Ian Beales

Search results

• 2025

  Efficacy and safety of filgotinib as induction and maintenance therapy for Crohn's disease (DIVERSITY): A phase 3, double-blind, randomised, placebo-controlled trial

  Vermeire, S., Schreiber, S., Rubin, D. T., D'Haens, G., Reinisch, W., Watanabe, M., Mehta, R., Roblin, X., Beales, I., Gietka, P., Hibi, T., Hospodarskyy, I., Ritter, T., Genovese, M. C., Kwon, P., Santermans, E., Le Brun, F-O., Barron, R., Masior, T. & Danese, S., Feb 2025, In: The Lancet Gastroenterology & Hepatology. 10, 2, p. 138-153 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  1 Citation (Scopus)

  1 Downloads (Pure)

• The association between obesity and malignant progression of Barrett’s Esophagus: A systematic review and dose-response meta-analysis

  Ko, M. T., Thomas, T., Holden, E., Beales, I. L. P. & Alexandre, L., Apr 2025, In: Clinical Gastroenterology and Hepatology. 23, 5, p. 726-738.e28 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File
  13 Downloads (Pure)
• 2021

  Leptin activates Akt in oesophageal cancer cells via multiple atorvastatin-sensitive small GTPases

  Beales, I. L. P. & Ogunwobi, O. O., Jun 2021, In: Molecular and Cellular Biochemistry. 476, 6, p. 2307–2316 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  6 Citations (Scopus)

  20 Downloads (Pure)
• 2018

  Comparison of different strategies for providing fecal microbiota transplantation to treat patients with recurrent Clostridium difficile infection in two English hospitals: A review

  Goldenberg, S. D., Batra, R., Beales, I., Digby-Bell, J. L., Irving, P. M., Kellingray, L., Narbad, A. & Franslem-Elumogo, N., Mar 2018, In: Infectious Diseases and Therapy. 7, 1, p. 71–86 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  41 Citations (SciVal)

  20 Downloads (Pure)

• Microbial taxonomic and metabolic alterations during faecal microbiota transplantation to treat Clostridium difficile infection

  Kellingray, L., Gall, G. L., Defernez, M., Beales, I. L. P., Franslem-Elumogo, N. & Narbad, A., Aug 2018, In: Journal of Infection. 77, 2, p. 107-118

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  32 Citations (SciVal)

  34 Downloads (Pure)

• Systematic review and meta-analysis: Use of statins is associated with a reduced incidence of oesophageal adenocarcinoma

  Thomas, T., Loke, Y. & Beales, I. L. P., Dec 2018, In: Journal of Gastrointestinal Cancer. 49, 4, p. 442–454 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  32 Citations (Scopus)

  26 Downloads (Pure)
• 2016

  Reduced risk of Barrett’s esophagus in statin users: case–control study and meta-analysis

  Beales, I., Dearman, L., Vardi, I. & Loke, Y., Jan 2016, In: Digestive Diseases and Sciences. 61, 1, p. 238-246 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  27 Citations (SciVal)

  31 Downloads (Pure)
• 2014

  Adiponectin inhibits leptin-induced oncogenic signalling in oesophageal cancer cells by activation of PTP1B

  Beales, I. L. P., Garcia-Morales, C., Ogunwobi, O. O. & Mutungi, G., 25 Jan 2014, In: Molecular and Cellular Endocrinology. 382, 1, p. 150-8 9 p.

  Research output: Contribution to journal › Article › peer-review
  51 Citations (Scopus)

• Colonoscopic polyp detection rate is stable throughout the workday including evening colonoscopy sessions

  Thurtle, D., Pullinger, M., Tsigarides, J., McIntosh, I., Steytler, C. & Beales, I., 13 May 2014, In: F1000Research. 3, 107.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  6 Citations (Scopus)

  20 Downloads (Pure)

• Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma

  Alexandre, L., Long, E. & Beales, I. L. P., 15 Nov 2014, In: World Journal of Gastrointestinal Pathophysiology. 5, 4, p. 534-549 16 p.

  Research output: Contribution to journal › Article › peer-review
• 2013

  Management of ulcerative colitis shows the failings in chronic disease management in the current NHS

  Beales, I. L. P., 2013, In: BMJ-British Medical Journal. 346, p. f1189

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Citation (Scopus)

• Prevention of upper gastrointestinal haemorrhage: Current controversies and clinical guidance

  Brooks, J., Warburton, R. & Beales, I. L. P., Sept 2013, In: Therapeutic Advances in Chronic Disease. 4, 5, p. 206-222 17 p.

  Research output: Contribution to journal › Article › peer-review
  29 Citations (Scopus)

• Reduced esophageal cancer incidence in statin users, particularly with cyclo-oxygenase inhibition

  Beales, I. L. P., Hensley, A. & Loke, Y., 6 Aug 2013, In: World Journal of Gastrointestinal Pharmacology and Therapeutics. 4, 3, p. 69-79 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  Meta-analysis: Risk of esophageal adenocarcinoma with medications which relax the lower esophageal sphincter

  Alexandre, L., Broughton, T., Loke, Y. & Beales, I. L. P., Aug 2012, In: Diseases of the Esophagus. 25, 6, p. 535-544 10 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• Regular statin and aspirin use in patients with Barrett's oesophagus is associated with a reduced incidence of oesophageal adenocarcinoma

  Beales, I. L. P., Vardi, I. & Dearman, L., Aug 2012, In: European Journal of Gastroenterology & Hepatology. 24, 8, p. 917-23 7 p.

  Research output: Contribution to journal › Article › peer-review
  39 Citations (Scopus)

• Statin use is associated with a reduced incidence of colorectal cancer: a colonoscopy-controlled case-control study

  Broughton, T., Sington, J. & Beales, I. L. P., 24 Apr 2012, In: BMC Gastroenterology. 12, 36.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  32 Citations (Scopus)
• 2011

  Barrett's esophagus: progression to adenocarcinoma and markers

  Fang, D., Das, K. M., Cao, W., Malhotra, U., Triadafilopoulos, G., Najarian, R. M., Hardie, L. J., Lightdale, C. J., Beales, I. L. P., Felix, V. N., Schneider, P. M. & Bellizzi, A. M., Sept 2011, In: Annals of the New York Academy of Sciences. 1232, p. 210-29 20 p.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• Statins use is associated with a reduced incidence of colorectal adenomatous polyps: a case-control study

  Beales, I., Broughton, T. & Sington, J., Apr 2011, In: Gut. 60, Suppl 1, A5.

  Research output: Contribution to journal › Article
• 2010

  Microsomal prostaglandin E synthase-1 inhibition blocks proliferation and enhances apoptosis in oesophageal adenocarcinoma cells without affecting endothelial prostacyclin production

  Beales, I. L. P. & Ogunwobi, O. O., 1 May 2010, In: International Journal of Cancer. 126, 9, p. 2247-2255 9 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• Risk of oesophageal adenocarcinoma with medications which relax the lower oesophageal sphincter: a meta-analysis

  Alexandre, L., Broughton, T., Loke, Y. & Beales, I., 2010, p. A233.

  Research output: Contribution to conference › Paper
• 2009

  A Novel 3D Ex Vivo Model of Native Human Barrett's Oesophagus

  Scobioala-Laker, N., Reynolds, A., Parris, A., Mitchell, E. M., Lewis, M., Kennedy, H. J., Stebbings, W., Prior, A., Phillips, M., Beales, I. & Williams, M. R., May 2009, p. A596-A597.

  Research output: Contribution to conference › Paper

• Clopidogrel in patients with peptic ulcer

  Beales, I. L. P., 2009, In: British Medical Journal. 338, 3, b1932.

  Research output: Contribution to journal › Article

• Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation

  Beales, I. L. P. & Ogunwobi, O. O., Apr 2009, In: Molecular Endocrinol. 42, p. 305-318 14 p.

  Research output: Contribution to journal › Article
  24 Citations (Scopus)

• Recent advances in peptic ulcer bleeding

  Beales, I. L. P., 28 May 2009, In: F1000 Medicine Reports. 1, 44.

  Research output: Contribution to journal › Article
• 2008

  Clinical trial: oral prednisolone metasulfobenzoate (predocol) versus oral prednisolone for active ulcerative colitis

  Rhodes, J. M., Robinson, R., Beales, I., Pugh, S., Dickinson, R., Dronfield, M., Speirs, C. J., Wilkinson, P. & Wilkinson, S. R., Feb 2008, In: Alimentary Pharmacology and Therapeutics. 27, 3, p. 228-240 13 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Globular adiponectin, acting via adiponectin receptor-1, inhibits leptin-stimulated oesophageal adenocarcinoma cell proliferation

  Ogunwobi, O. O. & Beales, I. L. P., 28 Mar 2008, In: Molecular and Cellular Endocrinology. 285, 1-2, p. 43-50 8 p.

  Research output: Contribution to journal › Article
  79 Citations (Scopus)

• Glycine-extended gastrin stimulates proliferation via JAK2- and Akt-dependent NF-kappaB activation in Barrett's oesophageal adenocarcinoma cells

  Ogunwobi, O. O. & Beales, I. L. P., 2008, In: Molecular and Cellular Endocrinology. 296, p. 94-102 9 p.

  Research output: Contribution to journal › Article
  22 Citations (Scopus)

• Isothiocyanates inhibits proliferation of barrett's oesophagus and oesophageal adenocarcinoma cells.

  Ogunwobi, O. O., Mutungi, G. & Beales, I. L. P., Jan 2008, In: Gut. 57, p. A1271 1 p.

  Research output: Contribution to journal › Article

• Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and TGFa mediated transactivation of the epidermal growth factor receptor

  Ogunwobi, O. O. & Beales, I. L. P., 2008, In: British Journal of Biomedical Science. 65, 3, p. 121-127 7 p.

  Research output: Contribution to journal › Article
  46 Citations (Scopus)

• Oestrodiol inhibits proliferation of Barrett's oesophagus and oesophageal adenocarcinoma cells

  Ogunwobi, O. O. & Beales, I. L. P., 2008, In: Gut. 57, Supp 1

  Research output: Contribution to journal › Article

• Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells

  Ogunwobi, O. O. & Beales, I. L. P., 2008, In: American Journal of Gastroenterology. 103, 4, p. 825-837 13 p.

  Research output: Contribution to journal › Article
  130 Citations (Scopus)
• 2007

  Activation of Akt is increased in the dysplasia-carcinoma sequence in Barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study

  Beales, I. L. P., Ogunwobi, O., Cameron, E., El-Amin, K., Mutungi, G. & Wilkinson, M., 8 Jun 2007, In: BMC Cancer. 7, 97.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  42 Citations (Scopus)

• Adiponectin receptor-1 mediates the inhibitory effect of globular adiponectin on leptin-induced proliferation of oesophageal adenocarcinoma cells

  Ogunwobi, O. O. & Beales, I. L. P., 2007, In: Annals of Oncology. 18, Suppl 7

  Research output: Contribution to journal › Article

• AMPK and adiponectin receptor-1 mediate the inhibitory effect of globular adiponectin on leptin-induced proliferation of oesophageal adenocarcinoma cells

  Ogunwobi, O. O. & Beales, I. L. P., 2007, In: Gut. 56, Suppl 3

  Research output: Contribution to journal › Article

• Cyclo-oxygenase-independent inhibition of apoptosis and stimulation of proliferation by leptin in human colon cancer cells

  Ogunwobi, O. O. & Beales, I. L. P., 2007, In: Digestive Diseases and Sciences. 52, 8, p. 1934-1945 12 p.

  Research output: Contribution to journal › Article
  27 Citations (Scopus)

• Globular adiponectin inhibits leptin-induced proliferation of oesophageal adenocarcinoma cells via activation of andiponectin receptor 1

  Beales, I. L. P. & Ogunwobi, O. O., 2007, In: Gut. 56, A73

  Research output: Contribution to journal › Article

• HB-EGF and TGF-alpha mediate leptin-induced epidermal growth factor receptor transactivation and proliferation in oesophageal adenocarcinoma

  Ogunwobi, O. O. & Beales, I. L. P., 2007, In: Gut. 56, Suppl 2, p. 72 1 p.

  Research output: Contribution to journal › Article

• Leptin-induced epidermal growth factor receptor transactivation and proliferation in oesophageal adenocarcinoma cells is dependent on HB-EGF and TGF-alpha

  Ogunwobi, O. O. & Beales, I. L. P., 2007, In: Annals of Oncology. 18, Suppl 7, p. 0067 1 p.

  Research output: Contribution to journal › Article

• Leptin synergistically enhances the anti-apoptotic and growth-promoting effects of acid in OE33 oesophageal adenocarcinoma cells in culture

  Beales, I. L. P. & Ogunwobi, O. O., 2007, In: Molecular and Cellular Endocrinology. 274, 1-2, p. 60-68 9 p.

  Research output: Contribution to journal › Article
  45 Citations (Scopus)

• Taurodeoxycholic acid induces calcium oscillations in isolated human colonic crypts

  Williams, M. R., Spahos, T., Reynolds, A., Parris, A., Tighe, R., Speakman, C., Beales, I. L. P. & Lewis, M., 2007, In: Gastroenterology. 132, Suppl 2, p. 8 1 p.

  Research output: Contribution to journal › Article › peer-review

• The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt

  Ogunwobi, O. O. & Beales, I. L. P., Apr 2007, In: International Journal of Colorectal Disease. 22, 4, p. 401-409 9 p.

  Research output: Contribution to journal › Article › peer-review
  116 Citations (Scopus)

• The EP4 receptor mediates prostaglandin E2-induced proliferative and anti-apoptotic signals in Barrett's oesophagus and adenocarcinoma

  Ogunwobi, O. O. & Beales, I. L. P., 2007, In: Annals of Oncology. 18, Suppl 7, p. 0068 1 p.

  Research output: Contribution to journal › Article

• The role of adiponectin in colitis

  Ogunwobi, O. O. & Beales, I. L. P., Mar 2007, In: Gastroenterology. 132, 3, p. 1199-1200 2 p.

  Research output: Contribution to journal › Comment/debate
• 2006

  Adipokines and gastrointestinal disease

  Beales, I. L. P. & Ogunwobi, O., 2006, In: Alimentary Pharmacology and Therapeutics. 24, 7, p. 1127-1128 2 p.

  Research output: Contribution to journal › Comment/debate
  1 Citation (Scopus)

• Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells

  Ogunwobi, O. O. & Beales, I. L. P., 2006, In: Regulatory Peptides. 134, 2-3, p. 105-113 9 p.

  Research output: Contribution to journal › Article
  131 Citations (Scopus)

• A safety and efficacy study of a novel formulation of prednisolone metasulfobenzoate (predocol) in the induction of remission and maintenance in ulcerative colitis

  Rhodes, J. M., Robinson, R., Beales, I. L. P., Pugh, S., Dickinson, R., Dronfield, M. & Wilkinson, S. R., 2006, In: Gastroenterology. 130, Suppl 2, p. 1130 1 p.

  Research output: Contribution to journal › Article

• Ethical and effective research protocol development in gastroenterology

  Beales, I. L. P., Mathers, N. J., Howe, A. C. & Hunn, A., 2006, In: Gastroenterology. 16, p. 55 1 p.

  Research output: Contribution to journal › Article

• Globular adiponectin inhibits leptin-induced proliferation of oesophageal cells in vitro

  Ogunwobi, O. O. & Beales, I. L. P., 2006, In: Gut. 55, Suppl 5, p. 13 1 p.

  Research output: Contribution to journal › Article

• Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways

  Beales, I. L. P. & Ogunwobi, O., 9 Mar 2006, In: Molecular and Cellular Endocrinology. 247, 1-2, p. 140-149 10 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Glycine-extended gastrin stimulates proliferation and inhibits apoptosis in colon cancer cells via cyclo-oxygenase-independent pathways

  Ogunwobi, O. O. & Beales, I. L. P., 2006, In: Regulatory Peptides. 134, 1, p. 1-8 8 p.

  Research output: Contribution to journal › Article
  27 Citations (Scopus)