Projects per year
Julea is Professor of Biophysical Chemistry at UEA. Her research has provided fresh insights into the mechanisms used by infectious bacteria to survive in the intestinal tract, by ‘electric’ bacteria to produce green electricity from resources typically considered as waste, and by environmental bacteria for nitrogen-cycling. Julea’s present work provides fundamental insight into the coupling of enzymes to electrodes and synthetic light-harvesting materials with the aims of inspiring new biotechnology including sustainable electronic materials and approaches to semi-artificial photosynthesis. A range of methods are employed including molecular biology, protein engineering, electrochemical, voltammetric and spectroscopic characterisations. In recognition of her achievements Julea received the 2021 Katsumi Niki Prize for Bioelectrochemistry from the International Society of Electrochemistry, a Royal Society Leverhulme Trust Senior Research Fellowship in 2015 and the inaugural Young Investigator Medal from the British Biophysical Society. Previously, Julea pioneered the study of adsorbed electroactive proteins for novel perspectives of their biochemistry with Professor Fraser Armstrong, FRS (University of Oxford). This approach, adopted by groups around the world, has become known as protein-film electrochemistry (PFE).
Julea contributes to teaching in the Schools of Chemistry and Biological Sciences through lectures, seminars and laboratory classes with a focus on topics in biochemistry, reaction kinetics, spectroscopy, electrochemistry and protein structure. She is the current Director of Research in the School of Chemistry. Previous roles have included Deputy Head of the School of Chemistry (2011-2015), Associate Dean for Post-Graduate Research in the Faculty of Science (2011-2014), Director of the Biochemistry Degree Programmes (2006-2011) and a member of the team that launched the School of Pharmacy at UEA.
Find out more about Julea's research here: Research Group Website
Enquiries from potential postgraduate and post-doctoral scientists interested in our lab are always welcome (email@example.com). Studentship and employment opportunities will be advertised via the usual channels and UEA website. You can also click here for current PhD opportunities in the Schools of Chemistry and Biology.
Selected Recent Publications:
Photocatalytic removal of the greenhouse gas nitrous oxide by liposomal microreactors
Piper SEH, Casadevall C, Reisner E, Clarke TA, Jeuken LJC, Gates AJ and Butt JN.
Angew. Chemie. Int. Ed. (2022) e202210572
Nanosecond heme-to-heme electron transfer rates in a multiheme cytochrome nanowire reported by a spectrally unique His/Met-ligated heme
van Wonderen JH, Adamczyk K, Wu X, Jiang X, Piper SEH, Hall CR, Edwards MJ, Clarke TA, Zhang H, Jeuken LJC, Sazanovich IV, Towrie M, Blumberger J, Meech SR, Butt JN.
Proc. Nat. Acad. Sci. USA (2021) DOI: 10.1073/pnas.2107939118
Bespoke biomolecular wires for transmembrane electron transfer: spontaneous assembly of a functionalized multiheme electron conduit
Piper SEH, Edwards MJ, van Wonderen JH, Casadevall C, Martel A, Jeuken LJC, Reisner E, Clarke TA and Butt JN.
Frontiers in Microbiology (2021) 12: Article 714508
The Crystal Structure of a Biological Insulated Transmembrane Molecular Wire
Edwards MJ, White GF, Butt JN, Richardson DJ and Clarke TA
Cell (2020) 181:665-673
Coherent electron transport across a 3 nm bioelectronic junction made of multi-heme proteins
Futera Z, Ide I, Kayser B, Garg K, Jiang X, van Wonderen JH, Butt JN, Ishii H, Pecht I, Sheves M, Cahen D, Blumberger J.
J. Phys. Chem. Lett. (2020) 11:9766-9774
Which multi-heme protein complex transfers electrons more efficiently? Comparing MtrCAB from Shewanella with OmcS from Geobacter
Jiang X, van Wonderen JH, Butt JN, Edwards MJ, Clarke TA, Blumberger J.
J. Phys. Chem. Lett. (2020) 11:9421-9425
Ultrafast Light-Driven Electron Transfer in a Ru(II)tris(bipyridine)-Labeled Multiheme Cytochrome.
van Wonderen JH, Hall CR, Jiang X, Adamczyk K, Carof A, Heisler I, Piper SEH, Clarke TA, Watmough NJ, Sazanovich IV, Towrie M, Meech SR, Blumberger J and Butt JN.
Journal of the American Chemical Society (2019) 141:15190-15200
- Royal Society Leverhulme Trust Senior Research Fellow 09/2015 to 09/2016
- Professor of Biophysical Chemistry, University of East Anglia 09/2010 - present
- Reader, University of East Anglia 09/2004 to 08/2010
- Lecturer, University of East Anglia 09/2001 to 08/2004
- Wellcome Trust Career Development Fellow, University of East Anglia 09/1997 to 08/2001
- Post Doctoral Research Fellow, University of Wageningen, NL 05/1995 to 07/1997
- Post Doctoral Research Fellow, National Institutes of Health, USA 09/1993 to 03/1995
- PhD, University of California Irvine, USA 1993
- BA Natural Science - Chemistry, First Class Honours with Distinction in Quantum Mechanics, University of Oxford, 1989
Key Research Interests
Located in the School of Chemistry at the University of East Anglia in Norwich, we use a diverse array of tools including molecular biology, synthetic biology, optical spectroscopies, electrochemistry, mass spectrometry and protein engineering for our research. Our focus is the interface of chemistry and biology as we study metalloproteins to resolve their structures and function and inspire the development of biohybrid materials for light-driven production of electricity and fuels.
Photochemistry: Light-Activated Molecular Wires and Solar Fuels. Many metalloproteins resemble molecular wires. Chains of redox active transition metal containing cofactors conduct electrons through poly-peptide matrices. Labeling such proteins with synthetic photosensitisers allows light-driven electron injection into the proteins. We are using this strategy to gain fundamental insight into electron transfer in multiheme cytochromes and to inspire approaches to solar fuel production. Collaborators: Steve Meech and Tom Clarke (UEA), Erwin Reisner (Cambridge), Lars Jeuken (Leiden), Jochen Blumberger (UCL).
Biochemistry Underpinning the Biogeochemical Cycling of Fe, S and N. Bacteria live in amazing and often apparently hostile environments. This is possible because they gain energy from redox transformations of inorganic forms of nitrogen, sulfur and iron that are present in those environments. We purify the proteins that catalyse these reactions. We define their structures and electron transfer properties to better understand how these proteins contribute to bacterial metabolism related to health and infection, electricity production by microbial fuel cells and mineral/nutrient cycling in anoxic sediments. Collaborators: Tom Clarke, David Richardson and Myles Cheesman (UEA), Lars Jeuken (Leiden), Erwin Reisner (Cambridge), Christiane Dahl (University of Bonn).
Protein Film Electrochemistry and Spectroscopy. Exquisite insights into electron transfer properties of purified metalloproteins are available when they are adsorbed as electro-active films on electrode materials. A defined voltage is applied to the electrode and the resulting flow of current quantified that electron transfer providing unique insight into redox catalysis, inhibition, activation and reduction potentials. Simultaneous spectroscopy of the adsorbed protein provides direct insight into the identity of the redox active cofactors.
Further details can be found here.
Post-Doctoral Research Associates: Jessica van Wonderen, Colin Lockwood
Research Technician: Simone Payne
Final Year Project Students: Adam Greenhalgh, Alex Sutton-Cook, Mary Emmerson, Keir Whiting
Enquiries from potential postgraduate and post-doctoral scientists interested in our lab are always welcome (firstname.lastname@example.org). Studentship and employment opportunities will be advertised via the usual channels and UEA website. Click here for current PhD opportunities in the School of Chemistry and Biology.
Dive into details
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Butt, J. & Van Wonderen, J.
1/09/22 → 31/08/23
New high resolution mass spectrometry facilities for macromolecules and metabolites at the University of East Anglia
5/11/20 → 4/04/21
1/01/19 → 31/12/21
18/06/18 → 12/08/18
Piper, S. E. H., Casadevall, C., Reisner, E., Clarke, T. A., Jeuken, L. J. C., Gates, A. J. & Butt, J. N., 11 Aug 2022, (E-pub ahead of print) In: Angewandte Chemie International Edition.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Reaction of Thiosulfate Dehydrogenase with a Substrate Mimic Induces Dissociation of the Cysteine Heme Ligand Giving Insight into the Mechanism of Oxidative CatalysisJenner, L., Crack, J., Kurth, J. M., Soldanova, Z., Brandt, L., Sokol, K., Reisner, E., Bradley, J., Dahl, C., Cheesman, M. & Butt, J., 13 Sep 2022, (Accepted/In press) In: Journal of the American Chemical Society.
Research output: Contribution to journal › Article › peer-review
Bespoke biomolecular wires for transmembrane electron transfer: Spontaneous assembly of a functionalized multiheme electron conduitPiper, S., Edwards, M., van Wonderen, J., Casadevall, C., Martel, A., Jeuken, L. J. C., Reisner, E., Clarke, T. & Butt, J., 16 Aug 2021, In: Frontiers in Microbiology. 12, 714508.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile3 Citations (Scopus)20 Downloads (Pure)
Nanosecond heme-to-heme electron transfer rates in a multiheme cytochrome nanowire reported by a spectrally unique His/Met ligated hemeVan Wonderen, J., Adamczyk, K., Wu, X., Jiang, X., Piper, S., Hall, C., Edwards, M., Clarke, T., Zhang, H., Jeuken, L., Sazanovich, I., Towrie, M., Blumberger, J., Meech, S. & Butt, J., 28 Sep 2021, In: Proceedings of the National Academy of Sciences. 118, 39, e2107939118.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile10 Citations (Scopus)5 Downloads (Pure)
Alqurashi, A., Alfs, L., Swann, J., Butt, J. N. & Kelly, D. J., Jul 2021, In: Molecular Microbiology. 116, 1, p. 343-358 16 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (SciVal)2 Downloads (Pure)
Data sets for: Photocatalytic removal of the greenhouse gas nitrous oxide by liposomal microreactors
Butt, J. (Creator), Angewandte Chemie International Edition, 2022
Piper, S. (Creator), Edwards, M. (Creator), Van Wonderen, J. (Contributor), Casadevall, C. (Creator), Martel, A. (Contributor), Jeuken, L. J. C. (Contributor), Reisner, E. (Contributor), Clarke, T. (Contributor) & Butt, J. (Contributor), Frontiers Media S.A., 27 Jul 2021
van Wonderen et al Data sets for 'Nanosecond Heme-to-Heme Electron Transfer Rates in a Multiheme Cytochrome Nanowire...'
Butt, J. (Creator), Van Wonderen, J. (Creator), Adamczyk, K. (Creator), Wu, X. (Creator), Jiang, X. (Creator), Piper, S. (Creator), Hall, C. (Creator), Edwards, M. (Creator), Clarke, T. (Creator), Zhang, H. (Creator), Jeuken, L. J. C. (Creator), Sazanovich, I. (Creator), Towrie, M. (Creator), Blumberger, J. (Creator) & Meech, S. (Creator), National Academy of Sciences, 2021
Li, D. (Creator), Edwards, M. (Creator), Blake, A. (Creator), Payne, S. (Creator), Piper, S. (Creator), Jenner, L. (Creator), Sokol, K. P. (Creator), Reisner, E. (Creator), Van Wonderen, J. (Creator), Clarke, T. (Creator) & Butt, J. (Creator), University of East Anglia, 2020
Reaction of Thiosulfate Dehydrogenase with a Substrate Mimic Induces Dissociation of the Cysteine Heme Ligand Giving Insight into the Mechanism of Oxidative Catalysis
Butt, J. (Creator), American Chemical Society, 2022