Projects per year
Key Research Interests and Expertise
Mitochondria are central to energy metabolism in our cells. My interests cover the molecular and bioenergetic processes that occur in mitochondria and how they relate to our health. Membrane proteins are fundamental to mitochondrial energy transduction and uncoupling proteins (UCP1-5), in particular, are a current research focus of mine. UCP1 is the protein in mammals that allows brown adipose tissue to burn off calories as heat in response to cold temperatures. If activated in humans, UCP1-dependent thermogenesis can contribute to energy expenditure and help combat obesity and related disease. Other UCPs have been linked to metabolic disorders, cancer, inflammation, ischemic shock and aging, though their exact function is not clear. My research aims to resolve the molecular and structural mechanisms that underlie UCP activity and regulation and, importantly, the function that these unusual proteins may play in pathophysiology and prevention of disease.
Dr Paul Crichton
- 2016- Principle Investigator/Lecturer, Norwich Medical School, UEA, Norwich, UK
- 2008-16 Investigator Scientist, MRC Mitochondrial Biology Unit, Cambridge, UK
- 2005-08 MRC Career Development Fellow, MRC Mitochondrial Biology Unit, Cambridge, UK
- 2001-04 PhD Biochemistry, University of Sussex, UK
Research Group Membership
Danielle Copeman (senior technician)
Camila Cotrim (post-doc)
Riccardo Cavalieri (PhD student)
Margeoux Dela Rosa (PhD student)
Eden Joyce (MSc student)
Doctor of Science, University of Sussex
Award Date: 31 Dec 2004
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- 1 Active
Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondrial efficiency in mice and humansNtessalen, M., Procter, N., Schwarz, K., Loudon, B., Minnion, M., Fernandez, B., Vassiliou, V., Vauzour, D., Madhani, M., Constantin‐Teodosiu, D., Horrowitz, J., Dawson, D., Crichton, P. & Frenneaux, M., Jan 2020, In : The American Journal of Clinical Nutrition. 111, 1, p. 79-89 11 p.
Research output: Contribution to journal › ArticleOpen AccessFile5 Citations (Scopus)21 Downloads (Pure)
Crichton, P. G., Steyaert, J. & Kunji, E. R. S., 24 Jan 2019, In : Cell. 176, 3, p. 435-447.e15 13 p.
Research output: Contribution to journal › ArticleOpen AccessFile77 Citations (Scopus)13 Downloads (Pure)
Crichton, P. G., Ruprecht, J. J. & Kunji, E. R. S., 3 Sep 2018, In : Nature Structural & Molecular Biology. 25, p. 747–749
Research output: Contribution to journal › Comment/debate6 Citations (Scopus)
Calcium regulation of the human mitochondrial ATP-Mg/Pi carrier SLC25A24 uses a locking pin mechanismHarborne, S. P. D., King, M. S., Crichton, P. G. & Kunji, E. R. S., 28 Mar 2017, In : Scientific Reports. 7, 45383.
Research output: Contribution to journal › ArticleOpen AccessFile21 Citations (Scopus)10 Downloads (Pure)