Projects per year
Marco obtained his Master’s degree in Chemistry and Pharmaceutical Technology (2011) at the University of Milan (Italy). An internship at the Korea Research Institute of Bioscience & Biotechnology (South Korea) led him to undertake a research career. He then moved to the University of East Anglia for his doctoral training under the supervision of Dr Susan E. Matthews.
His thesis work revolved around the evaluation of resorcinol based structures as dendrimer cores, antimicrobials and antioxidants.
After completion of the doctoral studies, he became a Research Fellow at the University of East Anglia (2015). Since then he worked with Professor Mark Searcey. He worked on inhibitors of the protein-protein interactions between HDM2/X and p53. A major focus of his work are duocarmycins and their derivatives as potential antitumor therapeutics. He is also interested in P2X4 and CXCR4 receptors.
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1/06/16 → 30/11/16
Ivens, E., Cominetti, M. M. D. & Searcey, M., 1 Sep 2022, In: Bioorganic & Medicinal Chemistry. 69, 116897.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile4 Citations (Scopus)3 Downloads (Pure)
Bidula, S., Nadzirin, I. B., Cominetti, M., Hickey, H., Cullum, S. A., Searcey, M., Schmid, R. & Fountain, S. J., 1 Jan 2022, In: Molecular Pharmacology. 101, 1, p. 33-44 12 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile8 Citations (Scopus)
Amino DSA analogues as payloads for antibody-drug conjugates with multiple sites for conjugation. Initial studies and solid phase synthesisM. M. D. Cominetti, M., Goddard, Z. R., Howman, C. E., O'Connell, M. A. & Searcey, M., 25 May 2021, In: Tetrahedron Letters. 72, 153058.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile9 Downloads (Pure)
Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancersGoddard, Z. R., Beekman, A. M., Cominetti, M. M. D., O'Connell, M. A., Chambrier, I., Cook, M. J., Marin, M. J., Russell, D. A. & Searcey, M., 1 Feb 2021, In: RSC Medicinal Chemistry. 12, 2, p. 288-292 5 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile7 Citations (Scopus)17 Downloads (Pure)
A peptide-duocarmycin conjugate targeting the Thomsen-Friedenreich antigen has potent and selective antitumour activityCartwright, O. C., Beekman, A. M., Cominetti, M. M. D., Russell, D. A. & Searcey, M., 15 Jul 2020, In: Bioconjugate Chemistry. 31, 7, p. 1745–1749 5 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile5 Citations (Scopus)1 Downloads (Pure)