Projects per year
- BIO Open Lecture Coordinator
- Professor in Cell and Developmental Biology 2020-present
- Reader in Cell and Developmental Biology 2015-2020
- Senior Lecturer in Cell & Developmental Biology 2010-2014
- Lecturer in Cell and Developmental Biology at University of East Anglia, Norwich, England, 2001-2009
- Postdoctoral Research Associate and Honorary Lecturer in the lab of Dr Stefan Hoppler, University of Dundee. Studying Wnt signalling in Xenopus development. 1998-2001.
- Postdoctoral Research Assistant in the lab of Prof. Birgitte Lane, University of Dundee. Looking at the biology of plectin, a component of hemidesmosomes. 1996-1998.
- Postdoctoral research with Prof. Richard Hynes at the MIT, Cambridge, MA, U.S.A. Studying cytoskeletal interactions of integrins. 1992-1996
- Postgraduate studies at the N.I.M.R. in Mill Hill, London, U.K. with Dr. Tony Magee on the cell and molecular biology of desmosomes. 1988-1991
- Undergraduate studies in Biochemistry at King's College, University of London, including a sandwich year at the Advanced Drug Delivery Research Unit, Ciba Geigy, Horsham. 1984-1988
- Ambassador for the British Society for Cell Biology (BSCB)
Key Research Interests and Expertise
My group works on the molecular events that govern the origin and migration of different cell types within the developing embryo. The model organism we use is the amphibian Xenopus laevis.
Current Research Projects
- Regulation of Neural Crest development by transcritional elongation
- The role of micro RNAs in Xenopus development
- The effects of Wnt signalling on early development and later organogenesis. In particular we are studying the function of frizzleds in neural crest, neural and heart development
- The role of the cell adhesion/migration in development. We are currently focused on matrix metalloproteinases, ADAMs and ADAMTS's and their roles in early development including during neural crest and embryonic macrophage cell migration
- Chemical genetic screens to identify small molecules that affect aspects of development focussing on cell migration and movement
- Identification of small molecules as potential drugs for treatment of melanoma
Life in our research group
We are a dynamic group using the amphibian Xenopus laevis as a model organism to study aspects of cell and developmental biology in a whole animal situation. We use modern methods of embryology and molecular biology in the lab. We have our own lab meetings as well as joint lab meetings with Professor Andrea Munsterberg's group who work on other aspects of developmental biology. We also encourage attendance at seminars in BIO and beyond. Recently Students and Postdocs in the lab have participated in courses and conferences in Europe and the USA.
Postdocs & Fellows
I am always happy to discuss possibilities for postdoctoral work and collaborations. Possible funding routes include applying for fellowships, e.g. EMBO or EU Marie Curie fellowships, with me acting as sponsor, or grant applications with you as a named postdoc.
Dive into details
Select a country/territory to view shared publications and projects
1/04/21 → 30/09/21
8/07/19 → 1/09/19
Characterising open chromatin in chick embryos identifies cis-regulatory elements important for paraxial mesoderm formation and axis extensionMok, G. F., Folkes, L., Weldon, S. A., Maniou, E., Martinez-Heredia, V., Godden, A. M., Williams, R. M., Sauka-Spengler, T., Wheeler, G. N., Moxon, S. & Münsterberg, A. E., 19 Feb 2021, In : Nature Communications. 12, 1, 1157 .
Research output: Contribution to journal › ArticleOpen AccessFile9 Downloads (Pure)
Münsterberg, A. E. & Wheeler, G. N., Mar 2021, In : Gene Expression Patterns. 39, 119167.
Research output: Contribution to journal › Article
FZD10 regulates cell proliferation and mediates Wnt1 induced neurogenesis in the developing spinal cordAlrefaei, A., Munsterberg, A. & Wheeler, G., 12 Jun 2020, In : PLoS One. 15, 6, 17 p., e0219721.
Research output: Contribution to journal › ArticleOpen AccessFile18 Downloads (Pure)
Wheeler, G. N., Nov 2020, In : Cold Spring Harbor Protocols. p. 470-477 8 p.
Research output: Contribution to journal › ArticleOpen AccessFile1 Citation (Scopus)5 Downloads (Pure)
Microsyntenic Clusters Reveal Conservation of lncRNAs in Chordates Despite Absence of Sequence ConservationHerrera-Úbeda, C., Marín-Barba, M., Navas-Pérez, E., Gravemeyer, J., Albuixech-Crespo, B., Wheeler, G. N. & Garcia-Fernàndez, J., 24 Aug 2019, In : Biology. 8, 3.
Research output: Contribution to journal › ArticleOpen AccessFile11 Citations (Scopus)18 Downloads (Pure)