Projects per year
Matthew obtained his MCHEM degree from the University of Liverpool in 2013. He went on to do a PhD at Liverpool under the direction of Professor Dave Adams and Dr Jon Iggo, developing novel Nuclear Magnetic Resonance (NMR) techniques to study self-assembled peptide gel materials. He won the 2017 Ronald Belcher Award from the Royal Society of Chemistry for his PhD research. He also won a Research Fellowship from the Royal Commission for the Exhibition of 1851 to work with Professor Yaroslav Khimyak at the School of Pharmacy at UEA. His work focuses on the combination of localised NMR measurements (also known as chemical shift imaging CSI) with the deliberate introduction of controlled concentration gradients into samples and materials. These methods offer very significant savings in the time and amount of sample requried to analyse how a system responds to changes in the environmental conditions (pH, salt, ligand concentration).
In August 2020, Matthew was awarded a UKRI Future Leaders Fellowship to develop the CSI/gradient tools for a wide range of purposes across materials science, chemical biology and drug discovery. For example, the fast measurement of the dissociation constants (pKa values) of organic molecules in water and organic media (doi.org/10.1021/acs.analchem.8b00181, doi.org/10.1021/acs.analchem.2c00200).
We are also investigating the association of cations with anionic polymers and nanomaterials (doi.org/10.1021/acs.analchem.2c01166), methods to determine the properties of surfactants, and methods to probe the interactions of small molecules with proteins.
Postgraduate Research Opportunities
I am always happy to discuss potential projects for Masters or PhD study. Currently advertised projects: Probing the speciation of metal cations in the intestine by NMR spectroscopy (WALLACEM_U23SF) (uea.ac.uk)
Research Group or Lab Membership
Haider Hussain - October 2021 - email@example.com
Dr Todor Koev - September 2021 - firstname.lastname@example.org
Dr Serena Monaco - December 2021 - email@example.com
Doctor of Science, University of Liverpool
4 Oct 2013 → 18 Sep 2017
Award Date: 18 Sep 2017
Master of Chemistry, University of Liverpool
25 Sep 2009 → 17 Jul 2013
Award Date: 17 Jul 2013
Honorary Research Associate, University of Liverpool
4 Oct 2017 → 4 Oct 2018
- QD Chemistry
- soft matter
- drug discovery
- Analytical chemistry
Dive into details
Select a country/territory to view shared publications and projects
1/01/21 → 31/12/24
21/06/21 → 14/08/21
15/03/19 → 14/03/20
1/10/17 → 31/12/20
Ravarino, P., Panja, S., Bianco, S., Koev, T., Wallace, M. & Adams, D. J., 23 Nov 2022, (E-pub ahead of print) In: Angewandte Chemie International Edition.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Downloads (Pure)
Does it bind? A method to determine the affinity of calcium and magnesium ions for polymers using 1H NMR spectroscopyWallace, M., Holroyd, J., Kuraite, A. & Hussain, H., 9 Aug 2022, In: Analytical Chemistry. 94, 31, p. 10976–10983 8 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile3 Downloads (Pure)
Schenck, G., Baj, K., Iggo, J. A. & Wallace, M., 14 Jun 2022, In: Analytical Chemistry. 94, 23, p. 8115–8119 5 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile11 Downloads (Pure)
Self-assembling, supramolecular chemistry and pharmacology of amphotericin B: Poly-aggregates, oligomers and monomersFernández-García, R., Muñoz-García, J. C., Wallace, M., Fabian, L., González-Burgos, E., Gómez-Serranillos, M. P., Raposo, R., Bolás-Fernández, F., Ballesteros, M. P., Healy, A. M., Khimyak, Y. Z. & Serrano, D. R., Jan 2022, In: Journal of Controlled Release. 341, p. 716-732 17 p.
Research output: Contribution to journal › Article › peer-review5 Citations (Scopus)
Data for Rapid determination of the acidity, alkalinity and carboxyl content of aqueous samples by 1H NMR with minimal sample quantity
Raw titration data for Schenck_et_al "Efficient pKa Determination in a Non-Aqueous Solvents using Chemical Shift Imaging", Anal. Che., 2022
Iggo, J. A. (Creator), Schenck, G. (Creator), Baj, K. (Creator) & Wallace, M. (Creator), University of Liverpool, 29 Apr 2022
Data for: Does it bind? a method to determine the affinity of calcium and magnesium ions for polymers using 1H NMR spectroscopy