Projects per year
Personal profile
Academic Background
I joined the Norwich Medical School at UEA as a lecturer in March 2019.
BIOGRAPHY
I studied organic chemistry (MSc) at the University of Nantes in France and obtained a PhD in 2001 on food authentication using proton Nuclear Magnetic Resonance (1H NMR) and multivariate statistics (University of East Anglia). This was followed by postdoctoral appointments at the Quadram Institute (formerly the Institute of Food Research) on authentication of genetically modified foods and typical foods using metabolomics. In 2009, I took a sabbatical year from the IFR and took a postdoctoral position at the University of Nantes on nutritional imprinting. In 2010, I became the manager of the metabolomics unit in the IFR Analytical Science group and provided metabolite analysis on an open-access basis to staff and students. I have expertise in metabolomics/ lipidomics and over 20 years expertise in the field of metabolite analysis using techniques such as NMR and Mass Spectrometry (MS). My expertise covers data processing, deconvolution and multi and univariate analysis as well as compound identification. My knowledge extends to mammalian, food, plant and microbial metabolism. I have worked on numerous projects covering human nutrition and health, food authenticity, bacterial substrate specificity and the interactions between the host and the microbiota. In 2018, I was appointed in the Qi lab to develop a new thermal technique called Thermal Analysis by Structural Charaterization (TASC) and optimise the formulation of organogels for long term drug release.
I am an author or co-author of over 50 peer-reviewed articles, 5 book chapters, a Henri Stewart tutorial (NMR workflow from data analysis to metabolite identification, https://hstalks.com/bs/3611/) and numerous conference proceedings and posters. I also delivered tutorials at the “Introduction to metabolomics analysis” course at the European Bioinformatics Institute (EMBL-EBI) in Hinxton Cambridge and to UEA master students taking modules in forensic sciences and microbial cell biology (https://csr.quadram.ac.uk/wp-content/uploads/Microbial-Cell-Biology-lecture_Metabolomics.pdf).
https://scholar.google.co.uk/citations?user=GypJUOEAAAAJ&hl=en
https://orcid.org/0000-0002-1379-2196
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of the University, Quadram Institute Bioscience
1 May 1998 → 4 Apr 2002
Award Date: 4 Apr 2002
Master of Chemistry, University of Nantes
1 Oct 1996 → 13 Sep 1997
Award Date: 13 Sep 1997
Bachelor of Science
1 Oct 1995 → 1 Sep 1996
Award Date: 1 Sep 1996
External positions
Senior researcher, Quadram Institute Bioscience
1 Apr 2010 → 31 Mar 2018
Post-doc, Quadram Institute Bioscience
1 Oct 2001 → 31 Mar 2010
Keywords
- Biochemistry
- microbial metabolites
- Chemistry
- short chain fatty acids
- bile acids
- tryptophan
- amines
- sugars
- nucleosides
- phenolics
- metabolomics
- lipidomics
Network
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Identifying the Dietary Signatures of Arthritis through metabolomics (the DeSignA study)
Macgregor, A., Clark, I., Davidson, R., Le Gall, G., Yates, M. & Chipping, J.
1/05/23 → 30/04/25
Project: Research
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New high resolution mass spectrometry facilities for macromolecules and metabolites at the University of East Anglia
Le Brun, N., Butt, J., Gates, A., Hutchings, M., Le Gall, G., Searcey, M., Todd, J., Waller, Z., Wilson, P., Goodey, K. & Hinchliffe, A.
Biotechnology and Biological Sciences Research Council
5/11/20 → 4/04/21
Project: Research
Research output
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(-)-Epicatechin mitigates anxiety-related behavior in a mouse model of high fat diet-induced obesity
Kang, J., Wang, Z., Cremonini, E., Gall, G. L., Pontifex, M. G., Muller, M., Vauzour, D. & Oteiza, P. I., Dec 2022, In: Journal of Nutritional Biochemistry. 110, 109158.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E., Vauzour, D., Rudder, S., Blackshaw, L. A., Jeffery, G. & Carding, S. R., 29 Apr 2022, In: Microbiome. 10, 68.Research output: Contribution to journal › Article › peer-review
Open AccessFile42 Citations (Scopus)9 Downloads (Pure) -
Lipid based intramuscular long-acting injectables: Current state of the art
Wilkinson, J., Ajulo, D., Tamburrini, V., Le Gall, G., Kimpe, K., Holm, R., Belton, P. & Qi, S., 1 Nov 2022, In: European Journal of Pharmaceutical Sciences. 178, 106253.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)17 Downloads (Pure) -
Lipopolysaccharide associated with β-2,6 fructan mediates TLR4-dependent immunomodulatory activity in vitro
Young, I. D., Nepogodiev, S. A., Black, I. M., Le Gall, G., Wittmann, A., Latousakis, D., Visnapuu, T., Azadi, P., Field, R. A., Juge, N. & Kawasaki, N., 1 Feb 2022, In: Carbohydrate Polymers. 277, 118606.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)5 Downloads (Pure) -
Macrophage metabolism in the intestine is compartment specific and regulated by the microbiota
Scott, N. A., Lawson, M. A. E., Hodgetts, R. J., Le Gall, G., Hall, L. J. & Mann, E. R., May 2022, In: Immunology. 166, 1, p. 138-152 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)32 Downloads (Pure)
Activities
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Manuscripts submitted to various journals
Gwenaelle Le Gall (Contributor)
2018 → …Activity: Other activity types › Other
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NIHR gastrointestinal infection annual meeting
Gwenaelle Le Gall (Contributor)
Mar 2015Activity: Participating in or organising an event › Participation in workshop or seminar
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FSA workshop: The application of new technologies to the risk assessment of genetically modified organisms
Gwenaelle Le Gall (Contributor)
Dec 2014Activity: Participating in or organising an event › Participation in workshop or seminar
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International Probiotics Association (IPA) World Congress
Gwenaelle Le Gall (Speaker)
May 2014Activity: Participating in or organising an event › Participation in conference
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Metabolomics in sport science and nutrition – invited seminar speaker at the University of Greenwich
Gwenaelle Le Gall (Invited speaker)
Feb 2014Activity: Participating in or organising an event › Invited talk