Projects per year
Personal profile
Academic Background
I am a scientific group leader working with pluripotent stem cells at Norwich Medical School, University of East Anglia, UK. I completed my PhD at the University of Birmingham with a focus on mesenchymal stem cells and the extracellular matrix. I then undertook post-doctoral training at the University of Nottingham developing automated manufacture technologies for human pluripotent stem cells. I was later appointed as a senior research fellow, using CRISPR gene editing and hiPSCs as tools to investigate cardiovascular disease, before setting up my own group at UEA in 2019
Website: https://www.smithlabuea.com/
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 1 Active
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Investigating cardiomyocyte communication in hypertrophic cardiomyopathy
1/03/20 → 28/02/22
Project: Research
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Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics
Bhagwan, J. R., Mosqueira, D., Chairez-Cantu, K., Mannhardt, I., Bodbin, S. E., Bakar, M., Smith, J. G. W. & Denning, C., Aug 2020, In: Journal of Molecular and Cellular Cardiology. 145, p. 43-53 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)10 Downloads (Pure) -
Mitochondrial DNA: Hotspot for potential gene modifiers regulating hypertrophic cardiomyopathy
Kargaran, P. K., Evans, J. M., Bodbin, S. E., Smith, J. G. W., Nelson, T. J., Denning, C. & Mosqueira, D., Aug 2020, In: Journal of Clinical Medicine. 9, 8, 17 p., 2349.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)4 Downloads (Pure) -
Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour
Bhagwan, J. R., Collins, E., Mosqueira, D., Bakar, M., Johnson, B. B., Thompson, A., Smith, J. G. W. & Denning, C., 10 Jul 2020, (E-pub ahead of print) In: F1000Research. 8, 1911.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads (Pure) -
Modeling hypertrophic cardiomyopathy: Mechanistic insights and pharmacological intervention
Mosqueira, D., Smith, J., Bhagwan, J. R. & Denning, C., 1 Sep 2019, In: Trends in Molecular Medicine. 25, 9, p. 775-790 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile15 Citations (Scopus)9 Downloads (Pure) -
ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection
Mistry, J. J., Marlein, C. R., Moore, J. A., Hellmich, C., Wojtowicz, E. E., Smith, J. G. W., Macaulay, I., Sun, Y., Morfakis, A., Patterson, A., Horton, R. H., Divekar, D., Morris, C. J., Haestier, A., Di Palma, F., Beraza, N., Bowles, K. M. & Rushworth, S. A., 3 Dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24610-24619 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)22 Downloads (Pure)