Ian Clark

Search results

• 2024

  microRNA-324 mediates bone homeostasis and the regulation of osteoblast and osteoclast differentiation and activity

  Hayman, D. J., Johnson de Sousa Brito, F., Lin, H., Prior, A., Charlesworth, G., Hao, Y., Pearson, R. D., Soul, J., Clark, I. M., Piróg, K. A., Barter, M. J., van't Hof, R. J. & Young, D. A., Jan 2025, In: Bone. 190, 117273.

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• Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis

  Patel, K., Barter, M., Soul, J., Clark, P., Proctor, C., Clark, I., Young, D. & Shanley, D. P., 14 Oct 2024, In: eLife. 12, RP89701.

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• 2022

  HDAC6 regulates NF-κB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression

  Barter, M. J., Butcher, A., Wang, H., Tsompani, D., Galler, M., Rumsby, E. L., Culley, K. L., Clark, I. M. & Young, D. A., 22 Apr 2022, In: Scientific Reports. 12, 6640.

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  7 Citations (Scopus)

  18 Downloads (Pure)

• The microRNA-455 null mouse has memory deficit and increased anxiety, targeting key genes involved in Alzheimer’s disease

  Swingler, T. E., Niu, L., Pontifex, M. G., Vauzour, D. & Clark, I. M., Jan 2022, In: International Journal of Molecular Sciences. 23, 1, 554.

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  9 Citations (Scopus)

  29 Downloads (Pure)
• 2021

  Increased hippocampal excitability in miR-324-null mice

  Hayman, D. J., Modebadze, T., Charlton, S., Cheung, K., Soul, J., Lin, H., Hao, Y., Miles, C. G., Tsompani, D., Jackson, R. M., Briggs, M. D., Piróg, K. A., Clark, I. M., Barter, M. J., Clowry, G. J., Lebeau, F. E. N. & Young, D. A., 17 May 2021, In: Scientific Reports. 11, 10452.

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  7 Citations (Scopus)

  22 Downloads (Pure)

• TimiRGeN: R/Bioconductor package for time series microRNA-mRNA integration and analysis

  Patel, K., Chandrasegaran, S., Clark, I. M., Proctor, C. J., Young, D. A. & Shanley, D. P., 15 Oct 2021, In: Bioinformatics. 37, 20, p. 3604–3609 6 p.

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  3 Citations (Scopus)

  34 Downloads (Pure)
• 2020

  ADAMTS16 activates latent TGF-β, accentuating fibrosis and dysfunction of the pressure-overloaded heart

  Yao, Y., Hu, C., Song, Q., Li, Y., Da, X., Yu, Y., Li, H., Clark, I. M., Chen, Q. & Wang, Q. K., 1 Apr 2020, In: Cardiovascular Research. 116, 5, p. 956–969 14 p.

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  70 Citations (Scopus)

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• microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs

  Woods, S., Charlton, S., Cheung, K., Hao, Y., Soul, J., Reynard, L. N., Crowe, N., Swingler, T. E., Skelton, A. J., Piróg, K. A., Miles, C. G., Tsompani, D., Jackson, R. M., Dalmay, T., Clark, I. M., Barter, M. J. & Young, D. A., Nov 2020, In: RNA. 26, 11, p. 1575-1588 14 p.

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  13 Citations (Scopus)

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• The role of microRNA-3085 in chondrocyte function

  Le, L., Niu, L., Barter, M. J., Young, D. A., Dalmay, T., Clark, I. M. & Swingler, T. E., 14 Dec 2020, In: Scientific Reports. 10, 21923.

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  4 Citations (Scopus)

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• The scinderin gene (SCIN) is the direct target of miR3085-3p in chondrocytes

  Le, L., Ho, P. & Clark, I., 2020, In: Archives of Biological Sciences. 72, 3, p. 373-378 6 p.

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• 2019

  miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse

  Woods, S., Barter, M. J., Elliott, H. R., McGillivray, C. M., Birch, M. A., Clark, I. M. & Young, D. A., Apr 2019, In: Matrix Biology. 77, p. 87-100 14 p.

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  34 Citations (Scopus)

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• 2018

  Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo

  Legrand, C., Ahmed, U., Anwar, A., Rajpoot, K., Pasha, S., Lambert, C., Davidson, R., Clark, I., Thornalley, P., Henrotin, Y. & Rabbani, N., 22 Jun 2018, In: Arthritis Research & Therapy. 20, 131.

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  14 Citations (Scopus)

  29 Downloads (Pure)

• Identifying chondroprotective diet-derived bioactives and investigating their synergism

  Davidson, R. K., Green, J., Gardner, S., Bao, Y., Cassidy, A. & Clark, I. M., 21 Nov 2018, In: Scientific Reports. 8, 17173.

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  14 Citations (Scopus)

  79 Downloads (Pure)
• 2017

  Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint

  Davidson, R., Gardner, S., Jupp, O., Bullough, A., Butters, S., Watts, L., Donell, S., Traka, M., Saha, S., Mithen, R., Jeffers, M., Clegg, P., Bao, Y., Cassidy, A. & Clark, I., 13 Jun 2017, In: Scientific Reports. 7, 3398.

  Research output: Contribution to journal › Article › peer-review

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  21 Citations (Scopus)

  29 Downloads (Pure)

• Long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells

  Barter, M., Gomez, R., Hyatt, S., Cheung, K., Skelton, A., Xu, Y., Clark, I. & Young, D., 15 Dec 2017, In: Development. 144, 24, p. 4510-4521 12 p.

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  63 Citations (Scopus)

  45 Downloads (Pure)
• 2016

  Can sulforaphane prevent the onset or slow the progression of osteoarthritis?

  Davidson, R., Jupp, O., Bao, Y., MacGregor, A., Donell, S., Cassidy, A. & Clark, I., Jun 2016, In: Nutrition Bulletin. 41, 2, p. 175-179 5 p.

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  8 Citations (Scopus)

  21 Downloads (Pure)

• Connective tissue degeneration: Mechanisms of palmar fascia degeneration (Dupuytren’s disease)

  Karkampouna, S., Kreulen, M., Obdeijn, M. C., Kloen, P., Dorjée, A. L., Rivellese, F., Chojnowski, A., Clark, I. & Kruithof-de Julio, M., Sep 2016, In: Current Molecular Biology Reports. 2, 3, p. 133–140 8 p.

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• Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA

  Crowe, N., Swingler, T., Le, L., Barter, M., Wheeler, G., Pais, H., Donell, S., Young, D., Dalmay, T. & Clark, I., Mar 2016, In: Osteoarthritis and Cartilage. 24, 3, p. 534-543 10 p.

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  36 Citations (Scopus)

  20 Downloads (Pure)

• Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role

  Snelling, S., Davidson, R., Swingler, T., Le, T., Barter, M., Culley, K., Price, A., Carr, A. & Clark, I., May 2016, In: Osteoarthritis and Cartilage. 24, 5, p. 883–891 9 p.

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  41 Citations (Scopus)

  29 Downloads (Pure)

• The microRNA-29 family in cartilage homeostasis and osteoarthritis

  Le, L. T. T., Swingler, T. E., Crowe, N., Vincent, T. L., Barter, M. J., Donell, S. T., Delany, A. M., Dalmay, T., Young, D. A. & Clark, I. M., May 2016, In: Journal of Molecular Medicine. 94, 5, p. 583-596 14 p.

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  106 Citations (Scopus)

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• 2015

  Dietary intervention for osteoarthritis: Clinical trials after the 'Bone and Joint Decade'

  Davidson, R. K. & Clark, I. M., Sep 2015, In: Nutrition Bulletin. 40, 3, p. 203-210 8 p.

  Research output: Contribution to journal › Article
  1 Citation (Scopus)

• Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p

  Barter, M. J., Tselepi, M., Gómez, R., Woods, S., Hui, W., Smith, G. R., Shanley, D. P., Clark, I. M. & Young, D. A., Nov 2015, In: Stem Cells. 33, 11, p. 3266-3280 15 p.

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  66 Citations (Scopus)

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• 2014

  A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis

  Snelling, S., Rout, R., Davidson, R., Clark, I., Carr, A., Hulley, P. A. & Price, A. J., 1 Feb 2014, In: Osteoarthritis and Cartilage. 22, 2, p. 334-343 10 p.

  Research output: Contribution to journal › Article › peer-review
  65 Citations (Scopus)

• Novel ex vivo culture method for the study of Dupuytren's disease: Effects of TGFβ Type 1 receptor modulation by antisense oligonucleotides

  Karkampouna, S., Kruithof, B. P. T., Kloen, P., Obdeijn, M. C., van der Laan, A. M. A., Tanke, H. J., Kemaladewi, D. U., Hoogaars, W. M. H., 't Hoen, P. A. C., Aartsma-Rus, A., Clark, I. M., ten Dijke, P., Goumans, M-J. & Kruithof-De Julio, M., 21 Jan 2014, In: Molecular Therapy - Nucleic Acids. 3, e142.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  18 Citations (Scopus)

• The potential for dietary factors to prevent or treat osteoarthritis

  Green, J. A., Hirst-Jones, K. L., Davidson, R. K., Jupp, O., Bao, Y., Macgregor, A. J., Donell, S. T., Cassidy, A. & Clark, I. M., May 2014, In: Proceedings of the Nutrition Society. 73, 02, p. 278-288 11 p.

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  29 Citations (Scopus)

  19 Downloads (Pure)
• 2013

  Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation

  Culley, K. L., Hui, W., Barter, M. J., Davidson, R. K., Swingler, T. E., Destrument, A. P. M., Scott, J. L., Donell, S. T., Fenwick, S., Rowan, A. D., Young, D. A. & Clark, I. M., 1 Jul 2013, In: Arthritis & Rheumatism. 65, 7, p. 1822-1830 9 p.

  Research output: Contribution to journal › Article › peer-review
  73 Citations (Scopus)

• Matrix metalloproteinase 13 expression in response to double-stranded RNA in human chondrocytes

  Radwan, M., Gavriilidis, C., Robinson, J. H., Davidson, R., Clark, I. M., Rowan, A. D. & Young, D. A., 1 May 2013, In: Arthritis & Rheumatism. 65, 5, p. 1290-1301 12 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• Novel WWP2 ubiquitin ligase isoforms as potential prognostic markers and molecular targets in cancer

  Soond, S. M., Smith, P. G., Wahl, L., Swingler, T. E., Clark, I. M., Hemmings, A. M. & Chantry, A., 1 Dec 2013, In: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1832, 12, p. 2127-2135 39 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Review: The role of microRNAs in osteoarthritis and chondrogenesis

  Le, L. T. T., Swingler, T. E. & Clark, I. M., 1 Aug 2013, In: Arthritis & Rheumatism. 65, 8, p. 1963-1974 12 p.

  Research output: Contribution to journal › Article › peer-review
  116 Citations (SciVal)

• Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo

  Davidson, R. K., Jupp, O., de Ferrars, R., Kay, C. D., Culley, K. L., Norton, R., Driscoll, C., Vincent, T. L., Donell, S. T., Bao, Y. & Clark, I. M., Dec 2013, In: Arthritis and Rheumatism. 65, 12, p. 3130-3140 11 p.

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• 2012

  Current concepts in osteolysis

  Ollivere, B., Wimhurst, J. A., Clark, I. M. & Donell, S. M., 2012, In: Journal of Bone and Joint Surgery - British Volume. 94-B, 1, p. 10-15 6 p.

  Research output: Contribution to journal › Article › peer-review
  97 Citations (Scopus)

• MMP-14 and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction

  Wilkinson, J. M., Davidson, R. K., Swingler, T. E., Jones, E. R., Corps, A. N., Johnston, P., Riley, G. P., Chojnowski, A. J. & Clark, I. M., Jun 2012, In: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1822, 6, p. 897-905 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  33 Citations (Scopus)

• The expression and function of microRNAs in chondrogenesis and osteoarthritis

  Swingler, T. E., Wheeler, G., Carmont, V., Elliott, H. R., Barter, M. J., Abu-Elmagd, M., Donell, S. T., Boot-Handford, R. P., Hajihosseini, M. K., Munsterberg, A., Dalmay, T., Young, D. A. & Clark, I. M., 2012, In: Arthritis & Rheumatism. 64, 6, p. 1909-1919 11 p.

  Research output: Contribution to journal › Article › peer-review
  187 Citations (Scopus)
• 2011

  CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1

  Fields, J., Gardner-Mercer, J., Borgmann, K., Clark, I. M. & Ghorpade, A., 2011, In: Journal of Neurochemistry. 118, p. 93-104 12 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

  3 Downloads (Pure)

• Response of lung epithelial cells to inflammatory stimuli following exposure to the active form of vitamin D

  Norton, R., Sexton, D. W., Clark, I. M., Wilson, A. M., Hughes, D. A. & O'Connell, M. A., 2011, In: Proceedings of the Nutrition Society. 70, OCE3

  Research output: Contribution to journal › Article › peer-review
• 2010

  Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level

  Pais, H., Nicolas, F. E., Soond, S. M., Swingler, T. E., Clark, I. M., Chantry, A., Moulton, V. & Dalmay, T., 13 Jan 2010, In: RNA. 16, 3, p. 489-494 6 p.

  Research output: Contribution to journal › Article › peer-review
  106 Citations (Scopus)

• Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action

  Williams, F. M. K., Skinner, J., Spector, T. D., Cassidy, A., Clark, I. M., Davidson, R. M. & MacGregor, A. J., 8 Dec 2010, In: BMC Musculoskeletal Disorders. 11, 280.

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  31 Citations (Scopus)

  14 Downloads (Pure)

• HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes

  Barter, M. J., Pybus, L., Litherland, G. J., Rowan, A. D., Clark, I. M., Edwards, D. R., Cawston, T. E. & Young, D. A., 2010, In: Matrix Biology. 29, 7, p. 602-612 11 p.

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  76 Citations (Scopus)

  19 Downloads (Pure)

• Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis

  Milner, J. M., Patel, A., Davidson, R. K., Swingler, T. E., Desilets, A., Young, D. A., Kelso, E. B., Donell, S. T., Cawston, T. E., Clark, I. M., Ferrell, W. R., Plevin, R., Lockhart, J. C., Leduc, R. & Rowan, A. D., Jul 2010, In: Arthritis & Rheumatism. 62, 4, p. 1955-1966 12 p.

  Research output: Contribution to journal › Article › peer-review
  75 Citations (Scopus)

  1 Downloads (Pure)

• MMP28gene expression is regulated by Sp1 transcription factor acetylation

  Swingler, T. E., Kevorkian, L., Culley, K. L., Illman, S. A., Young, D. A., Parker, A. E., Lohi, J. & Clark, I. M., 2010, In: Biochemical Journal. 427, 3, p. 391-400 10 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

  Scott, J. L., Gabrielides, C., Davidson, R. K., Swingler, T. E., Clark, I. M., Wallis, G. A., Boot-Handford, R. P., Kirkwood, T. B. L., Talyor, R. W. & Young, D. A., May 2010, In: Annals of the Rheumatic Diseases. 69, 8, p. 1502-1510 9 p.

  Research output: Contribution to journal › Article › peer-review

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  198 Citations (Scopus)

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• 2009

  Characterization and regulation of ADAMTS-16

  Surridge, A. K., Rodgers, U. R., Swingler, T. E., Davidson, R. K., Kevorkian, L., Norton, R., Waters, J. G., Goldring, M. B., Parker, A. E. & Clark, I. M., Sep 2009, In: Matrix Biology. 28, 7, p. 416-424 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  29 Citations (Scopus)

• Degradome expression profiling in human articular cartilage

  Swingler, T. E., Waters, J. G., Davidson, R. K., Pennington, C. J., Puente, X. S., Darrah, C., Cooper, A., Donell, S. T., Guile, G. R., Wang, W. & Clark, I. M., 23 Jun 2009, In: Arthritis Research & Therapy. 11, 96.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  62 Citations (Scopus)

• Expression and function of matrix metalloproteinase (MMP)-28

  Rodgers, U. R., Kevorkian, L., Surridge, A. K., Waters, J. G., Swingler, T. E., Culley, K., Illman, S., Lohi, J., Parker, A. E. & Clark, I. M., 2009, In: Matrix Biology. 28, 5, p. 263-272 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  36 Citations (Scopus)
• 2008

  Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes

  Sampieri, C. L., Nuttall, R. K., Young, D. A., Goldspink, D., Clark, I. M. & Edwards, D. R., 2008, In: Matrix Biology. 27, 2, p. 128-138 11 p.

  Research output: Contribution to journal › Article › peer-review
  31 Citations (Scopus)

• Differential Toll-like receptor-dependent collagenase expression in chondrocytes

  Zhang, Q., Hu, W., Litherland, G. J., Barter, M. J., Davidson, R., Darrah, C., Donell, S. T., Clark, I. M., Cawston, T. E., Robinson, J. H., Rowan, A. D. & Young, D. A., Nov 2008, In: Annals of the Rheumatic Diseases. 67, p. 1633-1641 9 p.

  Research output: Contribution to journal › Article › peer-review
  84 Citations (Scopus)

• Metalloproteinase gene expression correlates with clinical outcome in Dupuytren's disease

  Johnston, P., Larson, D., Clark, I. M. & Chojnowski, A. J., 2008, In: Journal of Hand Surgery-American Volume. 33, 7, p. 1160-1167 8 p.

  Research output: Contribution to journal › Article › peer-review
  47 Citations (Scopus)

• The genetic association between asporin and osteoarthritis

  Clark, I., MacGregor, A. & Donell, S. T., 2008, In: The Knee. 15, 3, p. vii-viii 2 p.

  Research output: Contribution to journal › Article › peer-review

• The regulation of matrix metalloproteinases and their inhibitors

  Clark, I. M., Swingler, T. E., Sampieri, C. L. & Edwards, D. R., Jun 2008, In: International Journal of Biochemistry & Cell Biology. 40, 6-7, p. 1362-1378 17 p.

  Research output: Contribution to journal › Article › peer-review

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  478 Citations (Scopus)

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• 2007

  Acetylation in the regulation of MMP and TIMP gene expression

  Clark, I. M., Swingler, T. E. & Young, D. A., 2007, In: Frontiers in Bioscience. 12, p. 528-535 8 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)