Projects per year
- Director of Year Abroad Degree Courses
- Module Organiser of Cell Biology and Mechanisms of Disease (BIO-3C18)
- Chair of Bio-Imaging committee
- Member of UEA's BBSRC Review Committee
- Member of DTP Studentship selection panel
- Senior Lecturer in Cell and Developmental Biology, UEA (2009 - present)
- Lecturer in Cell and Developmental Biology, UEA (2001- 2009)
- Welcome Trust Lecturer / Research Fellow, Univ of Dundee. (1997-2000)
- Senior Postdoctoral Research Associate, Univ of St. Andrews (1991-1997)
- Postdoctoral Research Associate, University of St. Andrews (1985-1991)
- Demonstrator in Cell Biology, University of Manchester (1983-1985)
- Post Graduate Certificate in Higher Education Practice (2004)
- Ph.D. in Cell Biology, University of Manchester (1985)
- B.Sc. in Genetics and Cell Biology, University of Manchester (1980)
- Member of BSCB and ECF
- Invited book chapter: Microtubule organising centres in polarised epithelial cells. In: Nigg, E.A. (Ed.) Centrosomes in Development and Disease. 2004. Wiley-VCH, Weinheim, 299-319.
- BBSRC grant reviewer and manuscript reviewer for J. Cell Science and Cell Motility and the Cytoskeleton
- National and international external PhD examiner
Key Research Interests and Expertise
Our research is concerned with the cytoskeleton in health and disease with a main focus on microtubule and centrosome reorganization during epithelial differentiation. The aims are to determine the mechanisms and molecular bases for the generation and maintenance of non-centrosomal apico-basal microtubules arrays in polarised epithelial cells. The studies address basic cell biological problems as well as issues of importance for advancing our understanding of cancer. Lab.
Web page: http://mettemogensen.com/
Current Research Projects
- Microtubule and centrosomal organisation in normal and cancer cells
- Role of +TIP in the formation of apico-basal arrays in polarised epithelial cells
- Microtubule associated protein in cell migration and epithelial remodelling
Life in our research group
Our group is located in a well equipped research lab within the BMRC in the School of Biological Sciences. We use a combination of cell, tissue and organoid model systems to study microtubule and centrosomal organisation during epithelial polarisation in normal and cancer cells. GFP- and RNAi-technology and widefield fluorescence, confocal, multiphoton and electron microscopy are being used for live and fixed cell analyses (see http://www.uea.ac.uk/bio/biobmi/ for our Bio-imaging facility). We have weekly lab meetings and regularly attend international conferences on the centrosome and the cytoskeleton.
- Fundamentals of Cell Biology and Biochemistry (BIO-4004B)
- Physical and Analytical Methods in the Biomolecular Sicences (BIO-4007Y)
- Foundations for Chemistry and Physiology (BIO-4009Y)
- Cell Biology (BIO-2B06)
- Human Physiology (BIO-2B05)
- Cell Biology and Mechanisms of Disease (BIO-3C18)
- Masters - Modern Experimental Techniques in Molecular Medicine (M203)
- Undergraduate Final Year Projects
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 19 Finished
28/06/21 → 22/08/21
Mogensen, M. & Thomas, P.
1/03/19 → 29/02/20
Mogensen, M. & Thomas, P.
1/10/16 → 31/03/20
Consumables to support the RCF funded Project in Dr Jelena Gavrilovic’s lab, “Understanding mechanisms underpinning Primary Scelrosing Cholangitis: a pilot study”, supporting post-doc Megan Murray.
9/07/15 → 30/03/16
Understanding mechanisms underpinning primary sclerosing cholangitis: pilot studies of liver biopsy transcriptomics and establishment of an ex-vivo organotypic model (funding for Megan Murray)
27/05/15 → 31/03/16
Meiosis and beyond – understanding the mechanistic and evolutionary processes shaping the germline genomeBergero, R., Ellis, P., Haerty, W., Larcombe, L., Macaulay, I., Mehta, T., Mogensen, M., Murray, D., Nash, W., Neale, M. J., O'Connor, R., Ottolini, C., Peel, N., Ramsey, L., Skinner, B., Suh, A., Summers, M., Sun, Y., Tidy, A., Rahbari, R. & 2 others, , Jun 2021, In: Biological Reviews. 96, 3, p. 822-841 20 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)8 Downloads (Pure)
Johnson, R. T., Fowler, W. J., Kirkup, B. M., Silva, B. C., Harry, B. E., Schneider, J. G., Weilbaecher, K. N., Mogensen, M. M., Bass, M. D., Parsons, M., Edwards, D. R. & Robinson, S. D., 1 Jun 2018, In: EMBO reports. 19, 6, e44578.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile6 Citations (Scopus)22 Downloads (Pure)
Immuno-fluorescent Labeling of Microtubules and Centrosomal Proteins in Ex Vivo Intestinal Tissue and 3D In Vitro Intestinal OrganoidsGoldspink, D. A., Matthews, Z. J., Lund, E. K., Wileman, T. & Mogensen, M. M., 13 Dec 2017, In: Journal of Visualized Experiments. 130, e56662.
Research output: Contribution to journal › Article › peer-reviewOpen Access3 Citations (Scopus)
Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centresGoldspink, D., Rookyard, C., Tyrrell, B., Gadsby, J., Perkins, J., Lund, E., Galjart, N., Thomas, P., Wileman, T. & Mogensen, M., 8 Feb 2017, In: Open Biology. 7, 160274, 160274.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile23 Citations (Scopus)15 Downloads (Pure)
Foot-and-mouth disease virus 3C protease induces fragmentation of the Golgi compartment and blocks intra-Golgi transportZhou, Z., Mogensen, M. M., Powell, P. P., Curry, S. & Wileman, T., Nov 2013, In: Journal of Virology. 87, 21, p. 11721-11729 9 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile27 Citations (Scopus)9 Downloads (Pure)