ResearcherID

Jesus Angulo Profile ResearcherID: H-1253-2011

Google Scholar Citations

http://scholar.google.com/citations?user=Fmfn4-8AAAAJ

PhD Positions

Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Postdoctoral Positions

I am always open to discuss possibilities for postdoctoral work and collaborations.

Jesús studied Chemistry at the University of Seville (Spain). He then obtained his doctorate working at the Instituto de Investigaciones Químicas (IIQ) of the Consejo Superior de Investigaciones Cientificas and University of Seville, in 2002, in the “Carbohydrate Group” led by Prof. Manuel Martín-Lomas, under the supervision of Dr. Pedro Nieto. His thesis was based on the study of the 3D structures and dynamics of oligosaccharides models of glycosaminoglycans (GAGs) by NMR spectroscopy and molecular dynamics simulations. He then moved to Germany for a three-year postdoctoral stay in the research group of Prof. Thomas Peters at the University of Lübeck, where he got a Marie Curie Intra-European Individual Fellwoship to specialize in ligand-based NMR spectroscopy for protein-ligand interactions, with a focus on molecular recognition of substrates by the human blood group B galactosyltransferase (GTB). After that, he joined back the Carbohydrate Group of IIQ (Seville) in 2006 as a "Juan de la Cierva" postdoctoral scientist, and from 2008 to 2013 he worked at the “Glycosystems Laboratory” of the IIQ as a senior scientist, with a prestigious "Ramón y Cajal" award, on NMR and computational chemistry for the study of the interactions of glycosaminoglycans, glycomimetics, and gold glyconanoparticles with protein receptors of relevance in infection processes (anti-HIV-1 2G12 antibody, DC-SIGN and langerin lectins). From September 2012 to September 2013 he is the Secretary of the NMR Group of the Spanish Royal Society of Chemistry. Jesus joined the School of Pharmacy of the University of East Anglia in August 2013 as a Research Fellow was promoted to Lecturer in August 2016 and is currently Senior Lecturer in NMR Spectroscopy since August 2017 within the research area of Drug Delivery and Pharmaceutical Materials.

Jesús main research interests focus on the structural and dynamics characterization of biologically active molecules, with a particular focus on glycans, and the molecular recognition of ligands by receptors of both kinds, natural (proteins, nucleic acids,…), or non-natural (materials), heavily relying on NMR spectroscopy and computational techniques.

Research areas

- Structural characterization of Ligand-Receptor interactions by NMR Spectroscopy

• Carbohydrate-Protein interactions. Carbohydrates in drug-delivery.
• Drug-carrier interactions
• Ligand-based NMR for “in-cell” ligand-protein interactions

- Structure and dynamics of biologically active small/medium-sized molecules

Selected publications

Differential Epitope Mapping by STD NMR Spectroscopy To Reveal the Nature of Protein–Ligand Contacts
S.Monaco, L.E. Tailford, N. Juge, J. Angulo
Angew. Chem. Int. Ed., 2017, 56, 15289-15293
DOI: 10.1002/chem.201600114

Unveiling the "Three Finger Pharmacophore" required for p53-MDM2 Inhibition by Saturation Transfer Difference NMR Initial Growth Rates Approach
J. Angulo, S. Goffin, D. Gandhi, M. Searcey, L. Howell
Chem.Eur.J., 2016, 22, 5858-5862
DOI: 10.1002/chem.201600114

Kinetics of Intramolecular Chemical Exchange by Initial Growth Rates of Spin Saturation Transfer Difference Experiments (SSTD NMR)
M.T. Quiros, J. Angulo, and M.P. Muñoz
Chem. Comm., 2015, 51, 10222-10225
DOI: 10.1039/C5CC02941D

Langerin-Heparin Interaction: Two Binding Sites for Small and Large Ligands as revealed by a combination of NMR Spectroscopy and Cross-Linking Mapping Experiments
J.C. Munoz-Garcia, E. Chabrol, R.R. Vives, A. Thomas, J.L. de Paz, J. Rojo, A. Imberty, F. Fieschi, P.M. Nieto, and  J. Angulo
J. Am. Chem. Soc., 2015, 137 (12), 4100-4110
DOI:10.1021/ja511529x

Structure of a Glycomimetic Ligand in the Carbohydrate Recognition Domain of C-type Lectin DC-SIGN. Structural Requirements for Selectivity and Ligand Design
Thepaut, M., C. Guzzi, I. Sutkeviciute, S. Sattin, R. Ribeiro-Viana, N. Varga, E. Chabrol, J. Rojo, A. Bernardi, J. Angulo, P. M. Nieto and F. Fieschi
J. Am. Chem. Soc., 2013, 135(7), 2518-2529
DOI: 10.1021/ja3053305

sp2-Iminosugar O-, S-, and N-Glycosides as Conformational Mimics of a-Linked Disaccharides; Implications for Glycosidase Inhibition
Sanchez-Fernandez, E. M., R. Risquez-Cuadro, C. Ortiz Mellet, J. M. Garcia Fernandez, P. M. Nieto and J. Angulo
Chem. Eur. J., 2012, 18(27), 8527-8539
DOI: 10.1002/chem.201200279

A Solution NMR Study of the Interactions of Oligomannosides and the Anti-HIV-1 2G12 Antibody Reveals Distinct Binding Modes for Branched Ligands
Enriquez-Navas, P. M., M. Marradi, D. Padro, J. Angulo and S. Penades
Chem. Eur. J., 2011, 17(5), 1547-1560
DOI: 10.1002/chem.201002519

Ligand-Receptor Binding Affinities from Saturation Transfer Difference (STD) NMR Spectroscopy: The Binding Isotherm of STD Initial Growth Rates
Angulo, J., P. M. Enriquez-Navas and P. M. Nieto
Chem. Eur. J., 2010, 16(26), 7803-7812
DOI: 10.1002/chem.200903528
(Highlighted on the Journal Issue as a Very Important “VIP” paper)

Media

• Press release September 2017: "Completing the drug design jigsaw"

• https://www.uea.ac.uk/about/-/completing-the-drug-design-jigsaw

• Press release June 2016: "£2.8 million project to make new types of gel from waste food"

• https://www.uea.ac.uk/about/-/-2-8-million-project-to-make-new-types-of-gels-from-waste-food

• Press release March 2015: "Blood thinning drug helps in understanding a natural HIV barrier"

• https://www.uea.ac.uk/about/-/blood-thinning-drug-helps-in-understanding-a-natural-hiv-barrier

Refereeing

• Nature Communications, Journal of the American Chemical Society (JACS), Chemistry: A European Journal, Carbohydrate Research, Glycoconjugate Journal, Biochemistry, and Drug Discovery Today

Grant reviewer

• BBSRC
• EPSRC
• Agencia Nacional de Evaluación y Prospectiva (ANEP)
• Romanian National Council for Scientific Research

Invited talks

• RSC Carbohydrate Group 50^th Anniversary Meeting. 2016. University of Warwick (UK). Unveiling the Structural Details of Protein-Carbohydrate Interactions by Saturation Transfer Difference (STD) NMR Spectroscopy.
• Frontiers in Glycostructure and Membrane Biology. International Meeting by the Borstel Research Centre. 2011. Borstel (Germany). Glycan-Receptor Interactions in Infection Processes Studied by STD NMR Spectroscopy.
• IX Conference of the Spanish Society of Medicinal Chemistry “New perspectives and emerging technologies in drug discovery”. 2010. Baeza, Jaén (Spain). Binding Activity of Small Molecules to Protein Targets by STD NMR: Key Information for Structure-Based Drug Design.
• II Biannual Meeting of the NMR Group of the Spanish Royal Society of Chemistry. 2006. Sant Joan, Alicante (Spain). Molecular Recognition of Activated Sugars by Human Blood Group B Galactosyltransferase: Insights from NMR Experiments

Plenary lectures

• IV Iberoamerican NMR Meeting. 2012. Aveiro (Portugal). Ligand-Receptor Interactions by Saturation Transfer Difference (STD) NMR Spectroscopy: Quantitative Studies

Other invited talks

• Max Planck Institute of Colloids and Interfaces. 2016. Potsdam (Germany). Combining X-ray, NMR, and Molecular Modeling: a powerful holistic approach to understand weak protein-ligand interactions at molecular level.
• University of Luebeck. Institute of Chemistry. 2016. Luebeck (Germany). Combining X-ray, NMR, and Molecular Modeling: a powerful holistic approach to understand weak protein-ligand interactions at molecular level.
• University of Milan. Faculty of Chemistry. 2015. Milan (Italy). Structural Details of Glycan-Receptor Interactions by Quantitative Saturation Transfer Difference (STD) NMR Spectroscopy.
• University of Seville. Faculty of Pharmacy. 2013. Seville (Spain). Saturation Transfer Difference NMR Spectroscopy (STD NMR) for the Structural Characterization of Protein-Ligand Interactions.
• University of Campinas. Instituto de Quimica. 2013. Campinas, Sao Paulo (Brazil). Quantitative STD NMR Spectroscopy for the Study of Protein-Ligand Interactions.
• Intitute of Structural Biology (IBS). 2013. Grenoble (France). Glycan-Receptor Interactions Studied by STD NMR.
• University Joseph Fourier. Faculty of Chemistry. 2013. Grenoble (France). NMR Spectroscopy for the Study of Protein-Carbohydrate Interactions.
• University Jaume-I. Faculty of Chemistry. 2012. Castellon (Spain). Ligand-Receptor Molecular Recognition Studied by Nuclear Magnetic Resonance.
• University of La Rioja. Faculty of Chemistry. 2012. Logrono (Spain). Protein-Carbohydrate Interactions in Infection Processes Analysed by STD NMR Spectroscopy.
• “Alberta Ingenuity Center for Carbohydrate Sciences”, University of Alberta. 2004. Edmonton (Canada). Binding of Ligands to Human Blood Group B Galactosyltransferase as Studied by NMR.

Our research interests focus on the characterization of the three-dimensional structures and dynamics of biologically active molecules, with a particular focus on carbohydrates (Structural Glycobiology), and their molecular recognition by receptors, either natural (proteins, nucleic acids,…), or synthetic (polymeric matrices, hydrogels,…). The group heavily rely on NMR spectroscopy and computational techniques.

Research Funding

BBSRC New Investigator grant 2017-2020

"Towards understanding the glycan code: next generation structural glycobiology for accurate description of protein-glycan complexes"

Jesus Angulo (PI)

£482,820.00

EPSRC IB Catalyst 2016-2020

"New Enzymatically Produced Interpenetrating Starch-Cellulose Gels (Structural Studies)"

Jesus Angulo (Co-PI), Yaroslav Khimyak (PI)

£786,059

NRP DTP 2016-2020

"Sweetening Drug Delivery for Future Therapies: Hydrogels Based on Sugars for Biomedical Applications"

Jesus Angulo (PI)

£76,228

Big C student research bursary (Jul-Aug 2016)

"A 3D view of the inhibition of MDM2/p53 interaction with novel gold-based organometallic compounds by Saturation Transfer Difference NMR spectroscopy"

Thomas Hick, Jesus Angulo

£1,400

NRP Science Links Seed Fund (SLSF) 2016

"Unveiling Commensal Bacteria Protein Glycosylation by High-Resolution NMR Spectroscopy"

Jesus Angulo (PI)

£15,000

NRP DTP 2015-2019

"Structural Glycobiology of Leukocyte Adhesion/Migration in the Lymphatics studied by NMR spectroscopy"

Jesus Angulo (PI)

£76,228

Serena Monaco (UEA PhD student)

Sam Walpole (NRP DTP PhD student)

Valeria Gabrielli (NRP DTP PhD student)

Juan Carlos Muñoz Garcia (Postdoctoral Research Associate; join with Yaroslav Khimyak)

Hassan Doukani (undergraduate project student 2016/2017)

Ian Ho (undergraduate project student 2016/2017)

Sarah Kirk (undergraduate project student 2016/2017)

Audrey Panjaitan (undergraduate project student 2016/2017)

Former group members

Francesca Vitulo (Erasmus postgraduate student)

Larissa Lopes Rodrigues (undergraduate Brazil “Science Without Borders” student)

Aditya Aggarwal (undergraduate project student 2015/2016)

Shamir Vekaria (undergraduate project student 2015/2016)

Pantea Shahiri (undergraduate project student 2015/2016)

Arinjay Kishan (undergraduate project student 2013/2014)

Anushka Dewan (undergraduate project student 2013/2014)

Module leader of "Special Topics for Pharmacists (year-4)"

Module leader of "From Molecules to Medicines (year-4)"

School of Pharmacy Library Liaison Representative

Modules:

SPECIAL TOPICS FOR PHARMACISTS (Module Leader)

FROM MOLECULES TO MEDICINES (Module Leader)

PHYSICAL PHARMACY

INTRODUCTION TO PHARMACY SKILLS: THERMODYNAMICS