Projects per year
- Module Organiser for second year Cell Biology (5005B)
- Director of Enterprise for School of Biological Sciences, UEA
- Director of Postgraduate Research, School of Biological Sciences, UEA
We are interested in how cells interact with their environment - with other cells, with the extracellular matrix, in inflammatory situations.
We currently focus on studies of human skin function in health and disease. We are interested in how epithelial cells heal wounds in healthy tissue and in conditions such as diabetes. With our collaborators, consultant Diabetologist, Dr Ketan Dhatariya, (Norfolk and Norwich University Hosiptal; NNUH) and Dr Gerhard Saalbach at the John Innes Centre and funding from the Humane Research Trust and the UEA Innovation Fund, we are taking a new approach to study impaired wound healing in diabetes with MALDI Imaging Mass Spectrometry as well as quantitative proteomics We are taking a similar approach in Big C and NNUH funded studies with Consultant Plastic Surgeon/Surgical Oncologist, Prof Marc Moncrieff (NNUH) to explore the margins of melanomas.
- Norwich Skin Platform: Founder with Dr Damon Bevan in 2015
- Present appointment: Senior Lecturer in Cell Biology, University of East Anglia (full-time since 2014)
- Lecturer in Cell Biology (75% time), University of East Anglia (1997-2002)
- Group Leader (60% time) Strangeways Research Laboratory (1994-1997)
- Post-doctoral Associate (50% time) , Strangeways Research Laboratory, Cambridge (1993-1994)
- One-year career break after birth of first child (1992-1993)
- Post-doctoral Fellow, University College London (1989-1992)
- Royal Society and EMBO Post-doctoral Fellow Ecole Normale Superieure, Paris, France(1987-1989)
- Ph.D. - Strangeways Research Laboratory, Cambridge (1987)
- B.Sc. - Cell Biology, University College London (1978)
- Editorial Board Member "Metalloproteinases in Medicine"
- Co-organiser "Metalloproteinases: beginnings, present and future" Oxford, August 2016
- British Society of Matrix Biology Committee Member 2006-2010.
- Organiser of BSMB meeting at UEA September 6th/7th 2010 “Inflammation Meets Matrix Biology”.
Key Research Interests and Expertise
Our interests lie in cell-cell and cell-matrix interactions in skin health and disease, with an emphasis on inflammation, diabetes and melanoma.
Current Research Projects
- "Shining a light on diabetic foot ulcers: exploiting imaging mass spectrometry to explore impaired healing and to refine an ex-vivo chronic wound model" Dr Damon Bevan. Funded by The Humane Research Trust and UEA Innovation Fund. Joint project with Dr Ketan Dhatariya (Consultant Diabetologist, NNUH) and Prof Marc Moncrieff (Consultant Plastic Surgeon/Surgical Oncologist, NNUH)
- "Exploring melanoma margins: analysis and validation of data generated with MALDI Imaging mass spectrometry". Ruby Driver, Dr Damon Bevan. Funded by the Big C and RCF. This is a joint project with Prof Marc Moncrieff (NNUH)
- Norwich Skin Platform: exploring the effects of plant extracts on skin biology in health and disease (collaboration with Cathie Martin, JIC, Jeremy Turner, NNUH, Marc Moncrieff, NNUH). https://www.uea.ac.uk/norwich-skin-platform/home
Life in our research group
We are cell biologists studying several key disease processes. Using in vivo and in vitro approaches and state-of-the-art imaging techniques we work to unravel the complex mechanisms involved in inflammation in health and disease, with a focus on human skin models. We also have interests in modelling in vivo disease scenarios by growing cells in a 3-dimensional matrix and at appropriate oxygen tension. Our work benefits from collaborations within BIO and with colleagues across the Norwich Research Park and across the UK, Europe and the USA and in pharmaceutical companies.
Master's by Research
Our projects lend themselves very well to one-year research projects. Please get in touch for more information.
Postdocs & Fellows
I am always happy to discuss possibilities for postdoctoral work and collaborations.
Cell migration in health and disease; metalloproteinase expression and function
- I teach Cell Biology in second and third year modules and on Biomedicine modules and Masters Medical Biotechnology module
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Dive into details
Select a country/territory to view shared publications and projects
1/10/20 → 30/09/24
1/09/20 → 31/08/23
Novel specific human and mouse stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) antibodies for biochemical and immunohistochemical analysesMirastschijski, U., Dinesh, N., Baskaran, S., Wedekind, D., Gavrilovic, J., Murray, M. Y., Bevan, D. & Kelm, S., Jul 2019, In: Wound Repair and Regeneration. 27, 4, p. 309-323
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile9 Citations (Scopus)10 Downloads (Pure)
Bevan, D., Hajihosseini, M. K., Lee, M. & Gavrilovic, J., 2018, In: Histology and Histopathology. 33, p. 1253-1270
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile5 Citations (Scopus)25 Downloads (Pure)
N-3 fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLDVauzour, D., Rodriguez Ramiro, I., Rushbrook, S., Ipharraguerre, I. R., Bevan, D., Davies, S., Tejera, N., Mena, P., de Pascual-Teresa, S., Del Rio, D., Gavrilovic, J. & Minihane, A-M., Jan 2018, In: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864, 1, p. 69-78
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile12 Citations (Scopus)29 Downloads (Pure)
Imaging of compartmentalised intracellular nitric oxide, induced during bacterial phagocytosis, using a metalloprotein–gold nanoparticle conjugateLeggett, R., Thomas, P., Marín, M. J., Gavrilovic, J. & Russell, D. A., 7 Nov 2017, In: Analyst. 142, 21, p. 4099-4105
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile3 Citations (Scopus)15 Downloads (Pure)
Bevan, D., Baker, N., Goldring, MB., Donell, ST. & Gavrilovic, J., 1 Sep 2016, In: Metalloproteinases in Medicine. 3, p. 63-74 12 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile14 Downloads (Pure)