Stearns, V. & Stebbing, J., 27 Jul 2010, In: British Journal of Cancer. 103, 3, p. 291-296 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  34 Citations (Scopus)

• Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens

  Malavaud, B., Pchejetski, D., Mazerolles, C., de Paiva, G. R., Calvet, C., Doumerc, N., Pitson, S., Rischmann, P. & Cuvillier, O., Dec 2010, In: European Journal of Cancer. 46, 18, p. 3417-24 8 p.

  Research output: Contribution to journal › Article › peer-review
  78 Citations (Scopus)
• 2009

  Serum molecular signatures of weight change during early breast cancer chemotherapy

  Keun, H. C., Sidhu, J., Pchejetski, D., Lewis, J. S., Marconell, H., Patterson, M., Bloom, S. R., Amber, V., Coombes, R. C. & Stebbing, J., 1 Nov 2009, In: Clinical Cancer Research. 15, 21, p. 6716-23 8 p.

  Research output: Contribution to journal › Article › peer-review
  56 Citations (Scopus)

• Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel

  Sauer, L., Nunes, J., Salunkhe, V., Skalska, L., Kohama, T., Cuvillier, O., Waxman, J. & Pchejetski, D., 1 Dec 2009, In: International Journal of Cancer. 125, 11, p. 2728-36 9 p.

  Research output: Contribution to journal › Article › peer-review
  54 Citations (Scopus)

• Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug

  Guillermet-Guibert, J., Davenne, L., Pchejetski, D., Saint-Laurent, N., Brizuela, L., Guilbeau-Frugier, C., Delisle, M-B., Cuvillier, O., Susini, C. & Bousquet, C., Apr 2009, In: Molecular Cancer Therapeutics. 8, 4, p. 809-20 12 p.

  Research output: Contribution to journal › Article › peer-review
  115 Citations (Scopus)
• 2008

  Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models

  Pchejetski, D., Doumerc, N., Golzio, M., Naymark, M., Teissié, J., Kohama, T., Waxman, J., Malavaud, B. & Cuvillier, O., Jul 2008, In: Molecular Cancer Therapeutics. 7, 7, p. 1836-45 10 p.

  Research output: Contribution to journal › Article › peer-review
  107 Citations (SciVal)
• 2007

  Critical role for sphingosine kinase-1 in regulating survival of neuroblastoma cells exposed to amyloid-beta peptide

  Gomez-Brouchet, A., Pchejetski, D., Brizuela, L., Garcia, V., Altié, M-F., Maddelein, M-L., Delisle, M-B. & Cuvillier, O., Aug 2007, In: Molecular Pharmacology. 72, 2, p. 341-9 9 p.

  Research output: Contribution to journal › Article › peer-review
  57 Citations (Scopus)

• Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis

  Pchejetski, D., Kunduzova, O., Dayon, A., Calise, D., Seguelas, M-H., Leducq, N., Seif, I., Parini, A. & Cuvillier, O., 5 Jan 2007, In: Circulation Research. 100, 1, p. 41-9 9 p.

  Research output: Contribution to journal › Article › peer-review
  175 Citations (Scopus)
• 2006

  Modest intracellular acidification suppresses death signaling in ouabain-treated cells

  Akimova, O. A., Pchejetski, D., Hamet, P. & Orlov, S. N., Jan 2006, In: Pflügers Archiv European Journal of Physiology. 451, 4, p. 569-78 10 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1

  Bonhoure, E., Pchejetski, D., Aouali, N., Morjani, H., Levade, T., Kohama, T. & Cuvillier, O., Jan 2006, In: Leukemia. 20, 1, p. 95-102 8 p.

  Research output: Contribution to journal › Article › peer-review
  162 Citations (Scopus)
• 2005

  Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression

  Le Scolan, E., Pchejetski, D., Banno, Y., Denis, N., Mayeux, P., Vainchenker, W., Levade, T. & Moreau-Gachelin, F., 1 Sep 2005, In: Blood. 106, 5, p. 1808-16 9 p.

  Research output: Contribution to journal › Article › peer-review
  94 Citations (Scopus)

• Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models

  Pchejetski, D., Golzio, M., Bonhoure, E., Calvet, C., Doumerc, N., Garcia, V., Mazerolles, C., Rischmann, P., Teissié, J., Malavaud, B. & Cuvillier, O., 15 Dec 2005, In: Cancer Research. 65, 24, p. 11667-75 9 p.

  Research output: Contribution to journal › Article › peer-review
  187 Citations (Scopus)
• 2004

  Apoptosis in serum-deprived vascular smooth muscle cells: Evidence for cell volume-independent mechanism

  Orlov, S. N., Pchejetski, D., Taurin, S., Thorin-Trescases, N., Maximov, G. V., Pshezhetsky, A. V., Rubin, A. B. & Hamet, P., Jan 2004, In: Apoptosis. 9, 1, p. 55-66 12 p.

  Research output: Contribution to journal › Article › peer-review
  28 Citations (Scopus)

• Na+/K+ pump and endothelial cell survival: [Na+]i/[K+]i-independent necrosis triggered by ouabain, and protection against apoptosis mediated by elevation of [Na+]i

  Orlov, S. N., Thorin-Trescases, N., Pchejetski, D., Taurin, S., Farhat, N., Tremblay, J., Thorin, E. & Hamet, P., Jun 2004, In: Pflügers Archiv European Journal of Physiology. 448, 3, p. 335-45 11 p.

  Research output: Contribution to journal › Article › peer-review
  55 Citations (Scopus)