Maria Paz Munoz-Herranz

Dr

  • 3.51 Chemistry

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Personal profile

Biography

 

Paz was born in Madrid (Spain), where she studied Chemistry at the Universidad Autónoma de Madrid until June 1999, when she finished her Master in Chemistry (Organic Chemistry). In July 2001 she obtained her Diploma Thesis at the same University under the supervision of Prof. Antonio M. Echavarren (“Desarrollo de Nuevos Métodos de Formación de  Enlace C-C Catalizados por Pt, Ru y Pd”. Apto), and then carried out her Ph.D. in Chemistry in the same group (October 2004. “Competing Pathways in the Cyclization of 1,6-Enynes Catalyzed by Transition Metals: Selectivity Studies”). On 22nd October 2004, she passed her viva (Summa Cum Laude) and, one week later undertook her new life as a postdoc in Bristol, in the group of Prof. Lloyd-Jones. During her time in Bristol she held the positions of Research Assistant (November 2004) working on “Synthesis of New 3,3'-Binol Derived Substituted Phosphoramidites” for the Ligand Bank (European Community's Sixth Framework Programme); Post-Doctoral Fellow from the Ministerio de Educación y Ciencia (August 2005), working in “Mechanistic and Kinetics Aspects of the Palladium-Catalyzed Cyclization of Dienes and Related Reactions”; and finally Research Associate (August 2007), working on “Development of New Protocols for Alkene Difuntionalisation” financed by the (Engineering and Physical Sciences Research Council (EPSRC), UK). In May 2009, Dr. Muñoz returned to Madrid, Spain with a prestigious Ramón y Cajal Award to work at the Insituto de Química Orgánica General (IQOG-CSIC), where she started her research into the discovery of new platinum-catalysed reactions of allenes. She joined the UEA as Lecturer in Organic Chemistry from September 2011 and was promoted to Senior Lecturer / Associate Professor in 2017.


Research interests

Dr Muñoz is an organic chemist with particular interest in the discovery and development of new organic and organometallic reactions, the use of physical-organic-inorganic chemistry knowledge to study the mechanisms involved, in particular using isotopic labelling, kinetics, simulations and NMR techniques, and the application of the knowledge acquire to the synthesis of small organic and organometallic molecules with potential biological activity.

Her current research involves the discovery and development of novel transition metal-catalysed reactions of allenes, and the design and synthesis of novel fluorescent tetrazolium salts as dyes for new dual-fluorescent respiration assays with diverse applicatons (in drug discovery and marine science).

Selected publications

Precious metal complexes of bis(pyridil)allenes: synthesis, catalytic and medicinal applications

Hanna K. Maliszewska, Carla Arnau del Valle, Ying Xia, María J. Marín, Zoë A. E. Waller and M. Paz Muñoz

Dalton Transactions, 2021, 50, 16739-16750.

Allene-derived gold and platinum complexes: synthesis and first application in catalysis

Hanna K. Maliszewska, David L. Hughes and M. Paz Muñoz

Dalton Trans., 202049, 4034-4038.

Unraveling mechanistic insights in the plainum-catalysed dihydroalkoxylation of allenes

M. T. Quirós, E. Gómez-Bengoa, M. P. Muñoz

Pure Appl. Chem. 2020, 92(1), 167-177.

Article for a collection of invited papers based on presentations at the 24th IUPAC International Conference on Physical Organic Chemistry (ICPOC 24) held in Faro, Portugal, 1–6 July 2018.

Platinum and Gold Catalysis: a la Carte Hydroamination of Terminal Activated Allenes with Azoles.

 J. M. Alonso, M. P. Muñoz*

Org. Lett. 2019, 21 (18), 7639-7644.

Evidence of hybrid homo-heterogeneous catalysis in a Pt/Aheterobimetallic system

 J. M. Alonso, M. P. Muñoz*
 ChemCatChem, 201810, 2646.
 

Synthesis of a Novel Type of 2,3'-BIMs via Platinum-Catalysed Reaction of Indolylallenes with Indoles

L. Cooper, J. M. Alonso, L. Eagling, H. Newson, S. Herath, C. Thomson, A. Lister, C. Howsham, B. Cox,
M. P. Muñoz*

Chem. Eur. J. 2018, 24, 6105.

Twists and Turns of Platinum-Allene Complexes: NMR Techniques for the Study of the Dynamic Behavior in Solution

M. Teresa Quiroś, MaríaPazMuñoz,* Jeppe Christensen and Simon J.Coles 

Organometallics201736 (2), pp 318–330.

External Activities

Membership of Learned Societies

  • Member of the Spanish Royal Society of Chemistry (RSEQ).
  • Member of the Royal Society of Chemistry (RSC).
  • Member of the RSC POC Committee (since 2016).
  • Secretary of the RSC East Anglia Section Trust 2015-2016.
  • Fellow of the Higher Education Academy.

  

Oral Communications and Invited Lectures as PI:

25th IUAPC Conference on Physical Organic Chemistry (ICPOC25). To be delivered in the summer of 2022 (cancelled in 2020 due to Covid-19 pandemic). Hiroshima, Japan.

- RSC Dalton Joint Interest group conference 2021 (online meeting). June 2021. “Bis(pyridyl)allenes: versatile ligands for novel metal complexes with diverse applications”

- School of Chemistry’s (virtual) seminar series (Host: Dr M. J. Marín and T. E. Storr). May 2021. “Precious metals and allenes: from unexpected mechanisms to novel applications”

- Universidad Autonoma de Madrid, Spain (Host: Prof Diego Cardenas). October 2019. "Precious Metals and Allenes: form Divergent Systems to Bimetallic catalysis"

- Universidade Da Coruña  (Host: Prof Jose Perez Sestelo). June 2019. "Precious Metals and Allenes: form Divergent Systems to Bimetallic catalysis"

 - Chemical Synthesis Centre for Doctoral Training Summer Conference, University of Bristol. Invited lecture. July 2018.

- 24th IUAPC Conference on Physical Organic Chemistry (ICPOC24). July 2018. Faro, Portugal. "Precious metal catalysis in Allene chemistry: from divergent systems to heterobimetallic catalysis". Invited talk.

 - University of Cardiff (Host: Dr Niek Buurma). March 2018. "Precious metal catalysis in Allene chemistry: from divergent systems to heterobimetallic catalysis"

- University of Sheffield (Host: Dr Nick Williams). November 2017. "Twists and Turns of Platinum-Allene Chemistry"

- European Symposium on Organic Reactivity 2017, Durham,  September 2017. "Twists and Turns of Platinum-Allene Chemistry". Invited talk

- Institute of Chemical Sciewnces, Heriot-Watt University (Host Dr. Ai-Lan Lee), Edinburgh, November 2016. "Twists and Turns of Platinum-Allene Chemistry"

- RSC Heterocycles and Synthesis Meeting, London, January 2016. “Platinum, allenes and indoles: a new approach towards the synthesis of BIMs

- JIC Seminar Programme 2015 (Host Dr DavidM. Lawson), Norwich Research Park, November 2015. “Metal-Allene Chemistry: New Interactions for New Adventures

- Dr Reddy’s, Cambridge Research Park (Host: Dr Christopher Cobley), October 2015, “Metal-Allene Chemistry: New Interactions for New Adventures

- GSK Emerging Academics Symposium. GSK, Stevenage, 15th October 2014. “Metal-Allene Chemistry: New Interactions for New Adventures

- ANORQC XII 2014. Norwich. June 2014. “Metal-Allene Chemistry: New Interactions for New Adventures

- RSC South Eastern Regional Meeting 2014. University of Cambridge. April 2014. “Metal-Allene Chemistry: New Interactions for New Adventures

- University of Edinburgh (Host: Dr Stephen Thomas). April 2014. “Different Metals = Different Products! Gold vs Platinum in the reaction of allenes with nucleophiles

- St Andrews University (Host: Dr Euan Kay). April 2014. “Different Metals = Different Products! Gold vs Platinum in the reaction of allenes with nucleophiles

- Young Chemists 2014. Imperial College London. April 2014. “Metal-Allene Chemistry: New Interactions for New Adventures

- Durham University (Host: AnnMarie O’Donoghue). January 2014. “Different Metals = Different Products! Gold vs Platinum in the reaction of allenes with nucleophiles

- Gregynog Synthesis Workshop. September 2013. “Gold-Catalysed Hydroazidation of Allenes

- Interreg Exchange speakers program. Universities of Southampton, UK; Le Havre, Rouen and Caen, France. May 2013. “Allenes… Exotic curiosities or exciting intermediates for new reaction pathways?

- ICPOC21. Durham, UK. September 2012. “Platinum-Catalysed Reactions of Allenes with Nucleophiles: A complementary alternative to other metals

- Novartis Institutes for Biomedical Research, Horsham Research Centre, UK. (Host: Catharine Howsham) June 2012. “Allenes … Exotic curiosities or exciting intermediates for new reaction pathways?

- What’s new in Sci Research? UEA Symposium, Norwich, UK. May 2012. “New Transition Metal-Catalysed Reactions involving allenes

- Gregynog Synthesis Workshop. September 2011. “Platinum-Catalysed Dihydroalkoxylation vs Bisinlolylation of allenes:   Same mechanism or alternative pathways?

- 46th Bürgenstock Conference. Brunnen, Switzerland. May 2011.12. “Novel Transition Metal Catalysed Reactions of Allenes: Unravelling Mechanistic Subtleties and Beyond”. Short Oral Presentation Selected as Poster Appetizer

- University of Stockholm. (Host: Dr Belen Martin-Matute). October 2010.“From Acid to Metal Catalysis: new reactions and mechanisms

- IQOG – CSIC. (Host: Dr Bernardo Herradon). October 2009. “Isotopic Labelling: A Useful Tool for Mechanistic Studies” 

Key Research Interests and Expertise

Allenes are rather unique structures that contain two p-orbitals perpendicular to each other. Although the structure of allenes was predicted a long time ago, they were considered as chemical curiosities due to the difficulty to distinguish them from the corresponding alkynes. The development of the IR and Raman spectroscopy made possible the characterisation of these compounds and the development of their chemistry. The synthetic utility of allenes is extensive, and chemo-, regio-, stereo- and positional-selective transformations have been developed. Over 150 natural products contain allenes or cumulenic structures, some of them showing pharmacological activity (steroids, prostaglandines, amino acids, nucleosides, etc.). The industrial potential has also been shown, and numerous patents cover the use of allenes as dyes, drugs, antioxidants, (co)polymers suitable for paints, fibres, elastomers, printable films and heat- or corrosion-resistant materials.

During the past 15 years different reactions involving allenes and other components (alkenes, alkynes), rearrangements, or cycloadditions have been developed. However, there is still room for new chemistry of allenic systems to be discovered.

Research in our group involves the development of novel and exciting chemistry of allenic systems, from acid to transition metal catalysis, to the understanding of interactions of allenes containing products in living systems and their application as drugs.

- Platinum- and gold-catalysed addition of nucleophiles to allenes

- Metal-catalysed reaction of polyallenic systems

- Synthesis of metal complex with allenic ligands for catalysis and as metallodrugs

- Mechanistic studies on metal-catalysed reactions of allenes

- Developing of new methodologies involing heterobimetallic catalysis

 

Research Group Membership

 

Past members

Post Doctoral Researchers

Jose Miguel Alonso-Gomez, PDRA funded by a Leverhulem Trust Reseaarch Grant. December 2015-December 2018, working on "New Transition-Metal Catalysed cascade Cyclisationof N-Tris(allenes).  

Lewis Williams, PDRA funded by NERC. January-December 2018, working on the synthesis of fluororescent tetrazolium salts to measure plankton respiration in a collaborative project with ENV-UEA (Dr Carol Robinson) and international groups as part of the REMAIN project. 

 Maria Teresa Quiros, PDRA funded by a Marie Curie Fellowship April 2015-April 2016, working on the "Platinum-Catalysed Reaction of Bis(allenes): Mechanistic Insights and Future Application". Teresa worked in the group since March 2014 (funded by an EPSRC First Grant), working on "Understanding the Platinum-Catalysed Reaction of Allenes with Nucleophiles: Towards New Reactivities and Novel Structures".

 

Postgraduates (PhD students)

Cesar Hurtado, PhD student graduated in 2016  (Studentship from School of Chemistry; Matching fund for AI-Chem Channel Program), working on: “Gold-catalysed azidation of allenes” and New Transition Metal Catalysed Reaction of Allenes and Bisallenes.”

 Lisa Cooper, PhD student graduated in 2017 (Studentship from School of Chemistry – Novartis; Matching fund for AI-Chem Channel Program), working on: “Synthesis of multi-heteroaromatic structures by metal-catalysed reaction of allenes with nucleophiles.” 

Hanna K. Maliszewska, PhD studetn graduated in 2021 (Studentship from School of Chemistry - Faculty of Sciences competition funding), working on: "Synthesis of heteroatom containing allenes as ligands in metal catalysis and therapeutic applications."

 

Master (MSc) Students

Stefanie Höehne, German Master Students from Ruprecht-Karls-University of Heidelberg, April-September 2012, working on: “Gold-catalysed addition reactions of azides to allenes.”

Salomé Poyer, French Master Students from University of Rouen (Interreg Program), January-June 2012, working on: “Stereochemistry of the Lactonisation of Allyl Malonates Promoted by Triflic Acid; an NMR Study.”

Ahad Alsahli, MSc Student from January-Spetember 2014 (Self-funded), working on "Platinum-catlaysed reactions of ynamide propargyl esters." in collaboration with Dr David Carbery (University of Bath). 

Valentin Payet, Erasmus student from April to June 2018, working on fluorescent tetrazolium salts

Bandar Alshammari, MSc studetn from January-September 2019 (Self-funded), working on the synthesis of fluororescent tetrazolium salts.

Anu Sha, MSc studetn from January-September 2020 (Self-funded), working on the synthesis of fluororescent tetrazolium salts.

 

Undergraduate Final Year Project Students

2020-2021

Dominic Dennis,  MChem student working on the synthesis of fluororescent tetrazolium salts.

Miguel Rosales, MChem student working on the synthesis of heteroatom containing allenes as ligands in metal complexes.

2019-2020

Tino Freestone, MChem student working on the synthesis of heteroatom containing allenes as ligands in metal complexes.

Mei Young, BSc student working on the synthesis of fluororescent tetrazolium salts.

2018-2019

Jamellah Paragas, MChem student working on the synthesis of fluororescent tetrazolium salts.

Elizabeth Crlly, BSc student working on the synthesis of heteroatom containing allenes as ligands in metal complexes.

2017-2018

Greg Sharp, MChem studetns working on: "Gold-platinum bimetallic catalysis in the nucleophilic addition to allenes".

Jimmy Tran, BSc student working on: "Transition metal catalysed reaction of indolyl bisallene and indolyl bisalkyne structures and other derivatives".

2016-2017

Kirsty Smith, MChem studetn working on: "Using platinum catalysis for the rational design of non-natural products with potential biological activity from C2-indolyl allenes".

Nafimul Haque, MChem studetn working on: "Using platinum catalysis for the rational design of non-natural products with potential biological activity from C3-indolyl allenes".

2015-2016

Sachini Herath, MChem Student, working on: “Platinum-catalysed ireaction of indolylallenes with indoles: alternative technologies for the synthesis of substituted tetrhydropyrido[1,2a]indoles with potential biological activity”. 

Henry Bell, BSc Students, working on "Synthesis if 1,5-Bisallenes". 

2014-2015

Louise Eagling, MChem with a year in Industry Student, working on: “Platinum-catalysed ireaction of indolylallenes with indoles: alternative technologies for the synthesis of substituted tetrhydropyrido[1,2a]indoles with potential biological activity” in collaboration with Novartis. 

Ben Julian, MChem Student, working on: “Platinum-catalysed synthesis of multiindole structures".

Carlos Perez Guerrero, Erasmus Student, working on:“Synthesis on new Au(III) complexes with allenic ligands". 

2013-2014

Helen Newson, MChem with a year in Industry Student, working on: “Platinum-catalysed inter- and intra-molecular addition of nucleophiles to indolylallenes” in collaboration with Novartis. 

Laura Hone, MChem Student working on: “Synthesis on new Au(III) complexes with allenic ligand for cancer treatment”

Lucia Castillo-Nieto, Erasmus Student, working on: “Platinum-Catalysed cyclisation of substituted bisallenes.”

Lydia Jacobs, BSc Student, working on literature project based on “Cyclisations of Bisallenes.” 

2012-2013

Lisa Cooper, MChem Student, working on: “Acid-Promoted / Catalysed Synthesis of Lactones From β- And γ-Allenic Esters.”

Adam Green, MChemStudent, working on: “Investigating the active catalyst in the platinum-catalysed dihydroalkoxylation of allenes.”

2011-2012

Elisabeth Pinneh, 2nd year undergraduate at the School of Chemistry, UEA, working on: “Synthesis of 1,3-disubstituted allenes in the microwave, and Platinum catalysed reaction with nucleophilic azides.”

Charlie Gibbons, BSc, working on: “Triflic acid mediated dealkylative lactonisation of allylmalonates.”

Specialisms

Synthetic organic chemistry; organometallic chemistry; mechanistic studies; isotopic labelling.

Areas Of Expertise

ISOTOPIC LABELLING||MECHANISTIC STUDIES||ORGANOMETALLICS||SYNTHETIC ORGANIC

Career

  • 1994 to 1999 Universidad Autónoma de Madrid, Spain. BSc (Hons) in Organic Chemistry. First Class
  • 1999 to 2001 Universidad Autónoma de Madrid, Spain. MSc in Organic Chemistry.
  • 2001 to 2004 Universidad Autónoma de Madrid, Spain. PhD. Summa Cum Laude.
  • 2004 to 2005 University of Bristol, UK. Research assistant.
  • 2005 to 2007 University of Bristol, UK. Postdoctoral fellow.
  • 2007 to 2009 University of Bristol, UK. Research Associate.
  • 2009 to 2011 Instituto de Química Orgánica General (IQOG) – CSIC, Madrid, Spain. Ramón y Cajal Fellow.
  • 2011 to 2017 University of East Anglia, UK. Lecturer in Organic Chemistry.
  • 2017 to date University of East Anglia, UK. Senior Lecturer in Organic Chemistry.

Expertise related to UN Sustainable Devlopment Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Network

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