Projects per year
Personal profile
Academic Background
I joined the Norwich Medical School at UEA as a lecturer in March 2019.
BIOGRAPHY
I studied organic chemistry (MSc) at the University of Nantes in France and obtained a PhD in 2001 on food authentication using proton Nuclear Magnetic Resonance (1H NMR) and multivariate statistics (University of East Anglia). This was followed by postdoctoral appointments at the Quadram Institute (formerly the Institute of Food Research) on authentication of genetically modified foods and typical foods using metabolomics. In 2009, I took a sabbatical year from the IFR and took a postdoctoral position at the University of Nantes on nutritional imprinting. In 2010, I became the manager of the metabolomics unit in the IFR Analytical Science group and provided metabolite analysis on an open-access basis to staff and students. I have expertise in metabolomics/ lipidomics and over 20 years expertise in the field of metabolite analysis using techniques such as NMR and Mass Spectrometry (MS). My expertise covers data processing, deconvolution and multi and univariate analysis as well as compound identification. My knowledge extends to mammalian, food, plant and microbial metabolism. I have worked on numerous projects covering human nutrition and health, food authenticity, bacterial substrate specificity and the interactions between the host and the microbiota. In 2018, I was appointed in the Qi lab to develop a new thermal technique called Thermal Analysis by Structural Charaterization (TASC) and optimise the formulation of organogels for long term drug release.
I am an author or co-author of over 50 peer-reviewed articles, 5 book chapters, a Henri Stewart tutorial (NMR workflow from data analysis to metabolite identification, https://hstalks.com/bs/3611/) and numerous conference proceedings and posters. I also delivered tutorials at the “Introduction to metabolomics analysis” course at the European Bioinformatics Institute (EMBL-EBI) in Hinxton Cambridge and to UEA master students taking modules in forensic sciences and microbial cell biology (https://csr.quadram.ac.uk/wp-content/uploads/Microbial-Cell-Biology-lecture_Metabolomics.pdf).
https://scholar.google.co.uk/citations?user=GypJUOEAAAAJ&hl=en
https://orcid.org/0000-0002-1379-2196
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of the University, Food authenticity and quality assessment using 1H NMR spectroscopy and chemometrics, Quadram Institute Bioscience
1 May 1998 → 4 Apr 2002
Award Date: 4 Apr 2002
Master of Chemistry, Use of 1H NMR and chemometrics for the authentication of fruit purees, University of Nantes
1 Oct 1996 → 13 Sep 1997
Award Date: 13 Sep 1997
Bachelor of Science, Asymmetric cyclopropanations using the Simmons-Smith reaction
1 Oct 1995 → 1 Sep 1996
Award Date: 1 Sep 1996
External positions
Senior researcher, Quadram Institute Bioscience
1 Apr 2010 → 31 Mar 2018
Post-doc, Quadram Institute Bioscience
1 Oct 2001 → 31 Mar 2010
Keywords
- Biochemistry
- microbial metabolites
- Chemistry
- short chain fatty acids
- bile acids
- tryptophan
- amines
- sugars
- nucleosides
- phenolics
- metabolomics
- lipidomics
Collaborations and top research areas from the last five years
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Metabolomic signatures in menopause mediated Alzheimer’s development
1/07/24 → 30/06/25
Project: Research
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Identifying the Dietary Signatures of Arthritis through metabolomics (the DeSignA study)
Macgregor, A., Clark, I., Davidson, R., Kemsley, K., Le Gall, G., Yates, M. & Chipping, J.
1/05/23 → 30/04/25
Project: Research
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New high resolution mass spectrometry facilities for macromolecules and metabolites at the University of East Anglia
Le Brun, N., Butt, J., Gates, A., Hutchings, M., Le Gall, G., Searcey, M., Todd, J., Waller, Z., Wilson, P., Goodey, K. & Hinchliffe, A.
Biotechnology and Biological Sciences Research Council
5/11/20 → 4/04/21
Project: Research
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(Poly)phenol-rich grape and blueberry extract prevents LPS-induced disruption of the blood-brain barrier through the modulation of the gut microbiota-derived uremic toxins
Connell, E., Le Gall, G., McArthur, S., Lang, L., Breeze, B., Pontifex, M. G., Sami, S., Pourtau, L., Gaudout, D., Müller, M. & Vauzour, D., Nov 2024, In: Neurochemistry International. 180, 105878.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
A novel Mediterranean diet-inspired supplement ameliorates cognitive, microbial, and metabolic deficits in a mouse model of low-grade inflammation
Pontifex, M. G., Connell, E., Le Gall, G., Lang, L., Pourtau, L., Gaudout, D., Angeloni, C., Zallocco, L., Ronci, M., Giusti, L., Müller, M. & Vauzour, D., Jun 2024, In: Gut Microbes. 16, 1, 2363011.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure) -
Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor
Shah, S. N., Knausenberger, T. B-A., Pontifex, M. G., Connell, E., Le Gall, G., Hardy, T. A. J., Randall, D. W., McCafferty, K., Yaqoob, M. M., Solito, E., Müller, M., Stachulski, A. V., Glen, R. C., Vauzour, D., Hoyles, L. & McArthur, S., 31 Dec 2024, In: Gut Microbes. 16, 1, 2431651.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Exploring the sequence-function space of microbial fucosidases
Martínez Gascueña, A., Wu, H., Wang, R., Owen, C. D., Hernando, P. J., Monaco, S., Penner, M., Xing, K., Le Gall, G., Gardner, R., Ndeh, D., Urbanowicz, P. A., Spencer, D. I. R., Walsh, M., Angulo, J. & Juge, N., 18 Jun 2024, In: Communications Chemistry. 7, 1, 137.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure) -
Identifying the dietary signatures of arthritis through metabolomics
Cobas, C., Defernez, M., Kemsley, E. K., Lachenmann, M., Le Gall, G., MacGregor, A., Pirt, J., Varshavi, D. & Wachowiak, E., 15 Sep 2024.Research output: Contribution to conference › Poster › peer-review
Open AccessFile12 Downloads (Pure)
Activities
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Manuscripts submitted to various journals
Gwenaelle Le Gall (Contributor)
2018 → …Activity: Other activity types › Other
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NIHR gastrointestinal infection annual meeting
Gwenaelle Le Gall (Contributor)
Mar 2015Activity: Participating in or organising an event › Participation in workshop or seminar
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FSA workshop: The application of new technologies to the risk assessment of genetically modified organisms
Gwenaelle Le Gall (Contributor)
Dec 2014Activity: Participating in or organising an event › Participation in workshop or seminar
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International Probiotics Association (IPA) World Congress
Gwenaelle Le Gall (Speaker)
May 2014Activity: Participating in or organising an event › Participation in conference
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Metabolomics in sport science and nutrition – invited seminar speaker at the University of Greenwich
Gwenaelle Le Gall (Invited speaker)
Feb 2014Activity: Participating in or organising an event › Invited talk