Projects per year
Personal profile
Biography
Matthew obtained his MCHEM degree from the University of Liverpool in 2013. He went on to do a PhD at Liverpool under the direction of Professor Dave Adams and Dr Jon Iggo, developing novel Nuclear Magnetic Resonance (NMR) techniques to study self-assembled peptide gel materials. He won the 2017 Ronald Belcher Award from the Royal Society of Chemistry for his PhD research. He also won a Research Fellowship from the Royal Commission for the Exhibition of 1851 to work with Professor Yaroslav Khimyak at the School of Pharmacy at UEA. His work focuses on the combination of localised NMR measurements (also known as chemical shift imaging CSI) with the deliberate introduction of controlled concentration gradients into samples and materials. These methods offer very significant savings in the time and amount of sample requried to analyse how a system responds to changes in the environmental conditions (pH, salt, ligand concentration).
In August 2020, Matthew was awarded a UKRI Future Leaders Fellowship to develop the CSI/gradient tools for a wide range of purposes across materials science, chemical biology and drug discovery. For example, the fast measurement of the dissociation constants (pKa values) of organic molecules in water and organic media (doi.org/10.1021/acs.analchem.8b00181, doi.org/10.1021/acs.analchem.2c00200).
We are also investigating the association of cations with anionic polymers and nanomaterials (doi.org/10.1021/acs.analchem.2c01166), methods to determine the properties of surfactants, and methods to probe the interactions of small molecules with proteins.
Postgraduate Research Opportunities
I am always happy to discuss potential projects for Masters or PhD study.
Research Group or Lab Membership
PhD students
Haider Hussain - October 2021 - haider.hussain@uea.ac.uk
PDRAs
Dr Todor Koev - September 2021 - t.koev@uea.ac.uk
Dr Serena Monaco - December 2021 - s.monaco@uea.ac.uk
Education/Academic qualification
Doctor of Science, University of Liverpool
4 Oct 2013 → 18 Sep 2017
Award Date: 18 Sep 2017
Master of Chemistry, University of Liverpool
25 Sep 2009 → 17 Jul 2013
Award Date: 17 Jul 2013
External positions
Honorary Research Associate, University of Liverpool
4 Oct 2017 → 4 Oct 2018
Keywords
- Chemistry
- NMR
- soft matter
- gels
- carbohydrate
- imaging
- pKa
- drug discovery
- Analytical chemistry
Collaborations and top research areas from the last five years
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NMR imaging for the accelerated discovery of drugs and materials
1/01/21 → 31/12/24
Project: Fellowship
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Oscillating pH gradients: a new tool to study i-motif DNA by NMR spectroscopy
1/10/23 → 31/03/27
Project: Research
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Rapid determination of the base number of lubricating oils by 1H NMR
Analytical Chemistry Trust Fund
21/06/21 → 14/08/21
Project: Research
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An assembly platform for the rational design of cellulose nanocrystalline hydrogels.
15/03/19 → 14/03/20
Project: Research
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Elucidation of biopolymer dissolution and gelation using NMR-imaging techniques.
Royal Commission for the Exhibition of 1851
1/10/17 → 31/12/20
Project: Fellowship
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Controlled annealing in adaptive multicomponent gels
Ravarino, P., Panja, S., Bianco, S., Koev, T., Wallace, M. & Adams, D. J., 23 Jan 2023, In: Angewandte Chemie International Edition. 62, 4, e202215813.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)6 Downloads (Pure) -
Hierarchical composite self-sorted supramolecular gel noodles
Marshall, L. J., Wallace, M., Mahmoudi, N., Ciccone, G., Wilson, C., Vassalli, M. & Adams, D. J., 26 Apr 2023, In: Advanced Materials. 35, 17, 2211277.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)4 Downloads (Pure) -
Imaging Saturation Transfer Difference (STD) NMR: affinity and specificity of protein-ligand interactions from a single NMR sample
Monaco, S., Angulo, J. & Wallace, M., 2 Aug 2023, In: Journal of the American Chemical Society. 145, 30, p. 16391–16397 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Does it bind? A method to determine the affinity of calcium and magnesium ions for polymers using 1H NMR spectroscopy
Wallace, M., Holroyd, J., Kuraite, A. & Hussain, H., 9 Aug 2022, In: Analytical Chemistry. 94, 31, p. 10976–10983 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)9 Downloads (Pure) -
Efficient pKa determination in a nonaqueous solvent using chemical shift imaging
Schenck, G., Baj, K., Iggo, J. A. & Wallace, M., 14 Jun 2022, In: Analytical Chemistry. 94, 23, p. 8115–8119 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)63 Downloads (Pure)
Datasets
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Data for Rapid determination of the acidity, alkalinity and carboxyl content of aqueous samples by 1H NMR with minimal sample quantity
Wallace, M. (Creator), Lam, K. (Creator), Kuraite, A. (Creator) & Khimyak, Y. (Creator), American Chemical Society, 9 Sep 2020
DOI: 10.1021/acs.analchem.0c02594
Dataset
File -
NMR data for: Hierarchical composite self-sorted supramolecular gel noodles
Marshall, L. (Contributor), Wallace, M. (Creator), Mahmoudi, N. (Contributor), Ciccone, G. (Contributor), Wilson, C. (Contributor), Vassalli, M. (Contributor) & Adams, D. J. (Contributor), Wiley, 9 Mar 2023
Dataset
File -
Data for: Measurement of the pKa values of organic molecules in aqueous-organic solvent mixtures by 1H NMR without external calibrants
Wallace, M. (Creator), University of East Anglia, 19 Sep 2023
Dataset
File -
Raw titration data for Schenck_et_al "Efficient pKa Determination in a Non-Aqueous Solvents using Chemical Shift Imaging", Anal. Che., 2022
Iggo, J. A. (Creator), Schenck, G. (Creator), Baj, K. (Creator) & Wallace, M. (Creator), University of Liverpool, 29 Apr 2022
DOI: 10.17638/datacat.liverpool.ac.uk/1678
Dataset
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Data for: Does it bind? a method to determine the affinity of calcium and magnesium ions for polymers using 1H NMR spectroscopy
Wallace, M. (Creator), Holroyd, J. (Creator), Kuraite, A. (Creator) & Hussain, H. (Creator), American Chemical Society, 21 Jul 2022
Dataset
File