Kristian Bowles

Search results

• 2023

  HSC-derived fatty acid oxidation in steady-state and stressed hematopoiesis

  Mistry, J. J., Bowles, K. & Rushworth, S. A., Jan 2023, In: Experimental Hematology. 117, p. 1-8 8 p.

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  5 Citations (Scopus)

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• p16INK4A-dependent senescence in the bone marrow niche drives age-related metabolic changes of hematopoietic progenitors

  Hellmich, C., Wojtowicz, E., Moore, J. A., Mistry, J. J., Jibril, A., Johnson, B. B., Smith, J. G. W., Beraza, N., Bowles, K. M. & Rushworth, S. A., 24 Jan 2023, In: Blood Advances. 7, 2, p. 256-268 13 p.

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  5 Citations (Scopus)

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• Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion

  Wojtowicz, E. E., Mistry, J. J., Uzun, V., Hellmich, C., Scoones, A., Chin, D. W., Kettyle, L. M., Grasso, F., Lord, A. M., Wright, D. J., Etherington, G. J., Woll, P. S., Belderbos, M. E., Bowles, K. M., Nerlov, C., Haerty, W., Bystrykh, L. V., Jacobsen, S. E. W., Rushworth, S. A. & Macaulay, I. C., 27 Jun 2023, In: Genome Biology. 24, 152.

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  1 Citation (Scopus)

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• Plasma cell derived mtDAMPs activate macrophage STING pathway which promotes myeloma progression

  Jibril, A., Hellmich, C., Wojtowicz, E. E., Hampton, K., Maynard, R., De Silva, R., Fowler-Shorten, D. J., Mistry, J. J., Moore, J. A., Bowles, K. M. & Rushworth, S. A., 22 Jun 2023, In: Blood. 141, 25, p. 3065–3077 13 p.

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  5 Citations (Scopus)

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• 2022

  LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation

  Moore, J. A., Mistry, J. J., Hellmich, C., Horton, R. H., Wojtowicz, E. E., Jibril, A., Jefferson, M., Wileman, T., Beraza, N., Bowles, K. M. & Rushworth, S. A., 1 Mar 2022, In: Journal of Clinical Investigation. 132, 5, e153157.

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  32 Citations (Scopus)

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• PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma

  Kumar, P. R., Saad, M., Hellmich, C., Mistry, J. J., Moore, J. A., Conway, S., Morris, C. J., Bowles, K. M., Moncrieff, M. D. & Rushworth, S. A., 1 Jul 2022, In: British Journal of Cancer. 127, p. 69–78 10 p.

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  16 Citations (Scopus)

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• 2021

  Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection

  Mistry, J. J., Hellmich, C., Moore, J. A., Jibril, A., Macaulay, I., Moreno-Gonzalez, M., Di Palma, F., Beraza, N., Bowles, K. M. & Rushworth, S. A., 8 Dec 2021, In: Nature Communications. 12, 1, 7130 .

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  51 Citations (Scopus)

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• Front-line management of post-transplantation lymphoproliferative disorder in adult solid organ recipient patients — A British Society for Haematology Guideline

  Shah, N., Eyre, T. A., Tucker, D., Kassam, S., Parmar, J., Featherstone, C., Andrews, P., Asgari, E., Chaganti, S., Menne, T. F., Fox, C. P., Pettit, S., Suddle, A., Bowles, K., The Haemato‐Oncology Task Force of the British Society for Haematology & British Transplantation Society, May 2021, In: British Journal of Haematology. 193, 4, p. 727-740 14 p.

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  20 Citations (Scopus)

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• Mitochondrial oxidative phosphorylation in cutaneous melanoma

  Kumar, P. R., Moore, J. A., Bowles, K. M., Rushworth, S. A. & Moncrieff, M. D., 5 Jan 2021, In: British Journal of Cancer. 124, 1, p. 115-123 9 p.

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  39 Citations (Scopus)

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• Siglec-7 mediates immunomodulation by colorectal cancer-associated Fusobacterium nucleatum ssp. animalis

  Lamprinaki, D., Garcia-Vello, P., Marchetti, R., Hellmich, C., McCord, K. A., Bowles, K. M., Macauley, M. S., Silipo, A., De Castro, C., Crocker, P. R. & Juge, N., 1 Oct 2021, In: Frontiers in Immunology. 12, 744184.

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  17 Citations (Scopus)

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• Synthesis of carboxamide-containing tranylcypromine analogues as LSD1 (KDM1A) inhibitors targeting acute myeloid leukemia

  Teresa Borrello, M., Benelkebir, H., Lee, A., Hin Tam, C., Shafat, M., Rushworth, S. A., Bowles, K. M., Douglas, L., Duriez, P. J., Bailey, S., Crabb, S. J., Packham, G. & Ganesan, A., 20 Apr 2021, In: ChemMedChem. 16, 8, p. 1316-1324 9 p.

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  7 Citations (Scopus)

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• 2020

  Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter?

  Gamble, D. T., Buono, R., Mamas, M. A., Leslie, S., Bettencourt-Silva, J. H., Clark, A., Bowles, K., Metcalf, A. K., Potter, J. & Myint, P., 1 May 2020, In: European Journal of Preventive Cardiology. 27, 7, p. 729-737 9 p.

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  3 Citations (Scopus)

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• Erdheim-Chester Disease: Two cases from an ophthalmic perspective

  Brodie, J., Zhou, S., Makkuni, D., Beadsmoore, C., Mukhtyar, C., Saada, J., Bowles, K. M., Beigi, B. & Burton, B. J. L., 1 Dec 2020, In: American Journal of Ophthalmology Case Reports. 20, 100984.

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  10 Citations (Scopus)

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• 2019

  Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment

  Abdul-Aziz, A. M., Sun, Y., Hellmich, C., Marlein, C. R., Mistry, J., Forde, E., Piddock, R. E., Shafat, M. S., Morfakis, A., Mehta, T., Di Palma, F., Macaulay, I., Ingham, C. J., Haestier, A., Collins, A., Campisi, J., Bowles, K. M. & Rushworth, S. A., 31 Jan 2019, In: Blood. 133, 5, p. 446-456 11 p.

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  66 Citations (Scopus)

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• CD38-driven mitochondrial trafficking promotes bioenergetic plasticity in multiple myeloma

  Marlein, C., Piddock, R. E., Mistry, J. J., Zaitseva, L., Hellmich, C., Horton, R. H., Zhou, Z., Auger, M. J., Bowles, K. M. & Rushworth, S. A., May 2019, In: Cancer Research. 79, 9, p. 2285-2297 13 p.

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  154 Citations (Scopus)

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• Effect of Bruton's tyrosine kinase inhibitors on platelet aggregation in patients with acute myocardial infarction

  Bhatti, M., Ayton, S., Michail, O., Gollop, N. D., Ryding, A., Rushworth, S., Bowles, K., Geisler, T. & Flather, M., Jul 2019, In: Thrombosis Research. 179, p. 64-68 5 p.

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  6 Citations (Scopus)

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• Estimated glomerular filtration rate and risk of poor outcomes after stroke

  Vart, P., Barlas, R. S., Bettencourt-Silva, J. H., Metcalf, A. K., Bowles, K. M., Potter, J. F. & Myint, P. K., Dec 2019, In: European Journal of Neurology. 26, 12, p. 1455-1463

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  6 Citations (Scopus)

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• ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

  Mistry, J. J., Marlein, C. R., Moore, J. A., Hellmich, C., Wojtowicz, E. E., Smith, J. G. W., Macaulay, I., Sun, Y., Morfakis, A., Patterson, A., Horton, R. H., Divekar, D., Morris, C. J., Haestier, A., Di Palma, F., Beraza, N., Bowles, K. M. & Rushworth, S. A., 3 Dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24610-24619 10 p.

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  89 Citations (Scopus)

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• 2018

  Bruton’s tyrosine kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia

  Nimmagadda, S. C., Frey, S., Edelmann, B., Hellmich, C., Zaitseva, L., König, G. M., Kostenis, E., Bowles, K. M. & Fischer, T., 2018, In: Leukemia. 32, p. 846–849

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  6 Citations (Scopus)

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• Effect of antiplatelet therapy (aspirin +dipyridamole versus clopidogrel) on mortality outcome in ischemic stroke

  Barlas, R. S., Loke, Y. K., Mamas, M. A., Bettencourt-Silva, J. H., Ford, I., Clark, A. B., Bowles, K. M., Metcalf, A. K., Potter, J. F. & Myint, P. K., 15 Sep 2018, In: The American Journal of Cardiology. 122, 6, p. 1085-1090 6 p.

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  10 Citations (Scopus)

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• HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia

  Abdul-Aziz, A. M., Shafat, M. S., Sun, Y., Marlein, C. R., Piddock, R. E., Robinson, S. D., Edwards, D. R., Zhou, Z., Collins, A., Bowles, K. M. & Rushworth, S. A., 2018, In: Oncogene. 37, p. 2676–2686 11 p.

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  21 Citations (Scopus)

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• High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma

  Sun, Y., Abdul Aziz, A., Bowles, K. & Rushworth, S., 1 Jan 2018, In: Cancer Letters. 412, p. 37-45 9 p.

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  26 Citations (Scopus)

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• Hyperglycaemia and the SOAR stroke score in predicting mortality

  McCall, S. J., Alanazi, T. A., Clark, A. B., Musgrave, S. D., Bettencourt-Silva, J. H., Bachmann, M. O., Metcalf, A. K., Bowles, K. M., Mamas, M. A., Potter, J. F. & Myint, P. K., 1 Mar 2018, In: Diabetes & Vascular Disease Research. 15, 2, p. 114-121 8 p.

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  6 Citations (Scopus)

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• Impact of stroke‐associated pneumonia on mortality, length of hospitalization, and functional outcome

  Teh, W. H., Smith, C. J., Barlas, R. S., Wood, A. D., Bettencourt-Silva, J. H., Clark, A. B., Metcalf, A. K., Bowles, K. M., Potter, J. F. & Myint, P. K., Oct 2018, In: Acta Neurologica Scandinavica. 138, 4, p. 293-300 8 p.

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  102 Citations (Scopus)

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• Long-term factors associated with falls and fractures poststroke

  Foster, E. J., Barlas, R. S., Bettencourt-Silva, J. H., Clark, A. B., Metcalf, A. K., Bowles, K. M., Potter, J. F. & Myint, P. K., 3 Apr 2018, In: Frontiers in Neurology. 9, 210.

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  16 Citations (Scopus)

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• Low estimated glomerular filtration rate and pneumonia in stroke patients: findings from a prospective stroke registry in the East of England

  Vart, P., Bettencourt-Silva, J. H., Metcalf, A. K., Bowles, K. M., Potter, J. F. & Myint, P. K., 1 Aug 2018, In: Clinical Epidemiology. 2018, 10, p. 887-896

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  4 Citations (Scopus)

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• Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC

  Piddock, R. E., Marlein, C. R., Abdul-Aziz, A., Shafat, M. S., Auger, M. J., Bowles, K. M. & Rushworth, S. A., 16 May 2018, In: Journal of Hematology & Oncology. 11, 66.

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  19 Citations (Scopus)

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• PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts

  Marlein, C., Zaitseva, L., Piddock, R., Raso-Barnett, L., Scott, M., Ingham, C., Collins, A., Bowles, K. & Rushworth, S., 20 Jul 2018, In: Leukemia. 32, p. 2073–2077 5 p.

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  15 Citations (Scopus)

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• Results of a multicentre UK-wide compassionate use programme evaluating the efficacy of idelalisib monotherapy in relapsed, refractory follicular lymphoma

  Eyre, T. A., Osborne, W. L., Gallop-Evans, E., Ardeshna, K. M., Kassam, S., Sadullah, S., Sidra, G., Culligan, D., Arumainathan, A., Shankara, P., Bowles, K. M., Eyre, D. W., Peng, Y. Y., Pettengell, R., Bloor, A., Vandenberghe, E. & Collins, G. P., May 2018, In: British Journal of Haematology. 181, 4, p. 555-559 5 p.

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  11 Citations (Scopus)

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• 2017

  Addition of sodium criterion to SOAR stroke score

  Adekunle-Olarinde, I. R., McCall, S. J., Barlas, R. S., Wood, A. D., Clark, A. B., Bettencourt-Silva, J. H., Metcalf, A. K., Bowles, K. M., Soiza, R. L., Potter, J. F. & Myint, P. K., May 2017, In: Acta Neurologica Scandinavica. 135, 5, p. 553–559 7 p.

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  3 Citations (Scopus)

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• A history of falls is associated with a significant increase in acute mortality in women after stroke

  Foster, E. J., Barlas, R. S., Wood, A. D., Bettencourt-Silva, J. H., Clark, A. B., Metcalf, A. K., Bowles, K. M., Potter, J. F. & Myint, P. K., 27 Sep 2017, In: Journal of Clinical Neurology. 13, 4, p. 411-421 11 p.

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  1 Citation (Scopus)

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• Determinants of length of stay following total anterior circulatory stroke

  Curtain, J. P., Yu, M., Clark, A. B., Gollop, N. D., Bettencourt-Silva, J. H., Metcalf, A. K., Bowles, K. M., Flather, M. D., Potter, J. F. & Myint, P. K., 4 Aug 2017, In: BMC Geriatrics. 2, 3, 26.

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  2 Citations (Scopus)

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• Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register

  Barlas, R. S., McCall, S. J., Bettencourt-Silva, J. H., Clark, A. B., Bowles, K. M., Metcalf, A. K., Mamas, M. A., Potter, J. F. & Myint, P. K., 15 Dec 2017, In: Journal of the Neurological Sciences. 383, p. 26-30

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  8 Citations (Scopus)

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• Inflammatory differences in plaque erosion and rupture in patients with ST-segment elevation myocardial infarction

  Chandran, S., Watkins, J., Abdul‐Aziz, A., Shafat, M., Calvert, P. A., Bowles, K. M., Flather, M. D., Rushworth, S. A. & Ryding, A. D., 3 May 2017, In: Journal of the American Heart Association. 6, 5, e005868.

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  37 Citations (Scopus)

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• Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment

  Shafat, M. S., Oellerich, T., Mohr, S., Robinson, S. D., Edwards, D. R., Marlein, C. R., Piddock, R. E., Fenech, M., Zaitseva, L., Abdul-Aziz, A., Turner, J., Watkins, J. A., Lawes, M., Bowles, K. M. & Rushworth, S. A., 9 Mar 2017, In: Blood. 129, 10, p. 1320-1332 13 p.

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  241 Citations (Scopus)

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• MIF-induced stromal PKCβ/IL8 is essential in human acute myeloid leukemia

  Abdul-Aziz, A., Shafat, M., Mehta, T., Di Palma, F., Lawes, M., Rushworth, S. A. & Bowles, K., Jan 2017, In: Cancer Research. 77, 2, p. 303-311 9 p.

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  69 Citations (Scopus)

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• NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts

  Marlein, C. R., Zaitseva, L., Piddock, R. E., Robinson, S., Edwards, D., Shafat, M. S., Zhou, Z., Lawes, M., Bowles, K. M. & Rushworth, S. A., 5 Oct 2017, In: Blood. 130, 14, p. 1649-1660 12 p.

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  240 Citations (Scopus)

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• Nodular lymphocyte predominant Hodgkin lymphoma: A real-world case series of consecutive patients treated by a single multidisciplinary team in the east of England from 1999 to 2015

  Griffin, J. C., Sadullah, S., Igali, L., Shah, N. K., Wimperis, J. Z. & Bowles, K. M., Dec 2017, In: Clinical Lymphoma, Myeloma and Leukemia. 17, 12, p. e75-e78 4 p.

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• PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

  Piddock, R. E., Loughran, N., Marlein, C. R., Robinson, S. D., Edwards, D. R., Yu, S., Pillinger, G. E., Zhou, Z., Zaitseva, L., Auger, M. J., Rushworth, S. A. & Bowles, K. M., 10 Mar 2017, In: Blood Cancer Journal. 7, 3, e539.

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  24 Citations (Scopus)

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• The bone marrow microenvironment – Home of the leukemic blasts

  Shafat, M. S., Gnaneswaran, B., Bowles, K. M. & Rushworth, S. A., Sep 2017, In: Blood Reviews. 31, 5, p. 277–286 10 p.

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  115 Citations (Scopus)

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• The role of PI3K isoforms in regulating bone marrow microenvironment signaling focusing on acute myeloid leukemia and multiple myeloma

  Piddock, R. E., Bowles, K. M. & Rushworth, S. A., 28 Mar 2017, In: Cancers. 9, 4, 29.

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• 2016

  A 6-point TACS score predicts in-hospital mortality following total anterior circulation stroke

  Wood, A. D., Gollop, N. D., Bettencourt-Silva, J. H., Clark, A. B., Metcalf, A. K., Bowles, K. M., Flather, M. D., Potter, J. F. & Myint, P. K., Oct 2016, In: Journal of Clinical Neurology. 12, 4, p. 407-413 7 p.

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  5 Citations (Scopus)

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• Dectin-2 recognises mannosylated O-antigens of human opportunistic pathogens and augments lipopolysaccharide activation of myeloid cells

  Wittmann, A., Lamprinaki, D., Bowles, K. M., Katzenellenbogen, E., Knirel, Y. A., Whitfield, C., Nishimura, T., Matsumoto, N., Yamamoto, K., Iwakura, Y., Saijo, S. & Kawasaki, N., 19 Aug 2016, In: Journal of Biological Chemistry. 291, 34, p. 17629-17638 10 p.

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• Ibrutinib for relapsed / refractory CLL: A UK and Ireland analysis of outcomes in 315 patients

  UK CLL Forum, 30 Nov 2016, In: Haematologica. 101, 12, p. 1563-1572 10 p.

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  138 Citations (Scopus)

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• Impact of hemoglobin levels and anemia on mortality in acute stroke: analysis of UK regional registry data, systematic review and meta-analysis

  Barlas, R. S., Honney, K., Loke, Y. K., McCall, S. J., Bettencourt-Silva, J. H., Clark, A. B., Bowles, K. M., Metcalf, A. K., Mamas, M. A., Potter, J. F. & Myint, P. K., Aug 2016, In: Journal of the American Heart Association. 5, 8, e003019.

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  108 Citations (Scopus)

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• Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection

  Pillinger, G., Loughran, N. V., Piddock, R. E., Shafat, M. S., Zaitseva, L., Abdul-Aziz, A., Lawes, M. J., Bowles, K. M. & Rushworth, S. A., 11 May 2016, In: Oncotarget. 7, 26, p. 39784-39795 12 p.

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• 2015

  Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells

  Rushworth, S. A., Pillinger, G., Abdul-Aziz, A., Piddock, R., Shafat, M. S., Murray, M. Y., Zaitseva, L., Lawes, M. J., MacEwan, D. J. & Bowles, K. M., 1 May 2015, In: The Lancet Haematology. 2, 5, p. e204-e211 8 p.

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  22 Citations (Scopus)

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• Hyponatremia predicts mortality after stroke

  Soiza, R. L., Cumming, K., Clark, A. B., Bettencourt-Silva, J. H., Metcalfe, A. K., Bowles, K. M., Potter, J. F. & Myint, P., Oct 2015, In: International Journal of Stroke. 10, A100, p. 50-55 6 p.

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  24 Citations (Scopus)

• Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma

  Murray, M. Y., Zaitseva, L., Auger, M. J., Craig, J. I. O., MacEwan, D., Rushworth, S. A. & Bowles, K. M., 18 Jul 2015, In: Cell Cycle. 14, 14, p. 2367-2375 9 p.

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  47 Citations (Scopus)

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• NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival

  Shah, N. M., Zaitseva, L., Bowles, K. M., MacEwan, D. J. & Rushworth, S. A., Apr 2015, In: Cell Death and Differentiation. 22, p. 654-664 11 p.

  Research output: Contribution to journal › Article › peer-review
  52 Citations (Scopus)