Projects per year
Personal profile
Biography
I am an academic gastroenterologist with an interest in the epidemiology of premalignant and malignant upper gastrointestinal disease. A key theme of my research is the application of epidemiological methods using routinely collected health data to develop interventions to improve outcomes in patients with upper gastrointestinal malignancy. My research background and training are in clinical epidemiology, including pharmacoepidemiology, clinical trials and systematic reviews. I am deputy director of the Norwich Academic Foundation Programme and module co-lead for the year 1 (MBBS) Medical Research Module.
Professional Qualifications
- Postgraduate Certificate in Clinical Education, University of East Anglia, 2018
- Fellowship of the Higher Education Academy, 2018
- PhD, University of East Anglia, 2017
- Postgraduate diploma in health research, University of East Anglia 2015
- MRCP(Gastroenterology), Royal College of Physicians (UK), 2014
- MRCP(UK), Royal College of Physicians (UK), 2011
- Bachelor of Medicine and Bachelor of Surgery, Brighton and Sussex Medical School, 2008
Career
- Consultant Clinical Senior Lecturer in Gastroenterology (UEA) and Honorary Consultant Gastroenterologist (NNUH), 7/9/20
- NIHR Clinical Lecturer in gastroenterology, UEA 1/7/17
- Clinical Lecturer in gastroenterology, UEA 1/1/17
- NIHR Doctoral Research Fellow in gastroenterology, UEA 1/1/14
- Honorary Gastroenterology Registrar, NNUH 1/1/14
- NIHR Academic Clinical Fellow in Gastroenterology, NNUH, QEH and UEA, 3/8/11
- Core Medical Trainee, NNUH and JPUH, 4/8/10
- Academic Foundation Programme, JPUH, NNUH, UEA 6/8/08
Collaborations and top research areas from the last five years
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A single arm pilot study of Brodalumab in the treatment of Primary Sclerosing Cholangitis
Elzubeir, A., ffrench-Constant, C., Alexandre, L., Rushbrook, S., Pond, M., Shepstone, L. & Swart, A. M.
National Institute for Health and Care Research
1/10/22 → 30/09/25
Project: Fellowship
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PREDICTion of GastroIntestinal malignancy in patients with IRON Deficiency Feasibility Study
Alexandre, L., Chan, S., Clark, A., Parretti, H., Parretti, H., Richardson, K., Steel, N. & Ncube, N.
NHS Norfolk & Waveney Integrated Care Board
1/10/22 → 29/04/23
Project: Research
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NIHR CL in Gastroenterology - Leo Alexandre
National Institute for Health and Care Research
29/08/17 → 7/09/20
Project: Research
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Statins and oesophageal adenocarcinoma - a prospective cohort study investigating if statins are inversely associated with the risk of the malignant progression of Barrett's oesophagus and a feasibility randomised controlled clinical trial of statin use in preventing cancer recurrence in patients post-oesophagectomy
Alexandre, L., Clark, A. & Hart, A.
National Institute for Health and Care Research
1/01/14 → 31/12/16
Project: Fellowship
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The association between obesity and malignant progression of Barrett’s Esophagus: a systematic review and dose-response meta-analysis
Ko, M. T., Thomas, T., Holden, E., Beales, I. L. P. & Alexandre, L., 3 Sep 2024, (E-pub ahead of print) In: Clinical Gastroenterology and Hepatology.Research output: Contribution to journal › Article › peer-review
Open Access -
Opioid burden in patients with inoperable pancreatic adenocarcinoma and the development of a multivariable risk prediction model for opioid use: A retrospective cohort study
Koulouris, A., Baio, G., Clark, A. & Alexandre, L., Nov 2023, In: Pancreatology. 23, 7, p. 818-828 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Clinical and endoscopic characteristics associated with post-endoscopy upper gastrointestinal cancers: A systematic review and meta-analysis
Alexandre, L., Tsilegeridis-Legeris, T. & Lam, S., Apr 2022, In: Gastroenterology. 162, 4, p. 1123-1135 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)29 Downloads (Pure) -
Endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) technique and analgesic efficacy in patients with pancreatic cancer: A systematic review and meta-analysis
Koulouris, A., Alexandre, L., Hart, A. & Clark, A., Mar 2021, In: Pancreatology. 21, 2, p. 434-442 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)11 Downloads (Pure) -
Iron deficiency: A modern primer to diagnosis and management
Alexandre, L. & Chan, S. S. M., 1 Mar 2021, In: Current Opinion in Gastroenterology. 37, 2, p. 121-127 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)32 Downloads (Pure)