Johannes Reinhold

Dr

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Key Research Interests and Expertise

I am interested in studying the effects of iron deficiency on the heart both in clinical studies and on a cellular level.

Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Cardiomyocytes rely on specialised metabolism to meet the high energy demand of the heart. During differentiation of pluripotent stem cells into cardiomyocytes their metabolism matures, however, cardiac diseases such as heart failure secondary to myocardial infarction are characterised by perturbed metabolism with a shift towards immature metabolism. A similar shift in metabolism can be observed during simulated iron deficiency using iron chelation.

My clinical research centres around the effects of iron deficiency on patients with acute coronary syndrome. Whilst the effects of iron deficiency on heart failure are well established, the evidence for a role of iron deficiency in acute coronary syndrome is currently still evolving.

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