Projects per year
Personal profile
Academic Background
I am a scientific group leader working with pluripotent stem cells at Norwich Medical School, University of East Anglia, UK. I completed my PhD at the University of Birmingham with a focus on mesenchymal stem cells and the extracellular matrix. I then undertook post-doctoral training at the University of Nottingham developing automated manufacture technologies for human pluripotent stem cells. I was later appointed as a senior research fellow, using CRISPR gene editing and hiPSCs as tools to investigate cardiovascular disease, before setting up my own group at UEA in 2019
Website: https://www.smithlabuea.com/
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
-
Investigating cardiomyocyte communication in hypertrophic cardiomyopathy
1/03/20 → 28/02/22
Project: Research
-
Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics
Bhagwan, J. R., Mosqueira, D., Chairez-Cantu, K., Mannhardt, I., Bodbin, S. E., Bakar, M., Smith, J. G. W. & Denning, C., Aug 2020, In : Journal of Molecular and Cellular Cardiology. 145, p. 43-53 11 p.Research output: Contribution to journal › Article
Open AccessFile -
Mitochondrial DNA: Hotspot for potential gene modifiers regulating hypertrophic cardiomyopathy
Kargaran, P. K., Evans, J. M., Bodbin, S. E., Smith, J. G. W., Nelson, T. J., Denning, C. & Mosqueira, D., 23 Jul 2020, In : Journal of Clinical Medicine. 9, 8Research output: Contribution to journal › Article
Open AccessFile -
Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour
Bhagwan, J. R., Collins, E., Mosqueira, D., Bakar, M., Johnson, B. B., Thompson, A., Smith, J. G. W. & Denning, C., 10 Jul 2020, In : F1000Research. 8, 1911.Research output: Contribution to journal › Article
Open AccessFile -
Modeling Hypertrophic Cardiomyopathy: Mechanistic Insights and Pharmacological Intervention
Mosqueira, D., Smith, J., Bhagwan, J. R. & Denning, C., 1 Sep 2019, In : Trends in Molecular Medicine. 25, 9, p. 775-790 16 p.Research output: Contribution to journal › Review article
Open AccessFile -
ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection
Mistry, J. J., Marlein, C. R., Moore, J. A., Hellmich, C., Wojtowicz, E. E., Smith, J. G. W., Macaulay, I., Sun, Y., Morfakis, A., Patterson, A., Horton, R. H., Divekar, D., Morris, C. J., Haestier, A., Di Palma, F., Beraza, N., Bowles, K. M. & Rushworth, S. A., 3 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24610-24619 10 p.Research output: Contribution to journal › Article
Open AccessFile