Maria O'Connell

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• Abstract

  Immunomodulatory effects of 1, 25 (OH)2 D-3 in normal and transformed human lung epithelium

  Norton, R., Sexton, DW., Clark, IM., Wilson, AM., Hughes, DA. & O'Connell, MA., Apr 2011, In: Anticancer Research. 31, 4, p. 1499 1 p.

  Research output: Contribution to journal › Abstract

  Open Access
• Article

  (C^N^pz^C)Au^III complexes of acyclic carbene ligands: synthesis and anticancer properties

  Williams, M., Green, A. I., Fernandez-Cestau, J., Hughes, D. L., O'Connell, M. A., Searcey, M., Bertrand, B. & Bochmann, M., Oct 2017, In: Dalton Transactions. 46, 39, p. 13397–13408 12 p.

  Research output: Contribution to journal › Article › peer-review

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  18 Citations (Scopus)

  12 Downloads (Pure)

• Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations

  Williams, M. RM., Bertrand, B., Fernandez-Cestau, J., Waller, Z. AE., O'Connell, M. A., Searcey, M. & Bochmann, M., 14 Oct 2018, In: Dalton Transactions. 47, 38, p. 13523-13534 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  5 Citations (Scopus)

  12 Downloads (Pure)

• A gold(III) pincer ligand scaffold for the synthesis of binuclear and bioconjugated complexes: synthesis and anticancer potential

  Benoît, B., O'Connell, M. A., Waller, Z. A. E. & Bochmann, M., 7 Mar 2018, In: Chemistry - A European Journal. 24, 14, p. 3613–3622 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  17 Citations (Scopus)

  10 Downloads (Pure)

• alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells

  Ogborne, R. M., Rushworth, S. A. & O'Connell, M. A., 2005, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 25, 10, p. 2100-2105 6 p.

  Research output: Contribution to journal › Article › peer-review
  108 Citations (Scopus)

• Amino DSA analogues as payloads for antibody-drug conjugates with multiple sites for conjugation. Initial studies and solid phase synthesis

  M. M. D. Cominetti, M., Goddard, Z. R., Howman, C. E., O'Connell, M. A. & Searcey, M., 25 May 2021, In: Tetrahedron Letters. 72, 153058.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  2 Downloads (Pure)

• Anti-inflammatory effect of a cell penetrating peptide targeting the Nrf2/Keap1 interaction

  Steel, R., Cowan, J., Payerne, E., O'Connell, M. A. & Searcey, M., 2012, In: ACS Medicinal Chemistry Letters. 3, 5, p. 407-410 4 p.

  Research output: Contribution to journal › Article › peer-review
  84 Citations (Scopus)

• A small molecule that induces assembly of a four way DNA junction at low temperature

  Howell, LA., Waller, Z. A. E., Bowater, RP., O'Connell, M. & Searcey, M., 2011, In: Chemical Communications. 47, 29, p. 8262-8264 3 p.

  Research output: Contribution to journal › Article › peer-review

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  21 Citations (Scopus)

  7 Downloads (Pure)

• A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules

  Reed, J., Stephenson, M. J., Miettinen, K., Brouwer, B., Leveau, A., Brett, P., Goss, R. J. M., Goossens, A., O'Connell, M. A. & Osbourn, A., Jul 2017, In: Metabolic Engineering. 42, p. 185–193 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  83 Citations (Scopus)

  15 Downloads (Pure)

• Cardiovascular mechanisms of action of anthocyanins may be associated with the impact of microbial metabolites on heme oxygenase-1 in vascular smooth muscle cells

  Warner, E. F., Rodriguez-Ramiro, I., O'Connell, M. A. & Kay, C. D., 13 Apr 2018, In: Molecules. 23, 4, 898.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  9 Citations (Scopus)

  21 Downloads (Pure)

• Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78

  O'Connell, M. A., Cleere, R., Long, A., O'Neill, L. A. J. & Kelleher, D., 31 Mar 1995, In: Journal of Biological Chemistry. 270, 13, p. 7399-7404 6 p.

  Research output: Contribution to journal › Article › peer-review
  56 Citations (Scopus)

• Common phenolic metabolites of flavonoids, but not their unmetabolized precursors, reduce the secretion of vascular cellular adhesion molecules by human endothelial cells

  Warner, E. F., Zhang, Q., Raheem, K. S., O'Hagan, D., O'Connell, M. A. & Kay, C. D., 1 Mar 2016, In: Journal of Nutrition. 146, 3, p. 465-473 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  57 Citations (Scopus)

  11 Downloads (Pure)

• Curcumin: potential for hepatic fibrosis therapy?

  O'Connell, M. & Rushworth, S., Feb 2008, In: British Journal of Pharmacology. 153, 3, p. 403-405 3 p.

  Research output: Contribution to journal › Article › peer-review
  60 Citations (Scopus)

• Cyclometallated Au(III) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

  Williams, M., Bertrand, B., Hughes, D. L., Waller, Z. A. E., Schmidt, C., Ott, I., O'Connell, M. A., Searcey, M. & Bochmann, M., 1 Nov 2018, In: Metallomics. 10, 11, p. 1655-1666

  Research output: Contribution to journal › Article › peer-review

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  20 Citations (Scopus)

  21 Downloads (Pure)

• Cytotoxicity of Pyrazine-Based Cyclometalated (C^N^pz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties

  Bertrand, B., Fernandez-Cestau, J., Angulo, J., Cominetti, M. M. D., Waller, Z. A. E., Searcey, M., O'Connell, M. A. & Bochmann, M., 15 May 2017, In: Inorganic Chemistry. 56, 10, p. 5728–5740 13 p.

  Research output: Contribution to journal › Article › peer-review

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  39 Citations (Scopus)

  19 Downloads (Pure)

• Design and synthesis of threading intercalators to target DNA

  Howell, L., Gulam, R., Mueller, A., O'Connell, M. & Searcey, M., 7 Oct 2010, In: Bioorganic & Medicinal Chemistry Letters. 1, 20, p. 6956-6959 4 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Developmental changes in leptin as a measure of energy status in human infants in a natural ecologic setting

  Collinson, A., Moore, S., O'Connell, M., Charalambos, C. & Prentice, A., 2005, In: American Journal of Clinical Nutrition. 81, 2, p. 488-494 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  15 Citations (Scopus)

• Dexamethasone enhances LPS induction of tissue factor expression in monocytic cells via a post-transcriptional mechanism

  Reddy, V., Bhattacharjee, G., Hollis, A., Kempf, K., O'Connell, M. A., Guha, M. & Mackman, N., 2003, In: The FASEB Journal. 17, 5, p. A1327-A1327

  Research output: Contribution to journal › Article › peer-review

• Disc-shaped polyoxyethylene glycol glycerides gel nanoparticles as novel protein delivery vehicles

  Codoni, D., Cowan, J., Bradley, J., O'Connell, M., McAuley, W. & Qi, S., 30 Dec 2015, In: International Journal of Pharmaceutics. 496, 2, p. 1015-1025 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  3 Citations (Scopus)

  6 Downloads (Pure)

• Elevated sialic acid, but not CRP, predicts features of the metabolic syndrome independently of BMI in women

  Browning, L. M., Jebb, S. A., Mishra, G. D., Cooke, J. H., O'Connell, M. A., Crook, M. A. & Krebs, J. D., 2004, In: International Journal of Obesity. 28, 8, p. 1004-1010 7 p.

  Research output: Contribution to journal › Article › peer-review
  34 Citations (Scopus)

• Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cδ and Nrf2

  Ogborne, R. M., Rushworth, S. & O'Connell, M., 27 Jun 2008, In: Biochemical and Biophysical Research Communications. 373, 4, p. 584-588 5 p.

  Research output: Contribution to journal › Article › peer-review
  45 Citations (Scopus)

• Ethnic differences in the relationship between fasting leptin and BMI in children

  Moore, S. E., Falorni, A., Bini, V., Fulford, A. J. C., O'Connell, M. A. & Prentice, A. M., 2004, In: International Journal of Obesity. 28, 1, p. 17-21 5 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Euglenatides, potent antiproliferative cyclic peptides isolated from the freshwater photosynthetic microalga Euglena gracilis

  Ganesan, A., Aldholmi, M., Ahmad, R., Carretero-Molina, D., Pérez-Victoria, I., Martín, J., Reyes, F., Genilloud, O., Gourbeyre, L., Gefflaut, T., Carlsson, H., Maklakov, A., Field, R. A., O'Neill, E., Wilkinson, B. & O'Connell, M., 7 Jun 2022, In: Angewandte Chemie International Edition. 61, 23, e202203175.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  2 Downloads (Pure)

• Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells

  Liu, R., O'Connell, M., Johnson, K., Pritzker, K., Mackman, N. & Terkeltaub, R., May 2000, In: Arthritis & Rheumatism. 43, 5, p. 1145-1155 11 p.

  Research output: Contribution to journal › Article › peer-review
  93 Citations (Scopus)

• Ferracyclic carbonyl complexes as anti-inflammatory agents

  Wright, M., Wooldridge, T., O'Connell, M. & Wright, J., 21 Apr 2020, In: Chemical Communications. 56, 31, p. 4300-4303 4 p.

  Research output: Contribution to journal › Article › peer-review

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  3 Citations (Scopus)

  2 Downloads (Pure)

• Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes

  Di Gesso, J., Kerr, J., Zhang, Q., Raheem, S., Krishna Yalamanchili, S., O'Hagan, D., Kay, C. & O'Connell, M., Jun 2015, In: Molecular Nutrition & Food Research. 59, 6, p. 1143–1154 12 p.

  Research output: Contribution to journal › Article › peer-review

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  65 Citations (Scopus)

  7 Downloads (Pure)

• Formal total synthesis of (+)-C9-deoxyomuralide from l-leucine using a double sacrificial chirality transfer approach

  Bulman Page, P. C., Goodyear, R. L., Horton, A. E., Chan, Y., Karim, R., O'Connell, M. A., Hamilton, C., Slawin, A. M. Z., Buckley, B. R. & Allin, S. M., 1 Dec 2017, In: The Journal of Organic Chemistry. 82, 23, p. 12209–12223 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  6 Citations (Scopus)

  26 Downloads (Pure)

• Fruit and vegetable intakes and bone mineral status: a cross-sectional study in 5 age and sex cohorts

  Prynne, C. J., Mishra, G. D., O'Connell, M. A., Muniz, G., Laskey, M. A., Yan, L., Prentice, A. & Ginty, F., Jun 2006, In: American Journal of Clinical Nutrition. 83, 6, p. 1420-1428 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  208 Citations (Scopus)

• Haem oxygenase-1: a target for dietary antioxidants

  Ogborne, R. M., Rushworth, S. A., Charalambos, C. A. & O'Connell, M. A., 2004, In: Biochemical Society Transactions. 32, 6, p. 1003-1005 3 p.

  Research output: Contribution to journal › Article › peer-review
  49 Citations (Scopus)

• Haem oxygenase-1 in inflammation

  Rushworth, S. A. & O'Connell, M. A., 2004, In: Biochemical Society Transactions. 32, p. 1093-1094 2 p.

  Research output: Contribution to journal › Article › peer-review

  18 Citations (Scopus)

• Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)

  Waller, Z. A. E., Howell, L. A., Macdonald, C. J., O'Connell, M. A. & Searcey, M., 25 Apr 2014, In: Biochemical and Biophysical Research Communications. 447, 1, p. 128-32 5 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin

  Cominetti, M., Goffin, S., Raffel, E., Turner, K., Ramoutar, J., O'Connell, M., Howell, L. & Searcey, M., 1 Nov 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 21, p. 4878-4880 3 p.

  Research output: Contribution to journal › Article › peer-review

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  15 Citations (Scopus)

  11 Downloads (Pure)

• Identification of selective protein-protein interaction inhibitors using efficient in silico peptide-directed ligand design

  Beekman, A. M., Cominetti, M. M. D., Walpole, S. J., Prabhu, S., O'Connell, M. A., Angulo Alvarez, J. & Searcey, M., 28 Apr 2019, In: Chemical Science. 10, 16, p. 4502-4508 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  6 Citations (Scopus)

  37 Downloads (Pure)

• Immunomodulatory effects of 1,25(OH)(2)D-3 in normal and transformed human lung epithelium

  Norton, R., Sexton, D. W., Clark, I. M., Wilson, A. M., Hughes, D. A. & O'Connell, M. A., 2011, In: Anticancer Research. 31, 4, p. 25 1 p.

  Research output: Contribution to journal › Article › peer-review

• Immunomodulatory effects of vitamin D in the respiratory epithelium

  Norton, R., Sexton, D. W., Clark, I. M., Wilson, A. M., Hughes, D. A. & O'Connell, M. A., 2010, In: Immunology. 131, p. 140 1 p.

  Research output: Contribution to journal › Article › peer-review

• Intake of B vitamins in childhood and adult life in relation to psychological distress among women in a British birth cohort

  Mishra, G. D., McNaughton, S. A., O'Connell, M., Prynne, C. J. & Kuh, D., 2009, In: Public Health Nutrition. 12, 02, p. 166 1 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Interferon-gamma and tumour necrosis factor production in patients with Helicobacter pylori infection

  Fan, X. J., Chua, A., O'Connell, M. A., Kelleher, D. & Keeling, P. W., Oct 1993, In: Irish Journal of Medical Science. 162, 10, p. 408-411 4 p.

  Research output: Contribution to journal › Article › peer-review
  33 Citations (Scopus)

• Leptin, malnutrition, and immune response in rural Gambian children

  Moore, S. E., Morgan, G., Collinson, A. C., Swain, J. A., O'Connell, M. A. & Prentice, A. M., 2002, In: Archives of Disease in Childhood. 87, 3, p. 192-197 6 p.

  Research output: Contribution to journal › Article › peer-review
  34 Citations (Scopus)

• Leptin and undernutrition

  Prentice, A. M., Moore, S. E., Collinson, A. C. & O'Connell, M. A., 2002, In: Nutrition Reviews. 60, 10, p. S56-S67

  Research output: Contribution to journal › Article › peer-review
  33 Citations (Scopus)

• Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression

  Guha, M., O'Connell, M. A., Pawlinski, R., Hollis, A., McGovern, P., Yan, S-F., Stern, D. & Mackman, N., 2001, In: Blood. 98, 5, p. 1429-1439 11 p.

  Research output: Contribution to journal › Article › peer-review
  320 Citations (Scopus)

• Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes

  Rushworth, S., Macewan, D. & O'Connell, M., 2008, In: Journal of Immunology. 181, p. 6730-6737 8 p.

  Research output: Contribution to journal › Article › peer-review

  155 Citations (Scopus)

• Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C

  Rushworth, S. A., Chen, X. L., Mackman, N., Ogborne, R. M. & O'Connell, M. A., 2005, In: Journal of Immunology. 175, 7, p. 4408-4415 8 p.

  Research output: Contribution to journal › Article › peer-review

  154 Citations (Scopus)

• LPS activation of the Nrf2 pathway in monocytes: role of PKC alpha

  White, H., Norton, R., Rushworth, S. A., Mc Carthy, E. & O'Connell, M. A., 2010, In: Immunology. 131, p. 146-147 2 p.

  Research output: Contribution to journal › Article › peer-review

• Microalbuminuria in inflammatory bowel disease

  Mahmud, N., Stinson, J., O'Connell, M. A., Mantle, T. J., Keeling, P. W., Feely, J., Weir, D. G. & Kelleher, D., Nov 1994, In: Gut. 35, 11, p. 1599-1604 6 p.

  Research output: Contribution to journal › Article › peer-review
  51 Citations (Scopus)

• Micronutrient deficiencies - Hohenheim Consensus Conference

  Biesalski, H. K., Brummer, R. J., König, J., O'Connell, M. A., Ovesen, L., Rechkemmer, G., Stos, K. & Thurnham, D. I., 2003, In: European Journal of Nutrition. 42, 6, p. 353-363 11 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Moderate alcohol consumption and increased bone mineral density: potential ethanol and non-ethanol mechanisms

  Jugdaohsingh, R., O'Connell, M. A., Sripanyakorn, S. & Powell, J. J., 2006, In: Proceedings of the Nutrition Society. 65, 3, p. 291-310 20 p.

  Research output: Contribution to journal › Article › peer-review
  47 Citations (Scopus)

• Peptide-directed binding for the discovery of modulators of α-helix-mediated protein-protein interactions: Proof-of-concept studies with the apoptosis regulator Mcl-1

  Beekman, A. M., O'Connell, M. A. & Howell, L. A., 21 Aug 2017, In: Angewandte Chemie International Edition. 56, 35, p. 10446–10450 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  6 Citations (Scopus)

  28 Downloads (Pure)

• Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

  Goddard, Z. R., Beekman, A. M., Cominetti, M. M. D., O'Connell, M. A., Chambrier, I., Cook, M. J., Marin, M. J., Russell, D. A. & Searcey, M., 1 Feb 2021, In: RSC Medicinal Chemistry. 12, 2, p. 288-292 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  2 Citations (Scopus)

  15 Downloads (Pure)

• Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction

  Steel, R. J., O'Connell, M. A. & Searcey, M., 1 Sep 2018, In: Bioorganic & Medicinal Chemistry Letters. 28, 16, p. 2728-2731 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  11 Citations (Scopus)

  24 Downloads (Pure)

• Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

  Tortorici, M., Borrello, M. T., Tardugno, M., Chiarelli, L. R., Pilotto, S., Ciossani, G., Vellore, N. A., Bailey, S. G., Cowan, J., O'Connell, M., Crabb, S. J., Packham, G., Mai, A., Baron, R., Ganesan, A. & Mattevi, A., 16 Aug 2013, In: ACS Chemical Biology. 8, 8, p. 1677-1682 6 p.

  Research output: Contribution to journal › Article › peer-review
  46 Citations (Scopus)