Projects per year
Marco obtained his Master’s degree in Chemistry and Pharmaceutical Technology (2011) at the University of Milan (Italy). An internship at the Korea Research Institute of Bioscience & Biotechnology (South Korea) led him to undertake a research career. He then moved to the University of East Anglia for his doctoral training under the supervision of Dr Susan E. Matthews.
His thesis work revolved around resorcinol based structures with two different purposes. Firstly, to create novel, easily accessible, dendrimer cores with defined topological features. Secondly, to develop halogenated resorcinol derivatives as antioxidants and antimicrobials.
After completion of the doctoral studies, he took up an Independent Research Fellowship at the University of East Anglia (2015). Since then he worked with Professor Mark Searcey. He currently works on inhibitors of the protein-protein interactions between MDM2 and p53 (and also MDM4-p53). He also works on duocarmycins and their derivatives as antitumor therapeutics, with the purpose of increasing the specificity of these ultra-potent drugs.
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1/06/16 → 30/11/16
Amino DSA analogues as payloads for antibody-drug conjugates with multiple sites for conjugation. Initial studies and solid phase synthesisM. M. D. Cominetti, M., Goddard, Z. R., Howman, C. E., O'Connell, M. A. & Searcey, M., 25 May 2021, In : Tetrahedron Letters. 72, 153058.
Research output: Contribution to journal › Article
Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancersGoddard, Z. R., Beekman, A. M., Cominetti, M. M. D., O'Connell, M. A., Chambrier, I., Cook, M. J., Marin, M. J., Russell, D. A. & Searcey, M., 1 Feb 2021, In : RSC Medicinal Chemistry. 12, 2, p. 288-292 5 p.
Research output: Contribution to journal › ArticleOpen AccessFile1 Citation (Scopus)13 Downloads (Pure)
A peptide-duocarmycin conjugate targeting the Thomsen-Friedenreich antigen has potent and selective antitumour activityCartwright, O. C., Beekman, A. M., Cominetti, M. M. D., Russell, D. A. & Searcey, M., 15 Jul 2020, In : Bioconjugate Chemistry. 31, 7, p. 1745–1749 5 p.
Research output: Contribution to journal › ArticleOpen AccessFile4 Citations (Scopus)1 Downloads (Pure)
Beekman, A., Cominetti, M., Cartwright, O., Boger, D. L. & Searcey, M., Dec 2019, In : MedChemComm. 10, 12, p. 2170-2174 5 p.
Research output: Contribution to journal › ArticleOpen AccessFile9 Downloads (Pure)
Beekman, A., Cominetti, M. M. D. & Searcey, M., 15 Jul 2019, Cytotoxic Payloads for Antibody-Drug Conjugates. Royal Society of Chemistry
Research output: Chapter in Book/Report/Conference proceeding › Chapter2 Citations (Scopus)