Projects per year
Key Research Interests and Expertise
My research uses human lens model systems to unravel the mechanisms mediating fibrotic events that lead to the disorder Posterior Capsule Opacification (PCO) that develops following cataract surgery. My current project is funded by James Tudor Foundation and The Humane Research Trust and examines the effect of both inhibiting VEGF receptors, and the implantation of open capsular bag intraocular lens (IOL) designs on the prevention of PCO.
After obtaining a 2:1 degree in Cell Biology at the University of East Anglia, I worked as a research assistant for Professor George Duncan looking at the intracellular signalling proteins SMADs that are associated with TGFb ligand binding. In addition, I worked with Dr Julie Sanderson developing organotypic tissue culture techniques to study cell populations in the human neural retinal. I subsequently completed a PhD with Professor George Duncan and Dr Julie Sanderson studying the role of extracellular ATP and Adenosine in the human lens and retinal pigment epithelium. Following completion of my PhD I have worked continuously as a senior research associate for Dr Michael Wormstone (https://www.uea.ac.uk/biological-sciences/people/profile/i-m-wormstone) . My post-doctoral research continues to unravel the mechanisms mediating the fibrotic events associated with Posterior Capsule Opacification (PCO) development using human lens model systems. My current project is funded by James Tudor Foundation (https://www.jamestudor.org.uk). This project examines both the effect of inhibiting VEGF receptors, and the implantation of open capsular bag IOL designs on the prevention of posterior capsule opacification (PCO). Our laboratory also benefits from infrastructure support from The Humane Research Trust (http://www.humaneresearch.org.uk).
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- 5 Finished
Assessment of intraocular lens/capsular bag biomechanical interactions following cataract surgery in a human in vitro graded culture capsular bag modelWormstone, I. M., Damm, N. B., Kelp, M. & Eldred, J. A., Apr 2021, In: Experimental Eye Research. 205, 108487.
Research output: Contribution to journal › Article › peer-review1 Citation (Scopus)
Wormstone, I. M., Wormstone, Y. M., Smith, A. J. O. & Eldred, J. A., May 2021, In: Progress in Retinal and Eye Research. 82, 100905.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile15 Citations (Scopus)2 Downloads (Pure)
An in vitro human lens capsular bag model adopting a graded culture regime to assess putative impact of IOLs on PCO formationEldred, J. A., Zheng, J., Chen, S. & Wormstone, I. M., Jan 2019, In: Investigative Ophthalmology and Visual Science. 60, 1, p. 113-122 10 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile14 Citations (Scopus)23 Downloads (Pure)
Resveratrol Inhibits Wound-healing and Lens Fibrosis: A Putative Candidate for Posterior Capsule Opacification PreventionSmith, A., Eldred, J. & Wormstone, M., 1 Sep 2019, In: Investigative Ophthalmology & Visual Science. 60, p. 3863-3877 15 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile10 Citations (Scopus)24 Downloads (Pure)
Wormstone, I. M. & Eldred, J. A., Jan 2016, In: Experimental Eye Research. 142, p. 2-12 11 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile65 Citations (Scopus)20 Downloads (Pure)