Projects per year
Personal profile
Biography
Marco obtained his Master’s degree in Chemistry and Pharmaceutical Technology (2011) at the University of Milan (Italy). An internship at the Korea Research Institute of Bioscience & Biotechnology (South Korea) led him to undertake a research career. He then moved to the University of East Anglia for his doctoral training under the supervision of Dr Susan E. Matthews.
His thesis work revolved around the evaluation of resorcinol based structures as dendrimer cores, antimicrobials and antioxidants.
After completion of the doctoral studies, he became a Research Fellow at the University of East Anglia (2015). Since then he worked with Professor Mark Searcey. He worked on inhibitors of the protein-protein interactions between HDM2/X and p53. A major focus of his work are duocarmycins and their derivatives as potential antitumor therapeutics. He is also interested in P2X4 and CXCR4 receptors.
Collaborations and top research areas from the last five years
Projects
- 2 Finished
-
More bang for your buck – Antibody directed conjugates with multiple warheads
1/06/16 → 30/11/16
Project: Research
-
The development of potent, competitive CXCR4 antagonists for the prevention of cancer metastasis
Hamshaw, I., Cominetti, M. M. D., Lai, W-Y., Searcey, M. & Mueller, A., Dec 2023, In: Biochemical Pharmacology. 218, 115921.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Junctions in DNA: underexplored targets for therapeutic intervention
Ivens, E., Cominetti, M. M. D. & Searcey, M., 1 Sep 2022, In: Bioorganic & Medicinal Chemistry. 69, 116897.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)5 Downloads (Pure) -
Structural basis of the negative allosteric modulation of 5-BDBD at human P2X4 receptors
Bidula, S., Nadzirin, I. B., Cominetti, M., Hickey, H., Cullum, S. A., Searcey, M., Schmid, R. & Fountain, S. J., 1 Jan 2022, In: Molecular Pharmacology. 101, 1, p. 33-44 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)7 Downloads (Pure) -
Amino DSA analogues as payloads for antibody-drug conjugates with multiple sites for conjugation. Initial studies and solid phase synthesis
M. M. D. Cominetti, M., Goddard, Z. R., Howman, C. E., O'Connell, M. A. & Searcey, M., 25 May 2021, In: Tetrahedron Letters. 72, 153058.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Downloads (Pure) -
Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers
Goddard, Z. R., Beekman, A. M., Cominetti, M. M. D., O'Connell, M. A., Chambrier, I., Cook, M. J., Marin, M. J., Russell, D. A. & Searcey, M., 1 Feb 2021, In: RSC Medicinal Chemistry. 12, 2, p. 288-292 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)26 Downloads (Pure)