Research output per year
Research output per year
- 31 results
Search results
-
2024
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis
Jones, S. A., Ruprecht, J. J., Crichton, P. G. & Kunji, E. R. S., Jun 2024, In: Trends in Biochemical Sciences. 49, 6, p. 506-519 14 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile2 Citations (Scopus)3 Downloads (Pure) -
Terrestrial birth and body size tune UCP1 functionality in seals
Gaudry, M. J., Khudyakov, J., Pirard, L., Debier, C., Crocker, D., Crichton, P. G. & Jastroch, M., Apr 2024, In: Molecular Biology and Evolution. 41, 4, msae075.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Two-stage evolution of mammalian adipose tissue thermogenesis
Keipert, S., Gaudry, M. J., Kutschke, M., Keuper, M., Dela Rosa, M. A. S., Cheng, Y., Monroy Kuhn, J. M., Laterveer, R., Cotrim, C. A., Giere, P., Perocchi, F., Feederle, R., Crichton, P. G., Lutter, D. & Jastroch, M., 7 Jun 2024, In: Science. 384, 6700, p. 1111-1117 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)4 Downloads (Pure) -
2023
Structural basis of purine nucleotide inhibition of human uncoupling protein 1
Jones, S. A., Gogoi, P., Ruprecht, J. J., King, M. S., Lee, Y., Zögg, T., Pardon, E., Chand, D., Steimle, S., Copeman, D. M., Cotrim, C. A., Steyaert, J., Crichton, P. G., Moiseenkova-Bell, V. & Kunji, E. R. S., 2 Jun 2023, In: Science Advances. 9, 22, eadh4251.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)8 Downloads (Pure) -
2022
Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis
Cavalieri, R., Hazebroek, M. K., Cotrim, C. A., Lee, Y., Kunji, E. R. S., Jastroch, M., Keipert, S. & Crichton, P. G., Aug 2022, In: Molecular Metabolism . 62, 101526.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)12 Downloads (Pure) -
2020
Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondrial efficiency in mice and humans
Ntessalen, M., Procter, N., Schwarz, K., Loudon, B., Minnion, M., Fernandez, B., Vassiliou, V., Vauzour, D., Madhani, M., Constantin‐Teodosiu, D., Horrowitz, J., Dawson, D., Crichton, P. & Frenneaux, M., Jan 2020, In: The American Journal of Clinical Nutrition. 111, 1, p. 79-89 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)32 Downloads (Pure) -
Reply to TA Schiffer et al.
Ntessalen, M., Procter, N. E. K., Feelisch, M., Crichton, P. G. & Frenneaux, M. P., 4 Feb 2020, In: The American Journal of Clinical Nutrition. 111, 2, p. 487-488 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
2019
The molecular mechanism of transport by the mitochondrial ADP/ATP carrier
Ruprecht, J. J., King, M. S., Zögg, T., Aleksandrova, A. A., Pardon, E., Crichton, P. G., Steyaert, J. & Kunji, E. R. S., 24 Jan 2019, In: Cell. 176, 3, p. 435-447.e15 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile206 Citations (Scopus)23 Downloads (Pure) -
2018
Correspondence: Concerns with yeast mitochondrial ADP/ATP carrier’s integrity in DPC
King, M. S., Crichton, P. G., Ruprecht, J. J. & Kunji, E. R. S., 3 Sep 2018, In: Nature Structural & Molecular Biology. 25, p. 747–749Research output: Contribution to journal › Comment/debate › peer-review
8 Citations (Scopus) -
2017
Calcium regulation of the human mitochondrial ATP-Mg/Pi carrier SLC25A24 uses a locking pin mechanism
Harborne, S. P. D., King, M. S., Crichton, P. G. & Kunji, E. R. S., 28 Mar 2017, In: Scientific Reports. 7, 45383.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)18 Downloads (Pure) -
Modelling the free energy profile of the mitochondrial ADP/ATP carrier
Springett, R., King, M. S., Crichton, P. G. & Kunji, E. R. S., Nov 2017, In: Biochimica et Biophysica Acta. 1858, 11, p. 906-914Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)23 Downloads (Pure) -
The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism
Crichton, P. G., Lee, Y. & Kunji, E. R. S., Mar 2017, In: Biochimie. 134, p. 35–50 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile97 Citations (Scopus)49 Downloads (Pure) -
2016
Formation of a cytoplasmic salt bridge network in the matrix state is a fundamental step in the transport mechanism of the mitochondrial ADP/ATP carrier
King, M. S., Kerr, M., Crichton, P. G., Springett, R. & Kunji, E. R. S., Jan 2016, In: Biochimica Et Biophysica Acta-Bioenergetics. 1857, 1, p. 14-22 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)23 Downloads (Pure) -
The transport mechanism of the mitochondrial ADP/ATP carrier
Kunji, E. R. S., Aleksandrova, A., King, M. S., Majd, H., Ashton, V. L., Cerson, E., Springett, R., Kibalchenko, M., Tavoulari, S., Crichton, P. G. & Ruprecht, J. J., Oct 2016, In: Biochimica Et Biophysica Acta-Molecular Cell Research. 1863, 10, p. 2379-2393 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile107 Citations (Scopus)15 Downloads (Pure) -
2015
Trends in thermostability provide information on the nature of substrate, inhibitor, and lipid interactions with mitochondrial carriers
Crichton, P. G., Lee, Y., Ruprecht, J. J., Cerson, E., Thangaratnarajah, C., King, M. S. & Kunji, E. R. S., 27 Mar 2015, In: Journal of Biological Chemistry. 290, 13, p. 8206-8217 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile62 Citations (Scopus)18 Downloads (Pure) -
Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin
Lee, Y., Willers, C., Kunji, E. R. S. & Crichton, P. G., 2 Jun 2015, In: Proceedings of the National Academy of Sciences of the United States of America (PNAS). 112, 22, p. 6973-6978 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile69 Citations (Scopus)31 Downloads (Pure) -
2014
Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism
Ruprecht, J. J., Hellawell, A. M., Harding, M., Crichton, P. G., McCoy, A. J. & Kunji, E. R. S., 28 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America (PNAS). 111, 4, p. E426–E434 9 p.Research output: Contribution to journal › Article › peer-review
167 Citations (Scopus) -
2013
Brown fat in a protoendothermic mammal fuels eutherian evolution
Oelkrug, R., Goetze, N., Exner, C., Lee, Y., Ganjam, G. K., Kutschke, M., Müller, S., Stöhr, S., Tschöp, M. H., Crichton, P. G., Heldmaier, G., Jastroch, M. & Meyer, C. W., 16 Jul 2013, In: Nature Communications. 4, 2140.Research output: Contribution to journal › Article › peer-review
Open AccessFile63 Citations (Scopus)15 Downloads (Pure) -
Lipid, detergent, and coomassie blue G-250 affect the migration of small membrane proteins in blue native gels: Mitochondrial carriers migrate as monomers not dimers
Crichton, P. G., Harding, M., Ruprecht, J. J., Lee, Y. & Kunji, E. R. S., 26 Jul 2013, In: Journal of Biological Chemistry. 288, 30, p. 22163-22173 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Citations (Scopus)36 Downloads (Pure) -
2010
Mitochondrial carriers function as monomers
Kunji, E. R. S. & Crichton, P. G., Jun 2010, In: Biochimica Et Biophysica Acta-Bioenergetics. 1797, 6-7, p. 817-831 15 p.Research output: Contribution to journal › Article › peer-review
77 Citations (Scopus) -
Mutagenesis of the Sauromatum guttatum alternative oxidase reveals features important for oxygen binding and catalysis
Crichton, P. G., Albury, M. S., Affourtit, C. & Moore, A. L., Jun 2010, In: Biochimica Et Biophysica Acta-Bioenergetics. 1797, 6-7, p. 732-737 6 p.Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus) -
Not all mitochondrial carrier proteins support permeability transition pore formation: no involvement of uncoupling protein 1
Crichton, P. G., Parker, N., Vidal-Puig, A. J. & Brand, M. D., 1 Jun 2010, In: Bioscience Reports. 30, 3, p. 187-192 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)22 Downloads (Pure) -
2009
Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria
Parker, N., Crichton, P. G., Vidal-Puig, A. J. & Brand, M. D., Aug 2009, In: Journal of Bioenergetics and Biomembranes. 41, 335.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)17 Downloads (Pure) -
2008
Compelling EPR evidence that the alternative oxidase is a diiron carboxylate protein
Moore, A. L., Carré, J. E., Affourtit, C., Albury, M. S., Crichton, P. G., Kita, K. & Heathcote, P., Apr 2008, In: Biochimica Et Biophysica Acta-Bioenergetics. 1777, 4, p. 327-330 4 p.Research output: Contribution to journal › Article › peer-review
Open Access49 Citations (Scopus) -
2007
Identification of a mitochondrial alcohol dehydrogenase in Schizosaccharomyces pombe: new insights into energy metabolism
Crichton, P. G., Affourtit, C. & Moore, A. L., 15 Jan 2007, In: Biochemical Journal. 401, 2, p. 459-464 6 p.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Novel Uncoupling Proteins
Affourtit, C., Crichton, P. G., Parker, N. & Brand, M. D., 5 Oct 2007, Mitochondrial Biology: New Perspectives: Novartis Foundation Symposium 287. Chadwick, D. J. & Goode, J. (eds.). Wiley, Vol. 287. p. 70-80 11 p. (Novartis Foundation Symposia).Research output: Chapter in Book/Report/Conference proceeding › Chapter
3 Citations (Scopus) -
2006
‘Green’ …yet wasting energy? - mitochondrial respiration in plants
Moore, A. L., Albury, M. S. & Crichton, P. G., Aug 2006, In: The Biochemist. 28, 4, p. 13-16 4 p.Research output: Contribution to journal › Article
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2005
Constitutive activity of Sauromatum guttatum alternative oxidase in Schizosaccharomyces pombe implicates residues in addition to conserved cysteines in α-keto acid activation
Crichton, P. G., Affourtit, C., Albury, M. S., Carré, J. E. & Moore, A. L., 17 Jan 2005, In: FEBS Letters. 579, 2, p. 331-336 6 p.Research output: Contribution to journal › Article › peer-review
39 Citations (Scopus) -
2002
Exploring the molecular nature of alternative oxidase regulation and catalysis
Affourtit, C., Albury, M. S., Crichton, P. G. & Moore, A. L., 16 Jan 2002, In: FEBS Letters. 510, 3, p. 121-126 6 p.Research output: Contribution to journal › Article › peer-review
116 Citations (Scopus) -
Function of the alternative oxidase: Is it still a scavenger?
Moore, A. L., Albury, M. S., Crichton, P. G. & Affourtit, C., 1 Nov 2002, In: Trends in Plant Science. 7, 11, p. 478-481 4 p.Research output: Contribution to journal › Article › peer-review
167 Citations (Scopus) -
Structure of the plant alternative oxidase: Site-directed mutagenesis provides new information on the active site and membrane topology
Albury, M. S., Affourtit, C., Crichton, P. G. & Moore, A. L., 11 Jan 2002, In: Journal of Biological Chemistry. 277, p. 1190-1194 5 p.Research output: Contribution to journal › Article › peer-review
63 Citations (Scopus)