Projects per year
Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.
Julie Sanderson obtained her BSc (Hons) in Pharmacology, University of Leeds, 1986 and her PhD in ocular physiology from the School of Biological Sciences, University of East Anglia, 1991. She then held research associate and senior demonstrator positions in the School of Biological Sciences, University of East Anglia, before being appointed to a post as a Lecturer in Pharmacology in the School of Chemical Sciences and Pharmacy, University of East Anglia in 2004. She is currently a Senior Lecturer in Pharmaceutical Cell Biology in the School of Pharmacy.
Research interests include: ocular cell biology, pharmacology and pathophysiology including purinoceptor signalling in the retina (neural retina and the retinal pigment epithelium), molecular mechanisms underlying visual field loss in glaucoma and mechanisms of cataract formation. A central theme is calcium cell signalling.
Human organotypic retinal cultures (HORCs) as a chronic experimental model for investigation of retinal ganglion cell degeneration.
Osborne, A., Hopes, M., Wright, P., Broadway, D. C., Sanderson, J.
Experimental Eye Research, 2016, 143, pp. 28-38
Hydrostatic Pressure does not cause detectable changes to Survival of Human Retinal Ganglion.
Osborne, A., Aldarwesh, A., Rhodes, J. D., Broadway, D. C., Everitt, C., Sanderson.
J.PLoS One, 2015. 10(1): e0115591.DOI: 10.1371/journal.pone.0115591
Purines in the eye : recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.
Sanderson, J., Dartt, D., Trinkaus-Randall, V., Pintor, J., Civan, M., Delamere, N., Fletcher, E., Salt, T., Grosche, A., Mitchell, C.
Experimental Eye Research, 2014, 127.pp. 270-279.
P2X7 receptor activation mediates retinal ganglion cell death in a human retina model of ischemic neurodegeneration.
Niyadurupola, N., Sidaway, P., Ma, N., Sanderson, J., Broadway, D., Rhodes, J.
Investigative Ophthalmology & Visual Science, 2013, 54. pp. 2163-2170.
The development of human organotypic retinal cultures (HORCs) to study retinal neurodegeneration
Niyadurupola N, Sidaway P, Osborne A, Broadway DC, Sanderson J.
Br. J. Ophthalmol. 2011, 95, 720-726.
- Calpain Therapeutics. Assessment of potential of calpain inhibitors as anti-cataract drugs.
- Pfizer. Novel ocular delivery devices.
- Evotec. In vitro evaluation of lens toxicity.
- Biologie Servier. In vitro evaluations of lens toxicity.
- Novatis UK Ltd. In vitro study of lens toxicology.
- Marine Harvest. Cataracts in farmed salmon.
- BBC television programme looking at the human body "Dr Alice Roberts: Don't die young".
- Sanderson, J., Dartt, D., Trinkaus-Randall, V., Pintor, J., Civan, M., Delamere, N., Fletcher, E., Salt, T., Grosche, A., Mitchell, C (2014). Purines in the eye : recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland. Exp. Eye Res, 127.pp. 270-279.
- Rhodes, JD & Sanderson J. (2009) The Mechanisms of Calcium Homeostasis and Signalling in the Lens. Exp. Eye Res. 88: 226-234.
- Sanderson, J & McLauchlan, R. (2003) The Role of Flavonoids in Protection against Cataract. In Phytochemicals in Health and Disease. Eds. Bao, Y-P & Fenwick, R., 227-240.
- Association for Research in Vision and Ophthalmology
- International Society for Ocular Cell Biology
Key Research Interests and Expertise
Role of calpain in cataract formation
Collaborators: Dr Michael Wormstone, School of Biological Sciences, UEA.
In cortical cataract, calcium increases I the lens cells which leads to activation of downstream calcium-mediated processes. This project uses a model of calcium-induced opacification in the human lens as a model of cortical cataract to investigate the potential anti-cataract activity of inhibitors targeting the calcium-activated protease calpain.
Funding: Calpain Therapeutics
Retinal Cell Signalling Mechanisms underlying visual loss in Glaucoma.
Collaborators: Mr David Broadway Consultant Ophthalmologist, Norfolk & Norwich University Hospital.
This project aims to look at mechanisms causing cell death in retinal ganglion cells as occurs in glaucoma. Glaucoma is a debilitating disease, which leads ultimately to blindness. Vision is lost due to death of retinal ganglion cells. In this project we are investigating mechanisms mediating neuronal cell death and potential neuroprotective strategies. Research primarily utilises our recently developed human retina explant culture model (Human Retinal Organotypic Cultures; HORCs). We are investigating the triggering mechanisms for glaucomatous neurodegeneration, looking specifically at the effects of pressure, mechanical strain and ischaemia on RGC death. We are also investigating downstream mechanisms, with a specific interest in signalling via ATP, investigating the mechanisms whereby stress-induced release of ATP from retinal cells contributes to neuronal cell death. We are particularly interested in the P2X7 receptor, which is a known mediator of neuronal cell death.
Current research personnel: Dr Phillip Wright, Matthew Felgate, Sofia Habib.
Funding: Humane Research Trust, NNUH Glaucoma Research Fund.
Development of an in vitro model for assessment of drug toxicity in the human retina.
Collaborators: Dr Guy Healing and Dr Janet Kelsall, AstraZeneca UK.
This project aims to assess our human organotypic retinal culture (HORC) model, to determine its potential as a model for determining retinal toxicity. Retinal toxicity is a significant reason for failure of new drugs to progress to clinical studies. The development of an in vitro model that uses human tissue could therefore be of great benefit.
Current research personnel: Dr Phillip Wright
Funding: AstraZeneca UK.
- The Humane Research Trust
- The Norwich Glaucoma Research Fund
- AstraZeneca UK
- Calpain Therapeutics
Research Group Membership
Post Doctoral Scientist
Recent past members
Post Doctoral Scientist
Dr Marina Hopes
Dr Ning Ma
Amal Al Darwesh
Areas of Expertise
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Dive into details
Select a country/territory to view shared publications and projects
1/04/19 → 31/03/22
1/10/09 → 30/09/22
16/09/19 → 15/09/21
Building an ex-vivo model for evaluation of effectiveness of drug-eluting contact lenses for treating glaucoma
5/11/18 → 4/11/21
11/09/14 → 31/10/16
Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal glandSanderson, J., Dartt, D. A., Trinkaus-Randall, V., Pintor, J., Civan, M. M., Delamere, N. A., Fletcher, E. L., Salt, T. E., Grosche, A. & Mitchell, C. H., Oct 2014, In: Experimental Eye Research. 127, p. 270-279 10 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access81 Citations (Scopus)
P2X7 receptor activation mediates retinal ganglion cell death in a human retina model of ischemic neurodegenerationNiyadurupola, N., Sidaway, P., Ma, N., Sanderson, J., Broadway, D. C. & Rhodes, J. D., 27 Mar 2013, In: Investigative Ophthalmology & Visual Science. 54, 3, p. 2163-2170 7 p.
Research output: Contribution to journal › Article › peer-review46 Citations (Scopus)
Niyadurupola, N., Sidaway, P., Osborne, A., Broadway, D. C. & Sanderson, J., Dec 2011, In: British Journal of Ophthalmology. 95, 5, p. 720-726 7 p.
Research output: Contribution to journal › Article › peer-review29 Citations (Scopus)
Differential expression of cyclin-dependent kinases in the adult human retina in relation to CDK inhibitor retinotoxicityWright, P., Kelsall, J., Healing, G. & Sanderson, J., Mar 2019, In: Archives of Toxicology. 93, 3, p. 659–671 13 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile4 Citations (Scopus)11 Downloads (Pure)
Dhuna, K., Felgate, M., Bidula, S., Walpole, S., Bibic, L., Cromer, B., Angulo, J., Sanderson, J., Stebbing, M. & Stokes, L., Jan 2019, In: Molecular Pharmacology. 95, 2, p. 210-221 12 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile13 Citations (Scopus)15 Downloads (Pure)