Projects per year
Personal profile
Administrative Posts
- Human Physiology (BIO-2B05) Module Organiser.
- Since January 2003-2005, I organised weekly seminars for the Cell Sector.
- I was a member of the Quinquennial review committee for the Biological Sciences degree course.
- From August 2006 to July 2011, I was Deputy Director of Teaching and Learning (School of Biological Sciences).
- From 2009-2011, I was Chair of the Assessment Working Group within the School of Biological Sciences.
- From August 2012-present, I am Senior Advisor with the School of Biological Sciences.
- From March 2018-present, I am Co-Director for Equality and Diversity in the School of Biological Sciences.
Career
- Professor of Ophthalmology, University of East Anglia (2018-present)
- Senior Lecturer, University of East Anglia (2008-2018)
- The Humane Research Trust Lecturer, University of East Anglia (2002-2008)
- Senior Research Associate - University of East Anglia (1997-2002)
- PhD - University of East Anglia (1997)
- BSc - Pharmacology, University of Portsmouth (1993)
Key Research Interests
I am a biomedical scientist with primary interests in the use of human tissue to study human eye disease. In particular, I am interested in wound-healing events that follow cataract surgery, which lead to a secondary visual loss known as posterior capsule opacification (PCO). Through the use of human tissue the laboratory aims to further our understanding of the cell and molecular mechanisms underpinning PCO and identify novel targets for future therapeutic development.
Current Research Projects
- Investigation of TGFß signalling involvement in matrix contraction and cell transdifferentiation
- Gene expression and functional analysis of ocular cells
- Development of human disease models to serve as pre-clinical evaluation tools
- Optimise novel drug delivery mechanisms to prevent PCO
- iPSC-derived lentoid formation
Life in our research group
The laboratory employs human ocular cell and tissue culture models as experimental systems to understand the human condition and develop appropriate therapies. The laboratory is equipped with dedicated state-of-the-art analysis tools that facilitate the research programme. There is a good blend of experienced post-doctoral scientists and enthusiastic students eager to learn. The group has international standing within our area of expertise and laboratory members get the opportunity to present their work across the world at meetings in North America, Asia and Europe. This experience is valuable to the development of individuals and the team as a whole.
PhD Positions
Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.
Postdocs & Fellows
I am always happy to discuss possibilities for post-doctoral work and collaborations and Fellowship schemes with me acting as a sponsor.
Teaching Interests
- Foundations for Physiology (BIO-1A58)
- Skills for Biologists (BIO-1A4Y)
- Introduction to Biomedicine (BIO-1A57)
- Cell Biology (BIO-2B06)
- Human Physiology (BIO-2B05)
- Advanced Cell Biology (BIO-3C18)
- Research Project (BIO-3C32)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 40 Finished
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Further evaluation of Ketorolac in the prevention of Posterior Capsule Opacification (PCO) following cataract surgery and the development of a drug screening platform
Wormstone, M. & Eldred, J.
1/10/20 → 30/04/21
Project: Research
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The Humane Research Trust Laboratory - Continued Funding 2020 onwards (Lab Funds)
Wormstone, M., Smith, A., Russell, S. & Wormstone, Y.
1/01/20 → 31/12/22
Project: Research
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Stereolithographic rapid prototyping of clear, foldable, non-refractive intraocular lens designs: A proof-of-concept study
Hidalgo-Alvarez, V., Falcon, N. D., Eldred, J., Wormstone, M. & Saeed, A., Aug 2024, In: Current Eye Research. 49, 8, p. 843-852 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure) -
Assessment of intraocular lens/capsular bag biomechanical interactions following cataract surgery in a human in vitro graded culture capsular bag model
Wormstone, I. M., Damm, N. B., Kelp, M. & Eldred, J. A., Apr 2021, In: Experimental Eye Research. 205, 108487.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)11 Downloads (Pure) -
Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells
Huangfu, J., Hao, C., Wei, Z., Wormstone, I. M., Yan, H. & Fan, X., 9 Apr 2021, In: Cell Death & Disease. 12, 4, 386.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)17 Downloads (Pure) -
Fluorofenidone inhibits the epithelial-mesenchymal transition in human lens epithelial cell line FHL 124: a promising therapeutic strategy against posterior capsular opacification
Wormstone, M., 27 May 2021, In: Arquivos Brasileiros de Oftalmologia. 84, 3, 303.Research output: Contribution to journal › Letter › peer-review
Open AccessFile12 Downloads (Pure) -
GSH levels serve as a biological redox switch regulating sulforaphane-induced cell fate in human lens cells
Huynh, T. P. N., Bowater, R. P., Bernuzzi, F., Saha, S. & Wormstone, I. M., 2 Dec 2021, In: Investigative Ophthalmology and Visual Science. 62, 15, 2.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)13 Downloads (Pure)
Prizes
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Elected Fellow of the Royal Society of Medicine
Wormstone, Ian (Recipient), 2008
Prize: Election to learned society
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Fellow of the Association for Research in Vision and Ophthalmology (ARVO)
Wormstone, Ian (Recipient), 2016
Prize: Prize (including medals and awards)
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National Foundation for Eye Research (NFER) Cataract Research Award
Wormstone, Ian (Recipient), 2015
Prize: Prize (including medals and awards)
Activities
- 1 Other
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Co-inventor on three international patents. Use of calcium intracellular store inactivators and formulations thereof as cell growth inhibitors (#95 16458.8); Treatment of fibrotic eye disorders US 61/095547; Treatment of fibrotic eye disorders using an MMP2 inhibitor US 61/0955541995
Michael Wormstone (Contributor)
1996 → 2009Activity: Other activity types › Other