Paul Crichton

Dr, Associate Professor

  • 01.01A Bio-Medical Research Centre (BMRC)

Accepting PhD Students

If you made any changes in Pure these will be visible here soon.

Personal profile

Key Research Interests

Mitochondria are central to energy metabolism in our cells. My interests cover the molecular and bioenergetic processes that occur in mitochondria and how they relate to our health. Membrane proteins are fundamental to mitochondrial energy transduction and uncoupling proteins (UCP1-5), in particular, are a current research focus of mine. UCP1 is the protein in mammals that allows brown adipose tissue to burn off calories as heat in response to cold temperatures. If activated in humans, UCP1-dependent thermogenesis can contribute to energy expenditure and help combat obesity and related disease. Other UCPs have been linked to metabolic disorders, cancer, inflammation, ischemic shock and aging, though their exact function is not clear. My research aims to resolve the molecular and structural mechanisms that underlie UCP activity and regulation and, importantly, the function that these unusual proteins may play in pathophysiology and prevention of disease.

Career

2021-     Biomedical Research Centre Director (MED), UEA

2019-     Associate Professor, Norwich Medical School, UEA

2016-19 Principle Investigator/Lecturer, Norwich Medical School, UEA

2008-16 Investigator Scientist, MRC Mitochondrial Biology Unit, Cambridge, UK

2005-08 MRC Career Development Fellow, MRC Mitochondrial Biology Unit, Cambridge, UK

2001-04 PhD Biochemistry, University of Sussex, UK

Research Group or Lab Membership

Danielle Copeman (senior technician)

Camila Cotrim (post-doc)

Riccardo Cavalieri (PhD student)

Margeoux Dela Rosa (PhD student)

Camila Fernandez Vidal (MRes student)

Past:

Eden Joyce (MSc student)

 

Postgraduate Research Opportunities

Please do get in contact if you would like to discuss PhD studentship opportunities in my lab or other postgraduate study possibilities.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Network

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or