Linda Troeberg

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• 2024

  Low protein diet protects the liver from Salmonella Typhimurium-mediated injury by modulating the mTOR/autophagy axis in macrophages

  Wojtowicz, E. E., Hampton, K., Moreno-Gonzalez, M., Utting, C. L., Lan, Y., Ruiz, P., Beasy, G., Bone, C., Hellmich, C., Maynard, R., Acton, L., Markham, M., Troeberg, L., Telatin, A., Kingsley, R. A., Macaulay, I. C., Rushworth, S. A. & Beraza, N., 30 Sep 2024, In: Communications Biology. 7, 1219.

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• Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes

  Johnson, B. B., Cosson, M-V., Tsansizi, L. I., Holmes, T. L., Gilmore, T., Hampton, K., Song, O-R., Vo, N. T. N., Nasir, A., Chabronova, A., Denning, C., Peffers, M. J., Merry, C. L. R., Whitelock, J., Troeberg, L., Rushworth, S. A., Bernardo, A. S. & Smith, J. G. W., 23 Jan 2024, In: Cell Reports. 43, 1, 113668.

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• Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy

  Troeberg, L. & Betts, J. H. J., 3 Mar 2024, In: Molecular Vision. 30, p. 74-91 18 p.

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• Suramin: Effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug

  Steverding, D., Tinson, R. A. J., Piras, M., Wren, S. P., Rushworth, S. A., Searcey, M. & Troeberg, L., May 2024, In: Experimental Parasitology. 260, 6 p., 108744.

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• The extracellular heparan sulfatase SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis

  Swart, M., Redpath, A. N., Ogbechi, J., Cardenas, R., Topping, L., Compeer, E. B., Goddard, M., Chanalaris, A., Williams, R., Brewer, D. S., Smart, N., Monaco, C. & Troeberg, L., 14 Aug 2024, In: Cellular and Molecular Life Sciences. 81, 350.

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• 2023

  Development of selective ADAMTS-5 peptide substrates to monitor proteinase activity

  Fowkes, M. M., Troeberg, L., Brennan, P. E., Vincent, T. L., Meldal, M. & Lim, N. H., 9 Mar 2023, In: Journal of Medicinal Chemistry. 66, 5, p. 3522-3539 18 p.

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• Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics

  Calligaris, M., Yang, C. Y., Bonelli, S., Spanò, D. P., Müller, S. A., Lichtenthaler, S. F., Troeberg, L. & Scilabra, S. D., 14 Jun 2023, In: Frontiers in Molecular Biosciences. 10, 1162504.

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  2 Citations (Scopus)

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• Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue

  Green, J., Tinson, R. A. J., Betts, J. H. J., Piras, M., Pelut, A., Steverding, D., Wren, S., Searcey, M. & Troeberg, L., 7 Sep 2023, In: Bioorganic & Medicinal Chemistry. 92, 14 p., 117424.

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  2 Citations (Scopus)

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• 2022

  ADAM17 mediates proteolytic maturation of voltage-gated calcium channel auxiliary α₂δ subunits, and enables calcium current enhancement

  Kadurin, I., Dahimene, S., Page, K. M., Ellaway, J. I. J., Chaggar, K., Troeberg, L., Nagase, H. & Dolphin, A. C., 17 Mar 2022, In: Function. 3, 3, zqac013.

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  4 Citations (Scopus)

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• Quantitative proteomics reveals that ADAM15 can have proteolytic-independent functions in the steady state

  Yang, C. Y., Bonelli, S., Calligaris, M., Carreca, A. P., Müller, S. A., Lichtenthaler, S. F., Troeberg, L. & Scilabra, S. D., Jun 2022, In: Membranes. 12, 6, 578.

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  2 Citations (Scopus)

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• 2021

  A guide to the composition and functions of the extracellular matrix

  Karamanos, N. K., Theocharis, A. D., Piperigkou, Z., Manou, D., Passi, A., Skandalis, S. S., Vynios, D. H., Orian‐Rousseau, V., Ricard‐Blum, S., Schmelzer, C. E. H., Duca, L., Durbeej, M., Afratis, N. A., Troeberg, L., Franchi, M., Masola, V. & Onisto, M., Dec 2021, In: FEBS Journal. 288, 24, p. 6850-6912 63 p.

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  397 Citations (Scopus)

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• Targeting cartilage degradation in osteoarthritis

  McClurg, O., Tinson, R. & Troeberg, L., 5 Feb 2021, In: Pharmaceuticals. 14, 2, 126.

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  26 Citations (Scopus)

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• 2020

  Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage

  Yang, C. Y., Chanalaris, A., Bonelli, S., McClurg, O., Hiles, G. L., Cates, A. L., Zarebska, J. M., Vincent, T. L., Day, M. L., Müller, S. A., Lichtenthaler, S. F., Nagase, H., Scilabra, S. D. & Troeberg, L., Dec 2020, In: Osteoarthritis and Cartilage Open. 2, 4, 100128.

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  9 Citations (Scopus)

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• TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1

  Carreca, A. P., Pravatà, V. M., Markham, M., Bonelli, S., Murphy, G., Nagase, H., Troeberg, L. & Scilabra, S. D., 21 Jul 2020, In: Scientific Reports. 10, 12067.

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  24 Citations (Scopus)

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• 2019

  ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells

  Mohammed, R. N., Wehenkel, S. C., Galkina, E. V., Yates, E-K., Preece, G., Newman, A., Watson, H. A., Ohme, J., Bridgeman, J. S., Durairaj, R. R. P., Moon, O. R., Ladell, K., Miners, K. L., Dolton, G., Troeberg, L., Kashiwagi, M., Murphy, G., Nagase, H., Price, D. A., Matthews, R. J., & 2 othersKnäuper, V. & Ager, A., 2 Apr 2019, In: Scientific Reports. 9, 5487.

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  16 Citations (Scopus)

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• Heparan sulfate proteoglycan synthesis is dysregulated in human osteoarthritic cartilage

  Chanalaris, A., Clarke, H., Guimond, S. E., Vincent, T. L., Turnbull, J. E. & Troeberg, L., Mar 2019, In: American Journal of Pathology. 189, 3, p. 632-647 16 p.

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  35 Citations (Scopus)

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• LRP1 controls TNF release via the TIMP-3/ADAM17 axis in endotoxin-activated macrophages

  Schubert, K., Collins, L. E., Green, P., Nagase, H. & Troeberg, L., 1 Mar 2019, In: Journal of Immunology. 202, 5, p. 1501-1509 9 p.

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  17 Citations (Scopus)
• 2018

  Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor

  Scilabra, S. D., Pigoni, M., Pravatá, V., Schätzl, T., Müller, S. A., Troeberg, L. & Lichtenthaler, S. F., 2 Oct 2018, In: Scientific Reports. 8, 14697.

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  21 Citations (Scopus)

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• Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma

  Lund, J., Elimar Bitsch, A. M., Grønbech Rasch, M., Enoksson, M., Troeberg, L., Nagase, H., Loftager, M., Overgaard, M. T. & Petersen, H. H., Jan 2018, In: MAbs. 10, 1, p. 118-128 11 p.

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  5 Citations (Scopus)

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• 2017

  Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue

  Scilabra, S. D., Yamamoto, K., Pigoni, M., Sakamoto, K., Müller, S. A., Papadopoulou, A., Lichtenthaler, S. F., Troeberg, L., Nagase, H. & Kadomatsu, K., May 2017, In: Matrix Biology. 59, p. 69-79 11 p.

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  24 Citations (Scopus)

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• Inhibition of shedding of low-density lipoprotein receptor-related protein 1 reverses cartilage matrix degradation in osteoarthritis

  Yamamoto, K., Santamaria, S., Botkjaer, K. A., Dudhia, J., Troeberg, L., Itoh, Y., Murphy, G. & Nagase, H., Jun 2017, In: Arthritis & Rheumatology. 69, 6, p. 1246-1256 11 p.

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  44 Citations (Scopus)

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• Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3

  Chanalaris, A., Doherty, C., Marsden, B. D., Bambridge, G., Wren, S. P., Nagase, H. & Troeberg, L., 1 Oct 2017, In: Molecular Pharmacology. 92, 4, p. 459-468 10 p.

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  15 Citations (Scopus)

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• 2016

  Brief Report: JNK-2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis

  Ismail, H. M., Miotla-Zarebska, J., Troeberg, L., Tang, X., Stott, B., Yamamoto, K., Nagase, H., Fosang, A. J., Vincent, T. L. & Saklatvala, J., May 2016, In: Arthritis & Rheumatology. 68, 5, p. 1165-1171 7 p.

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  52 Citations (Scopus)

• Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

  Doherty, C. M., Visse, R., Dinakarpandian, D., Strickland, D. K., Nagase, H. & Troeberg, L., 14 Oct 2016, In: The Journal of Biological Chemistry. 291, 42, p. 22160-22172 13 p.

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  23 Citations (Scopus)

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• MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

  Yamamoto, K., Okano, H., Miyagawa, W., Visse, R., Shitomi, Y., Santamaria, S., Dudhia, J., Troeberg, L., Strickland, D. K., Hirohata, S. & Nagase, H., Dec 2016, In: Matrix Biology. 56, p. 57-73 17 p.

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  128 Citations (Scopus)

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• 2015

  Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors

  Lund, J., Troeberg, L., Kjeldal, H., Olsen, O. H., Nagase, H., Sørensen, E. S., Stennicke, H. R., Petersen, H. H. & Overgaard, M. T., 6 Mar 2015, In: The Journal of Biological Chemistry. 290, 10, p. 6620-6629 10 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Interleukin-1 acts via the JNK-2 signaling pathway to induce aggrecan degradation by human chondrocytes

  Ismail, H. M., Yamamoto, K., Vincent, T. L., Nagase, H., Troeberg, L. & Saklatvala, J., Jul 2015, In: Arthritis & Rheumatology. 67, 7, p. 1826-1836 11 p.

  Research output: Contribution to journal › Article › peer-review
  69 Citations (Scopus)
• 2014

  Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding

  Yamamoto, K., Owen, K., Parker, A. E., Scilabra, S. D., Dudhia, J., Strickland, D. K., Troeberg, L. & Nagase, H., 7 Mar 2014, In: The Journal of Biological Chemistry. 289, 10, p. 6462-6474 13 p.

  Research output: Contribution to journal › Article › peer-review
  70 Citations (Scopus)

• Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3

  Troeberg, L., Lazenbatt, C., Anower-E-Khuda, M. F., Freeman, C., Federov, O., Habuchi, H., Habuchi, O., Kimata, K. & Nagase, H., 23 Oct 2014, In: Chemistry & Biology. 21, 10, p. 1300-1309 10 p.

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  63 Citations (Scopus)
• 2013

  Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1

  Scilabra, S. D., Troeberg, L., Yamamoto, K., Emonard, H., Thøgersen, I., Enghild, J. J., Strickland, D. K. & Nagase, H., 4 Jan 2013, In: The Journal of Biological Chemistry. 288, 1, p. 332-342 11 p.

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  63 Citations (Scopus)

• LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage

  Yamamoto, K., Troeberg, L., Scilabra, S. D., Pelosi, M., Murphy, C. L., Strickland, D. K. & Nagase, H., 1 Feb 2013, In: The FASEB Journal. 27, 2, p. 511-521 11 p.

  Research output: Contribution to journal › Article › peer-review
  82 Citations (Scopus)
• 2012

  Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity

  Lo Cicero, A., Majkowska, I., Nagase, H., Di Liegro, I. & Troeberg, L., May 2012, In: Matrix Biology. 31, 4, p. 229-233 5 p.

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  58 Citations (Scopus)

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• Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

  Troeberg, L., Mulloy, B., Ghosh, P., Lee, M-H., Murphy, G. & Nagase, H., 1 Apr 2012, In: Biochemical Journal. 443, 1, p. 307-315 9 p.

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  33 Citations (Scopus)
• 2009

  The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3

  Troeberg, L., Fushimi, K., Scilabra, S. D., Nakamura, H., Dive, V., Thøgersen, I. B., Enghild, J. J. & Nagase, H., Oct 2009, In: Matrix Biology. 28, 8, p. 463-469 7 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)
• 2008

  Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases

  Troeberg, L., Fushimi, K., Khokha, R., Emonard, H., Ghosh, P. & Nagase, H., 1 Oct 2008, In: The FASEB Journal. 22, 10, p. 3515-3524 10 p.

  Research output: Contribution to journal › Article › peer-review
  98 Citations (Scopus)

• Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity

  Fushimi, K., Troeberg, L., Nakamura, H., Lim, N. H. & Nagase, H., 14 Mar 2008, In: The Journal of Biological Chemistry. 283, 11, p. 6706-6016 11 p.

  Research output: Contribution to journal › Article › peer-review
  76 Citations (Scopus)
• 2002

  E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A)

  Troeberg, L., Tanaka, M., Wait, R., Shi, Y. E., Brew, K. & Nagase, H., 17 Dec 2002, In: Biochemistry. 41, 50, p. 15025-1535 11 p.

  Research output: Contribution to journal › Article › peer-review
  65 Citations (Scopus)