Research output per year
Research output per year
- 33 results
Search results
-
2023
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages
Dhuna, K., Helliwell, R., de Luca, S. N., Spencer, S. J. & Stokes, L., 14 Apr 2023, (E-pub ahead of print) In: Purinergic Signalling.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
P2X receptors: Insights from the study of the domestic dog
Sluyter, R., Sophocleous, R. A. & Stokes, L., 15 Feb 2023, In: Neuropharmacology. 224, 109358.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
2022
P2X receptor antagonists and their potential as therapeutics: a patent review (2010-2021)
Dane, C., Stokes, L. & Jorgensen, W. T., 11 May 2022, In: Expert Opinion on Therapeutic Patents. 32, 7, p. 769-790 22 p.Research output: Contribution to journal › Review article › peer-review
5 Citations (Scopus) -
2021
Dioscin-related glycosides as positive allosteric modulators of P2X7 receptors
Stokes, L., Bielecka, H., Felgate, M., Beekman, A., Ngameni, B., Chi, G. F., Stephenson, R. & Bidula, S., Dec 2021, In: British Journal of Pharmacology. 178, 24, p. 4947 1 p.Research output: Contribution to journal › Abstract › peer-review
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Insights into the structure-activity relationship of glycosides as positive allosteric modulators acting on P2X7 receptors
Piyasirananda, W., Beekman, A., Ganesan, A., Bidula, S. & Stokes, L., 1 Feb 2021, In: Molecular Pharmacology. 99, 2, p. 163-174 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)17 Downloads (Pure) -
2020
A P2RX7 single nucleotide polymorphism haplotype promotes exon 7 and 8 skipping and disrupts receptor function
Skarratt, K. K., Gu, B. J., Lovelace, M. D., Milligan, C. J., Stokes, L., Glover, R., Petrou, S., Wiley, J. S. & Fuller, S. J., Mar 2020, In: The FASEB Journal. 34, 3, p. 3884-3901 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)24 Downloads (Pure) -
Association of a P2RX7 gene missense variant with brachycephalic dog breeds
Sophocleous, R. A., Sluyter, V., Curtis, B. L., Curtis, S. J., Jurak, L. M., Faulks, M., Spildrejorde, M., Gates, S., Proctor, E. J., Seavers, A., Watson, D., Kuit, T., Dowton, M., Stokes, L. & Sluyter, R., 1 Feb 2020, In: Animal Genetics. 51, 1, p. 127-131 5 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Neuroinflammation and its resolution: From molecular mechanisms to therapeutic perspectives
Zusso, M., Stokes, L., Moro, S. & Giusti, P., 10 Apr 2020, In: Frontiers in Pharmacology. 11, 480.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile6 Citations (Scopus)10 Downloads (Pure) -
Pharmacological and genetic characterisation of the canine P2X4 receptor
Sophocleous, R. A., Berg, T., Finol‐Urdaneta, R. K., Sluyter, V., Keshiya, S., Bell, L., Curtis, S. J., Curtis, B. L., Seavers, A., Bartlett, R., Dowton, M., Stokes, L., Ooi, L. & Sluyter, R., Jun 2020, In: British Journal of Pharmacology. 177, 12, p. 2812-2829 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)24 Downloads (Pure) -
Revisiting the idea that amyloid-β peptide acts as an agonist for P2X7
Bibič, L. & Stokes, L., 17 Sep 2020, In: Frontiers in Molecular Neuroscience. 13, 166.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)20 Downloads (Pure) -
Revisiting the past to enhance the future: Traditional medicinal plant extracts in the discovery of novel drug lead to target P2X7
Bidula, S., Bibic, L., Moulton, A., Zhang, J. & Stokes, L., Jun 2020, In: British Journal of Pharmacology. 177, 11, p. 2628-2629 2 p.Research output: Contribution to journal › Abstract › peer-review
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To inhibit or enhance? Is there a benefit to positive allosteric modulation of P2X receptors?
Stokes, L., Bidula, S., Bibič, L. & Allum, E., 12 May 2020, In: Frontiers in Pharmacology. 11, 627.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)20 Downloads (Pure) -
2019
Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells
Akbar, M., Lukasewicz Ferreira, P., Giorgetti, M., Stokes, L. & Morris, C., 19 Dec 2019, In: Beilstein journal of Nanotechnology. 10, p. 2553–2562 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)18 Downloads (Pure) -
Bug off pain: An educational virtual reality game on spider venoms and chronic pain for public engagement
Bibic, L., Druskis, J., Walpole, S., Angulo Alvarez, J. & Stokes, L., 9 Jul 2019, In: Journal of Chemical Education. 96, 7, p. 1486-1490 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)13 Downloads (Pure) -
Development of high-throughput fluorescent-based screens to accelerate discovery of P2X inhibitors from animal venoms
Bibic, L., Herzig, V., King, G. & Stokes, L., 27 Sep 2019, In: Journal of Natural Products. 82, 9, p. 2559-2567 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)44 Downloads (Pure) -
Ginsenosides act as positive modulators of P2X4 receptors
Dhuna, K., Felgate, M., Bidula, S., Walpole, S., Bibic, L., Cromer, B., Angulo, J., Sanderson, J., Stebbing, M. & Stokes, L., Jan 2019, In: Molecular Pharmacology. 95, 2, p. 210-221 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)17 Downloads (Pure) -
Herbaceous homicide: The Panax ginseng metabolite compound K accelerates caspase-3/7 activation and enhances macrophage cell death in a P2X7-dependent manner
Bidula, S., Dhuna, K., Helliwell, R., Stebbing, M. & Stokes, L., Aug 2019, In: British Journal of Pharmacology. 176, 16, p. 3028-3028 1 p.Research output: Contribution to journal › Abstract › peer-review
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Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7
Bidula, S. M., Cromer, B. A., Walpole, S., Angulo, J. & Stokes, L., 1 Mar 2019, In: Scientific Reports. 9, 1, 3231.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)17 Downloads (Pure) -
Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages
Bidula, S., Dhuna, K., Helliwell, R. & Stokes, L., 2019, In: Cell Death & Disease. 10, 882.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)25 Downloads (Pure) -
Recording P2X Receptors Using Whole-Cell Patch Clamp from Native Monocytes and Macrophages
Stokes, L., 24 Oct 2019, Purinergic Signaling: Methods and Protocols. Pelegrín, P. (ed.). Springer (Humana Press), p. 275-283 9 p. (Purinergic Signaling; vol. 2041).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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2018
Correlation between thyroidal and peripheral blood total T cells, CD8+ T cells, and CD8+ T- regulatory cells and T-cell reactivity to calsequestrin and collagen XIII in patients with Graves’ ophthalmopathy
Al-Ansari, F., Lahooti, H., Stokes, L., Edirimanne, S. & Wall, J., May 2018, In: Endocrine Research. 43, 4, p. 264-274 11 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4
Mills, S., Howell, L., Beekman, A., Stokes, L. & Mueller, A., Jan 2018, In: Cellular Signalling. 42, p. 88–96 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)25 Downloads (Pure) -
2017
Neonatal overfeeding by small-litter rearing sensitises hippocampal microglial responses to immune challenge: Reversal with neonatal repeated injections of saline or minocycline
De Luca, S. N., Ziko, I., Dhuna, K., Sominsky, L., Tolcos, M., Stokes, L. & Spencer, S. J., Nov 2017, In: Journal of Neuroendocrinology. 29, 11, e12540.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)8 Downloads (Pure) -
P2X4 receptor function in the nervous system and current breakthroughs in pharmacology
Stokes, L., Layhadi, J. A., Bibic, L., Dhuna, K. & Fountain, S. J., 23 May 2017, In: Frontiers in Pharmacology. 8, 291.Research output: Contribution to journal › Article › peer-review
Open AccessFile92 Citations (Scopus)18 Downloads (Pure) -
Pharmacological evaluation of novel bioisosteres of an adamantanyl benzamide P2X7 receptor antagonist
Wilkinson, S. M., Barron, M. L., O'Brien-Brown, J., Janssen, B., Stokes, L., Werry, E. L., Chishty, M., Skarratt, K. K., Ong, J. A., Hibbs, D. E., Vugts, D. J., Fuller, S., Windhorst, A. D. & Kassiou, M., 15 Nov 2017, In: ACS Chemical Neuroscience. 8, 11, p. 2374–2380 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)23 Downloads (Pure) -
2016
Roles of ion channels in immune cells
Stokes, L., Mackenzie, A. & Sluyter, R., 15 Feb 2016, In: Frontiers in Immunology. 48, 7.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile5 Citations (Scopus)9 Downloads (Pure) -
Store-operated Ca2+ entry (SOCE) and purinergic receptor-mediated Ca2+ homeostasis in murine bv2 microglia cells: Early cellular responses to ATP-mediated microglia activation
Gilbert, D. F., Stebbing, M. J., Kuenzel, K., Murphy, R. M., Zacharewicz, E., Buttgereit, A., Stokes, L., Adams, D. J. & Friedrich, O., 28 Oct 2016, In: Frontiers in Molecular Neuroscience. 9, 111.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)10 Downloads (Pure) -
2015
Paroxetine suppresses recombinant human P2X7 responses
Dao-Ung, P., Skarratt, K., Fuller, S. & Stokes, L., 1 Dec 2015, In: Purinergic Signalling. 11, 4, p. 481-490 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)10 Downloads (Pure) -
Selected ginsenosides of the prptopanaxdiol series are novel positive allosteric modulators of P2X7 receptors
Helliwell, R., ShioukHuey, C., Dhuna, K., Molero, J., Ye, J., Xue, C. & Stokes, L., Jul 2015, In: British Journal of Pharmacology. 172, 13, p. 3326-3340 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)10 Downloads (Pure) -
Understanding the role of P2X7 in affective disorders—are glial cells the major players?
Stokes, L., Spencer, S. J. & Jenkins, T. A., 8 Jul 2015, In: Frontiers in Cellular Neuroscience. 9, 6 p., 258.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)12 Downloads (Pure) -
2014
Neonatal overfeeding alters hypothalamic microglial profiles and central responses to immune challenge long-term
Ziko, I., De Luca, S. N., Dinan, T., Barwood, J. M., Sominsky, L., Cai, G., Kenny, R., Stokes, L., Jenkins, T. A. & Spencer, S. J., Oct 2014, In: Brain, Behavior, and Immunity. 41, p. 32-43 12 p.Research output: Contribution to journal › Article › peer-review
57 Citations (Scopus) -
Nucleotides Regulate Secretion of the Inflammatory Chemokine CCL2 from Human Macrophages and Monocytes
Higgins, K. R., Kovacevic, W. & Stokes, L., 7 Sep 2014, In: Mediators of Inflammation. 2014, 13 p., 293925.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)6 Downloads (Pure) -
Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism
Bhaskaracharya, A., Dao-Ung, P., Jalilian, I., Spildrejorde, M., Skarratt, K. K., Fuller, S. J., Sluyter, R. & Stokes, L., 26 Mar 2014, In: PLoS One. 9, 3, e93058.Research output: Contribution to journal › Article › peer-review
Open AccessFile60 Citations (Scopus)18 Downloads (Pure)