Ian Clark

Search results

• 2009

  Epidemiological and Molecular Evidence for the Chondroprotective Effect of Garlic in Osteoarthritis

  Williams, F., Davidson, R., Skinner, J., Culley, K., Bao, Y. P., Cassidy, A., Clark, I. & MacGregor, A., Apr 2009, p. I5.

  Research output: Contribution to conference › Paper

  65 Citations (Scopus)

• Expression and function of matrix metalloproteinase (MMP)-28

  Rodgers, U. R., Kevorkian, L., Surridge, A. K., Waters, J. G., Swingler, T. E., Culley, K., Illman, S., Lohi, J., Parker, A. E. & Clark, I. M., 2009, In: Matrix Biology. 28, 5, p. 263-272 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  36 Citations (Scopus)
• 2008

  Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes

  Sampieri, C. L., Nuttall, R. K., Young, D. A., Goldspink, D., Clark, I. M. & Edwards, D. R., 2008, In: Matrix Biology. 27, 2, p. 128-138 11 p.

  Research output: Contribution to journal › Article › peer-review
  31 Citations (Scopus)

• Differential Toll-like receptor-dependent collagenase expression in chondrocytes

  Zhang, Q., Hu, W., Litherland, G. J., Barter, M. J., Davidson, R., Darrah, C., Donell, S. T., Clark, I. M., Cawston, T. E., Robinson, J. H., Rowan, A. D. & Young, D. A., Nov 2008, In: Annals of the Rheumatic Diseases. 67, p. 1633-1641 9 p.

  Research output: Contribution to journal › Article › peer-review
  84 Citations (Scopus)

• Editorial-The genetic association between asporin and osteoarthritis

  Clark, I. M., Macgregor, A. J. & Donell, S. T., Jun 2008, In: The Knee. 15, 3, p. vii-viii 2 p.

  Research output: Contribution to journal › Editorial

• Metalloproteinase gene expression correlates with clinical outcome in Dupuytren's disease

  Johnston, P., Larson, D., Clark, I. M. & Chojnowski, A. J., 2008, In: Journal of Hand Surgery-American Volume. 33, 7, p. 1160-1167 8 p.

  Research output: Contribution to journal › Article › peer-review
  47 Citations (Scopus)

• The genetic association between asporin and osteoarthritis

  Clark, I., MacGregor, A. & Donell, S. T., 2008, In: The Knee. 15, 3, p. vii-viii 2 p.

  Research output: Contribution to journal › Article › peer-review

• The regulation of matrix metalloproteinases and their inhibitors

  Clark, I. M., Swingler, T. E., Sampieri, C. L. & Edwards, D. R., Jun 2008, In: International Journal of Biochemistry & Cell Biology. 40, 6-7, p. 1362-1378 17 p.

  Research output: Contribution to journal › Article › peer-review

  File
  478 Citations (Scopus)

  13 Downloads (Pure)
• 2007

  Acetylation in the regulation of MMP and TIMP gene expression

  Clark, I. M., Swingler, T. E. & Young, D. A., 2007, In: Frontiers in Bioscience. 12, p. 528-535 8 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• A complete expression profile of matrix-degrading metalloproteinases in Dupuytren’s disease

  Johnston, P., Chojnowski, A. J., Davidson, R. K., Riley, G. P., Donell, S. T. & Clark, I. M., Mar 2007, In: The Journal of Hand Surgery. 32, 3, p. 343-351 9 p.

  Research output: Contribution to journal › Article › peer-review

  File
  51 Citations (Scopus)

  11 Downloads (Pure)
• 2006

  Controlling proteinase gene expression osteoarthritis.

  Davidson, R., Donell, S., Darrah, C., Cooper, A. & Clark, I., 2006, (Unpublished) p. 10. 1 p.

  Research output: Contribution to conference › Other

• Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage

  Davidson, R. K., Waters, J. G., Kevorkian, L., Darrah, C., Cooper, A., Donell, S. T. & Clark, I. M., 19 Jul 2006, In: Arthritis Research and Therapy. 8, R124 (2006).

  Research output: Contribution to journal › Article › peer-review

  Open Access
  193 Citations (Scopus)

• Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon

  Jones, G. C., Corps, A. N., Pennington, C. J., Clark, I. M., Edwards, D. R., Bradley, M. M., Hazleman, B. L. & Riley, G. P., Mar 2006, In: Arthritis & Rheumatism. 54, 3, p. 832-842 11 p.

  Research output: Contribution to journal › Article › peer-review

  File
  244 Citations (Scopus)

  35 Downloads (Pure)

• Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis

  Milner, J. M., Kevorkian, L., Young, D. A., Jones, D., Wait, R., Donell, S. T., Barksby, E., Patterson, A. M., Middleton, J., Cravatt, B. F., Clark, I. M., Rowan, A. D. & Cawston, T. E., 2006, In: Arthritis Research & Therapy. 8, 1, R23.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  78 Citations (Scopus)

• Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signalling

  Engers, R., Springer, E., Kehren, V., Simic, T., Young, D. A., Beier, J., Klotz, L-O., Clark, I. M., Sies, H. & Gabbert, H. E., 2006, In: FEBS Journal. 273, 20, p. 4754-4769 16 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells

  Tuddenham, L., Wheeler, G., Ntouniafousara, S., Waters, J., Hajihosseini, M., Clark, I. & Dalmay, T., 2006, In: FEBS Letters. 580, 17, p. 4214-4217 4 p.

  Research output: Contribution to journal › Article › peer-review
  393 Citations (Scopus)
• 2005

  Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta 1 induced murine tissue inhibitor of metalloproteinases-1 gene expression

  Young, D. A., Billingham, O., Sampieri, C. L., Edwards, D. R. & Clark, I. M., 2005, In: FEBS Journal. 272, 8, p. 1912-1926 15 p.

  Research output: Contribution to journal › Article › peer-review
  28 Citations (Scopus)

• Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption

  Young, D. A., Lakey, R. L., Pennington, C. J., Jones, D., Kevorkian, L., Edwards, D. R., Cawston, T. E. & Clark, I. M., 2005, In: Arthritis Research & Therapy. 7, 3, p. 503-512 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  161 Citations (Scopus)

• The ADAMTS metalloproteinases

  Porter, S., Clark, I. M., Kevorkian, L. & Edwards, D. R., 8 Feb 2005, In: Biochemical Journal. 386, 1, p. 15-27 13 p.

  Research output: Contribution to journal › Article › peer-review
  644 Citations (Scopus)
• 2004

  Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes.

  Young, D. A., Gavrilov, S., Pennington, C. J., Nuttall, R. K., Edwards, D. R., Kitsis, R. N. & Clark, I. M., 2004, In: Biochemical and Biophysical Research Communications. 322, 3, p. 759-765 7 p.

  Research output: Contribution to journal › Article › peer-review
  43 Citations (Scopus)

• Expression profiling of metalloproteinases and their inhibitors in cartilage

  Kevorkian, L., Young, D. A., Darrah, C., Donell, S. T., Shepstone, L., Porter, S., Brockbank, S. M. V., Edwards, D. R., Parker, A. E. & Clark, I. M., 2004, In: Arthritis and Rheumatism. 50, 1, p. 131-141 11 p.

  Research output: Contribution to journal › Article › peer-review
  358 Citations (Scopus)

• Matrix proteinases

  Clark, I. M. & Murphy, G., 2004, Dynamics of Bone and Cartilage Metabolism. Robins, S. P. & Seibel, M. J. (eds.). Academic Press

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• 2003

  Metalloproteinases: their role in arthritis and potential as therapeutic targets

  Clark, I. M. & Parker, A. E., 2003, In: Expert Opinion in Therapeutic Targets. 7, 1, p. 19-34 16 p.

  Research output: Contribution to journal › Article › peer-review
  78 Citations (Scopus)

• The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1.

  Hall, M-C., Young, D. A., Waters, J. G., Rowan, A. D., Chantry, A., Edwards, D. R. & Clark, I. M., 13 Jan 2003, In: Journal of Biological Chemistry. 278, 12, p. 10304-10313 10 p.

  Research output: Contribution to journal › Article › peer-review
  217 Citations (Scopus)

• TIMP-1 enhancer sequence: real or bacterial

  Clark, I. M., Young, D. A. & Edwards, D. R., 2003, In: British Journal of Cancer. 89, 1812.

  Research output: Contribution to journal › Comment/debate
• 2002

  Cryptic promoter activity of pBLCAT3 induced by overexpression of AP1 factors

  Hall, M. C., Young, D. A., Rowan, A. D., Edwards, D. R. & Clark, I. M., 2002, In: Biotechniques. 33, p. 1004-1008 5 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene

  Young, D. A., Philllips, B. W., Lundy, C., Nuttall, R. K., Hogan, A., Schultz, G. A., Leco, K. J., Clark, I. M. & Edwards, D. R., 2002, In: Biochemical Journal. 364, 1, p. 89-99 11 p.

  Research output: Contribution to journal › Article › peer-review
  61 Citations (Scopus)

• Matrix metalloproteinases in arthritic disease

  Murphy, G., Knäuper, V., Atkinson, S., Butler, G., English, W., Hutton, M., Stracke, J. & Clark, I., 9 May 2002, In: Arthritis Research and Therapy. 4, 3, S39.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  284 Citations (Scopus)

• Plant matrixins

  Clark, I. M., Thomas, M. D. & de Vos, S., 2002, Handbook of Proteolytic Enzymes (Second Edition) : Volume 1: Aspartic and Metallo Peptidases. Barrett, A. J., Woessner, J. F. & Rawlings, N. D. (eds.). Academic Press, p. 570-572 3 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  2 Citations (Scopus)

• The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: A time-course study using real-time quantitative reverse transcription–polymerase chain reaction

  Koshy, P. J. T., Lundy, C. J., Rowan, A. D., Porter, S., Edwards, D. R., Hogan, A., Clark, I. M. & Cawston, T. E., Apr 2002, In: Arthritis and Rheumatism. 46, 4, p. 961-967 7 p.

  Research output: Contribution to journal › Article › peer-review
  182 Citations (Scopus)

• The role of chondrocyte senescence in osteoarthritis

  Price, J. S., Waters, J. G., Darrah, C., Pennington, C., Edwards, D. R., Donell, S. T. & Clark, I. M., 2002, In: Aging Cell. 1, 1, p. 57-65 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  295 Citations (Scopus)
• 2001

  Matrix Metalloproteinase Protocols

  Clark, I. M. (ed.), 2001, Humana Press, Totowa, New Jersey, USA.

  Research output: Book/Report › Book
• 2000

  Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases

  Harvey, P., Clark, I., Jaurand, M-C., Warn, R. & Edwards, D., 1 Nov 2000, In: British Journal of Cancer. 83, 9, p. 1147-1153 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  70 Citations (SciVal)

• The human tissue inhibitor of metalloproteinases (TIMP)-1 gene contains repressive elements within the promoter and intron 1

  Dean, G., Young, D. A., Edwards, D. R. & Clark, I. M., 3 Aug 2000, In: Journal of Biological Chemistry. 275, 42, p. 32664-32671 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  34 Citations (Scopus)
• 1997

  Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1

  Clark, I. M., Rowan, A. D., Edwards, D. R., Bech-Hansen, T., Mann, D. A., Bahr, M. J. & Cawston, T. E., 1 Jun 1997, In: Biochemical Journal. 324, 2, p. 611-617 7 p.

  Research output: Contribution to journal › Article › peer-review
  81 Citations (Scopus)