Projects per year
- Director of Prostgraduate Studies in the School of Biological Sciences
- Course Director for Molecular Biology and Genetics and Genetics
- Module Organiser for Molecular Biology (2B02 and now 5003B; 2003-present)
- Member of the Exam Board
- Associate Professor, University of East Anglia (2014-present)
- Lecturer, University of East Anglia (2000-present)
- Post Doctoral Fellow, John Innes Centre (1993-2000)
- Post Doctoral Fellow, University of Leicester (1991-1993)
- Leverhulme Trust Fellowship, University of Leicester, Department of Biochemistry (1989-1990)
- Ph.D. - Eötvös Loránd University Budapest, Hungary (1987)
- B.Sc. - Chemistry; Eötvös Loránd University Budapest, Hungary (1984)
2014 June – 2nd International Workshop on the Biology and Physics of Bacterial Chromosomes, Birmingham UK; Talk: Molecular link between a polarity centre and chromosome organisation in Streptomyces.
2014 September- Meeting for OUC-UEA Strategic Alliance in Integrative Ocean Science, Talk: Polar growth in bacteria – is there a possible link to environmental adaptation?
2014 October – invited speaker at the XVII. International Symposium on the Biology of Actinomycetes ( ISBA'17) in Turkey, Izmir: Molecular link between TIPOC, a polarity centre, and chromosome organisation in Streptomyces.
Key Research Interests and Expertise
Our main research interest is studying bacterial development of Streptomyces coelicolor, a Gram-positive, filamentous bacterium. Unlike most bacteria that divide by binary fission, in Streptomyces coelicolor long, multigenomic filaments are formed with ocasional septa and regular branching. Cell division is completed only during sporulation when 50-100 sporulation septa are laid down synchronously in the aerial hyphae generating unigenomic spore compartments.
Current Research Projects
- Bacterial polarised growth and its control by cytoskeletal proteins
- Coiled-coil proteins as synthetic scaffolds
- Chromosome organisation during hyphal growth
- Signalling in bacterial development
- The role of specific RNA polymerase holoenzymes controlling development and stress response
- Global characterisation of spore maturation and germination
MSc (Master of Science) training by research is available in my laboratory. Please arrange a meeting with me if you are interested. Click here for further details.
Life in our Research Group
Our laboratory focuses on the biology of the model organism for bacterial development and antibiotic production, Streptomyces coelicolor. This exciting bacterium forms long, multigenomic filaments with complex branching patterns and at the end of its life cycle generates unigenomic spores ready for dispersal. Importantly, streptomycetes are the producers of more than 70% of the commercially available antibiotics. We are studying the mechanism of regulation of the complex developmental cycle of Streptomyces, including studies on gene expression, intra- and intercellular signalling and bacterial cytoskeletal proteins controlling cell shape and cell cycle using molecular biology, biochemistry and cell biology techniques. For localisation studies we access the Henry Wellcome Imaging laboratory for “state of the art” microscopy technologies. We have lab meetings and departmental seminars where we discuss experimental progress and recent publications. To present our results we regularly attend national and international conferences, such as the Society of General Microbiology meetings, the International Symposium on the Biology of Actinomycetes and Meetings on Bacterial Development.
We are seeking applicants for a PhD Studentship on “Coiled-coil proteins as nano-wire scaffolds”. Please contact me for any further information on this project.
Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.
Postdocs & Fellows
I am always happy to discuss possibilities for postdoctoral work and collaborations. Possible funding routes include fellowship appliactions, e.g. EU Marie Curie fellowships, with me acting as sponsor, or grant applications with you as a named postdoc.
Gene regulation in bacteria
Transcriptional regulation of development and antibiotic production in Streptomyces
Bacterial polar growth and cell division.
- Molecular Biology (2B02 or 5003B)
- Microbiology (2B28)
- Microbial Cell Biology (3C10)
- Mathematics and Statistics for Biologists (4008Y and 4009Y)
- Fundamentals of Cell Biology and Biochemistry (4003B)
Dive into details
Select a country/territory to view shared publications and projects
10/06/15 → 4/08/15
2/03/15 → 28/02/16
1/01/15 → 31/12/16
Alcock, E., Singh, A., Kelemen, G. & Bhatt, A., Sep 2020, In : Microbiology. 166, 9, p. 817-825 9 p., 000952.
Research output: Contribution to journal › ArticleOpen AccessFile1 Citation (Scopus)11 Downloads (Pure)
Kelemen, G. H., 13 May 2017, Prokaryotic Cytoskeletons. Löwe, J. & Amos, L. A. (eds.). Springer, p. 161-211 Chapter 6. (Subcellular Biochemistry; vol. 84).
Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution10 Citations (Scopus)
A sporulation specific, sigF -dependent protein, SspA, affects septum positioning in Streptomyces coelicolorTzanis, A., Dalton, K. A., Hesketh, A., Den Hengst, C. D., Buttner, M. J., Thibessard, A. & Kelemen, G. H., Jan 2014, In : Molecular Microbiology. 91, 2, p. 363-380 18 p.
Research output: Contribution to journal › Article8 Citations (Scopus)
Coiled-coil protein Scy is a key component of a multiprotein assembly controlling polarized growth in StreptomycesHolmes, N. A., Walshaw, J., Leggett, R. M., Thibessard, A., Dalton, K. A., Gillespie, M. D., Hemmings, A. M., Gust, B. & Kelemen, G. H., 2013, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 110, 5, p. 397-406 9 p.
Research output: Contribution to journal › Article63 Citations (Scopus)
Dynamic interplay of ParA with the polarity protein, Scy, coordinates growth with chromosome segregation in Streptomyces coelicolorDitkowski, B., Holmes, N., Rydzak, J., Donczew, M., Bezulska, M., Ginda, K., Kedzierski, P., Zakrzewska-Czerwinska, J., Kelemen, G. & Jakimowicz, D., 27 Mar 2013, In : Open Biology. 3, 3, 130006.
Research output: Contribution to journal › ArticleOpen Access35 Citations (Scopus)