Projects per year
Personal profile
Academic Background
I joined the Norwich Medical School at UEA as a lecturer in March 2019.
BIOGRAPHY
I studied organic chemistry (MSc) at the University of Nantes in France and obtained a PhD in 2001 on food authentication using proton Nuclear Magnetic Resonance (1H NMR) and multivariate statistics (University of East Anglia). This was followed by postdoctoral appointments at the Quadram Institute (formerly the Institute of Food Research) on authentication of genetically modified foods and typical foods using metabolomics. In 2009, I took a sabbatical year from the IFR and took a postdoctoral position at the University of Nantes on nutritional imprinting. In 2010, I became the manager of the metabolomics unit in the IFR Analytical Science group and provided metabolite analysis on an open-access basis to staff and students. I have expertise in metabolomics/ lipidomics and over 20 years expertise in the field of metabolite analysis using techniques such as NMR and Mass Spectrometry (MS). My expertise covers data processing, deconvolution and multi and univariate analysis as well as compound identification. My knowledge extends to mammalian, food, plant and microbial metabolism. I have worked on numerous projects covering human nutrition and health, food authenticity, bacterial substrate specificity and the interactions between the host and the microbiota. In 2018, I was appointed in the Qi lab to develop a new thermal technique called Thermal Analysis by Structural Charaterization (TASC) and optimise the formulation of organogels for long term drug release.
I am an author or co-author of over 50 peer-reviewed articles, 5 book chapters, a Henri Stewart tutorial (NMR workflow from data analysis to metabolite identification, https://hstalks.com/bs/3611/) and numerous conference proceedings and posters. I also delivered tutorials at the “Introduction to metabolomics analysis” course at the European Bioinformatics Institute (EMBL-EBI) in Hinxton Cambridge and to UEA master students taking modules in forensic sciences and microbial cell biology (https://csr.quadram.ac.uk/wp-content/uploads/Microbial-Cell-Biology-lecture_Metabolomics.pdf).
https://scholar.google.co.uk/citations?user=GypJUOEAAAAJ&hl=en
https://orcid.org/0000-0002-1379-2196
Education/Academic qualification
Doctor of the University, Food authenticity and quality assessment using 1H NMR spectroscopy and chemometrics, Quadram Institute Bioscience
1 May 1998 → 4 Apr 2002
Award Date: 4 Apr 2002
Master of Chemistry, Use of 1H NMR and chemometrics for the authentication of fruit purees, University of Nantes
1 Oct 1996 → 13 Sept 1997
Award Date: 13 Sept 1997
Bachelor of Science, Asymmetric cyclopropanations using the Simmons-Smith reaction
1 Oct 1995 → 1 Sept 1996
Award Date: 1 Sept 1996
External positions
Senior researcher, Quadram Institute Bioscience
1 Apr 2010 → 31 Mar 2018
Post-doc, Quadram Institute Bioscience
1 Oct 2001 → 31 Mar 2010
Keywords
- Biochemistry
- microbial metabolites
- Chemistry
- short chain fatty acids
- bile acids
- tryptophan
- amines
- sugars
- nucleosides
- phenolics
- metabolomics
- lipidomics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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Functional investigation of Salmonella microbiota-host interactions by using novel organoid models from humans and chickens
Schuller, S. (Principal Investigator) & Le Gall, G. (Co-Investigator)
Biotechnology and Biological Sciences Research Council
1/11/25 → 31/10/28
Project: Research
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Norfolk Arthritis Register: Resource Enhancement for Sustainability and Translation (NEST)
Macgregor, A. (Principal Investigator), Kemsley, K. (Co-Investigator), Le Gall, G. (Co-Investigator), Yates, M. (Co-Investigator) & Dainty, J. (Researcher)
1/11/25 → 31/10/28
Project: Research
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Development of a microaerobic human intestinal organoid model to determine the role of the gut microbiome in Crohn’s disease
Schuller, S. (Principal Investigator) & Le Gall, G. (Co-Investigator)
1/02/25 → 31/01/28
Project: Research
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Metabolomic signatures in menopause mediated Alzheimer’s development
Pontifex, M. G. (Principal Investigator) & Le Gall, G. (Co-Investigator)
1/07/24 → 30/06/25
Project: Research
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Short Chain Fatty Acid Analysis Service 2023
Le Gall, G. (Principal Investigator)
1/09/23 → 31/07/25
Project: Consultancy
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A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice
Connell, E., Le Gall, G., Mcarthur, S., Lang, L., Breeze, B., Liaquat, M., Pontifex, M. G., Sami, S., Pourtau, L., Gaudout, D., Müller, M. & Vauzour, D., 13 Jan 2026, In: Gut Microbes. 18, 1, 2614030.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)2 Downloads (Pure) -
Circulatory dietary and gut-derived metabolites predict early cognitive decline
Connell, E., Sami, S., Khondoker, M., Minihane, A. M., Pontifex, M. G., Müller, M., Mcarthur, S., Le gall, G. & Vauzour, D., 2026, In: Gut Microbes. 18, 1, 2649487.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)1 Downloads (Pure) -
Combining Lactiplantibacillus plantarum and Bifidobacterium adolescentis can improve GABA production in faecal fermentations
Xu, R., Mayer, M. J., Philo, M., Gall, G. L., Mulaw, G., Ponsero, A. & Narbad, A., Mar 2026, In: Journal of Applied Microbiology. 137, 3, lxag047.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus) -
Copper is an intestinal habitat filter affecting the gut microbiota interactions with Salmonella Typhimurium
Kolenda, R., Hassan, M. M., Arrieta-Gisasola, A., Kamara, A., Ansorge, R., Sidorczuk, K., Acton, L., Thilliez, G., Baker, D. J., Burdukiewicz, M., Stares, M. D., Browne, H. P., Le gall, G., Torres, R. C., Chavez-Arroyo, A., Garrett, J., Stevens, M. P., Lawley, T. D., Bäumler, A. J. & La ragione, R. & 2 others, , 28 Mar 2026, In: Microbiome. 14, 1, 110.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
APOE4 genotype shapes the role of dietary fibers in cognitive health through gut microbiota changes
Liaquat, M., Le Gall, G., Scholey, A., Pontifex, M. G., Bastiaanssen, T. F. S., Muller, M., Minihane, A. M. & Vauzour, D., 2 Jul 2025, In: Gut Microbes. 17, 1, 2526133.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)21 Downloads (Pure)
Activities
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Manuscripts submitted to various journals
Le Gall, G. (Contributor)
2018 → …Activity: Other activity types › Other
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NIHR gastrointestinal infection annual meeting
Le Gall, G. (Contributor)
Mar 2015Activity: Participating in or organising an event › Participation in workshop or seminar
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FSA workshop: The application of new technologies to the risk assessment of genetically modified organisms
Le Gall, G. (Contributor)
Dec 2014Activity: Participating in or organising an event › Participation in workshop or seminar
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International Probiotics Association (IPA) World Congress
Le Gall, G. (Speaker)
May 2014Activity: Participating in or organising an event › Participation in conference
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Metabolomics in sport science and nutrition – invited seminar speaker at the University of Greenwich
Le Gall, G. (Invited speaker)
Feb 2014Activity: Participating in or organising an event › Invited talk