• 02.01B Bio-Medical Research Centre (BMRC)

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Personal profile


My research aims to understand how the body forms and discover the causes of human birth defects



  • Lecturer in Biomedicine, University of East Anglia 2019 - Present 
  • Senior Research Associate, Center for Human Disease Modeling, Duke University, USA, 2018 - 2019
  • Senior Research Associate, Pediatric Genomics Discovery Program, Yale School of Medicine, Connecticut, USA 2010 - 2018
  • Visiting Research Fellow, CCRB, King's College London, 2016 - 2019
  • H.H.M.I. Scientific Teaching Fellow, Yale University, USA 2011 - 2012
  • E.U. Marie Curie Fellow, Department of Craniofacial Development, King's College London, 2005 - 2010
  • MSc Molecular Medicine, Trinity College Dublin, 2004 - 2005
  • BSc Microbiology, National University of Ireland, Galway



Professional Activities



Griffin, JN., Liu, KJ., Sempou, E. (2020) Editorial: Xenopus Models of Organogenesis and Disease. Frontiers in Physiology. doi: 10.3389/fphys.2020.00534 
Harel, T.*, Griffin, JN.*, Arbogast, T.*, Monroe, T., Palombo, Marcella Martinelli, Marco Seri, Tommaso Pippucci, Orly Elpeleg, Nicholas Katsanis (2020). Loss of function mutations in CCDC32 cause a congenital syndrome characterized by craniofacial, cardiac and neurodevelopmental anomalies. Human Molecular Genetics doi: 10.1093/hmg/ddaa073 (*Co-first author) 
Alharatani, R., Ververi, A., Beleza-Meireles, A., Ji, W., Mis, E., Patterson, Q., Griffin, JN., Bhujel, N., Chang, C., Dixit, A., Konstantino, M., Healy, C., Hannan, S., Neo, N., Cash, A., Li, D., Bhoj, E., Zackai, E., Cleaver, R., Baralle, D., McEntagart, M., Newbury-Ecob, R., Scott, R., Hurst, J., Au, P., Hosey, MT., Khokha, M., Marciano, D., Lakhani, S., Liu, KJ (2020). Novel truncating mutations in CTNND1 cause a dominant craniofacial and cardiac syndrome, Human Molecular Genetics, doi: 10.1093/hmg/ddaa050
Duncan, A., Robson, A., Khokha, M., and Griffin, JN. (2019) TMEM195, a heterotaxy candidate gene, regulates left-right patterning via Wnt signaling. Dev Biol doi: 10.1016/j.ydbio.2019.07.019.
Barrell, W., Griffin, JN, Harvey-Cox, J., Danovi, D., HipSci Consortium, Beales, P., Grigoriadis, A. and Liu, K. (2019) Induction of neural crest stem cells from Bardet-Biedl Syndrome patient derived hiPSCs. Frontiers in Molecular Neuroscience doi: 10.3389/fnmol.2019.00139.
Alharatani, R., Griffin, J. N., Liu, K.J., Expression of the small GTPase RAPGEF5 during mouse and human development (2019)Gene Expr Patterns. doi: 10.1016/j.gep.2019.119057
Griffin, JN, Sondalle, S., Robson, A., Mis, E., Baserga, Griffin, G., Deniz, E., S., Khokha. M. (2018). RPSA is required for rRNA processing and spleen development in XenopusDevelopment doi: 10.1242/dev.166181
Kulkarni, S. S., Griffin, J. N., Date, P. P., Liem, K. F., Jr. And Khokha, M. K. (2018). WDR5 Stabilizes Actin Architecture to Promote Multiciliated Cell Formation. Developmental Cell 46, 595-610 e593
Griffin, J.N., Del Viso, F., Duncan, A.R., Robson, A., Hwang, W., Kulkarni, S., Liu, K.J., Khokha, M.K., (2018). RAPGEF5 Regulates Nuclear Translocation of beta-Catenin. Developmental Cell 44, 248-260 e244.
Deniz, E., Jonas, S., Hooper, M., Griffin, J. N., Choma, M., Khokha, M. (2017). Analysis of Craniocardiac Malformations in Xenopus using OpticalCoherence Tomography. Scientific Reports 7, 42506; doi: 10.1038/srep42506
Robson, A., Owens, N. D., Baserga, S. J., Khokha, M. K. & Griffin, J. N.* (2016) Expression of ribosomopathy genes during Xenopus tropicalis embryogenesis. BMC Dev Biol 16, 38, doi:10.1186/s12861-016-0138-5. (* Author of correspondence)
Griffin, J. N., Sondalle, S. B., del Viso, F., Baserga, S. J., Khokha, M. K. (2015) The Ribosome Biogenesis Factor Nol11 Is Required for Optimal rDNA Transcription and Craniofacial Development in XenopusPLoS Genetics11(3): e1005018. doi:10.1371 (Faculty of 1000 recommended)
Compagnucci, C., Debiais, M., Coolen, M., Fish, J., Griffin, J. N., Bertocchini, F., Minoux, M., Rijli, FM., Borday-Birraux, V., Casane, D., Mazan, S., Depew, M. (2013). Pattern and Polarity in the Development and Evolution of the Gnathostome Jaw: Both Conservation and Heterotopy in the Branchial Arches of the Shark, Scyliorhinus canicula. Developmental Biology 1;374(1):185-97
Griffin J. N., Compagnucci, C., Hu, D., Fish, J., Klein, O., Marcucio. R., Depew, M. J., (2013). Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Developmental Biology.1;374(1):185-97

Suture Neontology and Paleontology: The Bases for Where, When and How Boundaries between Bones Have Been Established and Have Evolved. Depew, M.; Compagnucci, C.; Griffin, J. Craniofacial Sutures. Development, Disease and Treatment, Rice DP (ed)Front Oral Biol. Basel, Karger, 2008, vol 12, pp 57-78






























Expertise related to UN Sustainable Devlopment Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


Recent external collaboration on country/territory level. Dive into details by clicking on the dots or